WO2005007675A3 - TRIAZOLE ϵ-AMINO ACIDS - Google Patents

TRIAZOLE ϵ-AMINO ACIDS Download PDF

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Publication number
WO2005007675A3
WO2005007675A3 PCT/US2004/022081 US2004022081W WO2005007675A3 WO 2005007675 A3 WO2005007675 A3 WO 2005007675A3 US 2004022081 W US2004022081 W US 2004022081W WO 2005007675 A3 WO2005007675 A3 WO 2005007675A3
Authority
WO
WIPO (PCT)
Prior art keywords
epsiv
triazole
amino acids
peptides
small molecule
Prior art date
Application number
PCT/US2004/022081
Other languages
French (fr)
Other versions
WO2005007675A2 (en
Inventor
M Reza Ghadiri
William S Horne
Original Assignee
Scripps Research Inst
M Reza Ghadiri
William S Horne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst, M Reza Ghadiri, William S Horne filed Critical Scripps Research Inst
Publication of WO2005007675A2 publication Critical patent/WO2005007675A2/en
Publication of WO2005007675A3 publication Critical patent/WO2005007675A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Abstract

The invention provides 1,2,3-triazole ϵ-amino acids as well as peptides and polypeptides having at least one 1,2,3-­triazole ϵ-amino acid. The peptides of the invention can be linear or cyclic. In some embodiments, the cyclic peptides of the invention can assemble into supramolecular structures that can be used be used therapeutically or for small molecule transport and the modulation of small molecule transport within and between cells.
PCT/US2004/022081 2003-07-09 2004-07-09 TRIAZOLE ϵ-AMINO ACIDS WO2005007675A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48596103P 2003-07-09 2003-07-09
US60/485,961 2003-07-09

Publications (2)

Publication Number Publication Date
WO2005007675A2 WO2005007675A2 (en) 2005-01-27
WO2005007675A3 true WO2005007675A3 (en) 2005-07-14

Family

ID=34079174

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/022081 WO2005007675A2 (en) 2003-07-09 2004-07-09 TRIAZOLE ϵ-AMINO ACIDS

Country Status (1)

Country Link
WO (1) WO2005007675A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9175056B2 (en) 2006-12-14 2015-11-03 Alleron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US9493509B2 (en) 2007-02-23 2016-11-15 Aileron Therapeutics, Inc. Triazole macrocycle systems
US9527896B2 (en) 2007-01-31 2016-12-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7955738B2 (en) * 2004-03-05 2011-06-07 Honeywell International, Inc. Polymer ionic electrolytes
US7834038B2 (en) * 2005-11-09 2010-11-16 New York University Methods for preparing nonpeptidic oligomers from amino acids
US7981998B2 (en) 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
JP5631201B2 (en) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ Stitched polypeptide
CA2744088A1 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
DK2603600T3 (en) 2010-08-13 2019-03-04 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES
AU2013221433B2 (en) 2012-02-15 2018-01-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN112500466B (en) 2012-02-15 2022-05-03 艾瑞朗医疗公司 Peptidomimetic macrocycles
BR112015009470A2 (en) 2012-11-01 2019-12-17 Aileron Therapeutics Inc disubstituted amino acids and their methods of preparation and use
SG10201902598VA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
CN112245565A (en) 2014-09-24 2021-01-22 艾瑞朗医疗公司 Peptidomimetic macrocycles and uses thereof
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2018528217A (en) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Peptidomimetic macrocycles as modulators of MCL-1

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RANGANATHAN ET AL.: "Double-helical cyclic peptides: design, synthesis, and crystal structure of figure-eight mirror-iamge conformers of adamantane-constrained cystine-containing peptide cyclo(adm-Cyst)3", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, June 2000 (2000-06-01), pages 4415 - 4422 *
RANGANATHAN ET AL.: "Norborene constrained cyclic peptides with haipin architecture: design, synthesis, conformation, and membrane ion transport", JOURNAL OF ORGANIC CHEMISTRY, vol. 65, June 2000 (2000-06-01), pages 365 - 374 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9175056B2 (en) 2006-12-14 2015-11-03 Alleron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US9527896B2 (en) 2007-01-31 2016-12-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9493509B2 (en) 2007-02-23 2016-11-15 Aileron Therapeutics, Inc. Triazole macrocycle systems
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9522947B2 (en) 2011-10-18 2016-12-20 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

Also Published As

Publication number Publication date
WO2005007675A2 (en) 2005-01-27

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