WO2004096148A3 - Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof - Google Patents

Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof Download PDF

Info

Publication number
WO2004096148A3
WO2004096148A3 PCT/US2004/013099 US2004013099W WO2004096148A3 WO 2004096148 A3 WO2004096148 A3 WO 2004096148A3 US 2004013099 W US2004013099 W US 2004013099W WO 2004096148 A3 WO2004096148 A3 WO 2004096148A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue protective
assays
compounds
receptor complex
complex
Prior art date
Application number
PCT/US2004/013099
Other languages
French (fr)
Other versions
WO2004096148A2 (en
Inventor
Michael Brines
Anthony Cerami
Pietro Ghezzi
Fbio Fiordaliso
Maddalena Fratelli
Marcel Leist
Mette Nielsen
Thomas Sager
Lars Ostergaard Pedersen
Jens Gerwien
Thomas Coleman
Original Assignee
Kenneth S Warren Inst Inc
Michael Brines
Anthony Cerami
Pietro Ghezzi
Fbio Fiordaliso
Maddalena Fratelli
Marcel Leist
Mette Nielsen
Thomas Sager
Lars Ostergaard Pedersen
Jens Gerwien
Thomas Coleman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002523578A priority Critical patent/CA2523578A1/en
Priority to BRPI0409678-9A priority patent/BRPI0409678A/en
Priority to MXPA05011134A priority patent/MXPA05011134A/en
Priority to AU2004233985A priority patent/AU2004233985A1/en
Priority to JP2006513398A priority patent/JP2006524827A/en
Priority to EA200501667A priority patent/EA009745B1/en
Priority to EP04760431A priority patent/EP1622570A4/en
Priority to NZ543192A priority patent/NZ543192A/en
Application filed by Kenneth S Warren Inst Inc, Michael Brines, Anthony Cerami, Pietro Ghezzi, Fbio Fiordaliso, Maddalena Fratelli, Marcel Leist, Mette Nielsen, Thomas Sager, Lars Ostergaard Pedersen, Jens Gerwien, Thomas Coleman filed Critical Kenneth S Warren Inst Inc
Priority to US10/554,517 priority patent/US20090136519A1/en
Publication of WO2004096148A2 publication Critical patent/WO2004096148A2/en
Priority to IS8075A priority patent/IS8075A/en
Priority to US11/259,326 priority patent/US20060216757A1/en
Priority to NO20055525A priority patent/NO20055525L/en
Publication of WO2004096148A3 publication Critical patent/WO2004096148A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention is directed methods for identifying compounds that have a tissue protective activity using a heteromultimer receptor complex that mediates the tissue protective activities. The complex consists of at least one EPO-R in complex with at least one βc Receptor. These compounds used in the assays to identify tissue protective compounds include, but are not limited to, small molecules and biologics. The compounds identified using these assays can be used to treat or prevent various diseases, disorders, or conditions of the central and peripheral nervous systems as well as those of other erythropoietin-responsive or excitable cells, tissues, and organs.
PCT/US2004/013099 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof WO2004096148A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
EP04760431A EP1622570A4 (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
MXPA05011134A MXPA05011134A (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof.
AU2004233985A AU2004233985A1 (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
JP2006513398A JP2006524827A (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
EA200501667A EA009745B1 (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
CA002523578A CA2523578A1 (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
NZ543192A NZ543192A (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
BRPI0409678-9A BRPI0409678A (en) 2003-04-25 2004-04-26 methods for identifying a compound, for treating or preventing a disease or disorder in a human, for enhancing the function of excitable organs, tissues, or cells in a human, and for modulating the activity of a tissue-protecting cytokine receptor complex in a human human
US10/554,517 US20090136519A1 (en) 2003-04-25 2004-04-26 Tissue Protective Cytokine Receptor Complex, Assays for Identifying Tissue Protective Compounds and Uses Thereof
IS8075A IS8075A (en) 2003-04-25 2005-10-14 Tissue Receptor Cell Prototype, Tests to Identify Tissue Protective Compounds and Their Use
US11/259,326 US20060216757A1 (en) 2003-04-25 2005-10-25 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
NO20055525A NO20055525L (en) 2003-04-25 2005-11-23 Tissue Protective Cytokine Receptor Complex Assay for Identifying Tissue Protective Compounds and Uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46589103P 2003-04-25 2003-04-25
US60/465,891 2003-04-25
US10/676,694 US7718363B2 (en) 2003-04-25 2003-09-30 Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds
US10/676,694 2003-09-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/676,694 Continuation-In-Part US7718363B2 (en) 2003-04-25 2003-09-30 Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/259,326 Continuation US20060216757A1 (en) 2003-04-25 2005-10-25 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof

Publications (2)

Publication Number Publication Date
WO2004096148A2 WO2004096148A2 (en) 2004-11-11
WO2004096148A3 true WO2004096148A3 (en) 2006-03-02

Family

ID=33303293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/013099 WO2004096148A2 (en) 2003-04-25 2004-04-26 Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof

Country Status (13)

Country Link
US (2) US7718363B2 (en)
EP (1) EP1622570A4 (en)
JP (1) JP2006524827A (en)
KR (1) KR20050121270A (en)
AU (1) AU2004233985A1 (en)
BR (1) BRPI0409678A (en)
CA (1) CA2523578A1 (en)
EA (1) EA009745B1 (en)
IS (1) IS8075A (en)
MX (1) MXPA05011134A (en)
NO (1) NO20055525L (en)
NZ (1) NZ543192A (en)
WO (1) WO2004096148A2 (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7345019B1 (en) * 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
AU2002361784A1 (en) * 2001-12-20 2003-07-09 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
NZ542094A (en) 2003-03-14 2008-12-24 Neose Technologies Inc Branched polymer conjugates comprising a peptide and water-soluble polymer chains
SG155777A1 (en) 2003-04-09 2009-10-29 Neose Technologies Inc Glycopegylation methods and proteins/peptides produced by the methods
WO2006127896A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated factor ix
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
US20060216757A1 (en) * 2003-04-25 2006-09-28 The Kenneth S. Warren Institute, Inc. Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
US7718363B2 (en) 2003-04-25 2010-05-18 The Kenneth S. Warren Institute, Inc. Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds
EP1624847B1 (en) 2003-05-09 2012-01-04 BioGeneriX AG Compositions and methods for the preparation of human growth hormone glycosylation mutants
US10191028B1 (en) * 2003-06-06 2019-01-29 Ionwerks Inorganic nanoparticle matrices for sample analysis
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
EA010650B1 (en) * 2003-09-29 2008-10-30 Уоррен Фармасьютикалз, Инк. Tissue protective cytokines for the treatment and preservations of sepsis and the formation of adhesions
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US7842661B2 (en) 2003-11-24 2010-11-30 Novo Nordisk A/S Glycopegylated erythropoietin formulations
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
EP1765853B1 (en) 2004-01-08 2015-10-28 ratiopharm GmbH O-linked glycosylation of G-CSF peptides
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
EP3061461A1 (en) 2004-10-29 2016-08-31 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (fgf)
ES2449195T3 (en) 2005-01-10 2014-03-18 Ratiopharm Gmbh Glycopegylated granulocyte colony stimulating factor
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
LT2594279T (en) 2005-08-05 2018-01-10 Araim Pharmaceuticals, Inc. Tissue protective peptides and uses thereof
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
EP1760092A1 (en) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
US20070072795A1 (en) * 2005-09-28 2007-03-29 Anton Haselbeck Treatment of neurodegenerative disorders
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
US20080274958A1 (en) 2006-07-21 2008-11-06 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
NZ580030A (en) 2007-04-03 2012-06-29 Biogenerix Ag Methods of treatment using glycopegylated g-csf
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
AU2008328754B2 (en) * 2007-11-29 2015-04-16 Molecular Health Gmbh Novel tissue protective erythropoietin receptor (NEPOR) and methods of use
US8357501B2 (en) 2007-11-29 2013-01-22 Molecular Health Gmbh Tissue protective erythropoietin receptor (NEPOR) and methods of use
KR20190085187A (en) 2008-01-22 2019-07-17 아라임 파마슈티칼즈, 인크. Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
KR101582841B1 (en) 2008-02-27 2016-01-11 노보 노르디스크 에이/에스 Conjugated factor viii molecules
WO2010083532A1 (en) * 2009-01-19 2010-07-22 The Research Foundaton Of State University Of New York Fatty acid binding proteins as drug targets for modulation of endocannabinoids
ES2629850T3 (en) * 2010-07-19 2017-08-16 Otago Innovation Limited Signal biomarkers
DK2880170T3 (en) * 2012-08-02 2016-10-24 Hoffmann La Roche PROCEDURE FOR PREPARING SOLUBLE FcR AS Fc FUSION WITH INERT IMMUNOGLOBULIN Fc REGION AND APPLICATIONS THEREOF
CN105517561A (en) * 2013-07-17 2016-04-20 阿拉伊姆药品公司 Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
US10544472B2 (en) * 2014-01-18 2020-01-28 Attagene, Inc. Multiplexing transcription factor reporter protein assay process and system
RU2612913C2 (en) * 2015-05-12 2017-03-13 Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" Method of increasing life span of molluscs abra segmentum under conditions of hypoxia for period from 4 to 14 days
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US20240053325A1 (en) * 2020-12-11 2024-02-15 President And Fellows Of Harvard College Novel screening platform to identify immune modulatory agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278065A (en) * 1989-02-03 1994-01-11 Genetics Institute, Inc. Recombinant DNA endoding an erythropoietin receptor
US5997865A (en) * 1994-04-04 1999-12-07 Bennett; Brian D. Agonist antibodies against the flk2/flt3 receptor and uses thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292654A (en) 1990-12-13 1994-03-08 Whitehead Institute For Biomedical Research Mutant EPO receptor and uses therefor
DE4228839A1 (en) 1992-08-29 1994-03-03 Behringwerke Ag Methods for the detection and determination of mediators
JPH09501833A (en) 1993-08-16 1997-02-25 リー，ジョン・ワイ Human erythropoietin receptor fragment and antibody thereto
US5763198A (en) 1994-07-22 1998-06-09 Sugen, Inc. Screening assays for compounds
WO1996019579A1 (en) * 1994-12-22 1996-06-27 Novartis Ag Nuclear protein serine/threonine kinases
AUPN780096A0 (en) 1996-01-30 1996-02-22 Medvet Science Pty. Ltd. Cytokine antagonists and agonists
WO1998013513A2 (en) * 1996-09-24 1998-04-02 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
DE19857609A1 (en) 1998-12-14 2000-06-15 Hannelore Ehrenreich Use of erythropoietin for the treatment of human cerebral ischemia
NZ545478A (en) 1999-04-13 2008-04-30 Kenneth S Warren Inst Inc Modulation of excitable tissue function by peripherally administered erythropoietin
US7345019B1 (en) 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US7410941B1 (en) 1999-04-13 2008-08-12 The Kenneth S. Warren Institute, Inc. Methods for treatment of neurodegenerative conditions by peripherally administered erythropoietin
DK1325115T3 (en) 2000-06-26 2016-11-21 Zymogenetics Inc CYTOKINRECEPTOR ZCYTOR17
US7767643B2 (en) 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US6531121B2 (en) 2000-12-29 2003-03-11 The Kenneth S. Warren Institute, Inc. Protection and enhancement of erythropoietin-responsive cells, tissues and organs
PA8536201A1 (en) 2000-12-29 2002-08-29 Kenneth S Warren Inst Inc PROTECTION AND IMPROVEMENT OF CELLS, FABRICS AND ORGANS RESPONDING TO Erythropoietin
JP2006507228A (en) 2002-07-01 2006-03-02 ザ ケネス エス．ウォーレン インスティテュート，インコーポレーテッド Recombinant tissue protective cytokine and nucleic acid encoding the same for protecting, restoring and enhancing responsive cells, tissues and organs
CN1729015A (en) 2002-09-09 2006-02-01 沃伦药品公司 Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin
US20050176627A1 (en) 2002-09-09 2005-08-11 Anthony Cerami Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin
US20060216757A1 (en) 2003-04-25 2006-09-28 The Kenneth S. Warren Institute, Inc. Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
US7718363B2 (en) 2003-04-25 2010-05-18 The Kenneth S. Warren Institute, Inc. Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds
WO2005117927A2 (en) 2004-05-20 2005-12-15 The Kenneth S. Warren Institute, Inc. Tissue protective cytokines with an extended therapeutic window
KR20060013547A (en) * 2003-05-19 2006-02-10 더 케네쓰 에스. 워렌 인스티튜트 인코포레이티드 Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs with an extended therapeutic window
BRPI0409650A (en) 2003-09-09 2006-04-25 Warren Pharmaceuticals Inc methods for regulating hematocrit and human levels, artificial erythropoietin products, methods for preparing an erythropoietin product and for treating anemia in patients at risk of tissue damage, and, pharmaceutical composition
EA010650B1 (en) 2003-09-29 2008-10-30 Уоррен Фармасьютикалз, Инк. Tissue protective cytokines for the treatment and preservations of sepsis and the formation of adhesions
WO2005084364A2 (en) 2004-03-03 2005-09-15 The Kenneth S. Warren Institue, Inc. Long acting tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
AU2005270092A1 (en) 2004-07-02 2006-02-09 Cerami, Anthony Method of producing fully carbamylated erythropoietin
WO2006014466A2 (en) 2004-07-02 2006-02-09 The Kenneth S. Warren Institute, Inc. Novel carbamylated epo and method for its production
ES2325034T3 (en) 2004-07-07 2009-08-24 H. Lundbeck A/S NEW CARBAMILATED EPO AND METHOD FOR YOUR PRODUCTION.
EP1934226A2 (en) * 2006-08-14 2008-06-25 Sicor, Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
US20080045409A1 (en) 2006-08-16 2008-02-21 Buarque De Macedo Pedro M Ceramic catalysts
US8538421B2 (en) * 2008-10-20 2013-09-17 At&T Mobility Ii Llc Management of network technology selection and display in multi-technology wireless environments
US9030606B2 (en) * 2013-03-14 2015-05-12 Gopro, Inc. Wireless camera housing illuminators
US9290938B2 (en) * 2014-04-09 2016-03-22 Wickright, Inc. Construction system for releasing moisture from a hip, valley or gable roof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278065A (en) * 1989-02-03 1994-01-11 Genetics Institute, Inc. Recombinant DNA endoding an erythropoietin receptor
US5997865A (en) * 1994-04-04 1999-12-07 Bennett; Brian D. Agonist antibodies against the flk2/flt3 receptor and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1622570A4 *

Also Published As

Publication number Publication date
US20090136519A1 (en) 2009-05-28
US20040214236A1 (en) 2004-10-28
EP1622570A4 (en) 2009-07-08
IS8075A (en) 2005-10-14
KR20050121270A (en) 2005-12-26
AU2004233985A1 (en) 2004-11-11
MXPA05011134A (en) 2006-05-25
EA200501667A1 (en) 2006-06-30
NO20055525D0 (en) 2005-11-23
NZ543192A (en) 2008-07-31
CA2523578A1 (en) 2004-11-11
BRPI0409678A (en) 2006-05-02
JP2006524827A (en) 2006-11-02
WO2004096148A2 (en) 2004-11-11
US7718363B2 (en) 2010-05-18
NO20055525L (en) 2006-01-16
EA009745B1 (en) 2008-04-28
EP1622570A2 (en) 2006-02-08

Similar Documents

Publication Publication Date Title
WO2004096148A3 (en) Tissue protective cytokine receptor complex, assays for identifying tissue protective compounds and uses thereof
BRPI0415210A (en) compounds and compositions as protein kinase inhibitors
BRPI0409173A (en) compounds and compositions as protein kinase inhibitors
WO2005123048A3 (en) Screening methods using c-abl, fyn and syk in combination with tau protein
EP2275096A3 (en) Neurogenesis via modulation of the muscarinic receptors
WO2005116088A3 (en) Methods and compositions for treating diseases and disorders associated with siglec-8 expressing cells
HK1116349A1 (en) Pyrrolopyrimidines useful as inhibitors of protein kinase
DE60327999D1 (en) AZOLYLAMINOAZINES AS INHIBITORS OF PROTEIN KINASES
WO2007143098A8 (en) Hepatocyte growth factor (hgf) binding proteins
ATE464303T1 (en) COMPOSITIONS SUITABLE AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES
WO2007076473A3 (en) Substituted pyrimidinyloxy ureas useful as inhibitors of protein kinases
BRPI0511477A (en) compounds and compositions as modulators of ppar
WO2007134077A3 (en) 5 ht receptor mediated neurogenesis
WO2007143090A3 (en) Hepatocyte growth factor (hgf) binding proteins
CL2007002017A1 (en) COMPOUNDS DERIVED FROM [4,5 '] - BIPIRIMIDINIL-6,4'-DIAMINE; PHARMACEUTICAL COMPOSITION; AND USE AS AN INHIBITOR OF THE ACTIVITY OF CINASA IN CANCER DE VEJIGA, CANCER CERVICAL AND MIELOMA MULTIPLE.
BRPI0613859A8 (en) nitrocathecol derivatives, their use and preparation process, as well as pharmaceutical composition
WO2006073448A3 (en) Methods and compositions for treating diseases and conditions associated with mitochondrial function
IL177015B (en) Isolated human rpe cells and use thereof for the treatment of degenerative disease of the retina
WO2007056163A3 (en) Aminopyrimidines useful as kinase inhibitors
WO1998019167A3 (en) Cell stress regulated human mhc class i gene
WO2008097861A3 (en) MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS
MX2009006685A (en) Dr6 antagonists and uses thereof in treating neurological disorders.
WO2007079400A3 (en) Self-adhesive protective substrate
ATE435858T1 (en) PRODRUGS OF PYRROLYLPYRIMIDINES ACTING AS ERK PROTEIN KINASE INHIBITORS
BR0316296A (en) Lapacone compounds and their methods of use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: PA/a/2005/011134

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2005/08434

Country of ref document: ZA

Ref document number: 200508434

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: 171466

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 543192

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2004233985

Country of ref document: AU

Ref document number: 2006513398

Country of ref document: JP

Ref document number: 2750/CHENP/2005

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2523578

Country of ref document: CA

Ref document number: 11259326

Country of ref document: US

Ref document number: 1020057020323

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2004233985

Country of ref document: AU

Date of ref document: 20040426

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004233985

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 05119097

Country of ref document: CO

Ref document number: 200501667

Country of ref document: EA

WWE Wipo information: entry into national phase

Ref document number: 2004760431

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 20048177059

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 1020057020323

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2004760431

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0409678

Country of ref document: BR

WWP Wipo information: published in national office

Ref document number: 11259326

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 10554517

Country of ref document: US