WO2004103275A3 - Compositions and methods for the preparation of human growth hormone glycosylation mutants - Google Patents

Compositions and methods for the preparation of human growth hormone glycosylation mutants Download PDF

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Publication number
WO2004103275A3
WO2004103275A3 PCT/US2004/014254 US2004014254W WO2004103275A3 WO 2004103275 A3 WO2004103275 A3 WO 2004103275A3 US 2004014254 W US2004014254 W US 2004014254W WO 2004103275 A3 WO2004103275 A3 WO 2004103275A3
Authority
WO
WIPO (PCT)
Prior art keywords
mutants
growth hormone
human growth
methods
compositions
Prior art date
Application number
PCT/US2004/014254
Other languages
French (fr)
Other versions
WO2004103275A2 (en
Inventor
Shawn Defrees
Henrik Clausen
Original Assignee
Neose Technologies Inc
Shawn Defrees
Henrik Clausen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc, Shawn Defrees, Henrik Clausen filed Critical Neose Technologies Inc
Priority to JP2006532844A priority Critical patent/JP2007523630A/en
Priority to US10/556,094 priority patent/US7932364B2/en
Priority to ES04751591T priority patent/ES2380093T3/en
Priority to AU2004240553A priority patent/AU2004240553A1/en
Priority to BRPI0410164-2A priority patent/BRPI0410164A/en
Priority to MXPA05011832A priority patent/MXPA05011832A/en
Priority to AT04751591T priority patent/ATE540055T1/en
Priority to CA002524936A priority patent/CA2524936A1/en
Priority to EP04751591A priority patent/EP1624847B1/en
Publication of WO2004103275A2 publication Critical patent/WO2004103275A2/en
Publication of WO2004103275A3 publication Critical patent/WO2004103275A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates to mutants of human growth hormone, which contain newly introduced N-linked or O-linked glycosylation site(s), such that these recombinantly produced polypeptides have glycosylation patterns distinctly different from that of the naturally occurring human growth hormone. The polynucleotide coding sequences for the mutants, expression cassettes comprising the coding sequences, cells expressing the mutants, and methods for producing the mutants are also disclosed. Further disclosed are pharmaceutical compositions comprising the mutants and method for using the mutants.
PCT/US2004/014254 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants WO2004103275A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2006532844A JP2007523630A (en) 2003-05-09 2004-05-07 Composition and formulation of human growth hormone glycosylation mutants
US10/556,094 US7932364B2 (en) 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants
ES04751591T ES2380093T3 (en) 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants
AU2004240553A AU2004240553A1 (en) 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants
BRPI0410164-2A BRPI0410164A (en) 2003-05-09 2004-05-07 compositions and methods for preparing human growth hormone glycosylation mutants
MXPA05011832A MXPA05011832A (en) 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants.
AT04751591T ATE540055T1 (en) 2003-05-09 2004-05-07 COMPOSITIONS AND METHODS FOR PRODUCING HUMAN GROWTH HORMONE GLYCOSYLATION MUTANTS
CA002524936A CA2524936A1 (en) 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants
EP04751591A EP1624847B1 (en) 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US46911403P 2003-05-09 2003-05-09
US60/469,114 2003-05-09
US49475103P 2003-08-13 2003-08-13
US60/494,751 2003-08-13
US49507603P 2003-08-14 2003-08-14
US60/495,076 2003-08-14
US53529004P 2004-01-08 2004-01-08
US60/535,290 2004-01-08

Publications (2)

Publication Number Publication Date
WO2004103275A2 WO2004103275A2 (en) 2004-12-02
WO2004103275A3 true WO2004103275A3 (en) 2007-05-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/014254 WO2004103275A2 (en) 2003-05-09 2004-05-07 Compositions and methods for the preparation of human growth hormone glycosylation mutants

Country Status (11)

Country Link
US (1) US7932364B2 (en)
EP (1) EP1624847B1 (en)
JP (1) JP2007523630A (en)
KR (1) KR20060030023A (en)
AT (1) ATE540055T1 (en)
AU (1) AU2004240553A1 (en)
BR (1) BRPI0410164A (en)
CA (1) CA2524936A1 (en)
ES (1) ES2380093T3 (en)
MX (1) MXPA05011832A (en)
WO (1) WO2004103275A2 (en)

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