WO2004103455A3 - Selective nerve fiber stimulation for heart treatment - Google Patents

Selective nerve fiber stimulation for heart treatment Download PDF

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Publication number
WO2004103455A3
WO2004103455A3 PCT/IL2004/000440 IL2004000440W WO2004103455A3 WO 2004103455 A3 WO2004103455 A3 WO 2004103455A3 IL 2004000440 W IL2004000440 W IL 2004000440W WO 2004103455 A3 WO2004103455 A3 WO 2004103455A3
Authority
WO
WIPO (PCT)
Prior art keywords
nerve fiber
heart treatment
fiber stimulation
selective nerve
subject
Prior art date
Application number
PCT/IL2004/000440
Other languages
French (fr)
Other versions
WO2004103455A2 (en
Inventor
David Tamir Ben
Shai Ayal
Ezra Omry Ben
Ehud Cohen
Original Assignee
Biocontrol Medical Ltd
David Tamir Ben
Shai Ayal
Ezra Omry Ben
Ehud Cohen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IL2003/000431 external-priority patent/WO2003099377A1/en
Application filed by Biocontrol Medical Ltd, David Tamir Ben, Shai Ayal, Ezra Omry Ben, Ehud Cohen filed Critical Biocontrol Medical Ltd
Priority to EP04734481A priority Critical patent/EP1638645A4/en
Publication of WO2004103455A2 publication Critical patent/WO2004103455A2/en
Publication of WO2004103455A3 publication Critical patent/WO2004103455A3/en
Priority to IL172140A priority patent/IL172140A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4041—Evaluating nerves condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7217—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0556—Cuff electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3621—Heart stimulators for treating or preventing abnormally high heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

Apparatus (18) is provided that includes an electrode device (40), adapted to be coupled to a vagus nerve (36) of a subject (31), and a control unit (20), adapted to drive the electrode device (40) to apply to the vagus nerve (36) a current that reduces heart rate variability of the subject (31). Also provided is a method comprising applying to a vagus nerve (36) of a subject (31) a current that reduces heart rate variability of the subject (31).
PCT/IL2004/000440 2003-05-23 2004-05-23 Selective nerve fiber stimulation for heart treatment WO2004103455A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP04734481A EP1638645A4 (en) 2003-05-23 2004-05-23 Selective nerve fiber stimulation for heart treatment
IL172140A IL172140A (en) 2003-05-23 2005-11-23 Selective nerve fiber stimulation for heart treatment

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ILPCT/IL03/00431 2003-05-23
PCT/IL2003/000431 WO2003099377A1 (en) 2002-05-23 2003-05-23 Selective nerve fiber stimulation for treating heart conditions
US10/719,659 2003-11-20
US10/719,659 US7778711B2 (en) 2001-08-31 2003-11-20 Reduction of heart rate variability by parasympathetic stimulation

Publications (2)

Publication Number Publication Date
WO2004103455A2 WO2004103455A2 (en) 2004-12-02
WO2004103455A3 true WO2004103455A3 (en) 2005-01-06

Family

ID=33477801

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2004/000440 WO2004103455A2 (en) 2003-05-23 2004-05-23 Selective nerve fiber stimulation for heart treatment

Country Status (3)

Country Link
US (5) US7778711B2 (en)
EP (1) EP1638645A4 (en)
WO (1) WO2004103455A2 (en)

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US7778711B2 (en) 2010-08-17
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US20050197675A1 (en) 2005-09-08
US20050187586A1 (en) 2005-08-25
EP1638645A2 (en) 2006-03-29
US20080125827A1 (en) 2008-05-29
US20080132964A1 (en) 2008-06-05
US20040193231A1 (en) 2004-09-30
US8386056B2 (en) 2013-02-26

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