WO2005048977A3 - Therapeutic foam comprising a sclerosing solution - Google Patents

Therapeutic foam comprising a sclerosing solution Download PDF

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Publication number
WO2005048977A3
WO2005048977A3 PCT/GB2004/004848 GB2004004848W WO2005048977A3 WO 2005048977 A3 WO2005048977 A3 WO 2005048977A3 GB 2004004848 W GB2004004848 W GB 2004004848W WO 2005048977 A3 WO2005048977 A3 WO 2005048977A3
Authority
WO
WIPO (PCT)
Prior art keywords
foam
gas
sclerosing
solution
generated
Prior art date
Application number
PCT/GB2004/004848
Other languages
French (fr)
Other versions
WO2005048977A2 (en
Inventor
David Dakin Iorwerth Wright
Anthony David Harman
Nikki Robinson
Garry Hodges
Adil Kadar
Geoffrey D Moggridge
Liew Hugh Van
Original Assignee
Btg Int Ltd
David Dakin Iorwerth Wright
Anthony David Harman
Nikki Robinson
Garry Hodges
Adil Kadar
Geoffrey D Moggridge
Liew Hugh Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43013737&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005048977(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0326768A external-priority patent/GB0326768D0/en
Priority claimed from GB0422307A external-priority patent/GB0422307D0/en
Priority to EA200600985A priority Critical patent/EA009362B1/en
Priority to CN2004800339138A priority patent/CN1960705B/en
Priority to NZ547265A priority patent/NZ547265A/en
Priority to DK04798566.8T priority patent/DK1694292T4/en
Priority to DE602004022190T priority patent/DE602004022190D1/en
Priority to BRPI0416611A priority patent/BRPI0416611B8/en
Priority to IN7569DEN2014 priority patent/IN2014DN07569A/en
Priority to AU2004290965A priority patent/AU2004290965B2/en
Priority to KR1020067012055A priority patent/KR101172081B1/en
Priority to CA2546232A priority patent/CA2546232C/en
Priority to US10/522,527 priority patent/US7731986B2/en
Priority to EP04798566.8A priority patent/EP1694292B2/en
Priority to JP2006540586A priority patent/JP4988353B2/en
Application filed by Btg Int Ltd, David Dakin Iorwerth Wright, Anthony David Harman, Nikki Robinson, Garry Hodges, Adil Kadar, Geoffrey D Moggridge, Liew Hugh Van filed Critical Btg Int Ltd
Priority to SI200431254T priority patent/SI1694292T1/en
Priority to SI200431254A priority patent/SI1694292T2/en
Priority to MXPA06005526A priority patent/MXPA06005526A/en
Priority to ES04798566.8T priority patent/ES2330341T5/en
Priority to PL04798566T priority patent/PL1694292T5/en
Publication of WO2005048977A2 publication Critical patent/WO2005048977A2/en
Priority to IL175672A priority patent/IL175672A/en
Priority to EC2006006574A priority patent/ECSP066574A/en
Priority to NO20062866A priority patent/NO20062866L/en
Publication of WO2005048977A3 publication Critical patent/WO2005048977A3/en
Priority to HK07101977.8A priority patent/HK1094943A1/en
Priority to US12/765,980 priority patent/US8323677B2/en
Priority to US13/667,296 priority patent/US8734833B2/en
Priority to US14/248,715 priority patent/US20140221501A1/en
Priority to US14/708,096 priority patent/US10472100B2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00008—Vein tendon strippers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B17/00491—Surgical glue applicators
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    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
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    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/155—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by gas introduced into the reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/235—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids for making foam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
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    • B01F25/452—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4523—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through sieves, screens or meshes which obstruct the whole diameter of the tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
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    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
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Abstract

A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof . The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed. *
PCT/GB2004/004848 2003-11-17 2004-11-17 Therapeutic foam comprising a sclerosing solution WO2005048977A2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
EP04798566.8A EP1694292B2 (en) 2003-11-17 2004-11-17 Therapeutic foam comprising a sclerosing solution and a low quantity of gaseous nitrogen
ES04798566.8T ES2330341T5 (en) 2003-11-17 2004-11-17 Therapeutic foam comprising a sclerosing solution and a low amount of gaseous nitrogen
PL04798566T PL1694292T5 (en) 2003-11-17 2004-11-17 Therapeutic foam comprising a sclerosing solution and a low quanitiy of gaseous nitrogen
SI200431254A SI1694292T2 (en) 2003-11-17 2004-11-17 Therapeutic foam comprising a sclerosing solution and a low quanitiy of gaseous nitrogen
SI200431254T SI1694292T1 (en) 2003-11-17 2004-11-17 Therapeutic foam comprising a sclerosing solution and a low quanitiy of gaseous nitrogen
DK04798566.8T DK1694292T4 (en) 2003-11-17 2004-11-17 Therapeutic foam comprising a sclerosing solution and a low amount of gaseous nitrogen
CN2004800339138A CN1960705B (en) 2003-11-17 2004-11-17 Therapeutic foam
BRPI0416611A BRPI0416611B8 (en) 2003-11-17 2004-11-17 foam comprising a liquid phase and a gas phase
IN7569DEN2014 IN2014DN07569A (en) 2003-11-17 2004-11-17
AU2004290965A AU2004290965B2 (en) 2003-11-17 2004-11-17 Therapeutic foam
KR1020067012055A KR101172081B1 (en) 2003-11-17 2004-11-17 Therapeutic foam
CA2546232A CA2546232C (en) 2003-11-17 2004-11-17 Therapeutic foam
US10/522,527 US7731986B2 (en) 2003-11-17 2004-11-17 Therapeutic foam
MXPA06005526A MXPA06005526A (en) 2003-11-17 2004-11-17 Therapeutic foam.
JP2006540586A JP4988353B2 (en) 2003-11-17 2004-11-17 Therapeutic form
EA200600985A EA009362B1 (en) 2003-11-17 2004-11-17 Therapeutic foam
NZ547265A NZ547265A (en) 2003-11-17 2004-11-17 Therapeutic foam
DE602004022190T DE602004022190D1 (en) 2003-11-17 2004-11-17 THERAPEUTIC FOAM WITH A SCLEROSING SOLUTION AND A LOW CONTENT OF GASEOUS NITROGEN
EC2006006574A ECSP066574A (en) 2003-11-17 2006-05-16 THERAPEUTIC FOAM
IL175672A IL175672A (en) 2003-11-17 2006-05-16 Therapeutic foam
NO20062866A NO20062866L (en) 2003-11-17 2006-06-19 Therapeutic foam
HK07101977.8A HK1094943A1 (en) 2003-11-17 2007-02-21 Therapeutic foam comprising a sclerosing solution and a low quantity of gaseous nitrogen
US12/765,980 US8323677B2 (en) 2003-11-17 2010-04-23 Therapeutic foam
US13/667,296 US8734833B2 (en) 2003-11-17 2012-11-02 Therapeutic foam
US14/248,715 US20140221501A1 (en) 2003-11-17 2014-04-09 Therapeutic foam
US14/708,096 US10472100B2 (en) 2003-11-17 2015-05-08 Therapeutic foam

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0326768.9 2003-11-17
GB0326768A GB0326768D0 (en) 2003-11-17 2003-11-17 Generation of therapeutic microfoam
US54286604P 2004-02-10 2004-02-10
US54286704P 2004-02-10 2004-02-10
US60/542,866 2004-02-10
US60/542,867 2004-02-10
GB0422307.9 2004-10-07
GB0422307A GB0422307D0 (en) 2004-10-07 2004-10-07 Generation and delivery of therapeutic microfoam

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/522,527 A-371-Of-International US7731986B2 (en) 2003-11-17 2004-11-17 Therapeutic foam
US12/765,980 Continuation US8323677B2 (en) 2003-11-17 2010-04-23 Therapeutic foam

Publications (2)

Publication Number Publication Date
WO2005048977A2 WO2005048977A2 (en) 2005-06-02
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Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9912356D0 (en) * 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
GB0028692D0 (en) * 2000-11-24 2001-01-10 Btg Int Ltd Generation of therapeutic microform
US8512680B2 (en) * 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
US8048439B2 (en) * 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
CA2546232C (en) * 2003-11-17 2012-12-18 Btg International Limited Therapeutic foam
ITMI20041056A1 (en) * 2004-05-26 2004-08-26 Garrido Antonio Luis Cabrera USE IN THE DIAGNOSTIC MEDICAL FIELD AND LOGICAL FLEBUS OF A KISCELA OF STERILE AND PHYSIOLOGICALLY ACCEPTABLE GASES
GB0509845D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Preparation of therapeutic foam
GB0509824D0 (en) * 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
GB0509819D0 (en) * 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
WO2006120469A2 (en) * 2005-05-13 2006-11-16 Btg International Limited Therapeutic sclerosing foam made preferably xenon
DK1945533T3 (en) 2005-10-21 2011-08-08 Btg Int Ltd aerosol valve
US20080243068A1 (en) * 2005-12-29 2008-10-02 Kamal Ramzipoor Methods and apparatus for treatment of venous insufficiency
AU2013213741B2 (en) * 2006-01-17 2016-01-28 Baxter Healthcare Sa Device, system and method for mixing
US20090038701A1 (en) 2006-01-17 2009-02-12 Baxter International Inc. Device, system and method for mixing
CN101370433B (en) * 2006-01-17 2012-08-08 巴克斯特国际公司 Device, system and method for mixing
US9486594B2 (en) 2006-11-27 2016-11-08 Frank Levy Portable medical gas delivery system
US20100101579A1 (en) * 2006-11-27 2010-04-29 Frank Levy Portable Medical Gas Delivery System
US9662435B2 (en) 2006-01-31 2017-05-30 Frank Levy System and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid
US8876749B2 (en) 2006-11-27 2014-11-04 Frank Levy Apparatus and process for producing CO2 enriched medical foam
WO2007114934A2 (en) 2006-04-04 2007-10-11 Vnus Medical Technologies, Inc. Method and apparatus for generating vascular treatment foam
WO2008063222A2 (en) * 2006-05-11 2008-05-29 Dentsply International Inc. Aerosol delivery system for dispensing dental compositions
ES2289947B1 (en) * 2006-07-25 2009-02-16 Universidade De Santiago De Compostela MICROESPUMA CLOSING WITH CO2, PREPARATION DEVICE AND ITS APPLICATIONS.
US10149935B2 (en) 2006-11-27 2018-12-11 Frank Levy Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid
US11185671B2 (en) 2006-11-27 2021-11-30 Frank Levy Apparatus and process for producing CO2 enriched medical foam
US10350399B2 (en) 2006-11-27 2019-07-16 Frank Levy Apparatus and method for producing an enriched medical suspension of carbon dioxide
US9427522B2 (en) 2006-11-27 2016-08-30 Frank Levy Delivery system for the effective and reliable delivery of controlled amounts of a medical fluid
US10155093B2 (en) 2006-11-27 2018-12-18 Frank Levy Apparatus and method for producing CO2 enriched medical foam
US11833320B2 (en) 2006-11-27 2023-12-05 Frank Levy Apparatus and process for producing CO2 enriched medical foam
US20190070397A1 (en) * 2006-11-27 2019-03-07 Frank Levy Apparatus and method for producing co2 enriched medical foam
US11712510B2 (en) 2006-11-27 2023-08-01 Frank Levy Delivery system and method for the effective, reliable and foolproof delivery of controlled amounts of a medical fluid
US10322271B2 (en) 2006-11-27 2019-06-18 Frank Levy Delivery system and method for the effective and reliable delivery of controlled amounts of a medical fluid
US20080140002A1 (en) * 2006-12-06 2008-06-12 Kamal Ramzipoor System for delivery of biologically active substances with actuating three dimensional surface
PL2125322T3 (en) 2006-12-21 2013-08-30 Btg Int Ltd Device and method for producing therapeutic foam
JP5230023B2 (en) * 2007-01-25 2013-07-10 ハイパーブランチ メディカル テクノロジー， インコーポレイテッド Applicators and methods of use for multi-component formulations, etc.
US8596859B2 (en) * 2007-11-08 2013-12-03 Nexmed Holdings, Inc. Device and system for mixing and dispensing components stored separately from one another
US8753670B2 (en) 2008-03-26 2014-06-17 Baxter International Inc. Fibrin foam and process
US8512740B2 (en) 2008-03-26 2013-08-20 Baxter International Inc. Fibrin foam and process for making
CN102159141B (en) * 2008-09-22 2014-10-15 药物混合系统股份公司 Connector having mixing element for discharge arrangement
US8560968B1 (en) * 2009-03-26 2013-10-15 Vinod Nair Method and apparatus for evaluating a heart patient
US8376989B2 (en) * 2009-03-30 2013-02-19 Covidien Lp Compartmented syringe
EP2475308A1 (en) * 2009-09-08 2012-07-18 Baxter International Inc Reconstitution and applicator system for wound sealant product
US20110082340A1 (en) * 2009-10-07 2011-04-07 Tyco Healthercare Group LP Foam collar for surgical access devices
US8641661B2 (en) 2010-01-05 2014-02-04 Baxter International Inc. Mixing system, kit and mixer adapter
EP2384703A1 (en) * 2010-05-05 2011-11-09 Bioadhesives Meditech Solutions, S.L. Device for dispensing a two-component tissue adhesive or sealant
JP5993853B2 (en) * 2010-08-06 2016-09-14 ホスピラ・オーストラリア・プロプライエタリー・リミテツド Vial preparation method and system
US9737662B2 (en) * 2011-11-07 2017-08-22 Battelle Memorial Institute Processes for delivery of viscous drug therapies
US9937317B2 (en) * 2012-01-30 2018-04-10 Ipsumpro, S.L. Modified medical syringe with a flow regulator for the administration of local anaesthetic
CN204395138U (en) * 2012-04-09 2015-06-17 贝克顿·迪金森公司 For the induction system of point medicine
ES2843482T3 (en) * 2012-04-24 2021-07-19 Angioclinic Ag Composition to treat venous insufficiency and varicose veins
US8968449B2 (en) * 2012-07-04 2015-03-03 Vki Technologies Inc. Spout, system, and method for producing a foam
WO2014031150A1 (en) * 2012-08-24 2014-02-27 St. Jude Medical Puerto Rico Llc Sealant storage, preparation, and delivery systems and related methods
EP2722008B1 (en) * 2012-10-16 2018-01-17 Erbe Elektromedizin GmbH Nozzle for feeding of biological material, in particular cells, medical device having such a nozzle, use of a nozzle, method for mixing fluids and apparatus
DK2925391T3 (en) * 2012-11-30 2017-08-28 Unitract Syringe Pty Ltd COMBINING Piston Device for Dual Chamber Mixer
CA2906026A1 (en) * 2013-03-15 2014-09-18 Arsenal Medical, Inc. Systems and methods for the treatment of aneurysms
JP6171013B2 (en) * 2013-07-08 2017-07-26 テルモ株式会社 Applicator
AU2014361291B2 (en) 2013-12-11 2017-11-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US10000009B2 (en) * 2014-02-05 2018-06-19 Nathan Christopher Maier Sterile environment for additive manufacturing
EP3108846B1 (en) * 2014-02-19 2021-06-23 J. Morita Manufacturing Corporation Medical instrument element
WO2015153828A1 (en) 2014-04-04 2015-10-08 Hyperbranch Medical Technology, Inc. Extended tip spray applicator for two-component surgical selant, and methods of use thereof
US9861752B2 (en) 2014-04-18 2018-01-09 Covidien Lp Mixing nozzle
EP3131475A1 (en) 2014-04-18 2017-02-22 Covidien LP Mixing syringe
EP3151951B8 (en) 2014-06-03 2020-08-05 Vascular Barcelona Devices, S.L. Methods, devices, systems and kits for preparing compositions for care and repair of varicose veins
EP2962681A1 (en) * 2014-07-03 2016-01-06 Swiss VX Venentherapie und Forschung GmbH Devices and methods for injectable vascular sclerofoams using a carrier made of human blood and uses thereof
ES2763098T3 (en) * 2014-08-05 2020-05-27 Coop Goizper S Pressure spraying device
US9687455B2 (en) 2014-08-14 2017-06-27 John Daniel Dobak Sodium tetradecyl sulfate formulations for treatment of adipose tissue
US9351945B1 (en) * 2015-02-27 2016-05-31 John Daniel Dobak, III Reduction of adipose tissue
US20170014569A1 (en) * 2015-07-14 2017-01-19 Boston Scientific Scimed, Inc. Gel delivery catheters, systems, and methods
US11415019B2 (en) 2015-12-11 2022-08-16 General Electric Company Meta-stable detergent based foam cleaning system and method for gas turbine engines
EP3251654A1 (en) * 2016-05-30 2017-12-06 Chemische Fabrik Kreussler & Co. Gmbh Nonionic surfactants for reduction of adipose tissue
GB201612925D0 (en) * 2016-07-26 2016-09-07 Provensis Ltd Method and device for generating injectable foam
GB201612948D0 (en) * 2016-07-26 2016-09-07 Provensis Ltd syringe for administering foam
IL248775A0 (en) * 2016-11-06 2017-02-28 Technion Res & Dev Foundation Foam for pulmonary drug delivery
GB201703299D0 (en) * 2017-03-01 2017-04-12 Triple Line Tech Ltd Apparatus and method for generating a microfoam
CN110612096A (en) * 2017-03-27 2019-12-24 苏州医本生命科技有限公司 Chain medicine structure and preparation facilities and storage device thereof
RU2659632C1 (en) * 2017-04-04 2018-07-03 Федеральное государственное бюджетное образовательное учреждение высшего образования "Рязанский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации Device for foaming and administering a medicament
AU2018313859A1 (en) * 2017-08-08 2020-02-27 Tetrous, Inc. Therapeutic gas infused cosmetic and methods of infusion
US10786433B2 (en) * 2017-09-13 2020-09-29 William J Moore Buffering agent cartridge
JP2019074486A (en) * 2017-10-19 2019-05-16 大陽日酸株式会社 Method and device for analyzing nitrogen gas in carbon dioxide gas
EP3758772A4 (en) 2018-04-06 2021-12-15 Frank Levy Apparatus and method for producing an enriched medical suspension
RU2693344C1 (en) * 2018-07-05 2019-07-02 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский государственный медико-стоматологический университет имени А.И. Евдокимова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО МГМСУ имени А.И. Евдокимова Минздрава России) Method of sclerotherapy of micropenny arteriovenous malformations of patient's maxillofacial area under ultrasound control
EP3840867B1 (en) * 2018-08-21 2022-01-05 Vascular Barcelona Devices, S.L. Methods, devices, systems and kits for preparing compositions for care and repair of varicose veins
US11517527B2 (en) * 2018-11-05 2022-12-06 Ethicon, Inc. Systems, devices and methods for making and expressing foam used in medical procedures
WO2020231429A1 (en) * 2019-05-10 2020-11-19 Coll Mazzei Jose Vicente New use of a milk frother apparatus and a method for the preparation of a therapeutic foam for the treatment of varicose veins and other medical conditions.
CN110123757B (en) * 2019-05-28 2020-09-01 山东大学齐鲁医院 Ethanol foam hardening agent for treating vascular abnormality and preparation method thereof
EP3756705A1 (en) * 2019-06-27 2020-12-30 Adhesys Medical GmbH Applicator for a two-component tissue adhesive
WO2021043779A1 (en) * 2019-09-02 2021-03-11 Mirai Medical Limited An electroporation apparatus and method
EP3798138A1 (en) * 2019-09-30 2021-03-31 SCHOTT Schweiz AG Device and process for stoppering from below
WO2021113303A1 (en) * 2019-12-03 2021-06-10 Boston Scientific Scimed, Inc. Agent delivery devices
EP4106773A1 (en) * 2020-02-18 2022-12-28 Aviation Works Limited Oxygen/carbon dioxide compositions for medical uses
CN111437504B (en) * 2020-04-28 2022-02-18 山东大学齐鲁医院 Three-way valve for generating stable foam
WO2023022675A1 (en) * 2021-08-19 2023-02-23 Nanortopedi Teknoloji Sanayi Ve Ticaret A.S. Microfluidic injection device and method for use in cartilage repair
CN115708693B (en) * 2022-10-24 2024-02-27 无忧跳动医疗科技(深圳)有限公司 Full-automatic foaming device and method
US11911581B1 (en) 2022-11-04 2024-02-27 Controlled Delivery Systems, Inc. Catheters and related methods for the aspiration controlled delivery of closure agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072821A1 (en) * 1999-05-26 2000-12-07 Btg International Limited Generation of therapeutic microfoam
WO2002041872A1 (en) * 2000-11-24 2002-05-30 Btg International Limited Generation of therapeutic microfoam
WO2004062461A2 (en) * 2003-01-10 2004-07-29 Btg International Limited Therapeutic microfoam

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2630183A (en) * 1950-01-26 1953-03-03 Foutz Clinton Root Apparatus for forming and projecting a foam mixture
US2724383A (en) * 1951-06-28 1955-11-22 Compule Corp Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations
FR1547768A (en) 1967-10-09 1968-11-29 Fillable container with pressure relief device
US3670786A (en) * 1970-06-02 1972-06-20 American Home Prod Container filling apparatus
FR2105332A5 (en) * 1970-09-01 1972-04-28 Oreal
US3767085A (en) * 1971-08-02 1973-10-23 J Cannon Mixing syringe
US3763900A (en) * 1971-09-10 1973-10-09 Milchwirlschaftliche Forschung Process for sterilizing and filling aerosol containers
US3955720A (en) * 1972-11-15 1976-05-11 Malone David C Low pressure dispensing apparatus with air pump
US3970219A (en) * 1975-03-03 1976-07-20 Spitzer Joseph G Aerosol containers for foaming and delivering aerosols and process
US4019657A (en) * 1975-03-03 1977-04-26 Spitzer Joseph G Aerosol containers for foaming and delivering aerosols
US4019357A (en) * 1975-11-10 1977-04-26 Nippon Concrete Industries Co. Ltd. Method of making reinforcements for concrete
US4040420A (en) * 1976-04-22 1977-08-09 General Dynamics Packaging and dispensing kit
US4127131A (en) * 1977-06-20 1978-11-28 Johnson & Johnson Hub assembly for use in the filtration of fluids and method of making the same
FR2445018A1 (en) 1978-12-22 1980-07-18 Anvar ELECTRON MULTIPLIER TUBE WITH AXIAL MAGNETIC FIELD
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4292975A (en) * 1979-08-20 1981-10-06 Carolyn Champion Brassiere
US4358107A (en) * 1980-02-19 1982-11-09 Nissen George P Weight lifting machine
US4292972A (en) * 1980-07-09 1981-10-06 E. R. Squibb & Sons, Inc. Lyophilized hydrocolloio foam
DE3048744A1 (en) 1980-12-23 1982-07-22 Metzeler Kautschuk GmbH, 8000 München Multiple window pane sealed to timber frame - with elastomer strip and sealing cpd. laid in groove of elastomer
DE3050812C2 (en) 1980-12-23 1985-03-21 B. Braun Melsungen Ag, 3508 Melsungen Catheterization device
DE3048774C2 (en) 1980-12-23 1984-03-08 B. Braun Melsungen Ag, 3508 Melsungen Catheterization device
DE3141641A1 (en) 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
US4718433A (en) 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4538920A (en) * 1983-03-03 1985-09-03 Minnesota Mining And Manufacturing Company Static mixing device
DE3313947A1 (en) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3324754A1 (en) 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen ULTRASONIC CONTRASTING AGENTS AND THEIR PRODUCTION
DE3417182A1 (en) 1984-05-09 1985-11-14 Gerald Dr. 8000 München Hauer Syringe set
US4719433A (en) * 1984-09-14 1988-01-12 Siemens Aktiengesellschaft Attenuation bead for the suppression of interference radiation
GB8522813D0 (en) 1985-09-16 1985-10-23 Unilever Plc Package
DE8704600U1 (en) 1987-03-27 1987-10-15 Cocon Kunststoffen B.V., Arkel, Nl
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
DE58908194D1 (en) 1988-02-05 1994-09-22 Schering Ag ULTRASONIC CONTRAST AGENTS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS DIAGNOSTICS AND THERAPEUTICS.
CH676456A5 (en) * 1988-04-05 1991-01-31 Supermatic Kunststoff Ag
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
FR2641202B1 (en) * 1989-01-03 1991-03-15 Poizot Francis FOAM PRODUCTION DEVICE
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5084011A (en) * 1990-01-25 1992-01-28 Grady Daniel J Method for oxygen therapy using hyperbarically oxygenated liquid
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5064103A (en) * 1990-05-23 1991-11-12 Rjs Industries, Inc. Foam dispenser having a plurality of sieves
JP2910784B2 (en) * 1990-09-14 1999-06-23 大和製罐株式会社 Method for producing aerosol cans
AU635449B2 (en) 1990-10-05 1993-03-18 Bracco International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5425580A (en) * 1990-12-28 1995-06-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
ATE123930T1 (en) 1990-12-28 1995-07-15 Byk Gulden Lomberg Chem Fab PHARMACEUTICAL FORM FOR MICROBUBBLES ECHOCONTRAST AGENTS.
DE4100470A1 (en) 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echo contrast agent
FR2672038B1 (en) 1991-01-25 1993-05-14 Oreal FOAM DISPENSING DEVICE FROM A PRESSURIZED CONTAINER.
DE69230885T3 (en) 1991-09-17 2008-01-24 Ge Healthcare As GASOUS ULTRASONIC CONTRASTING AGENTS
DE4301820C2 (en) * 1993-01-23 1996-04-25 Henkel Kgaa Foaming emulsions, processes for their preparation and their use
FR2702196B1 (en) * 1993-03-05 1995-05-12 Oreal Pressure foam dispenser.
NL9300517A (en) 1993-03-23 1994-10-17 Airspray Int Bv Foam forming assembly, a suitable spray head and a spray can comprising such an assembly.
US5695740A (en) 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
ES2068151B1 (en) 1993-06-23 1995-11-16 Cabrera Garrido Juan INJECTABLE MICROS FOAM FOR SCLEROSIS.
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
EP0711179B2 (en) 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilized microbubble compositions for ultrasound
US5454805A (en) * 1994-03-14 1995-10-03 Brony; Seth K. Medicine vial link for needleless syringes
DE4432993C1 (en) 1994-09-16 1996-06-20 Byk Gulden Lomberg Chem Fab Mixing device for agents to be administered by means of a syringe
US5623085A (en) * 1994-09-23 1997-04-22 Rohm And Haas Company Method for reducing microfoam in a spray-applied waterborne composition
WO1996011162A1 (en) * 1994-10-11 1996-04-18 Monson James A Dispensing apparatus for foaming compositions and method
TW319763B (en) 1995-02-01 1997-11-11 Epix Medical Inc
GB9503119D0 (en) 1995-02-17 1995-04-05 Durand Ltd Medication and apparatus and method of applying medication
NL1001366C2 (en) 1995-10-06 1997-04-08 Airspray Int Bv Device for dispensing an air-liquid mixture, in particular foam and operating unit intended for this purpose.
JP2751899B2 (en) 1995-12-15 1998-05-18 ソニー株式会社 Optical pickup device
JPH1081895A (en) 1996-09-05 1998-03-31 Lion Corp Bleaching detergent product
GB9823029D0 (en) 1998-10-22 1998-12-16 Giltech Ltd Packaging system
FR2775433A1 (en) 1998-02-27 1999-09-03 Alain Monfreux DEVICE FOR PRODUCING FOAM IN A SYRINGE BODY
FR2775436A1 (en) 1998-02-27 1999-09-03 Alain Monfreux Syringe for parenteral administration of substance in foam form
FR2784296B1 (en) * 1998-09-18 2001-01-05 Imedex Biomateriaux DEVICE FOR FORMULATING AND DELIVERING A MIXTURE, PARTICULARLY FOR THE SURGICAL APPLICATION OF THIS MIXTURE
DE29819174U1 (en) 1998-10-28 1999-01-28 Vogelsang K Gmbh Protective cap for a two-component paint spray can
ES1043183Y (en) 1999-05-03 2000-04-01 Mingo Fco Javier Garcia DEVICE FOR PRODUCING FOAMED SCLEROSANT.
NL1012419C2 (en) 1999-06-23 2000-12-28 Airspray Nv Aerosol for dispensing a liquid.
US6561237B1 (en) * 2000-11-28 2003-05-13 Brasscorp Ltd. Apparatus and method for urging fluid into a pressurized system
GB2369996B (en) 2000-12-18 2004-06-23 S T D Pharmaceutical Products Method and apparatus for producing an injectable foam
US6592251B2 (en) * 2001-01-26 2003-07-15 Howmedica Osteonics Corp. Cement mixing and dispensing device
DK1424067T3 (en) 2001-08-08 2010-08-30 Dominguez Maria Antonia Garcia-Olmedo Injectable foam and novel pharmaceutical applications thereof
GB0212047D0 (en) * 2002-05-24 2002-07-03 Btg Int Ltd Generation of therapeutic microfoam
DE20218493U1 (en) 2002-11-28 2004-04-08 Chemische Fabrik Kreussler & Co. Gmbh Device for producing medical foam
JP4333186B2 (en) * 2003-04-07 2009-09-16 ソニー株式会社 Communication system and communication lighting device
US8048439B2 (en) * 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
CA2546232C (en) * 2003-11-17 2012-12-18 Btg International Limited Therapeutic foam
GB0509819D0 (en) * 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072821A1 (en) * 1999-05-26 2000-12-07 Btg International Limited Generation of therapeutic microfoam
WO2002041872A1 (en) * 2000-11-24 2002-05-30 Btg International Limited Generation of therapeutic microfoam
WO2004062461A2 (en) * 2003-01-10 2004-07-29 Btg International Limited Therapeutic microfoam

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KR20060127001A (en) 2006-12-11
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EA200600985A1 (en) 2006-10-27
AU2004290965B2 (en) 2011-04-28
EP1791519A2 (en) 2007-06-06
EP1791519B1 (en) 2017-07-19
ES2339117T5 (en) 2019-04-10
IL175672A0 (en) 2006-09-05
PL223344B1 (en) 2016-10-31
WO2005048976A2 (en) 2005-06-02
US7763269B2 (en) 2010-07-27
CA2546076A1 (en) 2005-06-02
DK1701701T3 (en) 2010-05-03
JP2007511312A (en) 2007-05-10
AU2004290957A1 (en) 2005-06-02
BRPI0416611B8 (en) 2021-05-25
JP4988353B2 (en) 2012-08-01
US20100203171A1 (en) 2010-08-12
US20130059923A1 (en) 2013-03-07
US8734833B2 (en) 2014-05-27
JP2007511592A (en) 2007-05-10
KR20060130074A (en) 2006-12-18
PT1694292E (en) 2009-10-26
SI1694292T2 (en) 2017-04-26
AU2004290963A1 (en) 2005-06-02
AU2004290965A1 (en) 2005-06-02
EP1701701B2 (en) 2018-11-28
US20060062736A1 (en) 2006-03-23
CA2546227A1 (en) 2005-06-02
AU2004290959A1 (en) 2005-06-02
CA2546232C (en) 2012-12-18
WO2005048977A2 (en) 2005-06-02
WO2005048984A1 (en) 2005-06-02
NO20062866L (en) 2006-08-11
DE602004022190D1 (en) 2009-09-03
EP1701701A1 (en) 2006-09-20
US20160101881A1 (en) 2016-04-14
US20070104651A1 (en) 2007-05-10
IL175672A (en) 2013-06-27
EP1694292B1 (en) 2009-07-22
EP1684718A1 (en) 2006-08-02
ES2330341T5 (en) 2017-06-21
KR20070005551A (en) 2007-01-10
US20140221501A1 (en) 2014-08-07
US20070003488A1 (en) 2007-01-04
WO2005048976A3 (en) 2006-10-26
SI1694292T1 (en) 2009-12-31
DK1694292T4 (en) 2017-03-06
KR101172081B1 (en) 2012-08-13
PL1694292T3 (en) 2010-01-29
US20060280690A1 (en) 2006-12-14
HK1094943A1 (en) 2007-04-20
IN2014DN07569A (en) 2015-04-24
CZ2006315A3 (en) 2006-10-11
PL1701701T5 (en) 2021-07-26
SI1701701T1 (en) 2010-05-31
ES2339117T3 (en) 2010-05-17
NZ547265A (en) 2010-11-26
MXPA06005526A (en) 2006-08-17
EP1694292B2 (en) 2017-01-04
EP1694292A2 (en) 2006-08-30
EA009362B1 (en) 2007-12-28
ATE453379T2 (en) 2010-01-15
KR20060130075A (en) 2006-12-18
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BRPI0416611A (en) 2007-01-16
ECSP066574A (en) 2006-11-24
CA2546108A1 (en) 2005-06-02
PL1694292T5 (en) 2018-03-30
JP2007511590A (en) 2007-05-10
DK1694292T3 (en) 2009-11-23
CY1110621T1 (en) 2015-04-29
JP2007511591A (en) 2007-05-10
BRPI0416611B1 (en) 2018-03-06
US7731986B2 (en) 2010-06-08
PT1701701E (en) 2010-04-05
EP1701701B1 (en) 2009-12-30
PL380484A1 (en) 2007-02-05
US8323677B2 (en) 2012-12-04
PL1701701T3 (en) 2010-06-30
ES2330341T3 (en) 2009-12-09
CN1960705A (en) 2007-05-09
CA2546232A1 (en) 2005-06-02
WO2005048983A1 (en) 2005-06-02
US10472100B2 (en) 2019-11-12
CN1960705B (en) 2010-11-24

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