WO2005032649A8 - Drug-eluting electrode - Google Patents

Drug-eluting electrode

Info

Publication number
WO2005032649A8
WO2005032649A8 PCT/US2004/032064 US2004032064W WO2005032649A8 WO 2005032649 A8 WO2005032649 A8 WO 2005032649A8 US 2004032064 W US2004032064 W US 2004032064W WO 2005032649 A8 WO2005032649 A8 WO 2005032649A8
Authority
WO
WIPO (PCT)
Prior art keywords
electrode
drug
eluting electrode
electrical conductor
layer adjacent
Prior art date
Application number
PCT/US2004/032064
Other languages
French (fr)
Other versions
WO2005032649A1 (en
Inventor
Christopher P Knapp
Steve Allex
Carolyn Wineland
Original Assignee
Cardiac Pacemakers Inc
Christopher P Knapp
Steve Allex
Carolyn Wineland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiac Pacemakers Inc, Christopher P Knapp, Steve Allex, Carolyn Wineland filed Critical Cardiac Pacemakers Inc
Priority to JP2006534073A priority Critical patent/JP4597133B2/en
Priority to EP04785284A priority patent/EP1670543B1/en
Priority to AT04785284T priority patent/ATE532556T1/en
Publication of WO2005032649A1 publication Critical patent/WO2005032649A1/en
Publication of WO2005032649A8 publication Critical patent/WO2005032649A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/0565—Electrode heads
    • A61N1/0568—Electrode heads with drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

An apparatus includes an electrical lead comprising a lead body and an electrical conductor, and an electrode coupled to the electrical conductor, wherein the electrode includes a coating on at least a portion of the electrode, the coating including two or more layers, with a first layer adjacent the surface of the electrode comprising an insulative material and a second layer adjacent the first layer comprising at least one pharmacological agent.
PCT/US2004/032064 2003-09-30 2004-09-30 Drug-eluting electrode WO2005032649A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2006534073A JP4597133B2 (en) 2003-09-30 2004-09-30 Device equipped with drug eluting electrode and method of manufacturing the device
EP04785284A EP1670543B1 (en) 2003-09-30 2004-09-30 Drug-eluting electrode
AT04785284T ATE532556T1 (en) 2003-09-30 2004-09-30 MEDICINAL ELUTION ELECTRODE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/675,920 US7953499B2 (en) 2003-09-30 2003-09-30 Drug-eluting electrode
US10/675,920 2003-09-30

Publications (2)

Publication Number Publication Date
WO2005032649A1 WO2005032649A1 (en) 2005-04-14
WO2005032649A8 true WO2005032649A8 (en) 2006-05-26

Family

ID=34377311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/032064 WO2005032649A1 (en) 2003-09-30 2004-09-30 Drug-eluting electrode

Country Status (5)

Country Link
US (1) US7953499B2 (en)
EP (1) EP1670543B1 (en)
JP (1) JP4597133B2 (en)
AT (1) ATE532556T1 (en)
WO (1) WO2005032649A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7013182B1 (en) * 2000-05-04 2006-03-14 Cardiac Pacemakers, Inc. Conductive polymer sheath on defibrillator shocking coils
US7953499B2 (en) 2003-09-30 2011-05-31 Cardiac Pacemakers, Inc. Drug-eluting electrode
US20050165452A1 (en) * 2004-01-28 2005-07-28 Medtronic, Inc. Antithrombogenic medical device
US20060024350A1 (en) * 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
WO2006023130A2 (en) * 2004-08-12 2006-03-02 Surmodics, Inc. Biodegradable controlled release bioactive agent delivery device
US7720550B2 (en) * 2004-12-03 2010-05-18 Medtronic, Inc. High impedance active fixation electrode of an electrical medical lead
DE102004062394B4 (en) * 2004-12-23 2008-05-29 Siemens Ag Intravenous pacemaker electrode and process for its preparation
US20060235499A1 (en) 2005-04-14 2006-10-19 Cardiac Pacemakers, Inc. Coated lead fixation electrode
US8175724B2 (en) * 2005-04-26 2012-05-08 Cardiac Pacemakers, Inc. Vascular fixation device
US7477946B2 (en) 2005-04-26 2009-01-13 Cardiac Pacemakers, Inc. Fixation device for coronary venous lead
US20070051531A1 (en) * 2005-09-08 2007-03-08 Harshad Borgaonkar Drug eluting coatings for a medical lead and method therefor
EP1993658B1 (en) * 2006-03-02 2009-10-07 St Jude Medical AB A medical implantable lead and a method for manufacturing of the same
AR059786A1 (en) * 2006-03-09 2008-04-30 Med El Elektromed Geraete Gmbh CONFIGURATION OF COCLEAR IMPLANT ELECTRODE TO ELECT PHARMACOS
US7881808B2 (en) * 2006-03-29 2011-02-01 Cardiac Pacemakers, Inc. Conductive polymeric coating with optional biobeneficial topcoat for a medical lead
DE102006015013B4 (en) * 2006-03-31 2010-06-02 Siemens Ag Implantable pacemaker
US8068921B2 (en) * 2006-09-29 2011-11-29 Vivant Medical, Inc. Microwave antenna assembly and method of using the same
US7813811B2 (en) * 2007-02-08 2010-10-12 Neuropace, Inc. Refillable reservoir lead systems
US7844345B2 (en) * 2007-02-08 2010-11-30 Neuropace, Inc. Drug eluting lead systems
US8000810B2 (en) * 2007-03-20 2011-08-16 Cardiac Pacemakers, Inc. Systems and methods for transvenous lead implantation
US20100106215A1 (en) * 2008-10-23 2010-04-29 Stubbs Scott R Systems and methods to detect implantable medical device configuaration changes affecting mri conditional safety
JP2012509141A (en) * 2008-11-20 2012-04-19 カーディアック ペースメイカーズ， インコーポレイテッド Overmolded parts for implantable medical leads and related methods
EP2385960B1 (en) 2009-01-12 2020-03-11 University Of Massachusetts Lowell Polyisobutylene-based polyurethanes
US9084883B2 (en) 2009-03-12 2015-07-21 Cardiac Pacemakers, Inc. Thin profile conductor assembly for medical device leads
EP2467174B1 (en) 2009-08-21 2018-09-26 Cardiac Pacemakers, Inc. Crosslinkable polyisobutylene-based polymers and medical devices containing the same
US8644952B2 (en) 2009-09-02 2014-02-04 Cardiac Pacemakers, Inc. Medical devices including polyisobutylene based polymers and derivatives thereof
US8753708B2 (en) * 2009-09-02 2014-06-17 Cardiac Pacemakers, Inc. Solventless method for forming a coating on a medical electrical lead body
US8374704B2 (en) 2009-09-02 2013-02-12 Cardiac Pacemakers, Inc. Polyisobutylene urethane, urea and urethane/urea copolymers and medical leads containing the same
WO2011043898A2 (en) * 2009-10-09 2011-04-14 Cardiac Pacemakers, Inc. Mri compatible medical device lead including transmission line notch filters
WO2011049684A1 (en) 2009-10-19 2011-04-28 Cardiac Pacemakers, Inc. Mri compatible tachycardia lead
US9320890B2 (en) * 2009-11-09 2016-04-26 W. L. Gore & Associates, Inc. Drug eluting composite
WO2011081701A1 (en) * 2009-12-30 2011-07-07 Cardiac Pacemakers, Inc. Implantable electrical lead including a cooling assembly to dissipate mri induced electrode heat
JP2013516222A (en) 2009-12-30 2013-05-13 カーディアック ペースメイカーズ， インコーポレイテッド Tapered drug-eluting color for medical electrical leads
WO2011081709A1 (en) 2009-12-30 2011-07-07 Cardiac Pacemakers, Inc. Mri-conditionally safe medical device lead
WO2011081713A1 (en) 2009-12-31 2011-07-07 Cardiac Pacemakers, Inc. Mri conditionally safe lead with multi-layer conductor
US8391994B2 (en) 2009-12-31 2013-03-05 Cardiac Pacemakers, Inc. MRI conditionally safe lead with low-profile multi-layer conductor for longitudinal expansion
US8825181B2 (en) 2010-08-30 2014-09-02 Cardiac Pacemakers, Inc. Lead conductor with pitch and torque control for MRI conditionally safe use
EP2838605A2 (en) 2012-04-20 2015-02-25 Cardiac Pacemakers, Inc. Implantable medical device lead including a unifilar coiled cable
US8954168B2 (en) 2012-06-01 2015-02-10 Cardiac Pacemakers, Inc. Implantable device lead including a distal electrode assembly with a coiled component
EP3156100B1 (en) 2012-08-31 2019-05-01 Cardiac Pacemakers, Inc. Mri compatible lead coil
EP2908903B1 (en) 2012-10-18 2016-08-31 Cardiac Pacemakers, Inc. Inductive element for providing mri compatibility in an implantable medical device lead
EP2922888B1 (en) 2012-11-21 2021-08-18 The University of Massachusetts High strength polyisobutylene polyurethanes
EP3110499B1 (en) 2014-02-26 2018-01-24 Cardiac Pacemakers, Inc. Construction of an mri-safe tachycardia lead
EP3592786B1 (en) 2017-03-07 2023-05-10 Cardiac Pacemakers, Inc. Hydroboration/oxidation of allyl-terminated polyisobutylene
US10835638B2 (en) 2017-08-17 2020-11-17 Cardiac Pacemakers, Inc. Photocrosslinked polymers for enhanced durability
CN111479596B (en) 2018-01-17 2023-04-07 心脏起搏器股份公司 Blocked polyisobutylene polyurethanes
US11083889B2 (en) 2018-01-31 2021-08-10 Medtronic, Inc. Helical fixation member assembly having bi-directional controlled drug release

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37463A (en) * 1863-01-20 Improvement in raking attachments for harvesters
US4280514A (en) * 1975-05-09 1981-07-28 Macgregor David C Endocardial pacemaker electrode
US4281669A (en) * 1975-05-09 1981-08-04 Macgregor David C Pacemaker electrode with porous system
EP0047013B1 (en) * 1980-09-02 1986-01-22 Medtronic, Inc. Subcutaneously implantable lead with drug dispenser means
US4506680A (en) * 1983-03-17 1985-03-26 Medtronic, Inc. Drug dispensing body implantable lead
US4606118A (en) * 1985-02-27 1986-08-19 Medtronic, Inc. Method of making a drug dispensing body
EP0388480A1 (en) * 1989-03-20 1990-09-26 Siemens Aktiengesellschaft Implantable stimulation electrode
US5411527A (en) * 1989-05-03 1995-05-02 Intermedics, Inc. Difibrillation electrodes and implantation
US5002067A (en) * 1989-08-23 1991-03-26 Medtronic, Inc. Medical electrical lead employing improved penetrating electrode
US4953564A (en) * 1989-08-23 1990-09-04 Medtronic, Inc. Screw-in drug eluting lead
US4972848A (en) * 1989-08-23 1990-11-27 Medtronic, Inc. Medical electrical lead with polymeric monolithic controlled release device and method of manufacture
US5003992A (en) * 1989-08-23 1991-04-02 Holleman Timothy W Atraumatic screw-in lead
US5255693A (en) * 1989-11-02 1993-10-26 Possis Medical, Inc. Cardiac lead
US5217028A (en) * 1989-11-02 1993-06-08 Possis Medical, Inc. Bipolar cardiac lead with drug eluting device
US5086787A (en) * 1989-12-06 1992-02-11 Medtronic, Inc. Steroid eluting intramuscular lead
US5009229A (en) * 1989-12-06 1991-04-23 Medtronic, Inc. Steroid eluting intramuscular lead
US5282844A (en) * 1990-06-15 1994-02-01 Medtronic, Inc. High impedance, low polarization, low threshold miniature steriod eluting pacing lead electrodes
US5154183A (en) * 1990-10-01 1992-10-13 Siemens-Pacesetter, Inc. Bipolar myocardial electrode assembly
US5342628A (en) * 1990-10-11 1994-08-30 Applied Medical Research, Inc. Drug diffusion polymer system and method
US5324325A (en) * 1991-06-27 1994-06-28 Siemens Pacesetter, Inc. Myocardial steroid releasing lead
SE9102778D0 (en) 1991-09-25 1991-09-25 Siemens Elema Ab IMPLANT MEDICAL DEVICE
EP0571797B2 (en) * 1992-05-25 2005-10-26 St. Jude Medical AB Heart stimulation apparatus
US5447533A (en) * 1992-09-03 1995-09-05 Pacesetter, Inc. Implantable stimulation lead having an advanceable therapeutic drug delivery system
US5324324A (en) * 1992-10-13 1994-06-28 Siemens Pacesetter, Inc. Coated implantable stimulation electrode and lead
US5423876A (en) * 1993-12-09 1995-06-13 Medtronic, Inc. Intramuscular lead having improved insertion
US5489294A (en) * 1994-02-01 1996-02-06 Medtronic, Inc. Steroid eluting stitch-in chronic cardiac lead
US5522874A (en) * 1994-07-28 1996-06-04 Gates; James T. Medical lead having segmented electrode
US5522875A (en) * 1994-07-28 1996-06-04 Medtronic, Inc. Medical electrical lead system having a torque transfer stylet
US5575814A (en) * 1995-01-27 1996-11-19 Medtronic, Inc. Active fixation medical electrical lead having mapping capability
US5551427A (en) * 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5987746A (en) 1996-02-21 1999-11-23 Medtronic, Inc. Method of making medical electrical lead
US5776178A (en) 1996-02-21 1998-07-07 Medtronic, Inc. Medical electrical lead with surface treatment for enhanced fixation
EP0796634B1 (en) * 1996-03-21 2005-11-16 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Implantable stimulation electrode
US6086582A (en) * 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US6547787B1 (en) * 1997-03-13 2003-04-15 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US6416510B1 (en) * 1997-03-13 2002-07-09 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
US5792140A (en) * 1997-05-15 1998-08-11 Irvine Biomedical, Inc. Catheter having cooled multiple-needle electrode
US6086562A (en) * 1997-10-27 2000-07-11 Sarcos, Inc. Disposable automatic injection device
US6501994B1 (en) * 1997-12-24 2002-12-31 Cardiac Pacemakers, Inc. High impedance electrode tip
US6221425B1 (en) * 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6296630B1 (en) * 1998-04-08 2001-10-02 Biocardia, Inc. Device and method to slow or stop the heart temporarily
US20020138123A1 (en) * 1998-04-21 2002-09-26 Medtronic, Inc. Medical electrical leads and indwelling catheters with enhanced biocompatibility and biostability
US6102887A (en) * 1998-08-11 2000-08-15 Biocardia, Inc. Catheter drug delivery system and method for use
US6546292B1 (en) 1998-11-04 2003-04-08 Gore Enterprise Holdings, Inc. High impedance, low polarization cardiac electrode
US6052625A (en) * 1998-11-09 2000-04-18 Medtronic, Inc. Extractable implantable medical lead
US6263249B1 (en) * 1999-02-26 2001-07-17 Medtronic, Inc. Medical electrical lead having controlled texture surface and method of making same
US6298272B1 (en) * 1999-03-29 2001-10-02 Cardiac Pacemakers, Inc. High impedance electrode tip with internal drug delivery capability
US6253110B1 (en) * 1999-04-27 2001-06-26 Medtronic Inc Method for tissue stimulation and fabrication of low polarization implantable stimulation electrode
US6405091B1 (en) * 1999-07-20 2002-06-11 Pacesetter, Inc. Lead assembly with masked microdisk tip electrode and monolithic controlled release device
US6363286B1 (en) * 1999-09-24 2002-03-26 Cardiac Pacemakers, Inc. High impedance electrode assembly
US6506408B1 (en) * 2000-07-13 2003-01-14 Scimed Life Systems, Inc. Implantable or insertable therapeutic agent delivery device
US6567704B2 (en) * 2000-12-20 2003-05-20 Medtronic, Inc. Medical electrical lead and method of use
US6879861B2 (en) * 2000-12-21 2005-04-12 Medtronic, Inc. Polymeric materials with improved dielectric breakdown strength
US7077859B2 (en) * 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US7187980B2 (en) * 2001-11-09 2007-03-06 Oscor Inc. Cardiac lead with steroid eluting ring
US6985777B2 (en) * 2001-11-26 2006-01-10 Terumo Kabushiki Kaisha Implantable electrode lead
US20030104028A1 (en) * 2001-11-29 2003-06-05 Hossainy Syed F.A. Rate limiting barriers for implantable devices and methods for fabrication thereof
US7953499B2 (en) 2003-09-30 2011-05-31 Cardiac Pacemakers, Inc. Drug-eluting electrode

Also Published As

Publication number Publication date
JP4597133B2 (en) 2010-12-15
US7953499B2 (en) 2011-05-31
EP1670543B1 (en) 2011-11-09
WO2005032649A1 (en) 2005-04-14
JP2007507303A (en) 2007-03-29
US20050070985A1 (en) 2005-03-31
ATE532556T1 (en) 2011-11-15
EP1670543A1 (en) 2006-06-21

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