WO2005009463A3 - Antigen-presenting cell vaccines and methods of use thereof - Google Patents

Antigen-presenting cell vaccines and methods of use thereof Download PDF

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Publication number
WO2005009463A3
WO2005009463A3 PCT/US2004/023881 US2004023881W WO2005009463A3 WO 2005009463 A3 WO2005009463 A3 WO 2005009463A3 US 2004023881 W US2004023881 W US 2004023881W WO 2005009463 A3 WO2005009463 A3 WO 2005009463A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microbes
modified
antigen
presenting cell
Prior art date
Application number
PCT/US2004/023881
Other languages
French (fr)
Other versions
WO2005009463A2 (en
Inventor
Thomas W Dubensky Jr
Dirk G Brockstedt
Keith Bahjat
John E Hearst
David Cook
William Stanford Luckett
Original Assignee
Cerus Corp
Thomas W Dubensky Jr
Dirk G Brockstedt
Keith Bahjat
John E Hearst
David Cook
William Stanford Luckett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/773,792 external-priority patent/US7691393B2/en
Priority claimed from US10/773,618 external-priority patent/US7833775B2/en
Application filed by Cerus Corp, Thomas W Dubensky Jr, Dirk G Brockstedt, Keith Bahjat, John E Hearst, David Cook, William Stanford Luckett filed Critical Cerus Corp
Priority to JP2006521287A priority Critical patent/JP2007523879A/en
Priority to AU2004314347A priority patent/AU2004314347B2/en
Priority to US11/021,441 priority patent/US7842289B2/en
Priority to JP2006547602A priority patent/JP5532280B2/en
Priority to EP04821230.2A priority patent/EP1708741B1/en
Priority to CA2551644A priority patent/CA2551644C/en
Priority to CN200480042020XA priority patent/CN1921884B/en
Priority to TW093140281A priority patent/TW200530399A/en
Priority to MXPA06007144A priority patent/MXPA06007144A/en
Priority to KR1020067014816A priority patent/KR101227419B1/en
Priority to PCT/US2004/044080 priority patent/WO2005071088A2/en
Priority to PCT/US2005/002987 priority patent/WO2005092372A2/en
Publication of WO2005009463A2 publication Critical patent/WO2005009463A2/en
Publication of WO2005009463A3 publication Critical patent/WO2005009463A3/en
Priority to US11/173,770 priority patent/US20070031457A1/en
Priority to HK07103786.5A priority patent/HK1098673A1/en
Priority to JP2011115257A priority patent/JP2011155988A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/07—Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided. Vaccine compositions comprising the modified microbes and/or the antigenpresenting cells and methods of using the vaccines are also provided. The microbes may be further modified to include heterologous antigens, such as tumor antigens or infectious disease antigens, for use as a vaccine against cancer or infectious diseases.
PCT/US2004/023881 2003-07-24 2004-07-23 Antigen-presenting cell vaccines and methods of use thereof WO2005009463A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP2006521287A JP2007523879A (en) 2003-07-24 2004-07-23 Antigen presenting cells and methods of use thereof
KR1020067014816A KR101227419B1 (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
PCT/US2004/044080 WO2005071088A2 (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof
TW093140281A TW200530399A (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
MXPA06007144A MXPA06007144A (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof.
JP2006547602A JP5532280B2 (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules encoding fusion proteins comprising an antigen and a bacterial secretion signal polypeptide, expression cassettes, and bacteria, and methods of using them
EP04821230.2A EP1708741B1 (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof
CA2551644A CA2551644C (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of usethereof
CN200480042020XA CN1921884B (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
AU2004314347A AU2004314347B2 (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof
US11/021,441 US7842289B2 (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
PCT/US2005/002987 WO2005092372A2 (en) 2004-02-06 2005-02-02 Modified bacillus anthracis vaccine compositions and methods of use thereof
US11/173,770 US20070031457A1 (en) 2004-02-06 2005-06-30 Modified Bacillus anthracis, vaccine compositions and methods of use thereof
HK07103786.5A HK1098673A1 (en) 2003-12-24 2007-04-11 Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof
JP2011115257A JP2011155988A (en) 2003-12-24 2011-05-23 Recombinant nucleic acid molecule encoding fused protein including antigen and bacterial secretion signal polypeptide, expression cassette and bacteria, and method for use thereof

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US49008903P 2003-07-24 2003-07-24
US60/490,089 2003-07-24
US51171903P 2003-10-15 2003-10-15
US51186903P 2003-10-15 2003-10-15
US51191903P 2003-10-15 2003-10-15
US60/511,919 2003-10-15
US60/511,719 2003-10-15
US60/511,869 2003-10-15
US53259803P 2003-12-24 2003-12-24
US60/532,598 2003-12-24
US54151504P 2004-02-02 2004-02-02
US60/541,515 2004-02-02
US10/773,618 US7833775B2 (en) 2003-02-06 2004-02-06 Modified free-living microbes, vaccine compositions and methods of use thereof
US10/773,792 2004-02-06
US10/773,618 2004-02-06
US10/773,792 US7691393B2 (en) 2003-02-06 2004-02-06 Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the Listeria, and methods of use thereof
US55674404P 2004-03-26 2004-03-26
US60/556,744 2004-03-26
US10/883,599 2004-06-30
US10/883,599 US7695725B2 (en) 2003-02-06 2004-06-30 Modified free-living microbes, vaccine compositions and methods of use thereof

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US10/773,792 Continuation-In-Part US7691393B2 (en) 2003-02-06 2004-02-06 Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the Listeria, and methods of use thereof
US10/773,618 Continuation-In-Part US7833775B2 (en) 2003-02-06 2004-02-06 Modified free-living microbes, vaccine compositions and methods of use thereof
US10/883,599 Continuation-In-Part US7695725B2 (en) 2003-02-06 2004-06-30 Modified free-living microbes, vaccine compositions and methods of use thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/021,441 Continuation-In-Part US7842289B2 (en) 2003-12-24 2004-12-23 Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
US11/173,770 Continuation-In-Part US20070031457A1 (en) 2004-02-06 2005-06-30 Modified Bacillus anthracis, vaccine compositions and methods of use thereof

Publications (2)

Publication Number Publication Date
WO2005009463A2 WO2005009463A2 (en) 2005-02-03
WO2005009463A3 true WO2005009463A3 (en) 2005-06-02

Family

ID=34109344

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/023881 WO2005009463A2 (en) 2003-07-24 2004-07-23 Antigen-presenting cell vaccines and methods of use thereof

Country Status (3)

Country Link
US (2) US7695725B2 (en)
JP (1) JP2007523879A (en)
WO (1) WO2005009463A2 (en)

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US7691393B2 (en) 2003-02-06 2010-04-06 Anza Therapeutics, Inc. Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the Listeria, and methods of use thereof
US7695725B2 (en) 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
US7833775B2 (en) 2003-02-06 2010-11-16 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
US7842289B2 (en) 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof

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US7935804B2 (en) 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
EP2150616A4 (en) 2007-05-10 2011-07-27 Univ Arizona Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety
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