WO2005010677A3 - Characterizing biological stimuli by response curves - Google Patents

Characterizing biological stimuli by response curves Download PDF

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Publication number
WO2005010677A3
WO2005010677A3 PCT/US2004/022519 US2004022519W WO2005010677A3 WO 2005010677 A3 WO2005010677 A3 WO 2005010677A3 US 2004022519 W US2004022519 W US 2004022519W WO 2005010677 A3 WO2005010677 A3 WO 2005010677A3
Authority
WO
WIPO (PCT)
Prior art keywords
response curves
stimulus
stimuli
cell
distance
Prior art date
Application number
PCT/US2004/022519
Other languages
French (fr)
Other versions
WO2005010677A2 (en
Inventor
Vadim Kutsyy
Daniel A Coleman
Eugeni A Vaisberg
Original Assignee
Cytokinetics Inc
Vadim Kutsyy
Daniel A Coleman
Eugeni A Vaisberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc, Vadim Kutsyy, Daniel A Coleman, Eugeni A Vaisberg filed Critical Cytokinetics Inc
Priority to GB0601434A priority Critical patent/GB2423988A/en
Priority to EP04778162A priority patent/EP1646926A2/en
Publication of WO2005010677A2 publication Critical patent/WO2005010677A2/en
Publication of WO2005010677A3 publication Critical patent/WO2005010677A3/en

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F1/00—Details not covered by groups G06F3/00 - G06F13/00 and G06F21/00
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
    • G06F18/241—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2413—Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on distances to training or reference patterns
    • G06F18/24133—Distances to prototypes
    • G06F18/24143—Distances to neighbourhood prototypes, e.g. restricted Coulomb energy networks [RCEN]
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
    • G06F2218/12—Classification; Matching

Abstract

A method for calculating distances between stimulus response curves (e.g., dose response curves) allows classification of stimuli, The response curves show how the phenotype of one or more cells changes in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype or signature for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The signatures are multivariate phenotypic representations of the cell (s). They include various features of the cell(s) obtained by image analysis. To facilitate the comparison of stimuli, distances between points on the response curves are calculated. First, the response curves may be aligned on a coordinate representing a separate distance, r, from a common point of negative control (e.g., the point where no stimulus is applied). Integration on r may be used to compute the distance between two response curves. The distance between response curves is used to classify stimuli.
PCT/US2004/022519 2003-07-18 2004-07-16 Characterizing biological stimuli by response curves WO2005010677A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB0601434A GB2423988A (en) 2003-07-18 2004-07-16 Characterizing biological stimuli by response curves
EP04778162A EP1646926A2 (en) 2003-07-18 2004-07-16 Characterizing biological stimuli by response curves

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50904003P 2003-07-18 2003-07-18
US60/509,040 2003-07-18

Publications (2)

Publication Number Publication Date
WO2005010677A2 WO2005010677A2 (en) 2005-02-03
WO2005010677A3 true WO2005010677A3 (en) 2007-06-07

Family

ID=34103048

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/022519 WO2005010677A2 (en) 2003-07-18 2004-07-16 Characterizing biological stimuli by response curves

Country Status (4)

Country Link
US (1) US7246012B2 (en)
EP (1) EP1646926A2 (en)
GB (1) GB2423988A (en)
WO (1) WO2005010677A2 (en)

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Also Published As

Publication number Publication date
EP1646926A2 (en) 2006-04-19
US7246012B2 (en) 2007-07-17
WO2005010677A2 (en) 2005-02-03
US20050137806A1 (en) 2005-06-23
GB0601434D0 (en) 2006-03-08
GB2423988A (en) 2006-09-13

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