WO2005031300A3 - Device for detecting biological and chemical particles - Google Patents

Device for detecting biological and chemical particles Download PDF

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Publication number
WO2005031300A3
WO2005031300A3 PCT/US2004/020640 US2004020640W WO2005031300A3 WO 2005031300 A3 WO2005031300 A3 WO 2005031300A3 US 2004020640 W US2004020640 W US 2004020640W WO 2005031300 A3 WO2005031300 A3 WO 2005031300A3
Authority
WO
WIPO (PCT)
Prior art keywords
suspended member
suspended
analyte
cantilever
nano
Prior art date
Application number
PCT/US2004/020640
Other languages
French (fr)
Other versions
WO2005031300A2 (en
Inventor
Dallas Morisette
Rashid Bashir
Amit Kumar Gupta
Oguz H Elibol
Gerold W Neudeck
John P Denton
Original Assignee
Purdue Research Foundation
Dallas Morisette
Rashid Bashir
Amit Kumar Gupta
Oguz H Elibol
Gerold W Neudeck
John P Denton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Dallas Morisette, Rashid Bashir, Amit Kumar Gupta, Oguz H Elibol, Gerold W Neudeck, John P Denton filed Critical Purdue Research Foundation
Priority to CA002530607A priority Critical patent/CA2530607A1/en
Priority to AU2004276725A priority patent/AU2004276725A1/en
Priority to EP04809462A priority patent/EP1651943A2/en
Publication of WO2005031300A2 publication Critical patent/WO2005031300A2/en
Publication of WO2005031300A3 publication Critical patent/WO2005031300A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
    • G01N5/02—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid by absorbing or adsorbing components of a material and determining change of weight of the adsorbent, e.g. determining moisture content
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples

Abstract

An exemplary micro or nano-electromechanical analyte detection device (100, 200, 300, 400, 500, 600, 700, 800, 900) includes a cantilever (106, 108, 110, 140, 208, 302, 320, 402, 502, 602, 604, 902), nano-wire (702, 824), or other suspended member (330) for detecting selected biological or chemical species (132, 304, 618) based on the change in resonant frequency, surface stress, or other characteristic of the suspended member upon interaction of a selected analyte. Dielectrophoresis is utilized to concentrate a selected analyte, for example at the free end (142, 306, 610, 612, 904) of the cantilever or other suspended member. The suspended member may also include a region (404, 510, 824) of a transistor (512), for example a channel of a field affect transistor to provide on chip electronic detection of selected analytes. Integrated devices having an array of suspended members for detecting selected analytes located within a fluid channel (104) are also disclosed as well as methods of use and methods of fabrication of the exemplary integrated devices.
PCT/US2004/020640 2003-06-27 2004-06-28 Device for detecting biological and chemical particles WO2005031300A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002530607A CA2530607A1 (en) 2003-06-27 2004-06-28 Device for detecting biological and chemical particles
AU2004276725A AU2004276725A1 (en) 2003-06-27 2004-06-28 Device for detecting biological and chemical particles
EP04809462A EP1651943A2 (en) 2003-06-27 2004-06-28 Device for detecting biological and chemical particles

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US48327403P 2003-06-27 2003-06-27
US60/483,274 2003-06-27
US55113104P 2004-03-08 2004-03-08
US60/551,131 2004-03-08

Publications (2)

Publication Number Publication Date
WO2005031300A2 WO2005031300A2 (en) 2005-04-07
WO2005031300A3 true WO2005031300A3 (en) 2006-07-13

Family

ID=34396104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/020640 WO2005031300A2 (en) 2003-06-27 2004-06-28 Device for detecting biological and chemical particles

Country Status (4)

Country Link
EP (1) EP1651943A2 (en)
AU (1) AU2004276725A1 (en)
CA (1) CA2530607A1 (en)
WO (1) WO2005031300A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109879238A (en) * 2019-01-15 2019-06-14 江苏大学 Micro-cantilever device, processing method and a kind of detection method of embedded channel-type
JP7371687B2 (en) 2019-06-03 2023-10-31 Ｉ－Ｐｅｘ株式会社 Substance detection system and substance detection method

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2042239A1 (en) * 2007-09-10 2009-04-01 Koninklijke Philips Electronics N.V. Dielectrophoretic device and method for cell membrane studies
US20120164718A1 (en) * 2008-05-06 2012-06-28 Innovative Micro Technology Removable/disposable apparatus for MEMS particle sorting device
US8945912B2 (en) 2008-09-29 2015-02-03 The Board Of Trustees Of The University Of Illinois DNA sequencing and amplification systems using nanoscale field effect sensor arrays
US9250113B2 (en) 2010-06-21 2016-02-02 The Board Of Trustees Of The University Of Illinois Cell mass measurement and apparatus
WO2013169940A2 (en) * 2012-05-09 2013-11-14 California Institute Of Technology Single-protein nanomechanical mass spectrometry in real time
GB2504527A (en) * 2012-08-02 2014-02-05 Rolls Royce Plc Method and apparatus for testing a sample surface
US20140166483A1 (en) * 2012-12-19 2014-06-19 Queen's University At Kingston Electrokinetics-assisted sensor
EP2959274A2 (en) * 2013-02-22 2015-12-30 California Institute of Technology Shape analysis and mass spectrometry of individual molecules by nanomechanical systems
WO2016143719A1 (en) 2015-03-06 2016-09-15 国立研究開発法人物質・材料研究機構 Molecular weight measurement method and molecular weight measurement device
WO2017165852A1 (en) 2016-03-24 2017-09-28 Biological Dynamics, Inc. Disposable fluidic cartridge and components
US10410883B2 (en) 2016-06-01 2019-09-10 Corning Incorporated Articles and methods of forming vias in substrates
US10134657B2 (en) 2016-06-29 2018-11-20 Corning Incorporated Inorganic wafer having through-holes attached to semiconductor wafer
US10794679B2 (en) 2016-06-29 2020-10-06 Corning Incorporated Method and system for measuring geometric parameters of through holes
IL270445B1 (en) 2017-05-08 2024-02-01 Biological dynamics inc Methods and systems for analyte information processing
US10580725B2 (en) 2017-05-25 2020-03-03 Corning Incorporated Articles having vias with geometry attributes and methods for fabricating the same
US11078112B2 (en) 2017-05-25 2021-08-03 Corning Incorporated Silica-containing substrates with vias having an axially variable sidewall taper and methods for forming the same
DE102017114349A1 (en) * 2017-06-28 2019-01-03 Technische Universität Darmstadt Detection system and method for its production
US11731132B2 (en) * 2017-12-19 2023-08-22 Biological Dynamics, Inc. Methods and devices for detection of multiple analytes from a biological sample
CN108279304A (en) * 2017-12-30 2018-07-13 华南农业大学 A kind of viral diagnosis device and its application method
WO2019147525A1 (en) 2018-01-26 2019-08-01 Advanced Electrofluidic Systems, Llc Method and apparatus for isolating and detecting biological and other particles
US11554984B2 (en) 2018-02-22 2023-01-17 Corning Incorporated Alkali-free borosilicate glasses with low post-HF etch roughness
CN117065932A (en) 2018-04-02 2023-11-17 生物动力学公司 Dielectric material
US20210255082A1 (en) * 2020-02-19 2021-08-19 Tdk Corporation Methods and Devices for Detecting Particles Using a Cantilever Sensor
GB2613311A (en) * 2020-08-17 2023-05-31 Univ Braunschweig Tech A sensor system and a method for sensing dielectric particles of biological materials in fluids
WO2022115755A1 (en) * 2020-11-30 2022-06-02 Opteev Technologies, Inc. Systems and processes for detecting aerosolized viral loads
WO2022271882A1 (en) * 2021-06-22 2022-12-29 Northwestern University Multiplexed antigen-based detection of sars-cov-2 and other diseases using nanomechanical sensors
CN115541438B (en) * 2022-12-02 2023-05-02 山东理工职业学院 Portable multi-environment atmospheric environmental pollution detector and use method thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3582690A (en) * 1969-06-09 1971-06-01 Gen Electric Semiconductor strain sensor with controlled sensitivity
US5115292A (en) * 1988-09-02 1992-05-19 Honda Giken Kogyo Kabushiki Kaisha Semiconductor sensor
US5719324A (en) * 1995-06-16 1998-02-17 Lockheed Martin Energy Systems, Inc. Microcantilever sensor
US5807758A (en) * 1995-07-21 1998-09-15 Lee; Gil U. Chemical and biological sensor using an ultra-sensitive force transducer
US6289717B1 (en) * 1999-03-30 2001-09-18 U. T. Battelle, Llc Micromechanical antibody sensor
US6325904B1 (en) * 1997-11-12 2001-12-04 Protiveris, Inc. Nanoelectrode arrays
US20020076825A1 (en) * 2000-10-10 2002-06-20 Jing Cheng Integrated biochip system for sample preparation and analysis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3582690A (en) * 1969-06-09 1971-06-01 Gen Electric Semiconductor strain sensor with controlled sensitivity
US5115292A (en) * 1988-09-02 1992-05-19 Honda Giken Kogyo Kabushiki Kaisha Semiconductor sensor
US5719324A (en) * 1995-06-16 1998-02-17 Lockheed Martin Energy Systems, Inc. Microcantilever sensor
US5807758A (en) * 1995-07-21 1998-09-15 Lee; Gil U. Chemical and biological sensor using an ultra-sensitive force transducer
US6325904B1 (en) * 1997-11-12 2001-12-04 Protiveris, Inc. Nanoelectrode arrays
US6289717B1 (en) * 1999-03-30 2001-09-18 U. T. Battelle, Llc Micromechanical antibody sensor
US20020076825A1 (en) * 2000-10-10 2002-06-20 Jing Cheng Integrated biochip system for sample preparation and analysis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CUI Y ET AL: "Nanowire Nanosensor for Highly Sensitive and Selective Dtection of Biological and Chemical Species.", SCIENCE., vol. 293, 17 August 2001 (2001-08-17), pages 1289 - 1292, XP002264236 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109879238A (en) * 2019-01-15 2019-06-14 江苏大学 Micro-cantilever device, processing method and a kind of detection method of embedded channel-type
JP7371687B2 (en) 2019-06-03 2023-10-31 Ｉ－Ｐｅｘ株式会社 Substance detection system and substance detection method

Also Published As

Publication number Publication date
EP1651943A2 (en) 2006-05-03
AU2004276725A1 (en) 2005-04-07
WO2005031300A2 (en) 2005-04-07
CA2530607A1 (en) 2005-04-07

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