WO2005001022A3 - Methods and compositions for enhancing immune response - Google Patents

Methods and compositions for enhancing immune response Download PDF

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Publication number
WO2005001022A3
WO2005001022A3 PCT/US2004/011085 US2004011085W WO2005001022A3 WO 2005001022 A3 WO2005001022 A3 WO 2005001022A3 US 2004011085 W US2004011085 W US 2004011085W WO 2005001022 A3 WO2005001022 A3 WO 2005001022A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
immune response
enhancing immune
irm
Prior art date
Application number
PCT/US2004/011085
Other languages
French (fr)
Other versions
WO2005001022A2 (en
Inventor
Richard L Miller
Mark A Tomai
Ross M Kedl
Isidro Angelo E Zarraga
Ronnie Ortiz
James D Stoesz
Paul D Wightman
Original Assignee
3M Innovative Properties Co
Richard L Miller
Mark A Tomai
Ross M Kedl
Isidro Angelo E Zarraga
Ronnie Ortiz
James D Stoesz
Paul D Wightman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/640,904 external-priority patent/US7427629B2/en
Application filed by 3M Innovative Properties Co, Richard L Miller, Mark A Tomai, Ross M Kedl, Isidro Angelo E Zarraga, Ronnie Ortiz, James D Stoesz, Paul D Wightman filed Critical 3M Innovative Properties Co
Priority to EP04775877A priority Critical patent/EP1617872A4/en
Priority to JP2006532393A priority patent/JP2007514644A/en
Priority to CA002521662A priority patent/CA2521662A1/en
Priority to AU2004252409A priority patent/AU2004252409A1/en
Publication of WO2005001022A2 publication Critical patent/WO2005001022A2/en
Publication of WO2005001022A3 publication Critical patent/WO2005001022A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.
PCT/US2004/011085 2003-04-10 2004-04-09 Methods and compositions for enhancing immune response WO2005001022A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04775877A EP1617872A4 (en) 2003-04-10 2004-04-09 Methods and compositions for enhancing immune response
JP2006532393A JP2007514644A (en) 2003-04-10 2004-04-09 Methods and compositions for improving immune response
CA002521662A CA2521662A1 (en) 2003-04-10 2004-04-09 Methods and compositions for enhancing immune response
AU2004252409A AU2004252409A1 (en) 2003-04-10 2004-04-09 Methods and compositions for enhancing immune response

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US46214003P 2003-04-10 2003-04-10
US60/462,140 2003-04-10
US10/640,904 US7427629B2 (en) 2002-08-15 2003-08-14 Immunostimulatory compositions and methods of stimulating an immune response
US10/640,904 2003-08-14
US51525603P 2003-10-29 2003-10-29
US60/515,256 2003-10-29
US53370303P 2003-12-31 2003-12-31
US60/533,703 2003-12-31
US54554204P 2004-02-18 2004-02-18
US54542404P 2004-02-18 2004-02-18
US60/545,542 2004-02-18
US60/545,424 2004-02-18

Publications (2)

Publication Number Publication Date
WO2005001022A2 WO2005001022A2 (en) 2005-01-06
WO2005001022A3 true WO2005001022A3 (en) 2005-09-15

Family

ID=34923557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/011085 WO2005001022A2 (en) 2003-04-10 2004-04-09 Methods and compositions for enhancing immune response

Country Status (5)

Country Link
EP (1) EP1617872A4 (en)
JP (1) JP2007514644A (en)
AU (1) AU2004252409A1 (en)
CA (1) CA2521662A1 (en)
WO (1) WO2005001022A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314535B2 (en) 2009-09-03 2016-04-19 Curevac Ag Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
US9572874B2 (en) 2008-09-30 2017-02-21 Curevac Ag Composition comprising a complexed (M)RNA and a naked mRNA for providing or enhancing an immunostimulatory response in a mammal and uses thereof
US11965000B2 (en) 2013-08-21 2024-04-23 CureVac SE Respiratory syncytial virus (RSV) vaccine

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006007433A1 (en) * 2006-02-17 2007-08-23 Curevac Gmbh Immunostimulant adjuvant useful in vaccines against cancer or infectious diseases comprises a lipid-modified nucleic acid
JP2010507361A (en) 2006-07-31 2010-03-11 キュアバック ゲーエムベーハー Specifically, a nucleic acid represented by the general formula (I): GlXmGn or the general formula (II): ClXmCn as an immunostimulant / adjuvant
WO2009030254A1 (en) 2007-09-04 2009-03-12 Curevac Gmbh Complexes of rna and cationic peptides for transfection and for immunostimulation
SG188104A1 (en) 2008-01-31 2013-03-28 Curevac Gmbh Nucleic acids comprising formula (nuglxmgnnv)a and derivatives thereof as an immunostimulating agents /adjuvants
ES2656813T3 (en) 2008-10-24 2018-02-28 Glaxosmithkline Biologicals Sa Lipidated Imidazoquinoline Derivatives
BR112013002298A2 (en) 2010-07-30 2016-05-24 Curevac Gmbh nucleic acid complexation with disulfide crosslinked cationic components for transfection and immune stimulation.
WO2013113326A1 (en) 2012-01-31 2013-08-08 Curevac Gmbh Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen
EP3065741B1 (en) 2013-11-05 2021-09-22 3M Innovative Properties Company Sesame oil based injection formulations
US10369216B2 (en) 2014-04-01 2019-08-06 Curevac Ag Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
WO2017056494A1 (en) 2015-09-29 2017-04-06 Sumitomo Dainippon Pharma Co., Ltd. Adenine conjugate compounds and their use as vaccine adjuvants
JP6769976B2 (en) 2015-10-07 2020-10-14 大日本住友製薬株式会社 Pyrimidine compound
MA44334A (en) 2015-10-29 2018-09-05 Novartis Ag ANTIBODY CONJUGATES INCLUDING A TOLL-TYPE RECEPTOR AGONIST
AU2017292934B2 (en) 2016-07-07 2024-04-04 Bolt Biotherapeutics, Inc. Antibody adjuvant conjugates
BR112021001188A8 (en) 2018-07-23 2022-12-06 Japan As Represented By The Director General Of Nat Institute Of Infectious Diseases COMPOSITION CONTAINING INFLUENZA VACCINE
WO2020190725A1 (en) 2019-03-15 2020-09-24 Bolt Biotherapeutics, Inc. Immunoconjugates targeting her2

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447724A (en) * 1990-05-17 1995-09-05 Harbor Medical Devices, Inc. Medical device polymer
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6486168B1 (en) * 1999-01-08 2002-11-26 3M Innovative Properties Company Formulations and methods for treatment of mucosal associated conditions with an immune response modifier
US6518280B2 (en) * 1998-12-11 2003-02-11 3M Innovative Properties Company Imidazonaphthyridines

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US5194581A (en) * 1989-03-09 1993-03-16 Leong Kam W Biodegradable poly(phosphoesters)
US5342940A (en) * 1989-05-27 1994-08-30 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, process for preparing the same
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
CA2361936C (en) * 1999-01-08 2009-06-16 3M Innovative Properties Company Formulations comprising imiquimod or other immune response modifiers for treating mucosal conditions
CA2430206A1 (en) * 2000-12-08 2002-06-13 3M Innovative Properties Company Screening method for identifying compounds that selectively induce interferon alpha
CN1292751C (en) * 2002-04-23 2007-01-03 四川大学 Imiquimod or its derivative liposome for local skin and its preparing method and use
ATE488246T1 (en) * 2002-08-15 2010-12-15 3M Innovative Properties Co IMMUNO-STIMULATORY COMPOSITIONS AND METHODS FOR STIMULATING AN IMMUNE RESPONSE
WO2004060967A1 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447724A (en) * 1990-05-17 1995-09-05 Harbor Medical Devices, Inc. Medical device polymer
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6518280B2 (en) * 1998-12-11 2003-02-11 3M Innovative Properties Company Imidazonaphthyridines
US6486168B1 (en) * 1999-01-08 2002-11-26 3M Innovative Properties Company Formulations and methods for treatment of mucosal associated conditions with an immune response modifier

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GIBSON S.J. ET AL: "Plasmacytoid dendritic cells produce cytokines and mature in response to the TLR7 agonists, imiquimod and resiquimod", CELL IMMUNOL, vol. 218, 2002, pages 74 - 86, XP002985828 *
See also references of EP1617872A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572874B2 (en) 2008-09-30 2017-02-21 Curevac Ag Composition comprising a complexed (M)RNA and a naked mRNA for providing or enhancing an immunostimulatory response in a mammal and uses thereof
US9314535B2 (en) 2009-09-03 2016-04-19 Curevac Ag Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids
US11965000B2 (en) 2013-08-21 2024-04-23 CureVac SE Respiratory syncytial virus (RSV) vaccine

Also Published As

Publication number Publication date
EP1617872A2 (en) 2006-01-25
WO2005001022A2 (en) 2005-01-06
EP1617872A4 (en) 2011-09-07
AU2004252409A1 (en) 2005-01-06
JP2007514644A (en) 2007-06-07
CA2521662A1 (en) 2005-01-06

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