WO2004105737A3 - Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents - Google Patents

Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents Download PDF

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Publication number
WO2004105737A3
WO2004105737A3 PCT/CA2004/000800 CA2004000800W WO2004105737A3 WO 2004105737 A3 WO2004105737 A3 WO 2004105737A3 CA 2004000800 W CA2004000800 W CA 2004000800W WO 2004105737 A3 WO2004105737 A3 WO 2004105737A3
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WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
various agents
methods relating
fibrous adhesions
inhibiting fibrous
Prior art date
Application number
PCT/CA2004/000800
Other languages
French (fr)
Other versions
WO2004105737A2 (en
Inventor
Johanne Cashman
Christopher Springate
Bruce Hay
Charles Winternitz
Original Assignee
Arc Pharmaceuticals Inc
Johanne Cashman
Christopher Springate
Bruce Hay
Charles Winternitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arc Pharmaceuticals Inc, Johanne Cashman, Christopher Springate, Bruce Hay, Charles Winternitz filed Critical Arc Pharmaceuticals Inc
Priority to JP2006529506A priority Critical patent/JP2007504273A/en
Priority to CA002527429A priority patent/CA2527429A1/en
Priority to BRPI0418384-3A priority patent/BRPI0418384A/en
Priority to EP04735180A priority patent/EP1631265A2/en
Priority to AU2004243513A priority patent/AU2004243513A1/en
Publication of WO2004105737A2 publication Critical patent/WO2004105737A2/en
Publication of WO2004105737A3 publication Critical patent/WO2004105737A3/en

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    • AHUMAN NECESSITIES
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    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/716Glucans
    • A61K31/717Celluloses
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    • A61K31/716Glucans
    • A61K31/718Starch or degraded starch, e.g. amylose, amylopectin
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    • A61K31/734Alginic acid
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    • A61K38/164Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A61K38/166Streptokinase
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    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/424Anti-adhesion agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
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    • C12N2320/00Applications; Uses
    • C12N2320/10Applications; Uses in screening processes
    • C12N2320/11Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/32Special delivery means, e.g. tissue-specific

Abstract

Compositions and methods involving administration of agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions.
PCT/CA2004/000800 2003-05-30 2004-05-28 Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents WO2004105737A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2006529506A JP2007504273A (en) 2003-05-30 2004-05-28 Pharmaceutical composition and method for inhibiting fibrous adhesion using various agents
CA002527429A CA2527429A1 (en) 2003-05-30 2004-05-28 Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents
BRPI0418384-3A BRPI0418384A (en) 2003-05-30 2004-05-28 pharmaceutical compositions and methods for inhibiting fibrous adhesions using various agents
EP04735180A EP1631265A2 (en) 2003-05-30 2004-05-28 Use of various agents for inhibiting fibrous adhesions
AU2004243513A AU2004243513A1 (en) 2003-05-30 2004-05-28 Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US47490703P 2003-05-30 2003-05-30
US60/474,907 2003-05-30
US47765403P 2003-06-10 2003-06-10
US60/477,654 2003-06-10
US50525803P 2003-09-22 2003-09-22
US50525703P 2003-09-22 2003-09-22
US60/505,257 2003-09-22
US60/505,258 2003-09-22
US52080803P 2003-11-17 2003-11-17
US52057403P 2003-11-17 2003-11-17
US52080403P 2003-11-17 2003-11-17
US60/520,808 2003-11-17
US60/520,804 2003-11-17
US60/520,574 2003-11-17
US52913603P 2003-12-11 2003-12-11
US60/529,136 2003-12-11
US53366903P 2003-12-31 2003-12-31
US60/533,669 2003-12-31

Publications (2)

Publication Number Publication Date
WO2004105737A2 WO2004105737A2 (en) 2004-12-09
WO2004105737A3 true WO2004105737A3 (en) 2005-06-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2004/000800 WO2004105737A2 (en) 2003-05-30 2004-05-28 Pharmaceutical compositions and methods relating to inhibiting fibrous adhesions using various agents

Country Status (8)

Country Link
EP (1) EP1631265A2 (en)
JP (1) JP2007504273A (en)
KR (1) KR20060034227A (en)
AU (1) AU2004243513A1 (en)
BR (1) BRPI0418384A (en)
CA (1) CA2527429A1 (en)
TW (1) TW200509949A (en)
WO (1) WO2004105737A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8940786B2 (en) 2012-10-01 2015-01-27 Teikoku Pharma Usa, Inc. Non-aqueous taxane nanodispersion formulations and methods of using the same

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1809303T3 (en) * 2004-09-23 2019-06-11 Arc Medical Devices Inc PHARMACEUTICAL COMPOSITION AND METHODS IN RELATION TO FIBROSE ADHESION OR INFLAMMATORIC DISEASE USING LOW SULPHATE FUCAN
JP5129122B2 (en) 2005-04-26 2013-01-23 トリオン ファーマ ゲーエムベーハー Combination of antibodies and glucocorticoids for cancer treatment
US20060251702A1 (en) * 2005-05-05 2006-11-09 Cook Biotech Incorporated Implantable materials and methods for inhibiting tissue adhesion formation
DE102005023170A1 (en) * 2005-05-19 2006-11-23 Curevac Gmbh Optimized formulation for mRNA
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