WO2005025449A2 - Cardiovascular stent with anti-platelet and angiogenic material - Google Patents

Cardiovascular stent with anti-platelet and angiogenic material Download PDF

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Publication number
WO2005025449A2
WO2005025449A2 PCT/US2004/029310 US2004029310W WO2005025449A2 WO 2005025449 A2 WO2005025449 A2 WO 2005025449A2 US 2004029310 W US2004029310 W US 2004029310W WO 2005025449 A2 WO2005025449 A2 WO 2005025449A2
Authority
WO
WIPO (PCT)
Prior art keywords
stent
platelet
cardiovascular stent
angiogenic
cardiovascular
Prior art date
Application number
PCT/US2004/029310
Other languages
French (fr)
Other versions
WO2005025449A3 (en
Inventor
Richard L. Watson, Jr.
Original Assignee
Spheric Products, Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spheric Products, Ltd filed Critical Spheric Products, Ltd
Publication of WO2005025449A2 publication Critical patent/WO2005025449A2/en
Publication of WO2005025449A3 publication Critical patent/WO2005025449A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/121—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Definitions

  • This invention relates generally to cardiovascular stents, and more particularly to a novel cardiovascular stent having anti-platelet material and/or angiogenic factors either embedded therein or on the exterior surface thereof.
  • blood platelets Shortly after a cardiac blood vessel is repaired with a stent, blood platelets begin to aggregate in the vicinity of the stent as a natural biodefense mechanism due to the presence of the foreign material (the stent) in the body. Such platelet aggregation tends to cause re-clogging of the vessel. Therefore, it would be a significant advancement in the art to provide a stent that inhibits platelet aggregation in order to prevent a stented vessel from re-clogging.
  • Figure 1 is a side view of a cardiovascular stent in accordance with the present invention.
  • Figure 2 is an end view of the cardiovascular stent of Figure 1.
  • a cardiovascular stent 10 in accordance with the present invention preferably comprises a structural tube 14 of wire mesh material, such as Titanium wire mesh or other suitable stent material, and an outer sheath 12 made of a fabric having anti-platelet material and/or angiogenic factors embedded therein.
  • wire mesh material such as Titanium wire mesh or other suitable stent material
  • outer sheath 12 made of a fabric having anti-platelet material and/or angiogenic factors embedded therein.
  • the outer sheath 12 engages the walls of the blood vessel.
  • the embedded anti-platelet material inhibits the aggregation of platelets, which tends to prevent or minimize re-clogging of the vessel.
  • the embedded angiogenic factors promote the growth of new blood vessels, which further enhances the healing process.
  • Sheath 12 is preferably made of a fabric that is absorbable by the body over a short period of time.
  • sheath 12 may be made of a bioabsorbable fabric composed of threads commonly found in synthetic absorbable sutures, such as coated VICRYL RAPIDETM (polyglactin 910) sutures available from Ethicon (Somerville, NJ). When placed inside the body, such suture material typically absorbs into the body within about 5 to 10 days.
  • the bioabsorbable material in which the anti-platelet material and/or the angiogenic factors are embedded may be woven together with the primary structural stent material in the structural tube 14 to form a composite mesh material from which the stent tube is fashioned.

Abstract

A cardiovascular stent comprising anti-platelet material and/or angiogenic material. The anti-platelet material and/or angiogenic material are preferably embedded in a bioabsorbable material. The bioabsorbable material may be woven into the primary stent material or formed into a sheath surrounding the primary stent material.

Description

CARDIOVASCULAR STENT WITH ANTI-PLATELET AND ANGIOGENIC MATERIAL INVENTOR: RICHARD L. WATSON, JR.
BACKGROUND OF THE INVENTION This invention relates generally to cardiovascular stents, and more particularly to a novel cardiovascular stent having anti-platelet material and/or angiogenic factors either embedded therein or on the exterior surface thereof. Shortly after a cardiac blood vessel is repaired with a stent, blood platelets begin to aggregate in the vicinity of the stent as a natural biodefense mechanism due to the presence of the foreign material (the stent) in the body. Such platelet aggregation tends to cause re-clogging of the vessel. Therefore, it would be a significant advancement in the art to provide a stent that inhibits platelet aggregation in order to prevent a stented vessel from re-clogging.
BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a side view of a cardiovascular stent in accordance with the present invention. Figure 2 is an end view of the cardiovascular stent of Figure 1.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
As shown in Figures 1 and 2, a cardiovascular stent 10 in accordance with the present invention preferably comprises a structural tube 14 of wire mesh material, such as Titanium wire mesh or other suitable stent material, and an outer sheath 12 made of a fabric having anti-platelet material and/or angiogenic factors embedded therein. Suitable anti-platelet materials and angiogenic materials are known in the art. When stent 10 is installed in a blood vessel according to methods known in the art, the outer sheath 12 engages the walls of the blood vessel. The embedded anti-platelet material inhibits the aggregation of platelets, which tends to prevent or minimize re-clogging of the vessel. The embedded angiogenic factors promote the growth of new blood vessels, which further enhances the healing process. Sheath 12 is preferably made of a fabric that is absorbable by the body over a short period of time. For example, sheath 12 may be made of a bioabsorbable fabric composed of threads commonly found in synthetic absorbable sutures, such as coated VICRYL RAPIDE™ (polyglactin 910) sutures available from Ethicon (Somerville, NJ). When placed inside the body, such suture material typically absorbs into the body within about 5 to 10 days. Alternatively, instead of having an outer sheath 12, the bioabsorbable material in which the anti-platelet material and/or the angiogenic factors are embedded may be woven together with the primary structural stent material in the structural tube 14 to form a composite mesh material from which the stent tube is fashioned. Although the invention has been described with reference to specific embodiments, this description is not meant to be construed in a limited sense. Various modifications of the disclosed embodiments, as well as alternative embodiments of the inventions will become apparent to persons skilled in the art upon the reference to the description of the invention. It is, therefore, contemplated that the appended claims will cover such modifications that fall within the scope of the invention.

Claims

CLAIMSI claim:
1. A cardiovascular stent comprising a bioabsorbable material.
2. A cardiovascular stent comprising: a primary stent tube; a sheath surrounding said stent tube; and said sheath comprising a bioabsorbable material.
3. The cardiovascular stent of Claim 2 wherein said bioabsorbable material comprises anti-platelet material.
4. The cardiovascular stent of Claim 2 wherein said bioabsorbable material comprises angiogenic material.
5. The cardiovascular stent of Claim 2 wherein said bioabsorbable material comprises anti-platelet material and angiogenic material.
6. A cardiovascular stent comprising a tube formed from a composite material comprising a metallic material and a bioabsorbable material.
7. The cardiovascular stent of Claim 6 wherein said bioabsorbable material comprises anti-platelet material.
8. The cardiovascular stent of Claim 6 wherein said bioabsorbable material comprises angiogenic material.
9. The cardiovascular stent of Claim 6 wherein said bioabsorbable material comprises anti-platelet material and angiogenic material.
PCT/US2004/029310 2003-09-10 2004-09-09 Cardiovascular stent with anti-platelet and angiogenic material WO2005025449A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50180103P 2003-09-10 2003-09-10
US60/501,801 2003-09-10

Publications (2)

Publication Number Publication Date
WO2005025449A2 true WO2005025449A2 (en) 2005-03-24
WO2005025449A3 WO2005025449A3 (en) 2005-09-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/029310 WO2005025449A2 (en) 2003-09-10 2004-09-09 Cardiovascular stent with anti-platelet and angiogenic material

Country Status (1)

Country Link
WO (1) WO2005025449A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8052744B2 (en) 2006-09-15 2011-11-08 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US8541027B2 (en) 2001-06-06 2013-09-24 Smith & Nephew, Inc. Fixation devices for tissue repair
US9616155B2 (en) 2008-06-13 2017-04-11 Smith & Nephew, Inc. Fixation devices for tissue repair

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
JP2010503494A (en) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Biodegradable endoprosthesis and method for producing the same
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
ES2506144T3 (en) 2006-12-28 2014-10-13 Boston Scientific Limited Bioerodible endoprosthesis and their manufacturing procedure
US8118857B2 (en) 2007-11-29 2012-02-21 Boston Scientific Corporation Medical articles that stimulate endothelial cell migration
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
EP2403546A2 (en) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US20020062147A1 (en) * 2000-03-13 2002-05-23 Jun Yang Stent having cover with drug delivery capability

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153252A (en) * 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US20020062147A1 (en) * 2000-03-13 2002-05-23 Jun Yang Stent having cover with drug delivery capability

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8541027B2 (en) 2001-06-06 2013-09-24 Smith & Nephew, Inc. Fixation devices for tissue repair
US8052744B2 (en) 2006-09-15 2011-11-08 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
US9616155B2 (en) 2008-06-13 2017-04-11 Smith & Nephew, Inc. Fixation devices for tissue repair

Also Published As

Publication number Publication date
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