WO2005030046B1 - Devices for vulnerable plaque detection - Google Patents

Devices for vulnerable plaque detection

Info

Publication number
WO2005030046B1
WO2005030046B1 PCT/US2004/031005 US2004031005W WO2005030046B1 WO 2005030046 B1 WO2005030046 B1 WO 2005030046B1 US 2004031005 W US2004031005 W US 2004031005W WO 2005030046 B1 WO2005030046 B1 WO 2005030046B1
Authority
WO
WIPO (PCT)
Prior art keywords
optical
intravascular probe
optical waveguide
ultrasound transducer
sheath
Prior art date
Application number
PCT/US2004/031005
Other languages
French (fr)
Other versions
WO2005030046A1 (en
Inventor
Simon Furnish
Andres Zuluaga
Jay Caplan
Daniel A Mcnulty
Original Assignee
Infraredx Inc
Simon Furnish
Andres Zuluaga
Jay Caplan
Daniel A Mcnulty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infraredx Inc, Simon Furnish, Andres Zuluaga, Jay Caplan, Daniel A Mcnulty filed Critical Infraredx Inc
Priority to JP2006528125A priority Critical patent/JP4972407B2/en
Priority to EP04784743.9A priority patent/EP1667576B1/en
Publication of WO2005030046A1 publication Critical patent/WO2005030046A1/en
Publication of WO2005030046B1 publication Critical patent/WO2005030046B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/445—Details of catheter construction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
    • G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
    • G01S15/899—Combination of imaging systems with ancillary equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy

Abstract

An intravascular probe includes a sheath with a distal portion and a proximal portion. The intravascular probe includes a first optical waveguide extending along the sheath, the first optical waveguide being configured to carry optical radiation between the distal and proximal portions, and a first beam redirector disposed at the distal portion in optical communication with the first optical waveguide. The intravascular probe also includes an optical detector configured to receive optical radiation from the first optical waveguide, and an ultrasound transducer disposed at the distal portion. The ultrasound transducer is configured to couple ultrasound energy between the intravascular probe and a transmission medium. A wire extends along the sheath in electrical communication with the ultrasound transducer.

Claims

AMENDED CLAIMS
[Received by the International Bureau on 25 March 2005 (25.03.2005): originals claims (1-21) replaced by amended claims (1-28) (4 pages)]
1. An intravascular probe comprising: a sheath having a distal portion and a proximal portion; a first optical waveguide extending along the sheath, the first optical waveguide being configured to carry optical radiation between the distal and proximal portions; an optical bench disposed at the distal portion, in which a disial end of the first optical waveguide is seated; a first bεam redirector disposed on the optical bench in optical communication with the first optical waveguide; all optical detector configured to receive optical radiation from the first optical waveguide; an ultrasound transducer disposed at the distal portion and coupled to the optical bench, the ultrasound transducer being configured to couple ultrasound energy between the intravascular probe and a transmission medium; and a wire extending along the sheath in electrical communication with the ultrasound transducer 2. The intravascular probe of claim 1 , further comprising; a second optical waveguide extending along the sheath, the second optical waveguide being configured to carry optical radiation between the distal and proximal portions, and having a distal end seated in the optical bench; a second beam redirector disposed on the optical bench in optical communication with the second optical waveguide. 3. The intravascular probe of claim 2, wherein the second beam redirector is configured to redirect an axlaUy directed bea of optical radiation incident thereon from the second optical waveguide into a beam propagating along a direction having a radial component. 22
4. The intravascular probe of claim 2, further comprising an optical source configured to couple optical radiation into the second optical waveguide. 5. An intravascular probe comprising: a sheath having a distal portion and a proximal portion; a first optical waveguide extending along the sheath, the first optical waveguide being configured to carry optical radiation between the distal and proximal portions; an opτioal bench disposed at the distal portion, in which a distal end of the first optical waveguide is seated; a first beam redirector disposed on the optical bench in optical communication ith the first optical waveguide; a second optical waveguide extending along the sheath, the second optical waveguide being configured to carry optical radiation between the distal and proximal portions, and having a distal end seated in the optical bench; a second beam redirector disposed on the optical bench in optical Communication with the second optical waveguide; an ultrasound transducer disposed at the distal portion and coupled to the optic-lbench., the ultrasound transducer being configured to couple ultrasound energy between the intravascular probe and a transmission medium; and a wire extending along the sheath in electrical communication with the ultrasound transducer. 6. The mtrβvascular probe of claim 5, wherein the first beam redirector is configured to redirect an axially directed beam of optical radiation incident thereon from the first optical waveguide into a beam propagating along a direction having a radial component. 7. The intravascular probe of claim 5, fiirmer comprising an optical detector configured to receive optical radiation from the first optical waveguide.
8. The intravascular probe of claim 5, further comprising an optical source configured to couple optical radiation into the first optical aveguide, 9. The intravascular probe of claim 8, wherein the optical source is configured to emit infrared radiation, 10. The intravascular probe of claim 5, wherein the first optical waveguide comprises an optical fiber. 11. The intravascular probe of claim 5, wherein the first beam redirector comprises an optical reflector. 12. The intravascular probe of claim 5, wherein the first beam redirector comprises a prism. 13. The intravascular probe of claim 5, wherein the first beam redirector comprises a be d in a distal tip of the first optical waveguide. 14. The lntravascular probe of claim 5, wherein the ultrasound transducer comprises a piezoelectric transducer. 15. The intravascular probe of claim 5, wherein the sheath comprises a material that is transparent to infrared radiation, 16. The Intravascular probe of claim 5, wherein the first beam redirector is rigidly connected to the ultrasound transducer. 17. The intravascular probe of claim 5, wherein the first beam redirector Is flexibly connected to the ultrasound transducer. 18. The intravascular probe of claim 5, wherein the first beam redirector is configured to emit light from a first axial location with respect to a longitudinal axis of the sheath, and the ultrasound transducer is configured to emit ultrasound energy from the first axial location. 19. The intravascular probe of claim 5, wherein the first beam redirector is configured to emit light from a first axial location with respect to a longitudinal axis of the sheath, and the ultrasound transducer is configured to emit ultrasound energy from a second axial location different from the first axial location.
24
20. The intravascular probe of claim 5, further comprising a rαtatable cable surrounding the first optical waveguide and the wire, the rotatable cable being configured to coaxlally rotate the first beam redirector and the ultrasound transducer, 2ϊ . The intravascular probe of claim 5, further comprising; a plurality of beam redirectors circumferential ly disposed about a longitudinal axis of the sheath; a plurality of optical waveguides in optical communication with the plurality of beam redirectors; and a plurality of ultrasound transducers circumferentially disposed about the longitudinal axis. 22. The intravascular probe of claim 1 , further comprising a rotatable cable surrounding the first optical waveguide and the wire, the rστaτable cable being configured to coaxially rotate the first beam redirector and the ultrasound transducer. 23. The intravascular probe of claim 22, wherein the optical bench is disposed beyond a distal end of the cable.
24. The intravascular probe of claim 20, wherein the optical bench is disposed beyond a distal end of the cable.
25. The intravascular probe of claim 1 , wherein the ultrasound transducer is rigidly coupled to the optical bench,
26. The intravascular probe of claim 1, wherein the ultrasound transducer is flexibly coupled to the optical bench.
27. The intravascular probe of claim S, herein the ultrasound transducer is rigidly coupled to the optical bench.
28. The intravascular probe of claim S, wherein the ultrasound transducer is flexibly coupled to the optical bench.
25
PCT/US2004/031005 2003-09-22 2004-09-21 Devices for vulnerable plaque detection WO2005030046A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006528125A JP4972407B2 (en) 2003-09-22 2004-09-21 Device for detecting unstable plaque
EP04784743.9A EP1667576B1 (en) 2003-09-22 2004-09-21 Devices for vulnerable plaque detection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/668,012 2003-09-22
US10/668,012 US6949072B2 (en) 2003-09-22 2003-09-22 Devices for vulnerable plaque detection

Publications (2)

Publication Number Publication Date
WO2005030046A1 WO2005030046A1 (en) 2005-04-07
WO2005030046B1 true WO2005030046B1 (en) 2005-06-02

Family

ID=34393402

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/031005 WO2005030046A1 (en) 2003-09-22 2004-09-21 Devices for vulnerable plaque detection

Country Status (4)

Country Link
US (1) US6949072B2 (en)
EP (1) EP1667576B1 (en)
JP (3) JP4972407B2 (en)
WO (1) WO2005030046A1 (en)

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US20050075574A1 (en) 2005-04-07
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WO2005030046A1 (en) 2005-04-07

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