WO2005005609A3 - Multi-staged absorbable nonwoven structures for culturing pancreatic cells - Google Patents

Multi-staged absorbable nonwoven structures for culturing pancreatic cells Download PDF

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Publication number
WO2005005609A3
WO2005005609A3 PCT/US2004/021044 US2004021044W WO2005005609A3 WO 2005005609 A3 WO2005005609 A3 WO 2005005609A3 US 2004021044 W US2004021044 W US 2004021044W WO 2005005609 A3 WO2005005609 A3 WO 2005005609A3
Authority
WO
WIPO (PCT)
Prior art keywords
fibers
present
staged
matrix
pancreatic cells
Prior art date
Application number
PCT/US2004/021044
Other languages
French (fr)
Other versions
WO2005005609A2 (en
Inventor
Alireza Rezania
Mark Zimmerman
Original Assignee
Liefscan Inc
Alireza Rezania
Mark Zimmerman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liefscan Inc, Alireza Rezania, Mark Zimmerman filed Critical Liefscan Inc
Priority to EP04777320A priority Critical patent/EP1644478A4/en
Publication of WO2005005609A2 publication Critical patent/WO2005005609A2/en
Publication of WO2005005609A3 publication Critical patent/WO2005005609A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers

Abstract

The present invention provides an implantable biodegradable device containing a fibrous matrix, which matrix is constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, and fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix possesses properties desirable for seeding and subsequent transplantation of cells bearing at least one characteristic of a pancreatic cell. The present invention also provides an implantable biodegradable device containing a fibrous matrix, which matrix has been seeded with cells bearing at least one characteristic of a pancreatic cell. Furthermore, the present invention provides a method for treating diabetes by implanting a device with seeded cells in a diabetic patient.
PCT/US2004/021044 2003-06-30 2004-06-29 Multi-staged absorbable nonwoven structures for culturing pancreatic cells WO2005005609A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04777320A EP1644478A4 (en) 2003-06-30 2004-06-29 Multi-staged absorbable nonwoven structures for culturing pancreatic cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48380503P 2003-06-30 2003-06-30
US60/483,805 2003-06-30

Publications (2)

Publication Number Publication Date
WO2005005609A2 WO2005005609A2 (en) 2005-01-20
WO2005005609A3 true WO2005005609A3 (en) 2007-08-09

Family

ID=34061991

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/021044 WO2005005609A2 (en) 2003-06-30 2004-06-29 Multi-staged absorbable nonwoven structures for culturing pancreatic cells

Country Status (2)

Country Link
EP (1) EP1644478A4 (en)
WO (1) WO2005005609A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0618787D0 (en) * 2006-09-23 2006-11-01 Univ Nottingham Degradable composite
KR20100097195A (en) * 2007-12-07 2010-09-02 애보트 게엠베하 운트 콤파니 카게 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases
GB201317636D0 (en) 2013-10-04 2013-11-20 Isis Innovation Scaffold
HUE052514T2 (en) * 2016-10-19 2021-05-28 Beta Cell Tech Pty Ltd Cell population seeding in dermal matrices for endocrine disorder management
US11730696B2 (en) 2016-10-20 2023-08-22 Australian Foundation for Diabetes Research Cell associated scaffolds for delivery of agents
CN109395095B (en) * 2017-09-18 2021-09-24 武汉原生原代生物医药科技有限公司 In vivo biological membrane and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6031148A (en) * 1990-12-06 2000-02-29 W. L. Gore & Associates, Inc. Implantable bioabsorbable article
US6113640A (en) * 1997-06-11 2000-09-05 Bionx Implants Oy Reconstructive bioabsorbable joint prosthesis
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6350284B1 (en) * 1998-09-14 2002-02-26 Bionx Implants, Oy Bioabsorbable, layered composite material for guided bone tissue regeneration

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192604B2 (en) * 2000-12-22 2007-03-20 Ethicon, Inc. Implantable biodegradable devices for musculoskeletal repair or regeneration
US20020119179A1 (en) * 2000-12-22 2002-08-29 Alireza Rezania Implantable biodegradable devices for musculoskeletal repair or regeneration

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6031148A (en) * 1990-12-06 2000-02-29 W. L. Gore & Associates, Inc. Implantable bioabsorbable article
US6113640A (en) * 1997-06-11 2000-09-05 Bionx Implants Oy Reconstructive bioabsorbable joint prosthesis
US6350284B1 (en) * 1998-09-14 2002-02-26 Bionx Implants, Oy Bioabsorbable, layered composite material for guided bone tissue regeneration
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1644478A4 *

Also Published As

Publication number Publication date
EP1644478A4 (en) 2008-07-23
WO2005005609A2 (en) 2005-01-20
EP1644478A2 (en) 2006-04-12

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