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Publication numberWO2005010677 A3
Publication typeApplication
Application numberPCT/US2004/022519
Publication date7 Jun 2007
Filing date16 Jul 2004
Priority date18 Jul 2003
Also published asEP1646926A2, US7246012, US20050137806, WO2005010677A2
Publication numberPCT/2004/22519, PCT/US/2004/022519, PCT/US/2004/22519, PCT/US/4/022519, PCT/US/4/22519, PCT/US2004/022519, PCT/US2004/22519, PCT/US2004022519, PCT/US200422519, PCT/US4/022519, PCT/US4/22519, PCT/US4022519, PCT/US422519, WO 2005/010677 A3, WO 2005010677 A3, WO 2005010677A3, WO-A3-2005010677, WO2005/010677A3, WO2005010677 A3, WO2005010677A3
InventorsDaniel A Coleman, Vadim Kutsyy, Eugeni A Vaisberg
ApplicantDaniel A Coleman, Cytokinetics Inc, Vadim Kutsyy, Eugeni A Vaisberg
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Characterizing biological stimuli by response curves
WO 2005010677 A3
Abstract
A method for calculating distances between stimulus response curves (e.g., dose response curves) allows classification of stimuli, The response curves show how the phenotype of one or more cells changes in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype or signature for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The signatures are multivariate phenotypic representations of the cell (s). They include various features of the cell(s) obtained by image analysis. To facilitate the comparison of stimuli, distances between points on the response curves are calculated. First, the response curves may be aligned on a coordinate representing a separate distance, r, from a common point of negative control (e.g., the point where no stimulus is applied). Integration on r may be used to compute the distance between two response curves. The distance between response curves is used to classify stimuli.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US6936012 *18 Jun 200230 Aug 2005Neurometrix, Inc.Method and apparatus for identifying constituent signal components from a plurality of evoked physiological composite signals
US20050137806 *16 Jul 200423 Jun 2005Cytokinetics, Inc. A Delaware CorporationCharacterizing biological stimuli by response curves
Classifications
International ClassificationG06F19/00, A61K49/00, G06F, G01N33/48, G06K9/00
Cooperative ClassificationG06K9/6274, G06K9/00536, G06K9/00147
European ClassificationG06K9/62C1D1R, G06K9/00B3, G06K9/00M3
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