WO2005059929A3 - Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes - Google Patents

Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes Download PDF

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Publication number
WO2005059929A3
WO2005059929A3 PCT/US2004/042022 US2004042022W WO2005059929A3 WO 2005059929 A3 WO2005059929 A3 WO 2005059929A3 US 2004042022 W US2004042022 W US 2004042022W WO 2005059929 A3 WO2005059929 A3 WO 2005059929A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic particles
rod devices
tip
electromagnetic rod
electromagnetic
Prior art date
Application number
PCT/US2004/042022
Other languages
French (fr)
Other versions
WO2005059929A2 (en
Inventor
Xing-Xiang Li
Tianxin Wang
Original Assignee
Xing-Xiang Li
Tianxin Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xing-Xiang Li, Tianxin Wang filed Critical Xing-Xiang Li
Publication of WO2005059929A2 publication Critical patent/WO2005059929A2/en
Publication of WO2005059929A3 publication Critical patent/WO2005059929A3/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F7/00—Magnets
    • H01F7/06—Electromagnets; Actuators including electromagnets
    • H01F7/20—Electromagnets; Actuators including electromagnets without armatures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use

Abstract

Disclosed herein are electromagnetic rod devices, systems and methods using the same, for manipulating magnetic particles within a fluid sample well to facilitate processing the magnetic particles for detection of analytes bound thereto. The electromagnetic rods are used to transfer magnetic particles between different sample wells in a multi-step analyte detection procedure and /or to facilitate washing of the magnetic particles within a sample well. The electromagnetic rod devices include an upper portion, and a lower portion configured as a tip or configured to engage a disposable tip sheath. Magnetic particles are alternatively engaged and disengaged with the surface of the tip or the tip sheath by turning the electromagnet on and off at selected times. The electromagnetic rod devices may optionally be configured with an actuator assembly to move the electromagnetic rod devices vertically and/or horizontally in an instrument system configured for performing biological assays.
PCT/US2004/042022 2003-12-12 2004-12-13 Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes WO2005059929A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52926103P 2003-12-12 2003-12-12
US60/529,261 2003-12-12

Publications (2)

Publication Number Publication Date
WO2005059929A2 WO2005059929A2 (en) 2005-06-30
WO2005059929A3 true WO2005059929A3 (en) 2005-08-04

Family

ID=34699957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/042022 WO2005059929A2 (en) 2003-12-12 2004-12-13 Magnetic rod apparatus and method for manipulating magnetic particles for detecting analytes

Country Status (1)

Country Link
WO (1) WO2005059929A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9329194B2 (en) 2007-11-05 2016-05-03 Abbott Laboratories Automated analyzer for clinical laboratory

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GB0715171D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
GB0715170D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
WO2009039437A1 (en) 2007-09-20 2009-03-26 Magarray, Inc. Analyte detection with magnetic sensors
US8691149B2 (en) * 2007-11-06 2014-04-08 Abbott Laboratories System for automatically loading immunoassay analyzer
EP2255183B1 (en) * 2008-01-25 2013-10-02 Luminex Corporation Assay preparation plates, fluid assay preparation and analysis systems, and methods for preparing and analyzing assays
KR20120032255A (en) * 2010-09-28 2012-04-05 삼성전자주식회사 Cell separation device and cell separation method using magnetic force
JP6101215B2 (en) * 2011-03-09 2017-03-22 マグアレイ，インコーポレイテッド System and method for high-throughput detection of analytes in a sample
EP2948466A4 (en) * 2013-01-25 2016-10-05 Douglas Scient Llc Silica-based biological material isolation
CN104087508B (en) * 2014-07-18 2016-04-13 东南大学 A kind of electromagnetic type biological specimen treatment unit
CN104263633B (en) * 2014-09-24 2015-12-09 东南大学 A kind of high-throughput biological specimen treatment unit based on Magneto separate
CN113186098B (en) * 2021-05-28 2024-03-26 宁波康程德诺生物医药有限公司 Integrated lower-opening nucleic acid quick-lifting test tube, quick-lifting detection device and method

Citations (12)

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US3569877A (en) * 1969-07-23 1971-03-09 Sperry Rand Corp High frequency switch
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4152210A (en) * 1971-08-27 1979-05-01 Beecham Group Limited Biologically active materials attached to a ferromagnetic support
US4272510A (en) * 1976-04-26 1981-06-09 Smith Kendall O Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods
US5046468A (en) * 1989-07-27 1991-09-10 Prufrex-Elektro-Apparatebau Inh. Helga Muller, geb./Dutschke Method and system with inductive rotary emitter for the control especially of the ignition timing of internal combustion engines
US5395498A (en) * 1991-11-06 1995-03-07 Gombinsky; Moshe Method for separating biological macromolecules and means therfor
US5567326A (en) * 1994-09-19 1996-10-22 Promega Corporation Multisample magnetic separation device
US5647994A (en) * 1993-06-21 1997-07-15 Labsystems Oy Method and apparatus for separating magnetic particles from a solution
US5921244A (en) * 1997-06-11 1999-07-13 Light Sciences Limited Partnership Internal magnetic device to enhance drug therapy
US6297062B1 (en) * 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
US6716642B1 (en) * 1999-03-15 2004-04-06 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3569877A (en) * 1969-07-23 1971-03-09 Sperry Rand Corp High frequency switch
US4152210A (en) * 1971-08-27 1979-05-01 Beecham Group Limited Biologically active materials attached to a ferromagnetic support
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4272510A (en) * 1976-04-26 1981-06-09 Smith Kendall O Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods
US5046468A (en) * 1989-07-27 1991-09-10 Prufrex-Elektro-Apparatebau Inh. Helga Muller, geb./Dutschke Method and system with inductive rotary emitter for the control especially of the ignition timing of internal combustion engines
US5395498A (en) * 1991-11-06 1995-03-07 Gombinsky; Moshe Method for separating biological macromolecules and means therfor
US5647994A (en) * 1993-06-21 1997-07-15 Labsystems Oy Method and apparatus for separating magnetic particles from a solution
US5567326A (en) * 1994-09-19 1996-10-22 Promega Corporation Multisample magnetic separation device
US6297062B1 (en) * 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
US5921244A (en) * 1997-06-11 1999-07-13 Light Sciences Limited Partnership Internal magnetic device to enhance drug therapy
US6716642B1 (en) * 1999-03-15 2004-04-06 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALENGHAT F.J. ET AL.: "Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 277, 2000, pages 93 - 99, XP002988676 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9329194B2 (en) 2007-11-05 2016-05-03 Abbott Laboratories Automated analyzer for clinical laboratory

Also Published As

Publication number Publication date
WO2005059929A2 (en) 2005-06-30

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