WO2004105626A2 - Fibrous marker and intracorporeal delivery thereof - Google Patents
Fibrous marker and intracorporeal delivery thereof Download PDFInfo
- Publication number
- WO2004105626A2 WO2004105626A2 PCT/US2004/014968 US2004014968W WO2004105626A2 WO 2004105626 A2 WO2004105626 A2 WO 2004105626A2 US 2004014968 W US2004014968 W US 2004014968W WO 2004105626 A2 WO2004105626 A2 WO 2004105626A2
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- WO
- WIPO (PCT)
- Prior art keywords
- marker
- intracorporeal
- fibrous
- inner lumen
- delivery device
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00637—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for sealing trocar wounds through abdominal wall
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00898—Material properties expandable upon contact with fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3904—Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
- A61B2090/3908—Soft tissue, e.g. breast tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/392—Radioactive markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3954—Markers, e.g. radio-opaque or breast lesions markers magnetic, e.g. NMR or MRI
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3987—Applicators for implanting markers
Definitions
- the invention is directed generally to a fibrous marker and devices and systems for the intracorporeal delivery thereof to a target site within a patient.
- BACKGROUND OF THE INVENTION In diagnosing and treating certain medical conditions, it is often desirable to mark a suspicious body site for the subsequent taking of a biopsy, delivery of medicine, radiation, or other treatment, to mark a location from which a biopsy was taken, or at which some other procedure was performed.
- obtaining a tissue sample by biopsy and the subsequent examination are typically employed in the diagnosis of cancers and other malignant tumors, or to confirm that a suspected lesion or tumor is not malignant.
- the information obtained from these diagnostic tests and/or examinations is frequently used to devise a therapeutic plan for the appropriate surgical procedure or other course of treatment.
- the suspicious tissue to be sampled is located in a subcutaneous site, such as inside a human breast.
- a small instrument such as a biopsy needle
- MRI magnetic resonance imaging
- Examination of tissue samples taken by biopsy is of particular significance in the diagnosis and treatment of breast cancer.
- the biopsy and treatment site described will generally be the human breast, although the invention is suitable for marking biopsy sites in other parts of the human and other mammalian body as well.
- a tissue specimen can be removed from the mass by a variety of techniques, including but not limited to open surgical biopsy, a technique known as Fine Needle Aspiration Biopsy (FNAB) and instruments characterized as "vacuum assisted large core biopsy devices".
- FNAB Fine Needle Aspiration Biopsy
- a biopsy procedure known as stereotactic needle biopsy may be used. In performing a stereotactic needle biopsy of a breast, the patient lies on a special biopsy table with her breast compressed between the plates of a mammography apparatus and two separate x-rays or digital video views are taken from two different points of view.
- a computer calculates the exact position of the lesion in the breast.
- a mechanical stereotactic apparatus is programmed with the coordinates and depth information calculated by the computer and such apparatus is used to precisely advance the biopsy needle into the lesion.
- this stereotactic technique may be used to obtain histologic specimens e.g., obtained through coring needle biopsy or, more commonly, a biopsy with a vacuum assisted large core biopsy device. Usually at least five separate biopsy specimens are obtained at or around the lesion.
- the available treatment options for cancerous lesions of the breast include various degrees of lumpectomy or mastectomy and radiation therapy, as well as chemotherapy and combinations of these treatments.
- a biopsy site marker may be placed in or on the patient's body to serve as a landmark for subsequent location of the lesion site.
- a biopsy site marker may be a permanent marker (e.g., a metal marker visible under X-ray examination), or a temporary marker (e.g., a bioresorbable marker detectable with ultrasound).
- the site must usually be marked with a location wire which has a hook on the end which is advanced into site of the previous procedure.
- the hook is meant to fix the tip of the location wire with respect to the site of the previous procedure so that the patient can then be removed from the confinement of the mammography apparatus and the follow-up procedure performed.
- the position of the location wire can change or shift in relation to the site of the previous procedure.
- USI ultrasonic imaging and visualization techniques
- USI can be used to image the tissue of interest at the site of interest during a surgical or biopsy procedure or follow-up procedure. USI is capable of providing precise location and imaging of suspicious tissue, surrounding .tissue and biopsy instruments within the patient's body during a procedure. Such imaging facilitates accurate and controllable removal or sampling of the suspicious tissue so as to minimize trauma to surrounding healthy tissue.
- the biopsy device is often imaged with USI while the device is being inserted into the patient's breast and activated to remove a sample of suspicious breast tissue.
- USI is often used to image tissue during follow-up treatment
- a marker enables a follow-up procedure to be performed without the need for traditional radiographic mammography imaging which, as discussed above, can be subject to inaccuracies as a result of shifting of the location wire as well as being tedious and uncomfortable for the patient.
- Placement of a marker or multiple markers at a location within a patient's body requires delivery devices capable of holding markers within the device until the device is properly situated within a breast or other body location. Accordingly, devices and methods for retaining markers within a marker delivery device while allowing their expulsion from the devices at desired intracorporeal locations are desired.
- the invention is directed to a fibrous, swellable marker which positions a long-term radiographically detectable marker element within a target site of a patient's body.
- short term ultrasound detectable markers are also delivered into the target site along with the fibrous marker.
- the fibrous marker embodying features of the invention is formed at least in part of a fibrous material, such as oxidized, regenerated cellulose, polylactic acid, a copolymer of polylactic acid and glycolic acid, polycaprolactone, in a felt and/or fabric or woven structure.
- the fibrous marker material is swellable in the presence of body fluid, such as blood or plasma, or other water based fluid.
- the fibrous material is formed into an elongated member and bound in a compressed condition to provide sufficient column strength to facilitate introduction into and discharge from a tubular delivery device.
- Suitable binding agents for holding the fibrous marker in a compressed condition are water soluble polymers such as polyvinyl alcohol, polyethylene glycol, polyvinyl pyrollidone.
- One or more radiographically detectable marker elements are provided with the fibrous marker, preferably centrally located, to ensure that the radiographically detectable element is disposed at a more or less central location within the target site rather than at a site margin.
- the one or more short term ultrasonically detectable markers which are preferably delivered with the fibrous markers, are formed of bioabsorbable materials. Details of suitable short term ultrasonically detectable markers can be found in U.S. Patent No. 6,161,034, issued December 12, 2000, U.S. Patent No. 6,347,241, issued February 112, 2002, co-pending application Serial No. 09/717,909, filed November 20, 2000 and co-pending application Serial No. 10/124,757. These patents and applications are assigned to the present assignee and are incorporated herein in their entirety by reference.
- Marker delivery systems embodying features of the invention include an elongated cannula with an inner lumen extending therein and a discharge opening or port in a distal portion of the cannula which is in fluid communication with the inner lumen.
- the fibrous marker embodying features of the invention is slidably disposed within the inner lumen of the cannula, preferably along with at least one short term marker.
- the short term marker is preferably disposed distal to the fibrous marker so that upon discharge from the cannula into a target site cavity, the fibrous marker will swell upon contact with body fluids to block the accessing passageway.
- the discharge opening of the delivery device is preferably closed with a plug to hold in the markers during handling and delivery and to prevent tissue and fluid from entering the inner lumen through the discharge opening during delivery.
- Any water based fluid which may enter into the inner lumen of the delivery device can result in the expansion or swelling of the marker bodies within the inner lumen and prevent their deployment.
- the plug is formed of a water swellable material, so that the plug occludes the opening upon contact with a water based fluid and thereby prevents the premature expansion of the markers within the inner lumen. The plug is easily pushed out of the discharge opening of the tubular delivery device.
- a movable plunger is slidably disposed within the inner lumen of the delivery cannula from an initial position accommodating the marker or markers and the plug within the tube, to a delivery position to push a marker against the plug to push the plug out of the discharge opening and to then eject one or more markers through the opening into the target tissue site.
- the fibrous marker Upon being discharged into the intracorporeal target site, the fibrous marker swells on contact with body fluid, e.g. blood. The expanded fibrous marker fills or partially fills the cavity at the target site, positioning the radiopaque marker element within the interior of the target cavity.
- a therapeutic agent, a diagnostic agent or other bioactive agent may be incorporated into the fibrous marker body.
- Such agents include a hemostatic agent to accelerate thrombus formation within the target cavity, an anesthetic agent, a coloring agent, an antibiotic agent, an antifungal agent, an antiviral agent, a chemotherapeutic agent, a radioactive agent and the like.
- the plug secures the discharge opening on the distal portion of the cannula, but it is easily ejected or removed from the orifice, allowing the delivery of the markers to a desired site within a patient's body.
- the plug or the cannula itself may have retaining features, such as recesses, protuberances, detents and the like which are configured to releasably retain the plug or the short term markers proximal to the plug until ejection of the plug from the delivery tube is desired.
- the retaining features may be complementary pairs, such as a plug protuberance configured to fit into a recess in the cannula interior.
- the invention provides the advantages of a relatively long term fibrous marker which is easily deployed into a target site and which positions a permanent radiographically detectable marker element within a central portion of the target site. When combined with short term ultrasound markers, the target site is easily detected at a later date by personnel with minimal training.
- Figure 1A is a partly cut-away perspective view of a marker delivery assembly showing a fibrous marker embodying features of the invention and several short term markers within a marker delivery device and a plug embodying occluding the discharge opening of the delivery device.
- Figure 1B is a transverse cross-sectional view of the marker delivery assembly of Figure 1A taken at line 1B-1B.
- Figure 1C is a transverse cross-sectional view of the marker delivery assembly of Figure 1A taken at line 1C-1C.
- FIGS 2A-2F schematically illustrate the manufacture and use of a fibrous marker embodying features of the invention.
- Figure 3 is a partially cut away, perspective view of a human breast having a biopsy cavity from which a biopsy specimen has been removed, and showing the delivery of a marker to the cavity.
- Figure 4 schematically illustrates the deployment of a plurality of markers, including a marker embodying features of the invention, into a biopsy cavity.
- the delivery cannula 11 has an elongated shaft 18 which defines at least in part the inner lumen 12 and has a handle 20 on the proximal end of the cannula shaft 18 to facilitate handling and advancement of the device.
- the plunger 13 has a plunger shaft 21 and a plunger handle 22 to facilitate advancement of the plunger shaft 21 within inner lumen 12 of cannula 11 to discharge markers 14 and 15 from the discharge opening 17 in the cannula.
- a plurality of short term ultrasonically detectable markers 15 are disposed within the inner lumen 12 distal to the fibrous marker 14.
- the cannula 11 has a sharp, tissue penetrating distal tip 23 to facilitate advancement through tissue to the target site within the patient.
- a ramp 24 within the discharge opening 17 of the cannula 11 is provided to guide the markers 14 and 15 out through the discharge opening 16.
- a felt pad or mat 31 of oxidized, regenerated cellulose about 0.125 to about 0.375 inch (3.2-9.3 mm), preferably about 0.25 inch (6.4 mm) thick is compressed and impregnated with a 10% (Wt.) polyethylene glycol in a 70% isopropyl alcohol solution to a mat about 0.03 to about 0.05 inch (0.76-1.3 mm) thick with a length of about 20 mm.
- a reduction in thickness of 80% or more may be suitable.
- the compressed mat 31 is cut up into elongated strips 32 with square or near square transverse cross-sectional shapes.
- the strips 32 are wrapped in a fabric 33 of oxidized regenerated cellulose about 5 to about 10 mm in width and about 20 mm in length, compressed and impregnated with a 10% PEG dispersion and then dried at elevated temperatures (e.g. about 70° F. to about 150° F.) to a diameter of about 0.065 inch (1.65 mm).
- the fabric 33 should make at least one, preferably two or more complete wraps about the strip 32.
- the wrapped and compressed strip may then be cut to a desired length to form the fibrous marker 13.
- the uncompressed mat 31, the strip 32 and fiber wrap 33 may be provided at the desired length for the fibrous marker 13.
- a radiographically detectable marker element 34 may be formed of a radiopaque material such as 316L stainless steel or titanium wire 35 (OD about 0.005-0.01 inch, 0.13-0.25 mm) may then be crimped about or embedded in a central portion (or other desired portion) of the marker 13. The fibrous marker 13 is then ready for deployment.
- a radiopaque material such as 316L stainless steel or titanium wire 35 (OD about 0.005-0.01 inch, 0.13-0.25 mm) may then be crimped about or embedded in a central portion (or other desired portion) of the marker 13.
- the fibrous marker 13 is then ready for deployment.
- the delivery cannula 11 is advanced within the inner lumen 43 until the discharge opening 17 of the delivery cannula is disposed within the cavity 40.
- the operator then presses the handle 22 on plunger 13 to eject markers 14 and 15 out the discharge opening 17.
- the pressure on the markers 14 and 15 is sufficient to dislodge the plug 16 which closes off the discharge opening 17.
- a ramp 24 provided in the discharge opening 17 ensures that the markers 14 and 15 and plug 16 are discharged from the delivery device into the biopsy cavity 40.
- the fibrous marker 14 begins to swell from the body fluids located in the biopsy cavity.
- the short term, markers 15 are preferably ejected first and the fibrous marker 14 ejected last. This allows the fibrous marker 14 to swell and unfurl so as to extend across a significant portion of the cavity 40.
- the marker With a radiographically detectable wire or clip holding a central portion of the marker 14 in a constricted condition, the marker expands into a bow-tie could also place clip/wire to allow full unrolling form rectangular mat shape, as shown in Fig. 4, to center the radiopaque marker element 34 within the cavity 40.
- the marker 14 is schematically illustrated in Fig. 2F as having felt layer 32 over the entire surface of fabric layer 33. However, in a clinical setting the layer 32 will cover only a portion of the layer 33.
- the fibrous marker is preferably formed of a felt and/or fiber material formed of oxidized regenerated cellulose.
- the fibrous marker may be formed of a bioabsorbable polymer such as polylactic acid, a co-polymer of polylactic acid and glycolic acid, polycaprolactone, collagen and mixtures thereof, including mixtures with oxidized regenerated cellulose.
- Suitable oxidized, regenerated cellulose includes SURGICELTM from the Ethicon Division of Johnson & Johnson or other suitably oxidized regenerated cellulose.
- the fibrous marker may be formed of naturally hemostatic materials such as oxidized, regenerated cellulose or a hemostatic agent such as collagen or gelatin may be incorporated into the fibrous material to provide the hemostasis upon contact with blood. A wide variety of other hemostatic agents may be incorporated into the marker.
- the thrombus formed by the hemostasis is formed very quickly to fill the cavity at the biopsy site and at least temporarily hold the markers 14 and 15 in position within the cavity.
- Anesthetic agents to control post procedure pain, chemotherapeutic agents to kill any residual neoplastic tissue, coloring agents (e.g. carbon black and methylene blue) for visual location of the biopsy site, may also be incorporated into the fibrous marker.
- the radiopaque marker element is preferably clamped about the exterior of the fibrous material. However, a suitable radiopaque marker may be incorporated or otherwise embedded into the fibrous material to facilitate the location of the marker element by the fibrous marker within the biopsy cavity.
- the fibrous marker is generally configured to be slidably disposed within the inner lumen of the delivery cannula, and before delivery is about 0.5 mm to about 12 mm, preferably about 1 to about 8 mm in diameter and about 5 to about 30 mm, preferably about 10 to about 25 mm in length.
- the length of the fibrous marker Upon contact with a body fluid or other water based fluid, the length of the fibrous marker remains about the same but the wrapped structure unfolds upon swelling to a width of about 5 to about 25 mm, usually about 10 to about 20 mm.
- a radiopaque marker element clamped about a center portion of the wrapped fibrous marker, the fibrous marker expands into a generally bow-tie shape when exposed to body fluids. However, even though secured to the fibrous marker, the radiopaque marker element need not restrict the expansion of the fibrous marker.
- the short term marker which is primarily designed for ultrasound detection over a period of several hours to several months, is preferably formed of a bioabsorbable material such as polylactic acid-glycolic acid copolymer.
- the short term marker may be formed of other bioabsorbable materials including polylactic acid and porcine gelatin.
- the short term marker materials are processed to include bubbles about 20 to about 1000 micrometers in diameter for ultrasound detection.
- the bubble formation is preferably formed by the addition of sodium bicarbonate, but air may be physically incorporated while mixing the bioabsorbable material.
- the life of a particular short term marker may be controlled by the molecular weight of the polymer material from which it is made, with the higher molecular weights providing longer marker life.
- Suitable short term markers include the GelMark, which is a gelatin based marker, and GelMark Ultra which is a polylactic acid-glycolic acid copolymer based marker, sold by the present assignee. See also U.S. Patent No. 6,161,034, U.S. Patent No. 6,427,081 , U.S. Patent No. 6,347,241 and co-pending application Serial No. 09/717,909, filed on November 20, 2000 and co-pending application Serial No. 10/174,401, filed on June 17, 2002 which are incorporated herein by reference in their entirety.
- the short term markers are configured to be slidably disposed within the inner lumen of the delivery cannula and generally are about 0.5 mm to about 12 mm, preferably about 1 to about 3 mm in diameter, typically about 1.5 mm, and about 1 to about 20 mm, preferably about 2.5 to about 15 mm in length.
- the short term markers are preferably shorter than the fibrous marker.
- the plug used to occlude the discharge opening of the delivery cannula may be formed of the same material as the short term marker and indeed may be employed as a short term marker itself.
- the plug is preferably formed of or coated with polyethylene glycol which readily hydrates in the presence of body fluids and which causes the plug to swell and occlude the discharge opening. This prevents premature contact between body fluids and the markers within the inner lumen of the delivery device which can cause the markers to swell in the lumen and prevent or retard their deployment to the target site.
- An operator may grasp a device handle 22 to guide the device 12 during insertion, and to steady the device 12 during depression of the plunger 28. Insertion of a device 12 results in the placement of at least a portion of the device 12 adjacent a desired location.
- the device 12, in particular the distal tip 36 and orifice 34 of the device 123, may be guided adjacent a desired location such as a lesion site, or a biopsy cavity, or other internal body site where delivery of a marker 24 is desired.
- the short term marker typically should remain in place and be detectable within a patient for a period of at least 2 weeks to have practical clinical value, preferably at least about 6 weeks, and may remain detectable for a time period of up to about 20 weeks, more preferably for a time period of up to about 12 weeks.
- the fibrous marker should have a life period of short duration, e.g.
- the radiographically detectable marker element of the fibrous marker should have a life of at least one year and preferably is permanently radiographically detectable
- the radiopaque elements may be made of suitable radiopaque materials such as platinum, gold, iridium, tantalum, tungsten, silver, rhodium, nickel, NiTi alloy.
- MRI contrast agents such as gadolinium and gadolinium compounds, for example, are also suitable for use with plugs and/or markers embodying features of the invention.
- Marker delivery devices other than those shown in Figs. 1A-1C may be employed. Other suitable delivery devices are depicted in U.S. Patent No. 6,347,241 and co-pending application Serial No. 09/717,909 which have been incorporated herein by reference.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04752090.3A EP1626667B1 (en) | 2003-05-23 | 2004-05-13 | Fibrous marker and intracorporeal delivery device |
JP2006533023A JP2006528907A (en) | 2003-05-23 | 2004-05-13 | Fibrous markers and their delivery in the body |
ES04752090.3T ES2561390T3 (en) | 2003-05-23 | 2004-05-13 | Fibrous marker and intracorporeal administration device |
AU2004243116A AU2004243116B2 (en) | 2003-05-23 | 2004-05-13 | Fibrous marker and intracorporeal delivery thereof |
CA2526592A CA2526592C (en) | 2003-05-23 | 2004-05-13 | Fibrous marker and intracorporeal delivery thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/444,770 US7983734B2 (en) | 2003-05-23 | 2003-05-23 | Fibrous marker and intracorporeal delivery thereof |
US10/444,770 | 2003-05-23 |
Publications (2)
Publication Number | Publication Date |
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WO2004105626A2 true WO2004105626A2 (en) | 2004-12-09 |
WO2004105626A3 WO2004105626A3 (en) | 2005-05-12 |
Family
ID=33450746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/014968 WO2004105626A2 (en) | 2003-05-23 | 2004-05-13 | Fibrous marker and intracorporeal delivery thereof |
Country Status (7)
Country | Link |
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US (6) | US7983734B2 (en) |
EP (2) | EP1626667B1 (en) |
JP (1) | JP2006528907A (en) |
AU (1) | AU2004243116B2 (en) |
CA (1) | CA2526592C (en) |
ES (2) | ES2561390T3 (en) |
WO (1) | WO2004105626A2 (en) |
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WO2008019001A2 (en) * | 2006-08-04 | 2008-02-14 | Senorx, Inc. | Marker formed of starch or other suitable polysaccharide |
JP2009505696A (en) * | 2005-08-10 | 2009-02-12 | シー・アール・バード・インコーポレーテッド | Single insertion multiple sampling biopsy device with linear drive |
JP2009509709A (en) * | 2005-10-03 | 2009-03-12 | シュロス・サージカル・システムズ・インコーポレーテッド | Site markers visible with multiple therapies |
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US8626269B2 (en) | 2003-05-23 | 2014-01-07 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
US8784433B2 (en) | 2002-06-17 | 2014-07-22 | Senorx, Inc. | Plugged tip delivery tube for marker placement |
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WO2019075548A1 (en) * | 2017-10-18 | 2019-04-25 | Sunnybrook Research Institute | Magnetic resonance visible markers for magnetic resonance imaging guided brachytherapy |
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US6161034A (en) * | 1999-02-02 | 2000-12-12 | Senorx, Inc. | Methods and chemical preparations for time-limited marking of biopsy sites |
US8498693B2 (en) | 1999-02-02 | 2013-07-30 | Senorx, Inc. | Intracorporeal marker and marker delivery device |
US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
US6725083B1 (en) * | 1999-02-02 | 2004-04-20 | Senorx, Inc. | Tissue site markers for in VIVO imaging |
US6575991B1 (en) | 1999-06-17 | 2003-06-10 | Inrad, Inc. | Apparatus for the percutaneous marking of a lesion |
CA2775170C (en) | 2000-11-20 | 2017-09-05 | Senorx, Inc. | An intracorporeal marker delivery system for marking a tissue site |
GB0120645D0 (en) | 2001-08-24 | 2001-10-17 | Smiths Group Plc | Medico-surgical devices |
JP4342319B2 (en) | 2002-03-19 | 2009-10-14 | バード ダブリン アイティーシー リミティッド | Biopsy device and biopsy needle module usable for biopsy device |
JP4260024B2 (en) | 2002-03-19 | 2009-04-30 | バード ダブリン アイティーシー リミティッド | Vacuum biopsy device |
EP1545316B1 (en) * | 2002-08-01 | 2008-01-09 | James E. Selis | Biopsy devices |
US20060036158A1 (en) | 2003-11-17 | 2006-02-16 | Inrad, Inc. | Self-contained, self-piercing, side-expelling marking apparatus |
DE10314240A1 (en) | 2003-03-29 | 2004-10-07 | Bard Dublin Itc Ltd., Crawley | Pressure generating unit |
GB0307350D0 (en) | 2003-03-29 | 2003-05-07 | Smiths Group Plc | Catheters |
US20050119562A1 (en) * | 2003-05-23 | 2005-06-02 | Senorx, Inc. | Fibrous marker formed of synthetic polymer strands |
US7877133B2 (en) * | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
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Also Published As
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US20150051477A1 (en) | 2015-02-19 |
AU2004243116A1 (en) | 2004-12-09 |
US20130310686A1 (en) | 2013-11-21 |
US20040236212A1 (en) | 2004-11-25 |
AU2004243116B2 (en) | 2010-12-16 |
JP2006528907A (en) | 2006-12-28 |
US9801688B2 (en) | 2017-10-31 |
CA2526592C (en) | 2013-10-29 |
US8880154B2 (en) | 2014-11-04 |
US20110237943A1 (en) | 2011-09-29 |
ES2561390T3 (en) | 2016-02-25 |
US8626269B2 (en) | 2014-01-07 |
CA2526592A1 (en) | 2004-12-09 |
EP1626667B1 (en) | 2015-12-02 |
US20040236213A1 (en) | 2004-11-25 |
US20090018439A1 (en) | 2009-01-15 |
EP2550927A1 (en) | 2013-01-30 |
WO2004105626A3 (en) | 2005-05-12 |
EP2550927B1 (en) | 2018-06-20 |
US7983734B2 (en) | 2011-07-19 |
US7970454B2 (en) | 2011-06-28 |
EP1626667A2 (en) | 2006-02-22 |
ES2680969T3 (en) | 2018-09-11 |
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