WO2005049801A3 - Dry protein formulation - Google Patents

Dry protein formulation Download PDF

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Publication number
WO2005049801A3
WO2005049801A3 PCT/US2004/038081 US2004038081W WO2005049801A3 WO 2005049801 A3 WO2005049801 A3 WO 2005049801A3 US 2004038081 W US2004038081 W US 2004038081W WO 2005049801 A3 WO2005049801 A3 WO 2005049801A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein formulation
dry protein
aat
unglycosylated
dry composition
Prior art date
Application number
PCT/US2004/038081
Other languages
French (fr)
Other versions
WO2005049801A2 (en
Inventor
Helen L Gibson
Philip J Barr
Philip A Pemberton
Ian C Bathurst
Rajiv Nayar
Mark Manning
Original Assignee
Arriva Pharmaceuticals Inc
Helen L Gibson
Philip J Barr
Philip A Pemberton
Ian C Bathurst
Rajiv Nayar
Mark Manning
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arriva Pharmaceuticals Inc, Helen L Gibson, Philip J Barr, Philip A Pemberton, Ian C Bathurst, Rajiv Nayar, Mark Manning filed Critical Arriva Pharmaceuticals Inc
Publication of WO2005049801A2 publication Critical patent/WO2005049801A2/en
Publication of WO2005049801A3 publication Critical patent/WO2005049801A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds

Abstract

A dry composition, particularly a dry composition comprising unglycosylated alpha 1-antitrypsin (AAT), including, e.g., unglycosylated human AAT, such as recombinant human AAT produced in Saccharomyces cerevisiae (rAAT), and methods of preparing and using the same, are presented.
PCT/US2004/038081 2003-11-14 2004-11-12 Dry protein formulation WO2005049801A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51994603P 2003-11-14 2003-11-14
US60/519,946 2003-11-14

Publications (2)

Publication Number Publication Date
WO2005049801A2 WO2005049801A2 (en) 2005-06-02
WO2005049801A3 true WO2005049801A3 (en) 2006-02-09

Family

ID=34619398

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/038081 WO2005049801A2 (en) 2003-11-14 2004-11-12 Dry protein formulation

Country Status (1)

Country Link
WO (1) WO2005049801A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2496246T3 (en) 2009-11-03 2018-09-28 Grifols Therapeutics Llc Composition, method, and kit for alpha-1 proteinase inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304971A2 (en) * 1982-08-13 1989-03-01 Zymogenetics, Inc. A method of producing a polypeptide having the protease inhibition activity of mammalan alpha-1-antitrypsin
US5346886A (en) * 1993-11-15 1994-09-13 John Lezdey Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304971A2 (en) * 1982-08-13 1989-03-01 Zymogenetics, Inc. A method of producing a polypeptide having the protease inhibition activity of mammalan alpha-1-antitrypsin
US5346886A (en) * 1993-11-15 1994-09-13 John Lezdey Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin

Also Published As

Publication number Publication date
WO2005049801A2 (en) 2005-06-02

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