WO2004093738A2 - Radiopaque embolic protection filter membrane - Google Patents

Radiopaque embolic protection filter membrane Download PDF

Info

Publication number
WO2004093738A2
WO2004093738A2 PCT/US2004/005344 US2004005344W WO2004093738A2 WO 2004093738 A2 WO2004093738 A2 WO 2004093738A2 US 2004005344 W US2004005344 W US 2004005344W WO 2004093738 A2 WO2004093738 A2 WO 2004093738A2
Authority
WO
WIPO (PCT)
Prior art keywords
filter
layer
embolic protection
radiopaque
filter material
Prior art date
Application number
PCT/US2004/005344
Other languages
French (fr)
Other versions
WO2004093738A3 (en
Inventor
Dnyanesh Talpade
Peter Hirshman
Yem Chin
Sheng-Ping Zhong
Original Assignee
Scimed Life Systems, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scimed Life Systems, Inc. filed Critical Scimed Life Systems, Inc.
Publication of WO2004093738A2 publication Critical patent/WO2004093738A2/en
Publication of WO2004093738A3 publication Critical patent/WO2004093738A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2002/018—Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0006—Rounded shapes, e.g. with rounded corners circular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004—Rounded shapes, e.g. with rounded corners
    • A61F2230/0008—Rounded shapes, e.g. with rounded corners elliptical or oval
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0073—Quadric-shaped
    • A61F2230/008—Quadric-shaped paraboloidal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0097—Harpoon-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105—Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0108—Steering means as part of the catheter or advancing means; Markers for positioning using radio-opaque or ultrasound markers

Definitions

  • the present invention pertains to embolic protection filter devices. More particularly, the present invention pertains to embolic protection filters having a radiopaque marker.
  • Heart and vascular disease are majors problem in the United States and throughout the world. Conditions such as atherosclerosis result in blood vessels becoming blocked or narrowed. This blockage can result in lack of oxygenation of the heart, which has significant consequences since the heart muscle must be well oxygenated in order to maintain its blood pumping action.
  • Occluded, stenotic, or narrowed blood vessels may be treated with a number of relatively non-invasive medical procedures including percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTC A), and atherectomy.
  • Angioplasty techniques typically involve the use of a balloon catheter. The balloon catheter is advanced over a guidewire such that the balloon is positioned adjacent a stenotic lesion. The balloon is then inflated and the restriction of the vessel is opened. During an atherectomy procedure, the stenotic lesion may be mechanically cut away from the blood vessel wall using an atherectomy catheter.
  • embolic debris can be separated from the wall of the blood vessel. If this debris enters the circulatory system, it could block other vascular regions including the neural and pulmonary vasculature. During angioplasty procedures, stenotic debris may also break loose due to manipulation of the blood vessel. Because of this debris, a number of devices, termed embolic protection devices, have been developed to filter out this debris.
  • an embolic protection filter assembly includes an elongate shaft and a filter coupled to the shaft.
  • the filter may include at least one radiopaque component that can enhance the ability of a clinician to visualize the filter.
  • the radiopaque component may be mixed or distributed throughout a polymer and the filter can be formed, for example, by dipping a mandrel into the mixture.
  • the filter may be formed from a plurality of layers and one or more of the layers may include a radiopaque material.
  • Figure 1 is a prospective view of an example embolic protection filter assembly
  • Figure 2 is a prospective view of a forming member appropriate for forming an embolic protection filter
  • Figure 3 is a plan view of a radiopaque filter material coupled to an embolic protection filter frame and a mandrel;
  • Figure 4 is a plan view of another example radiopaque filter material disposed adjacent a mandrel.
  • embolic debris may dislodge from the blood vessel.
  • This embolic debris can travel in the bloodstream and impair blood flow, possibly leading to tissue damage.
  • filtering devices have been developed that can be used in conjunction with a debris-producing intervention. These embolic protection filters can be disposed in the blood vessel downstream of the treatment site and expanded to capture the debris.
  • the clinician Often it is desirable for the clinician to be able to track and/or visualize the location of the filter within the body.
  • One way to accomplish this is to couple a radiopaque marker to the guidewire adjacent the filter or to the mouth of the filter frame.
  • the former strategies are effective, they tend to allow only a portion of the filter or a region adjacent the filter to be visualized. It may be desirable for the filter to be visualized more completely so that the clinician can perform an intravascular intervention with heightened precision.
  • the present invention relates to embolic protection filters (and methods of making the same) that allow for improved filter visualization.
  • FIG 1 illustrates an embolic protection filter assembly 10 including an elongate shaft or guidewire 12 having an embolic protection filter 14 coupled thereto.
  • Filter 14 includes a filter material 16 coupled to a filter frame 18 (best seen in Figure 3).
  • Filter material 16 includes one or more radiopaque components 20 shown as being homogeneously distributed throughout filter material 16. Having radiopaque components 20 distributed throughout filter material 16 allow essentially all of filter 12 to be visualized by the clinician.
  • Radiopaque components 20 may include one or more radiopaque materials that are disposed, distributed, doped, or otherwise a component of filter material 16.
  • Radiopaque materials are understood to be materials capable of producing a relatively bright image on a fluoroscopy screen or another imaging technique during a medical procedure. This relatively bright image aids the user of assembly 10 in determining its location.
  • Radiopaque materials can include, but are not limited to, bismuth subcarbonate, iodine, gold, platinum, palladium, tantalum, tungsten or tungsten alloy, and the like.
  • radiopaque components 20 are illustrated as being distributed throughout a generally polymeric filter material 16. The material can also be MRI compatible.
  • This manner of distribution can be achieved, for example, by mixing radiopaque components 20 with a molten or otherwise liquefied filter material 16 and then dipping a filter mandrel (an appropriate example is mandrel 22 illustrated in Figure 2) into the mixture.
  • a filter mandrel an appropriate example is mandrel 22 illustrated in Figure 2
  • Other techniques such as blow or vacuum molding, stretch forming, or spraying can be used.
  • the result of dip-molding mandrel 22 into a mixture of radiopaque components 20 and filter material 16 may result in filter 14 that has radiopaque components 20 distributed essentially homogeneously throughout. Although the distribution has been described as being homogeneous and throughout, it can be appreciated that the precise distribution may be altered in different embodiments. For example, it may be desirable for a greater portion of radiopaque components 20 to be disposed at a particular part of filter 14 such as a narrowed distal end 24 thereof. Because the amount of filter material 16 disposed at distal end 24 decreases (as the size of filter 12 decreases), having a greater concentration of radiopaque components 20 adjacent narrowed distal end 24 may enhance visualization of distal end 24.
  • filter material 16 may be generally comprised of a polymer or combination of polymers.
  • suitable polymers include polyurethane, polyester-ether (for example a polyester-ether elastomer such as AR ITEL® available from DSM Engineering Plastics), polyester (for example a polyester elastomer such as HYTREL® available from DuPont), or linear low density polyethylene (for example REXELL®), polypropylene (PP), polyvinylchloride (PVC), polytetrafluoroethylene (PTFE), polyether-ether ketone (PEEK), polyimide, polyamide (for example, DURETHAN® available from Bayer or CRISTAMID® available from Elf Atochem), elastomeric polyamides, polyphenylene sulfide (PPS), polyphenylene oxide (PPO), polysufone, perfluoro(propyl vinyl ether) (PFA), block polyamide-ethers, polyether block amide (PEBA, for example available under the trade name
  • Shaft 12 may comprise a guidewire, catheter, tube, or the like and can be made of any suitable material including metals, metal alloys, polymers, or the like, or combinations or mixtures thereof.
  • suitable metals and metal alloys include stainless steel, such as 304v stainless steel; nickel-titanium alloy, such as nitinol, nickel-chromium alloy, nickel-chromium-iron alloy, cobalt alloy, or the like; or other suitable material.
  • the entire shaft 12 can be made of the same material, or in some embodiments, can include portions or sections made of different materials. In some embodiments, the material used to construct shaft 12 is chosen to impart varying flexibility and stiffness characteristics to different portions of shaft 12.
  • the material used to construct a proximal region can be relatively stiff for pushability and torqueability (e.g., straightened 304 stainless steel wire), and the material used to construct a distal region can be relatively flexible by comparison for better lateral trackability and steerability (e.g., a straightened super elastic or linear elastic alloy such as nickel-titanium wire).
  • Filter 14 may be coupled to shaft 12 near a distal end 26 thereof; however, it can be appreciated that filter 14 could be disposed at essentially any position along shaft 12.
  • shaft 12 can pass through a portion of filter 14 so that the distal end of filter 14 and frame 18 (and/or struts 28 extending from frame 18) can be attached to shaft 12 as shown in Figure 1.
  • filter 14 operates between a first generally collapsed configuration and a second generally expanded configuration for collecting debris in a body lumen.
  • Frame 18 may be comprised of a "self-expanding" shape-memory material such as nickel-titanium alloy (to bias filter 14 to be in the second expanded configuration). Additionally, frame 18 may include a radiopaque material or include, for example, a radiopaque wire disposed about a portion thereof. Filter material 16 can be drilled (for example, formed by known laser techniques) or otherwise manufactured to include at least one opening 27. The holes or openings 27 are sized to allow blood flow therethrough but restrict flow of debris or emboli floating in the body lumen or cavity.
  • One or more struts 28 may extend between frame 18 and shaft 12 and be coupled to shaft 12 by a coupling 30. Coupling 30 may be one or more windings of struts 28 about shaft 12 or be a fitting disposed over an end of struts 28 to attach it to shaft 12.
  • Figure 2 is a prospective view of a forming member such as a mandrel 22, which is an appropriate example of a mandrel for forming filter 14.
  • Mandrel 22 includes a tapered or necked distal region 32, a mid-region 34, and a proximal region 36 that may also be tapered.
  • a central channel or lumen (not shown) may be formed through the center along the longitudinal axis of mandrel 22 that can be used, for example, as a location for shaft 12 to be disposed during the manufacturing of filter 14.
  • Mandrel 22 may be comprised of any appropriate material including metals and polymers.
  • Frame 18 may be disposed over mandrel 22 as shown in Figure 3. In some embodiments, frame 18 is disposed over distal region 32 and mid-region 34. The portion of frame 18 disposed adjacent distal region 32 may be attached to shaft 12. Additionally, struts 28 may extend from frame 18 over proximal region 36 in a manner amenable to having struts 28 being attached to shaft 12.
  • mandrel 22, together with or independently of frame 18, can be dipped into a container 38 of filter material 16.
  • Frame 18 may be coated or pre-treated with a tie-layer or adhesive such as thixon.
  • filter material 16 may be molten and include radiopaque component 20.
  • a layer of filter material 16 remains disposed on and generally conforms to the shape of mandrel 22.
  • Filter material 16 can be allowed to solidify. The now solidified layer of filter material 16 and frame 18, ultimately, will define filter 14.
  • the thickness of filter material 16 disposed on mandrel 22 can be altered in different embodiments. For example, it is believed that holding mandrel 22 within container 38 for an extended period of time may allow a greater amount of filter material 16 to become disposed adjacent mandrel 22. Alternatively, changing the speed of dipping (either the speed of entry or withdrawal from container 38), the polymer used for filter material 16, the temperature of filter material 16, or other conditions may also play a role in determining the thickness. In some embodiments, the dipping step may be repeated additional times to increase thickness or incorporate other desired properties. For example, an initial dipping step may include dipping mandrel 22 into a non-radiopaque filter material, followed by dipping into filter material 16 (including radiopaque component 20). A final dipping step may also be performed to effectively "sandwich" or embed the radiopaque layer.
  • assembly 10 may be used to facilitate an intravascular intervention.
  • assembly 10 may be loaded within a delivery sheath and advanced through the vasculature to a location adjacent (i.e., "downstream") of a lesion. The sheath can be retracted, allowing frame 18 to expand filter 12, and a therapeutic or diagnostic medical device, for example an angioplasty or atherectomy catheter, can be advanced over shaft 12. Debris generated by the medical device can be capture by filter 14 and later removed from the body.
  • FIG 4 is a plan view of another example radiopaque filter material 116 coupled disposed adjacent mandrel 22.
  • Filter material 116 is appropriate for forming filter 14 and is similar to filter material 16 except that it includes a plurality of layers that can be wrapped, spun, or braided about mandrel 22.
  • One or more of the individual layers may include radiopaque component 20.
  • filter material 116 may include a first layer 140, a second layer 142, and a third layer 144, and second layer 142 may comprise a radiopaque wire.
  • the multiple layers each may include a polymer, for example polycarbonate urethane.
  • one or more of the layers 140/142/144 may include radiopaque component 20 in the form described above, in the form of a radiopaque wire, or include radiopaque wire that is embedded within a polymer.
  • the embedded radiopaque component 20 and polymer (or other suitable structure) may then be spun or otherwise disposed about mandrel 22.
  • one of the layers for example second layer 142, may include radiopaque component 20 and may be disposed between two layers, for example first layer 140 and third layer 144.
  • layers 140/142/144 may be altered to incorporate a number of desired properties.
  • layers 140/142/144 can be braided or intertwined either with each other or with themselves, which may enhance the strength of filter 14.
  • including layers 140/142/142 may obviate the need for frame 18.
  • the thickness of each individual layer may vary.
  • layer 142 may be thicker than layer 140.
  • layers 140/142/144 can be configured so as to define holes 27.
  • layers 140/142/144 may be braided and holes 27 may be defined within the braids. This strategy may allow for greater control of the diameter and/or distribution of holes 27.

Abstract

An embolic protection filter assembly and method of making the same. In at least some embodiments, the present invention relates to embolic protection filters having at least one radiopaque component.

Description

RADIOPAQUE EMBOLIC PROTECTION FILTER MEMBRANE
Field of the Invention
The present invention pertains to embolic protection filter devices. More particularly, the present invention pertains to embolic protection filters having a radiopaque marker.
Background
Heart and vascular disease are majors problem in the United States and throughout the world. Conditions such as atherosclerosis result in blood vessels becoming blocked or narrowed. This blockage can result in lack of oxygenation of the heart, which has significant consequences since the heart muscle must be well oxygenated in order to maintain its blood pumping action.
Occluded, stenotic, or narrowed blood vessels may be treated with a number of relatively non-invasive medical procedures including percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTC A), and atherectomy. Angioplasty techniques typically involve the use of a balloon catheter. The balloon catheter is advanced over a guidewire such that the balloon is positioned adjacent a stenotic lesion. The balloon is then inflated and the restriction of the vessel is opened. During an atherectomy procedure, the stenotic lesion may be mechanically cut away from the blood vessel wall using an atherectomy catheter.
During angioplasty and atherectomy procedures, embolic debris can be separated from the wall of the blood vessel. If this debris enters the circulatory system, it could block other vascular regions including the neural and pulmonary vasculature. During angioplasty procedures, stenotic debris may also break loose due to manipulation of the blood vessel. Because of this debris, a number of devices, termed embolic protection devices, have been developed to filter out this debris.
Brief Summary
The present invention pertains to embolic protection. In some embodiments, an embolic protection filter assembly includes an elongate shaft and a filter coupled to the shaft. The filter may include at least one radiopaque component that can enhance the ability of a clinician to visualize the filter. The radiopaque component may be mixed or distributed throughout a polymer and the filter can be formed, for example, by dipping a mandrel into the mixture. Alternatively, the filter may be formed from a plurality of layers and one or more of the layers may include a radiopaque material. Brief Description of the Drawings
Figure 1 is a prospective view of an example embolic protection filter assembly;
Figure 2 is a prospective view of a forming member appropriate for forming an embolic protection filter;
Figure 3 is a plan view of a radiopaque filter material coupled to an embolic protection filter frame and a mandrel; and
Figure 4 is a plan view of another example radiopaque filter material disposed adjacent a mandrel.
Detailed Description
The following description should be read with reference to the drawings wherein like reference numerals indicate like elements throughout the several views. The detailed description and drawings illustrate example embodiments of the claimed invention.
When a physician performs an intravascular intervention such as angioplasty, atherectomy, and the like, embolic debris may dislodge from the blood vessel. This embolic debris can travel in the bloodstream and impair blood flow, possibly leading to tissue damage. In order to account for this embolic debris, a number of filtering devices have been developed that can be used in conjunction with a debris-producing intervention. These embolic protection filters can be disposed in the blood vessel downstream of the treatment site and expanded to capture the debris.
Often it is desirable for the clinician to be able to track and/or visualize the location of the filter within the body. One way to accomplish this is to couple a radiopaque marker to the guidewire adjacent the filter or to the mouth of the filter frame. Although the former strategies are effective, they tend to allow only a portion of the filter or a region adjacent the filter to be visualized. It may be desirable for the filter to be visualized more completely so that the clinician can perform an intravascular intervention with heightened precision. In at least some embodiments, the present invention relates to embolic protection filters (and methods of making the same) that allow for improved filter visualization.
Figure 1 illustrates an embolic protection filter assembly 10 including an elongate shaft or guidewire 12 having an embolic protection filter 14 coupled thereto. Filter 14 includes a filter material 16 coupled to a filter frame 18 (best seen in Figure 3). Filter material 16 includes one or more radiopaque components 20 shown as being homogeneously distributed throughout filter material 16. Having radiopaque components 20 distributed throughout filter material 16 allow essentially all of filter 12 to be visualized by the clinician.
Radiopaque components 20 may include one or more radiopaque materials that are disposed, distributed, doped, or otherwise a component of filter material 16. Radiopaque materials are understood to be materials capable of producing a relatively bright image on a fluoroscopy screen or another imaging technique during a medical procedure. This relatively bright image aids the user of assembly 10 in determining its location. Radiopaque materials can include, but are not limited to, bismuth subcarbonate, iodine, gold, platinum, palladium, tantalum, tungsten or tungsten alloy, and the like. In the embodiment show in Figure 1, radiopaque components 20 are illustrated as being distributed throughout a generally polymeric filter material 16. The material can also be MRI compatible. This manner of distribution can be achieved, for example, by mixing radiopaque components 20 with a molten or otherwise liquefied filter material 16 and then dipping a filter mandrel (an appropriate example is mandrel 22 illustrated in Figure 2) into the mixture. Other techniques such as blow or vacuum molding, stretch forming, or spraying can be used.
The result of dip-molding mandrel 22 into a mixture of radiopaque components 20 and filter material 16 may result in filter 14 that has radiopaque components 20 distributed essentially homogeneously throughout. Although the distribution has been described as being homogeneous and throughout, it can be appreciated that the precise distribution may be altered in different embodiments. For example, it may be desirable for a greater portion of radiopaque components 20 to be disposed at a particular part of filter 14 such as a narrowed distal end 24 thereof. Because the amount of filter material 16 disposed at distal end 24 decreases (as the size of filter 12 decreases), having a greater concentration of radiopaque components 20 adjacent narrowed distal end 24 may enhance visualization of distal end 24.
As suggested above, filter material 16 may be generally comprised of a polymer or combination of polymers. Some examples of suitable polymers include polyurethane, polyester-ether (for example a polyester-ether elastomer such as AR ITEL® available from DSM Engineering Plastics), polyester (for example a polyester elastomer such as HYTREL® available from DuPont), or linear low density polyethylene (for example REXELL®), polypropylene (PP), polyvinylchloride (PVC), polytetrafluoroethylene (PTFE), polyether-ether ketone (PEEK), polyimide, polyamide (for example, DURETHAN® available from Bayer or CRISTAMID® available from Elf Atochem), elastomeric polyamides, polyphenylene sulfide (PPS), polyphenylene oxide (PPO), polysufone, perfluoro(propyl vinyl ether) (PFA), block polyamide-ethers, polyether block amide (PEBA, for example available under the trade name PEBAX®), polycarbonate urethane (for example, CORETHANE® available from Corvita Corp.), silicones, nylons, polyethylene, Marlex high-density polyethylene, and the like, or mixtures, combinations, or copolymers thereof. The polymer may be doped or include radiopaque component 20 or be combined and/or mixed with radiopaque component 20 as described above. As a result, filter material 16 has the desired level of radiopaque components 20 that allow filter 14 has the desired radiopacity.
Shaft 12 may comprise a guidewire, catheter, tube, or the like and can be made of any suitable material including metals, metal alloys, polymers, or the like, or combinations or mixtures thereof. Some examples of suitable metals and metal alloys include stainless steel, such as 304v stainless steel; nickel-titanium alloy, such as nitinol, nickel-chromium alloy, nickel-chromium-iron alloy, cobalt alloy, or the like; or other suitable material. The entire shaft 12 can be made of the same material, or in some embodiments, can include portions or sections made of different materials. In some embodiments, the material used to construct shaft 12 is chosen to impart varying flexibility and stiffness characteristics to different portions of shaft 12. For example, the material used to construct a proximal region can be relatively stiff for pushability and torqueability (e.g., straightened 304 stainless steel wire), and the material used to construct a distal region can be relatively flexible by comparison for better lateral trackability and steerability (e.g., a straightened super elastic or linear elastic alloy such as nickel-titanium wire).
Filter 14 may be coupled to shaft 12 near a distal end 26 thereof; however, it can be appreciated that filter 14 could be disposed at essentially any position along shaft 12. For example, shaft 12 can pass through a portion of filter 14 so that the distal end of filter 14 and frame 18 (and/or struts 28 extending from frame 18) can be attached to shaft 12 as shown in Figure 1. However, it can be appreciated that a number of different styles or configurations of filter 14 can be utilized without departing from the spirit of the invention. In general, filter 14 operates between a first generally collapsed configuration and a second generally expanded configuration for collecting debris in a body lumen. Frame 18 may be comprised of a "self-expanding" shape-memory material such as nickel-titanium alloy (to bias filter 14 to be in the second expanded configuration). Additionally, frame 18 may include a radiopaque material or include, for example, a radiopaque wire disposed about a portion thereof. Filter material 16 can be drilled (for example, formed by known laser techniques) or otherwise manufactured to include at least one opening 27. The holes or openings 27 are sized to allow blood flow therethrough but restrict flow of debris or emboli floating in the body lumen or cavity. One or more struts 28 may extend between frame 18 and shaft 12 and be coupled to shaft 12 by a coupling 30. Coupling 30 may be one or more windings of struts 28 about shaft 12 or be a fitting disposed over an end of struts 28 to attach it to shaft 12.
Figure 2 is a prospective view of a forming member such as a mandrel 22, which is an appropriate example of a mandrel for forming filter 14. Mandrel 22 includes a tapered or necked distal region 32, a mid-region 34, and a proximal region 36 that may also be tapered. A central channel or lumen (not shown) may be formed through the center along the longitudinal axis of mandrel 22 that can be used, for example, as a location for shaft 12 to be disposed during the manufacturing of filter 14. Mandrel 22 may be comprised of any appropriate material including metals and polymers.
Frame 18 may be disposed over mandrel 22 as shown in Figure 3. In some embodiments, frame 18 is disposed over distal region 32 and mid-region 34. The portion of frame 18 disposed adjacent distal region 32 may be attached to shaft 12. Additionally, struts 28 may extend from frame 18 over proximal region 36 in a manner amenable to having struts 28 being attached to shaft 12.
In some embodiments, mandrel 22, together with or independently of frame 18, can be dipped into a container 38 of filter material 16. Frame 18 may be coated or pre-treated with a tie-layer or adhesive such as thixon. As described above, filter material 16 may be molten and include radiopaque component 20. When mandrel 22 is dipped into and then removed from container 38, a layer of filter material 16 remains disposed on and generally conforms to the shape of mandrel 22. Filter material 16 can be allowed to solidify. The now solidified layer of filter material 16 and frame 18, ultimately, will define filter 14.
The thickness of filter material 16 disposed on mandrel 22 can be altered in different embodiments. For example, it is believed that holding mandrel 22 within container 38 for an extended period of time may allow a greater amount of filter material 16 to become disposed adjacent mandrel 22. Alternatively, changing the speed of dipping (either the speed of entry or withdrawal from container 38), the polymer used for filter material 16, the temperature of filter material 16, or other conditions may also play a role in determining the thickness. In some embodiments, the dipping step may be repeated additional times to increase thickness or incorporate other desired properties. For example, an initial dipping step may include dipping mandrel 22 into a non-radiopaque filter material, followed by dipping into filter material 16 (including radiopaque component 20). A final dipping step may also be performed to effectively "sandwich" or embed the radiopaque layer.
Additional manufacturing steps may also be performed to complete the manufacturing of filter 14. For example, filter material 16 and frame 18 may be attached removed from mandrel 22 and attached to shaft 12. Additionally, a number of holes 27 may be drilled in filter material 16. When complete, assembly 10 may be used to facilitate an intravascular intervention. For example, assembly 10 may be loaded within a delivery sheath and advanced through the vasculature to a location adjacent (i.e., "downstream") of a lesion. The sheath can be retracted, allowing frame 18 to expand filter 12, and a therapeutic or diagnostic medical device, for example an angioplasty or atherectomy catheter, can be advanced over shaft 12. Debris generated by the medical device can be capture by filter 14 and later removed from the body.
Figure 4 is a plan view of another example radiopaque filter material 116 coupled disposed adjacent mandrel 22. Filter material 116 is appropriate for forming filter 14 and is similar to filter material 16 except that it includes a plurality of layers that can be wrapped, spun, or braided about mandrel 22. One or more of the individual layers may include radiopaque component 20. For example, filter material 116 may include a first layer 140, a second layer 142, and a third layer 144, and second layer 142 may comprise a radiopaque wire.
The multiple layers (e.g., layers 140, 142, and 144) each may include a polymer, for example polycarbonate urethane. In some embodiments, one or more of the layers 140/142/144 may include radiopaque component 20 in the form described above, in the form of a radiopaque wire, or include radiopaque wire that is embedded within a polymer. The embedded radiopaque component 20 and polymer (or other suitable structure) may then be spun or otherwise disposed about mandrel 22. Alternatively, one of the layers, for example second layer 142, may include radiopaque component 20 and may be disposed between two layers, for example first layer 140 and third layer 144.
The arrangement or configuration of layers 140/142/144 may be altered to incorporate a number of desired properties. For example, layers 140/142/144 can be braided or intertwined either with each other or with themselves, which may enhance the strength of filter 14. In some embodiments, including layers 140/142/142 may obviate the need for frame 18. Alternatively, the thickness of each individual layer may vary. For example, layer 142 may be thicker than layer 140. In some embodiments, layers 140/142/144 can be configured so as to define holes 27. For example, layers 140/142/144 may be braided and holes 27 may be defined within the braids. This strategy may allow for greater control of the diameter and/or distribution of holes 27.
It should be understood that this disclosure is, in many respects, only illustrative. Changes may be made in details, particularly in matters of shape, size, and arrangement of steps without exceeding the scope of the invention. The invention's scope is, of course, defined in the language in which the appended claims are expressed.

Claims

Claims What is claimed is:
1. A method of manufacturing an embolic protection filter assembly, comprising the steps of: providing a forming member; disposing a filter frame over at least a portion of the forming member; providing a filter material, the filter material including one or more radiopaque components; and disposing the filter material over at least a portion of the filter frame.
2. The method of claim 1, wherein the step of providing a filter material includes providing a molten polymer doped with a radiopaque substance.
3. The method of claim 2, wherein the forming member includes a mandrel.
4. The method of claim 1 , wherein the step of disposing the filter material over at least a portion of the filter frame includes disposing a first layer of the filter material over at least a portion of the filter frame and disposing a second layer of a second filter material adjacent the first layer.
5. The method of claim 4, further comprising the step of disposing a third layer of a third filter material adjacent the first layer and the second layer.
6. The method of claim 4, wherein at least one of the first layer, second layer, or third layer includes a radiopaque material.
7. A method of manufacturing an embolic protection filter, comprising the steps of: providing a mandrel member including a filter-shaped region; providing a filter material doped with a radiopaque material; applying the filter material to the filter-shaped region of the mandrel member, wherein a filter portion of the filter material attaches to and generally conforms to the shape of the filter-shaped region; and allowing the filter portion to solidify.
8. The method of claim 7, further comprising the step of separating the filter portion from the filter-shaped region.
9. The method of claim 7, further comprising the step of forming a plurality of holes in the filter portion.
10. The method of claim 7, further comprising the step of coupling the filter portion to an elongate shaft.
11. An embolic protection filter assembly, comprising: a filter frame having a body portion and a mouth portion; a filter material coupled to the filter frame; and wherein the filter material includes at least one radiopaque component disposed adjacent the body portion.
12. The embolic protection filter assembly of claim 11, wherein the filter frame comprises nickel-titanium alloy.
13. The embolic protection filter assembly of claim 11, wherein the filter material is polymeric.
14. The embolic protection filter assembly of claim 11, wherein the radiopaque component of the filter material is disposed homogeneously throughout the filter material.
15. The embolic protection filter assembly of claim 11, wherein the filter material includes a plurality of layers and wherein the radiopaque component comprises at least one of the layers.
16. The embolic protection filter assembly of claim 11, wherein the radiopaque component includes bismuth.
17. The embolic protection filter assembly of claim 11, wherein the radiopaque component includes iodine.
18. The embolic protection filter assembly of claim 11, wherein the filter material includes polyurethane.
19. A method of manufacturing an embolic protection filter assembly, comprising the steps of: providing a forming member; disposing a first layer of filter material over at least a portion of the mandrel layer; disposing a second layer of filter material over at least a portion of the first layer; disposing a third layer of filter material over at least a portion of the second layer; and wherein at least one of the layers includes a radiopaque material.
20. The method of claim 19, wherein the step of disposing a first layer of filter material over at least a portion of the mandrel layer includes braiding.
21. The method of claim 19, further comprising the step of coupling the filter portion to an elongate shaft.
22. An multi-layer embolic protection filter, comprising: a first polymeric layer; a second layer disposed adjacent the first layer; a third layer disposed adjacent the first layer and the second layer; and wherein at least one of the first layer, second layer, or third layer includes a radiopaque component.
23. The multi-layer embolic protection filter of claim 22, wherein the radiopaque component includes a radiopaque wire encapsulated in a polymer.
24. The multi-layer embolic protection filter of claim 22, wherein the radiopaque component includes bismuth.
25. The multi-layer embolic protection filter of claim 22, wherein the radiopaque component includes platinum.
26. The multi-layer embolic protection filter of claim 22, wherein the radiopaque component includes gold.
PCT/US2004/005344 2003-03-27 2004-02-24 Radiopaque embolic protection filter membrane WO2004093738A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/400,751 US20040193208A1 (en) 2003-03-27 2003-03-27 Radiopaque embolic protection filter membrane
US10/400,751 2003-03-27

Publications (2)

Publication Number Publication Date
WO2004093738A2 true WO2004093738A2 (en) 2004-11-04
WO2004093738A3 WO2004093738A3 (en) 2005-08-25

Family

ID=32989276

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/005344 WO2004093738A2 (en) 2003-03-27 2004-02-24 Radiopaque embolic protection filter membrane

Country Status (2)

Country Link
US (2) US20040193208A1 (en)
WO (1) WO2004093738A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8690907B1 (en) 2013-03-15 2014-04-08 Insera Therapeutics, Inc. Vascular treatment methods
US8845678B1 (en) 2013-07-29 2014-09-30 Insera Therapeutics Inc. Two-way shape memory vascular treatment methods
US9034007B2 (en) 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
US9179931B2 (en) 2013-03-15 2015-11-10 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy systems
US9314324B2 (en) 2013-03-15 2016-04-19 Insera Therapeutics, Inc. Vascular treatment devices and methods
US10390926B2 (en) 2013-07-29 2019-08-27 Insera Therapeutics, Inc. Aspiration devices and methods

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491216B2 (en) 1997-11-07 2009-02-17 Salviac Limited Filter element with retractable guidewire tip
US6660021B1 (en) 1999-12-23 2003-12-09 Advanced Cardiovascular Systems, Inc. Intravascular device and system
US6402771B1 (en) 1999-12-23 2002-06-11 Guidant Endovascular Solutions Snare
US6575997B1 (en) 1999-12-23 2003-06-10 Endovascular Technologies, Inc. Embolic basket
US6695813B1 (en) 1999-12-30 2004-02-24 Advanced Cardiovascular Systems, Inc. Embolic protection devices
US7918820B2 (en) 1999-12-30 2011-04-05 Advanced Cardiovascular Systems, Inc. Device for, and method of, blocking emboli in vessels such as blood arteries
US6964670B1 (en) 2000-07-13 2005-11-15 Advanced Cardiovascular Systems, Inc. Embolic protection guide wire
US6506203B1 (en) 2000-12-19 2003-01-14 Advanced Cardiovascular Systems, Inc. Low profile sheathless embolic protection system
US7338510B2 (en) 2001-06-29 2008-03-04 Advanced Cardiovascular Systems, Inc. Variable thickness embolic filtering devices and method of manufacturing the same
US6599307B1 (en) 2001-06-29 2003-07-29 Advanced Cardiovascular Systems, Inc. Filter device for embolic protection systems
US6638294B1 (en) 2001-08-30 2003-10-28 Advanced Cardiovascular Systems, Inc. Self furling umbrella frame for carotid filter
US6592606B2 (en) 2001-08-31 2003-07-15 Advanced Cardiovascular Systems, Inc. Hinged short cage for an embolic protection device
US8262689B2 (en) 2001-09-28 2012-09-11 Advanced Cardiovascular Systems, Inc. Embolic filtering devices
US7241304B2 (en) 2001-12-21 2007-07-10 Advanced Cardiovascular Systems, Inc. Flexible and conformable embolic filtering devices
US7331973B2 (en) 2002-09-30 2008-02-19 Avdanced Cardiovascular Systems, Inc. Guide wire with embolic filtering attachment
US7252675B2 (en) 2002-09-30 2007-08-07 Advanced Cardiovascular, Inc. Embolic filtering devices
US20040088000A1 (en) 2002-10-31 2004-05-06 Muller Paul F. Single-wire expandable cages for embolic filtering devices
US7163549B2 (en) * 2003-02-11 2007-01-16 Boston Scientific Scimed Inc. Filter membrane manufacturing method
US8591540B2 (en) 2003-02-27 2013-11-26 Abbott Cardiovascular Systems Inc. Embolic filtering devices
US7892251B1 (en) 2003-11-12 2011-02-22 Advanced Cardiovascular Systems, Inc. Component for delivering and locking a medical device to a guide wire
US7678129B1 (en) 2004-03-19 2010-03-16 Advanced Cardiovascular Systems, Inc. Locking component for an embolic filter assembly
US8617234B2 (en) 2004-05-25 2013-12-31 Covidien Lp Flexible vascular occluding device
AU2005247490B2 (en) 2004-05-25 2011-05-19 Covidien Lp Flexible vascular occluding device
KR101300437B1 (en) 2004-05-25 2013-08-26 코비디엔 엘피 Vascular stenting for aneurysms
US8628564B2 (en) 2004-05-25 2014-01-14 Covidien Lp Methods and apparatus for luminal stenting
US8147534B2 (en) 2005-05-25 2012-04-03 Tyco Healthcare Group Lp System and method for delivering and deploying an occluding device within a vessel
US20060206200A1 (en) 2004-05-25 2006-09-14 Chestnut Medical Technologies, Inc. Flexible vascular occluding device
US9259305B2 (en) 2005-03-31 2016-02-16 Abbott Cardiovascular Systems Inc. Guide wire locking mechanism for rapid exchange and other catheter systems
US8052714B2 (en) 2005-11-22 2011-11-08 Medtronic Vascular, Inc. Radiopaque fibers and filtration matrices
US8152833B2 (en) 2006-02-22 2012-04-10 Tyco Healthcare Group Lp Embolic protection systems having radiopaque filter mesh
US9089404B2 (en) 2006-03-31 2015-07-28 Covidien Lp Embolic protection devices having radiopaque elements
US8216209B2 (en) 2007-05-31 2012-07-10 Abbott Cardiovascular Systems Inc. Method and apparatus for delivering an agent to a kidney
US20110022149A1 (en) 2007-06-04 2011-01-27 Cox Brian J Methods and devices for treatment of vascular defects
US7867273B2 (en) 2007-06-27 2011-01-11 Abbott Laboratories Endoprostheses for peripheral arteries and other body vessels
US9220522B2 (en) 2007-10-17 2015-12-29 Covidien Lp Embolus removal systems with baskets
CA3048277C (en) 2008-05-02 2022-06-21 Sequent Medical Inc. Filamentary devices for treatment of vascular defects
US20170202657A1 (en) * 2009-01-16 2017-07-20 Claret Medical, Inc. Intravascular blood filters and methods of use
US20100268263A1 (en) * 2009-04-21 2010-10-21 Boston Scientific Scimed, Inc. Embolic protection filters, filter membranes, and methods for making and using the same
US20110152993A1 (en) 2009-11-05 2011-06-23 Sequent Medical Inc. Multiple layer filamentary devices or treatment of vascular defects
US9492262B2 (en) * 2011-09-27 2016-11-15 Kanji Inoue Device for capturing debris in blood vessels
US9301831B2 (en) 2012-10-30 2016-04-05 Covidien Lp Methods for attaining a predetermined porosity of a vascular device
US9456834B2 (en) 2012-10-31 2016-10-04 Covidien Lp Thrombectomy device with distal protection
US9452070B2 (en) 2012-10-31 2016-09-27 Covidien Lp Methods and systems for increasing a density of a region of a vascular device
US9943427B2 (en) 2012-11-06 2018-04-17 Covidien Lp Shaped occluding devices and methods of using the same
US9157174B2 (en) 2013-02-05 2015-10-13 Covidien Lp Vascular device for aneurysm treatment and providing blood flow into a perforator vessel
CN105377184B (en) * 2013-03-15 2017-06-30 微仙美国有限公司 Embolization protective device
US10143545B2 (en) * 2013-03-15 2018-12-04 W. L. Gore & Associates, Inc. Vascular filtration device
US9402708B2 (en) 2013-07-25 2016-08-02 Covidien Lp Vascular devices and methods with distal protection
US9955976B2 (en) 2013-08-16 2018-05-01 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9078658B2 (en) 2013-08-16 2015-07-14 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9629635B2 (en) 2014-04-14 2017-04-25 Sequent Medical, Inc. Devices for therapeutic vascular procedures
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
WO2019240676A2 (en) * 2017-08-31 2019-12-19 T.C. İstanbul Aydin Uni̇versi̇tesi̇ Coronary plaque liquefaction/cleaning catheter
CN113573765A (en) 2019-03-15 2021-10-29 后续医疗股份有限公司 Silk device for treating vascular defects
US11291453B2 (en) 2019-03-15 2022-04-05 Sequent Medical, Inc. Filamentary devices having a flexible joint for treatment of vascular defects
WO2020190620A1 (en) 2019-03-15 2020-09-24 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001045590A2 (en) * 1999-12-23 2001-06-28 Percusurge, Inc. Strut design for an occlusion device
US20010044632A1 (en) * 1997-03-06 2001-11-22 Scimed Life Systems, Inc. Distal protection device and method

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472230A (en) * 1966-12-19 1969-10-14 Fogarty T J Umbrella catheter
US3952747A (en) * 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US3996938A (en) * 1975-07-10 1976-12-14 Clark Iii William T Expanding mesh catheter
US4425908A (en) * 1981-10-22 1984-01-17 Beth Israel Hospital Blood clot filter
US4643184A (en) * 1982-09-29 1987-02-17 Mobin Uddin Kazi Embolus trap
US4494531A (en) * 1982-12-06 1985-01-22 Cook, Incorporated Expandable blood clot filter
US5625605A (en) * 1983-09-13 1997-04-29 The United States Of America As Represented By The Secretary Of The Navy Optic bundle towed array
US4590938A (en) * 1984-05-04 1986-05-27 Segura Joseph W Medical retriever device
US4842579B1 (en) * 1984-05-14 1995-10-31 Surgical Systems & Instr Inc Atherectomy device
US4926858A (en) * 1984-05-30 1990-05-22 Devices For Vascular Intervention, Inc. Atherectomy device for severe occlusions
US4790813A (en) * 1984-12-17 1988-12-13 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4807626A (en) * 1985-02-14 1989-02-28 Mcgirr Douglas B Stone extractor and method
US4706671A (en) * 1985-05-02 1987-11-17 Weinrib Harry P Catheter with coiled tip
US4662885A (en) * 1985-09-03 1987-05-05 Becton, Dickinson And Company Percutaneously deliverable intravascular filter prosthesis
US4650466A (en) * 1985-11-01 1987-03-17 Angiobrade Partners Angioplasty device
US4790812A (en) * 1985-11-15 1988-12-13 Hawkins Jr Irvin F Apparatus and method for removing a target object from a body passsageway
US4723549A (en) * 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
US5024232A (en) * 1986-10-07 1991-06-18 The Research Foundation Of State University Of Ny Novel radiopaque heavy metal polymer complexes, compositions of matter and articles prepared therefrom
US4857045A (en) * 1987-04-30 1989-08-15 Schneider (Usa) Inc., A Pfizer Company Atherectomy catheter
US4794928A (en) * 1987-06-10 1989-01-03 Kletschka Harold D Angioplasty device and method of using the same
US4873978A (en) * 1987-12-04 1989-10-17 Robert Ginsburg Device and method for emboli retrieval
FR2624747A1 (en) * 1987-12-18 1989-06-23 Delsanti Gerard REMOVABLE ENDO-ARTERIAL DEVICES FOR REPAIRING ARTERIAL WALL DECOLLEMENTS
US4886061A (en) * 1988-02-09 1989-12-12 Medinnovations, Inc. Expandable pullback atherectomy catheter system
US4921478A (en) * 1988-02-23 1990-05-01 C. R. Bard, Inc. Cerebral balloon angioplasty system
US4921484A (en) * 1988-07-25 1990-05-01 Cordis Corporation Mesh balloon catheter device
US5011488A (en) * 1988-12-07 1991-04-30 Robert Ginsburg Thrombus extraction system
US4969891A (en) * 1989-03-06 1990-11-13 Gewertz Bruce L Removable vascular filter
US5045072A (en) * 1989-06-13 1991-09-03 Cordis Corporation Catheter having highly radiopaque, flexible tip
DE8910603U1 (en) * 1989-09-06 1989-12-07 Guenther, Rolf W., Prof. Dr.
US5002560A (en) * 1989-09-08 1991-03-26 Advanced Cardiovascular Systems, Inc. Expandable cage catheter with a rotatable guide
DE8910856U1 (en) * 1989-09-12 1989-11-30 Schneider (Europe) Ag, Zuerich, Ch
GB2238485B (en) * 1989-11-28 1993-07-14 Cook William Europ A collapsible filter for introduction in a blood vessel of a patient
US5421832A (en) * 1989-12-13 1995-06-06 Lefebvre; Jean-Marie Filter-catheter and method of manufacturing same
US5071407A (en) * 1990-04-12 1991-12-10 Schneider (U.S.A.) Inc. Radially expandable fixation member
CA2048307C (en) * 1990-08-14 1998-08-18 Rolf Gunther Method and apparatus for filtering blood in a blood vessel of a patient
DE4025825A1 (en) * 1990-08-16 1992-02-20 Cook William Europ DEVICE FOR CRUSHING BLOOD CLOTS
US5160342A (en) * 1990-08-16 1992-11-03 Evi Corp. Endovascular filter and method for use thereof
US5100423A (en) * 1990-08-21 1992-03-31 Medical Engineering & Development Institute, Inc. Ablation catheter
US5415630A (en) * 1991-07-17 1995-05-16 Gory; Pierre Method for removably implanting a blood filter in a vein of the human body
US5192286A (en) * 1991-07-26 1993-03-09 Regents Of The University Of California Method and device for retrieving materials from body lumens
US5626605A (en) * 1991-12-30 1997-05-06 Scimed Life Systems, Inc. Thrombosis filter
US5224953A (en) * 1992-05-01 1993-07-06 The Beth Israel Hospital Association Method for treatment of obstructive portions of urinary passageways
US5324304A (en) * 1992-06-18 1994-06-28 William Cook Europe A/S Introduction catheter set for a collapsible self-expandable implant
US5527338A (en) * 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
FR2696092B1 (en) * 1992-09-28 1994-12-30 Lefebvre Jean Marie Kit for medical use composed of a filter and its device for placement in the vessel.
FR2699809B1 (en) * 1992-12-28 1995-02-17 Celsa Lg Device which can selectively constitute a temporary blood filter.
US5419774A (en) * 1993-07-13 1995-05-30 Scimed Life Systems, Inc. Thrombus extraction device
US5462529A (en) * 1993-09-29 1995-10-31 Technology Development Center Adjustable treatment chamber catheter
US5554673A (en) * 1993-11-29 1996-09-10 Polygenex International, Inc. Dip molded polyurethane film compositions
US5634942A (en) * 1994-04-21 1997-06-03 B. Braun Celsa Assembly comprising a blood filter for temporary or definitive use and a device for implanting it
DE9409484U1 (en) * 1994-06-11 1994-08-04 Naderlinger Eduard Vena cava thrombus filter
WO1996001079A1 (en) * 1994-07-01 1996-01-18 Scimed Life Systems, Inc. Intravascular device utilizing fluid to extract occlusive material
US5601595A (en) * 1994-10-25 1997-02-11 Scimed Life Systems, Inc. Remobable thrombus filter
US5549626A (en) * 1994-12-23 1996-08-27 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
US5807398A (en) * 1995-04-28 1998-09-15 Shaknovich; Alexander Shuttle stent delivery catheter
US5833650A (en) * 1995-06-05 1998-11-10 Percusurge, Inc. Catheter apparatus and method for treating occluded vessels
FR2737654B1 (en) * 1995-08-10 1997-11-21 Braun Celsa Sa FILTRATION UNIT FOR THE RETENTION OF BLOOD CLOTS
US5925016A (en) * 1995-09-27 1999-07-20 Xrt Corp. Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure
US5725517A (en) * 1995-10-05 1998-03-10 Deroyal Industries, Inc. Absorbent woven article including radiopaque element woven therein and anchored at the ends thereof
US6264663B1 (en) * 1995-10-06 2001-07-24 Metamorphic Surgical Devices, Llc Device for removing solid objects from body canals, cavities and organs including an invertable basket
US5779716A (en) * 1995-10-06 1998-07-14 Metamorphic Surgical Devices, Inc. Device for removing solid objects from body canals, cavities and organs
US5989281A (en) * 1995-11-07 1999-11-23 Embol-X, Inc. Cannula with associated filter and methods of use during cardiac surgery
US5769816A (en) * 1995-11-07 1998-06-23 Embol-X, Inc. Cannula with associated filter
US5749848A (en) * 1995-11-13 1998-05-12 Cardiovascular Imaging Systems, Inc. Catheter system having imaging, balloon angioplasty, and stent deployment capabilities, and method of use for guided stent deployment
US5728066A (en) * 1995-12-13 1998-03-17 Daneshvar; Yousef Injection systems and methods
US6231544B1 (en) * 1996-05-14 2001-05-15 Embol-X, Inc. Cardioplegia balloon cannula
US5669933A (en) * 1996-07-17 1997-09-23 Nitinol Medical Technologies, Inc. Removable embolus blood clot filter
US5662671A (en) * 1996-07-17 1997-09-02 Embol-X, Inc. Atherectomy device having trapping and excising means for removal of plaque from the aorta and other arteries
US6066158A (en) * 1996-07-25 2000-05-23 Target Therapeutics, Inc. Mechanical clot encasing and removal wire
US5876367A (en) * 1996-12-05 1999-03-02 Embol-X, Inc. Cerebral protection during carotid endarterectomy and downstream vascular protection during other surgeries
US6391044B1 (en) * 1997-02-03 2002-05-21 Angioguard, Inc. Vascular filter system
US5800457A (en) * 1997-03-05 1998-09-01 Gelbfish; Gary A. Intravascular filter and associated methodology
US6152946A (en) * 1998-03-05 2000-11-28 Scimed Life Systems, Inc. Distal protection device and method
US5827324A (en) * 1997-03-06 1998-10-27 Scimed Life Systems, Inc. Distal protection device
WO1998047447A1 (en) * 1997-04-23 1998-10-29 Dubrul William R Bifurcated stent and distal protection system
US5911734A (en) * 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6676682B1 (en) * 1997-05-08 2004-01-13 Scimed Life Systems, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US5846260A (en) * 1997-05-08 1998-12-08 Embol-X, Inc. Cannula with a modular filter for filtering embolic material
US6059814A (en) * 1997-06-02 2000-05-09 Medtronic Ave., Inc. Filter for filtering fluid in a bodily passageway
US5800525A (en) * 1997-06-04 1998-09-01 Vascular Science, Inc. Blood filter
US5848964A (en) * 1997-06-06 1998-12-15 Samuels; Shaun Lawrence Wilkie Temporary inflatable filter device and method of use
US6245088B1 (en) * 1997-07-07 2001-06-12 Samuel R. Lowery Retrievable umbrella sieve and method of use
US5919126A (en) * 1997-07-07 1999-07-06 Implant Sciences Corporation Coronary stent with a radioactive, radiopaque coating
US5928260A (en) * 1997-07-10 1999-07-27 Scimed Life Systems, Inc. Removable occlusion system for aneurysm neck
US6340367B1 (en) * 1997-08-01 2002-01-22 Boston Scientific Scimed, Inc. Radiopaque markers and methods of using the same
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6066149A (en) * 1997-09-30 2000-05-23 Target Therapeutics, Inc. Mechanical clot treatment device with distal filter
EP1752112B1 (en) * 1997-11-07 2009-12-23 Salviac Limited An embolic protection device
US6013085A (en) * 1997-11-07 2000-01-11 Howard; John Method for treating stenosis of the carotid artery
WO1999023952A1 (en) * 1997-11-12 1999-05-20 William Dubrul Biological passageway occlusion removal
US6221006B1 (en) * 1998-02-10 2001-04-24 Artemis Medical Inc. Entrapping apparatus and method for use
DE19804039A1 (en) * 1998-02-03 1999-08-05 Heidelberger Druckmasch Ag Suction gripper for transferring the rear edge of a sheet in a turning device of a sheet-fed rotary printing machine
US5925060A (en) * 1998-03-13 1999-07-20 B. Braun Celsa Covered self-expanding vascular occlusion device
US6206868B1 (en) * 1998-03-13 2001-03-27 Arteria Medical Science, Inc. Protective device and method against embolization during treatment of carotid artery disease
US6051014A (en) * 1998-10-13 2000-04-18 Embol-X, Inc. Percutaneous filtration catheter for valve repair surgery and methods of use
US6171327B1 (en) * 1999-02-24 2001-01-09 Scimed Life Systems, Inc. Intravascular filter and method
US6277139B1 (en) * 1999-04-01 2001-08-21 Scion Cardio-Vascular, Inc. Vascular protection and embolic material retriever
US6277138B1 (en) * 1999-08-17 2001-08-21 Scion Cardio-Vascular, Inc. Filter for embolic material mounted on expandable frame
US6918921B2 (en) * 1999-05-07 2005-07-19 Salviac Limited Support frame for an embolic protection device
US7014647B2 (en) * 1999-05-07 2006-03-21 Salviac Limited Support frame for an embolic protection device
US6964672B2 (en) * 1999-05-07 2005-11-15 Salviac Limited Support frame for an embolic protection device
US6068645A (en) * 1999-06-07 2000-05-30 Tu; Hosheng Filter system and methods for removing blood clots and biological material
US6179859B1 (en) * 1999-07-16 2001-01-30 Baff Llc Emboli filtration system and methods of use
US6203561B1 (en) * 1999-07-30 2001-03-20 Incept Llc Integrated vascular device having thrombectomy element and vascular filter and methods of use
US6214026B1 (en) * 1999-07-30 2001-04-10 Incept Llc Delivery system for a vascular device with articulation region
US6179861B1 (en) * 1999-07-30 2001-01-30 Incept Llc Vascular device having one or more articulation regions and methods of use
US6620182B1 (en) * 1999-07-30 2003-09-16 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
US6142987A (en) * 1999-08-03 2000-11-07 Scimed Life Systems, Inc. Guided filter with support wire and methods of use
US6346116B1 (en) * 1999-08-03 2002-02-12 Medtronic Ave, Inc. Distal protection device
US6245087B1 (en) * 1999-08-03 2001-06-12 Embol-X, Inc. Variable expansion frame system for deploying medical devices and methods of use
US6235044B1 (en) * 1999-08-04 2001-05-22 Scimed Life Systems, Inc. Percutaneous catheter and guidewire for filtering during ablation of mycardial or vascular tissue
US6168579B1 (en) * 1999-08-04 2001-01-02 Scimed Life Systems, Inc. Filter flush system and methods of use
US6325815B1 (en) * 1999-09-21 2001-12-04 Microvena Corporation Temporary vascular filter
US6375670B1 (en) * 1999-10-07 2002-04-23 Prodesco, Inc. Intraluminal filter
US6364895B1 (en) * 1999-10-07 2002-04-02 Prodesco, Inc. Intraluminal filter
US6425909B1 (en) * 1999-11-04 2002-07-30 Concentric Medical, Inc. Methods and devices for filtering fluid flow through a body structure
US6171328B1 (en) * 1999-11-09 2001-01-09 Embol-X, Inc. Intravascular catheter filter with interlocking petal design and methods of use
US6371971B1 (en) * 1999-11-15 2002-04-16 Scimed Life Systems, Inc. Guidewire filter and methods of use
WO2001035858A1 (en) * 1999-11-18 2001-05-25 Advanced Cardiovascular Systems, Inc. Embolic protection system and method including an emboli-capturing catheter
DE29920737U1 (en) * 1999-11-26 2000-02-03 Leybold Vakuum Gmbh Vacuum pump with outlet
US6645220B1 (en) * 1999-12-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Embolic protection system and method including and embolic-capturing filter
US6702834B1 (en) * 1999-12-30 2004-03-09 Advanced Cardiovascular Systems, Inc. Embolic protection devices
US6383206B1 (en) * 1999-12-30 2002-05-07 Advanced Cardiovascular Systems, Inc. Embolic protection system and method including filtering elements
US20040167567A1 (en) * 2001-03-23 2004-08-26 Cano Gerald G. Method and apparatus for capturing objects beyond an operative site in medical procedures
US6602271B2 (en) * 2000-05-24 2003-08-05 Medtronic Ave, Inc. Collapsible blood filter with optimal braid geometry
US6565591B2 (en) * 2000-06-23 2003-05-20 Salviac Limited Medical device
US6558405B1 (en) * 2000-08-29 2003-05-06 Advanced Cardiovascular Systems, Inc. Embolic filter
US6511496B1 (en) * 2000-09-12 2003-01-28 Advanced Cardiovascular Systems, Inc. Embolic protection device for use in interventional procedures
US20020072730A1 (en) * 2000-10-12 2002-06-13 Mcgill Scott A. Methods and apparatus for protecting the proximal end of a medical device
US6506203B1 (en) * 2000-12-19 2003-01-14 Advanced Cardiovascular Systems, Inc. Low profile sheathless embolic protection system
US6641607B1 (en) * 2000-12-29 2003-11-04 Advanced Cardiovascular Systems, Inc. Double tube stent
US6635082B1 (en) * 2000-12-29 2003-10-21 Advanced Cardiovascular Systems Inc. Radiopaque stent
US6818006B2 (en) * 2001-04-03 2004-11-16 Medtronic Vascular, Inc. Temporary intraluminal filter guidewire
US6866677B2 (en) * 2001-04-03 2005-03-15 Medtronic Ave, Inc. Temporary intraluminal filter guidewire and methods of use
US20020188314A1 (en) * 2001-06-07 2002-12-12 Microvena Corporation Radiopaque distal embolic protection device
EP2319453B1 (en) * 2001-09-28 2016-07-20 Boston Scientific Limited A cardiovascular balloon catheter comprising nanocomposites
ATE378019T1 (en) * 2002-03-05 2007-11-15 Salviac Ltd EMBOLIC FILTER AND RETRACTION LOOP SYSTEM
US7029440B2 (en) * 2002-03-13 2006-04-18 Scimed Life Systems, Inc. Distal protection filter and method of manufacture
US20030187495A1 (en) * 2002-04-01 2003-10-02 Cully Edward H. Endoluminal devices, embolic filters, methods of manufacture and use
US6830638B2 (en) * 2002-05-24 2004-12-14 Advanced Cardiovascular Systems, Inc. Medical devices configured from deep drawn nickel-titanium alloys and nickel-titanium clad alloys and method of making the same
US7174636B2 (en) * 2002-09-04 2007-02-13 Scimed Life Systems, Inc. Method of making an embolic filter
US7220271B2 (en) * 2003-01-30 2007-05-22 Ev3 Inc. Embolic filters having multiple layers and controlled pore size
US7163549B2 (en) * 2003-02-11 2007-01-16 Boston Scientific Scimed Inc. Filter membrane manufacturing method
US20040204737A1 (en) * 2003-04-11 2004-10-14 Scimed Life Systems, Inc. Embolic filter loop fabricated from composite material
US7027320B2 (en) * 2003-10-21 2006-04-11 Hewlett-Packard Development Company, L.P. Soft-reference magnetic memory digitized device and method of operation
US7144378B2 (en) * 2003-10-31 2006-12-05 Arnott Richard J Quick-release torquer apparatus for delivering and maintaining a medical guideware

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010044632A1 (en) * 1997-03-06 2001-11-22 Scimed Life Systems, Inc. Distal protection device and method
WO2001045590A2 (en) * 1999-12-23 2001-06-28 Percusurge, Inc. Strut design for an occlusion device

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9034007B2 (en) 2007-09-21 2015-05-19 Insera Therapeutics, Inc. Distal embolic protection devices with a variable thickness microguidewire and methods for their use
US8690907B1 (en) 2013-03-15 2014-04-08 Insera Therapeutics, Inc. Vascular treatment methods
US8852227B1 (en) 2013-03-15 2014-10-07 Insera Therapeutics, Inc. Woven radiopaque patterns
US9750524B2 (en) 2013-03-15 2017-09-05 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy systems
US8882797B2 (en) 2013-03-15 2014-11-11 Insera Therapeutics, Inc. Methods of embolic filtering
US10335260B2 (en) 2013-03-15 2019-07-02 Insera Therapeutics, Inc. Methods of treating a thrombus in a vein using cyclical aspiration patterns
US10251739B2 (en) 2013-03-15 2019-04-09 Insera Therapeutics, Inc. Thrombus aspiration using an operator-selectable suction pattern
US9901435B2 (en) 2013-03-15 2018-02-27 Insera Therapeutics, Inc. Longitudinally variable vascular treatment devices
US9179995B2 (en) 2013-03-15 2015-11-10 Insera Therapeutics, Inc. Methods of manufacturing slotted vascular treatment devices
US9179931B2 (en) 2013-03-15 2015-11-10 Insera Therapeutics, Inc. Shape-set textile structure based mechanical thrombectomy systems
US10463468B2 (en) 2013-03-15 2019-11-05 Insera Therapeutics, Inc. Thrombus aspiration with different intensity levels
US10342655B2 (en) 2013-03-15 2019-07-09 Insera Therapeutics, Inc. Methods of treating a thrombus in an artery using cyclical aspiration patterns
US8895891B2 (en) 2013-03-15 2014-11-25 Insera Therapeutics, Inc. Methods of cutting tubular devices
US8904914B2 (en) 2013-03-15 2014-12-09 Insera Therapeutics, Inc. Methods of using non-cylindrical mandrels
US8910555B2 (en) 2013-03-15 2014-12-16 Insera Therapeutics, Inc. Non-cylindrical mandrels
US9592068B2 (en) 2013-03-15 2017-03-14 Insera Therapeutics, Inc. Free end vascular treatment systems
US9314324B2 (en) 2013-03-15 2016-04-19 Insera Therapeutics, Inc. Vascular treatment devices and methods
US11298144B2 (en) 2013-03-15 2022-04-12 Insera Therapeutics, Inc. Thrombus aspiration facilitation systems
US9833251B2 (en) 2013-03-15 2017-12-05 Insera Therapeutics, Inc. Variably bulbous vascular treatment devices
US8870901B1 (en) 2013-07-29 2014-10-28 Insera Therapeutics, Inc. Two-way shape memory vascular treatment systems
US8932320B1 (en) 2013-07-29 2015-01-13 Insera Therapeutics, Inc. Methods of aspirating thrombi
US8932321B1 (en) 2013-07-29 2015-01-13 Insera Therapeutics, Inc. Aspiration systems
US8869670B1 (en) 2013-07-29 2014-10-28 Insera Therapeutics, Inc. Methods of manufacturing variable porosity devices
US8872068B1 (en) 2013-07-29 2014-10-28 Insera Therapeutics, Inc. Devices for modifying hypotubes
US8870910B1 (en) 2013-07-29 2014-10-28 Insera Therapeutics, Inc. Methods of decoupling joints
US8866049B1 (en) 2013-07-29 2014-10-21 Insera Therapeutics, Inc. Methods of selectively heat treating tubular devices
US8863631B1 (en) 2013-07-29 2014-10-21 Insera Therapeutics, Inc. Methods of manufacturing flow diverting devices
US8859934B1 (en) 2013-07-29 2014-10-14 Insera Therapeutics, Inc. Methods for slag removal
US10390926B2 (en) 2013-07-29 2019-08-27 Insera Therapeutics, Inc. Aspiration devices and methods
US8845679B1 (en) 2013-07-29 2014-09-30 Insera Therapeutics, Inc. Variable porosity flow diverting devices
US10751159B2 (en) 2013-07-29 2020-08-25 Insera Therapeutics, Inc. Systems for aspirating thrombus during neurosurgical procedures
US8845678B1 (en) 2013-07-29 2014-09-30 Insera Therapeutics Inc. Two-way shape memory vascular treatment methods

Also Published As

Publication number Publication date
US20040193208A1 (en) 2004-09-30
US20070135833A1 (en) 2007-06-14
WO2004093738A3 (en) 2005-08-25

Similar Documents

Publication Publication Date Title
US20040193208A1 (en) Radiopaque embolic protection filter membrane
US6878291B2 (en) Flexible tube for cartridge filter
US7137991B2 (en) Multi-wire embolic protection filtering device
EP1819296B1 (en) Improved sheath for use with an embolic protection filter
US7115138B2 (en) Sheath tip
US20060293707A1 (en) Embolic protection device with lesion length assessment markers
US20040249409A1 (en) Reinforced filter membrane
US20050159773A1 (en) Expandable retrieval device with dilator tip
WO2005072646A1 (en) Sheath for use with an embolic protection filtering system
US20110137334A1 (en) Electroactively Deployed Filter Device
US20070185525A1 (en) Floating on the wire filter wire
WO2007137011A2 (en) Mini cams on support loop for vessel stabilization
US20070219577A1 (en) Sprayed in delivery sheath tubes

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase