WO2005060361A3 - Pharmaceutical formulations for itraconazole - Google Patents

Pharmaceutical formulations for itraconazole Download PDF

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Publication number
WO2005060361A3
WO2005060361A3 PCT/KR2004/003422 KR2004003422W WO2005060361A3 WO 2005060361 A3 WO2005060361 A3 WO 2005060361A3 KR 2004003422 W KR2004003422 W KR 2004003422W WO 2005060361 A3 WO2005060361 A3 WO 2005060361A3
Authority
WO
WIPO (PCT)
Prior art keywords
itraconazole
pharmaceutical formulations
pharmaceutical composition
block copolymer
relates
Prior art date
Application number
PCT/KR2004/003422
Other languages
French (fr)
Other versions
WO2005060361A2 (en
Inventor
Hye-Jeong Yoon
Min Hyo Seo
Jeong-Kyung Kim
Original Assignee
Samyang Corp
Hye-Jeong Yoon
Min Hyo Seo
Jeong-Kyung Kim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp, Hye-Jeong Yoon, Min Hyo Seo, Jeong-Kyung Kim filed Critical Samyang Corp
Publication of WO2005060361A2 publication Critical patent/WO2005060361A2/en
Publication of WO2005060361A3 publication Critical patent/WO2005060361A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to a pharmaceutical composition containing as an active ingredient, itraconazole. More particularly, the present invention relates to the pharmaceutical composition comprising itraconazole, a polylactic acid derivative, and an amphiphilic block copolymer. The polylactic acid derivative may be combined with a metal ion at the carboxylic acid terminal, and the amphiphilic block copolymer forms micelles or nano-particles in an aqueous medium.
PCT/KR2004/003422 2003-12-23 2004-12-23 Pharmaceutical formulations for itraconazole WO2005060361A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2003-0095349 2003-12-23
KR1020030095349A KR20050064075A (en) 2003-12-23 2003-12-23 Pharmaceutical formulations for itraconazole

Publications (2)

Publication Number Publication Date
WO2005060361A2 WO2005060361A2 (en) 2005-07-07
WO2005060361A3 true WO2005060361A3 (en) 2005-09-15

Family

ID=34709248

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2004/003422 WO2005060361A2 (en) 2003-12-23 2004-12-23 Pharmaceutical formulations for itraconazole

Country Status (2)

Country Link
KR (2) KR20050064075A (en)
WO (1) WO2005060361A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009513321A (en) * 2005-10-26 2009-04-02 スティッチング ダッチ ポリマー インスティテュート Unimolecular micelles containing metal nanoparticles and their use as catalysts for the synthesis of carbon-carbon bonds
KR100858508B1 (en) * 2005-12-23 2008-09-12 주식회사 삼양사 Composition comprising azole antifungal drug and a preparation process thereof
CN101444510B (en) * 2008-12-31 2011-03-09 南京卡文迪许生物工程技术有限公司 Pharmaceutical preparation containing voriconazole and preparation method thereof
KR101267813B1 (en) * 2009-12-30 2013-06-04 주식회사 삼양바이오팜 An injectable composition comprising polymeric nanoparticles containing rapamycin with an improved water solubility and a method for preparing the same, and an anticancer composition comprising the same for a combination therapy with radiation
WO2015151952A1 (en) * 2014-03-31 2015-10-08 株式会社 島津製作所 Process for producing nanoparticles
KR102184768B1 (en) * 2018-12-31 2020-11-30 중앙대학교 산학협력단 Composition for mixed polymeric micelles and use thereof
CN111888523A (en) * 2020-09-08 2020-11-06 尹振宇 Preparation method of polylactic acid gel for improving skin

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0605933A1 (en) * 1992-12-24 1994-07-13 PHARMATECH GmbH Process for preparing pseudo-latices and micro- or nanoparticles and compositions containing them
US6365173B1 (en) * 1999-01-14 2002-04-02 Efrat Biopolymers Ltd. Stereocomplex polymeric carriers for drug delivery
JP2002138036A (en) * 2000-08-24 2002-05-14 Santen Pharmaceut Co Ltd System for controlling drug release
WO2002045689A1 (en) * 2000-12-07 2002-06-13 Samyang Corporation Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof
WO2003033592A1 (en) * 2001-10-18 2003-04-24 Samyang Corporation Polymeric micelle composition with improved stability
WO2003033593A1 (en) * 2001-10-18 2003-04-24 Samyang Corporation Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0605933A1 (en) * 1992-12-24 1994-07-13 PHARMATECH GmbH Process for preparing pseudo-latices and micro- or nanoparticles and compositions containing them
US6365173B1 (en) * 1999-01-14 2002-04-02 Efrat Biopolymers Ltd. Stereocomplex polymeric carriers for drug delivery
JP2002138036A (en) * 2000-08-24 2002-05-14 Santen Pharmaceut Co Ltd System for controlling drug release
WO2002045689A1 (en) * 2000-12-07 2002-06-13 Samyang Corporation Compositions for sustained delivery of hydrophobic drugs and process for the preparation thereof
WO2003033592A1 (en) * 2001-10-18 2003-04-24 Samyang Corporation Polymeric micelle composition with improved stability
WO2003033593A1 (en) * 2001-10-18 2003-04-24 Samyang Corporation Ph responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery

Also Published As

Publication number Publication date
KR100834148B1 (en) 2008-06-02
KR20050064075A (en) 2005-06-29
WO2005060361A2 (en) 2005-07-07
KR20060129289A (en) 2006-12-15

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