WO2004087957A3 - Hypermethylated genes and cervical cancer - Google Patents

Hypermethylated genes and cervical cancer Download PDF

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Publication number
WO2004087957A3
WO2004087957A3 PCT/IB2004/001516 IB2004001516W WO2004087957A3 WO 2004087957 A3 WO2004087957 A3 WO 2004087957A3 IB 2004001516 W IB2004001516 W IB 2004001516W WO 2004087957 A3 WO2004087957 A3 WO 2004087957A3
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WO
WIPO (PCT)
Prior art keywords
cervical cancer
hypermethylated genes
genes
detecting
hypermethylated
Prior art date
Application number
PCT/IB2004/001516
Other languages
French (fr)
Other versions
WO2004087957A2 (en
Inventor
N Reesink-Peters
Der Zee Ate G J Van
Original Assignee
Oncomethylome Sciences S A
N Reesink-Peters
Der Zee Ate G J Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0307739A external-priority patent/GB0307739D0/en
Application filed by Oncomethylome Sciences S A, N Reesink-Peters, Der Zee Ate G J Van filed Critical Oncomethylome Sciences S A
Publication of WO2004087957A2 publication Critical patent/WO2004087957A2/en
Publication of WO2004087957A3 publication Critical patent/WO2004087957A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Abstract

The present invention provides improved methods and kits for detecting cervical cancer in a sample. This is done by detecting the hypermethylation status of a panel of genes.
PCT/IB2004/001516 2003-04-03 2004-04-05 Hypermethylated genes and cervical cancer WO2004087957A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46003803P 2003-04-03 2003-04-03
GB0307739A GB0307739D0 (en) 2003-04-03 2003-04-03 Hypermethylated genes and cervical cancer
GB0307739.3 2003-04-03
US60/460,038 2003-04-03

Publications (2)

Publication Number Publication Date
WO2004087957A2 WO2004087957A2 (en) 2004-10-14
WO2004087957A3 true WO2004087957A3 (en) 2005-07-28

Family

ID=33133147

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/001516 WO2004087957A2 (en) 2003-04-03 2004-04-05 Hypermethylated genes and cervical cancer

Country Status (1)

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WO (1) WO2004087957A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005049861A2 (en) * 2003-11-10 2005-06-02 Epigenomics Ag Method for the analysis of gynaecological cell proliferative disorders
US20090023137A1 (en) * 2004-07-16 2009-01-22 Oncomethylome Sciences S.A. ESR1 and Cervical Cancer
WO2006088940A2 (en) * 2005-02-14 2006-08-24 The Johns Hopkins University Neoplasia screening compositions and methods of use
EP1869224A4 (en) * 2005-04-15 2009-11-18 Oncomethylome Sciences Inc Methylation markers for diagnosis and treatment of cancers
US20070059753A1 (en) 2005-09-15 2007-03-15 Tatiana Vener Detecting gene methylation
EP2201131B8 (en) 2007-09-17 2014-12-10 MDxHealth SA Improved methylation detection
EP2626435B1 (en) 2008-03-21 2016-06-01 MDxHealth S.A. Detection and prognosis of cervical cancer
WO2011036173A1 (en) 2009-09-24 2011-03-31 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer
US9096905B2 (en) * 2012-02-23 2015-08-04 Medical Diagnostic Laboratories, Llc Detecting DNA methylation of BCL2, CDKN2A and NID2 genes to predict bladder cancer in humans
CN107002136B (en) 2014-09-22 2021-09-21 格罗宁根大学 Biomarkers for cervical cancer
CN107287294A (en) * 2017-06-14 2017-10-24 广州中心法则生物科技有限公司 A kind of detection primer, probe, kit and its application of cervical cancer-related genes methylation
CN113718035B (en) * 2021-09-30 2023-03-28 安徽同科生物科技有限公司 Application of circular RNA hsa _ circ _0003552 and kit for detecting circular RNA hsa _ circ _0003552

Citations (10)

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Publication number Priority date Publication date Assignee Title
WO1996002674A1 (en) * 1994-07-19 1996-02-01 The Johns Hopkins University School Of Medicine Genetic diagnosis of prostate cancer
WO1997046705A1 (en) * 1996-06-03 1997-12-11 The Johns Hopkins University School Of Medicine Methylation specific detection
US5976799A (en) * 1996-03-21 1999-11-02 The Board Of Trustees Of The University Of Arkansas Early detection of ovarian carcinoma using P16 gene products
WO2001042467A2 (en) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
US6255293B1 (en) * 1998-07-24 2001-07-03 Yeda Research And Development Co., Ltd. Prevention of metastasis with 5-aza-2′-deoxycytidine
WO2001075172A1 (en) * 2000-03-31 2001-10-11 University Of Southern California Epigenetic sequences for esophageal adenocarcinoma
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6335170B1 (en) * 1999-02-22 2002-01-01 Torben F. Orntoft Gene expression in bladder tumors
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
WO2004086949A2 (en) * 2003-03-25 2004-10-14 John Wayne Cancer Institute Dna markers for management of cancer

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002674A1 (en) * 1994-07-19 1996-02-01 The Johns Hopkins University School Of Medicine Genetic diagnosis of prostate cancer
US5976799A (en) * 1996-03-21 1999-11-02 The Board Of Trustees Of The University Of Arkansas Early detection of ovarian carcinoma using P16 gene products
WO1997046705A1 (en) * 1996-06-03 1997-12-11 The Johns Hopkins University School Of Medicine Methylation specific detection
US6255293B1 (en) * 1998-07-24 2001-07-03 Yeda Research And Development Co., Ltd. Prevention of metastasis with 5-aza-2′-deoxycytidine
US6335170B1 (en) * 1999-02-22 2002-01-01 Torben F. Orntoft Gene expression in bladder tumors
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
WO2001042467A2 (en) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
WO2001075172A1 (en) * 2000-03-31 2001-10-11 University Of Southern California Epigenetic sequences for esophageal adenocarcinoma
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
WO2004086949A2 (en) * 2003-03-25 2004-10-14 John Wayne Cancer Institute Dna markers for management of cancer

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Title
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DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; June 1999 (1999-06-01), FERRERA A ET AL: "HLA DQA1 and DQB1 loci in Honduran women with cervical dysplasia and invasive cervical carcinoma and their relationship to human papillomavirus infection", XP002316717, Database accession no. PREV199900296447 *
DOBBIE Z ET AL: "EXPRESSION OF COX-2 AND WNT PATHWAY GENES IN ADENOMAS OF FAMILIAL ADENOMATOUS POLYPOSIS PATIENTS TREATED WITH MELOXICAM", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 22, no. 4, 2002, pages 2215 - 2220, XP008020863, ISSN: 0250-7005 *
DONG S M ET AL: "Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. JUL 2001, vol. 7, no. 7, July 2001 (2001-07-01), pages 1982 - 1986, XP002316652, ISSN: 1078-0432 *
DONG SEUNG M ET AL: "Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 42, March 2001 (2001-03-01), & 92ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; NEW ORLEANS, LA, USA; MARCH 24-28, 2001, pages 478, XP001183000, ISSN: 0197-016X *
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HURTEAU GREGORY J ET AL: "mRNA-specific reverse transcription-polymerase chain reaction from human tissue extracts", ANALYTICAL BIOCHEMISTRY, vol. 307, no. 2, 15 August 2002 (2002-08-15), pages 304 - 315, XP002324197, ISSN: 0003-2697 *
HUSNJAK KORALJKA ET AL: "Comparison of five different polymerase chain reaction methods for detection of human papillomavirus in cervical cell specimens", JOURNAL OF VIROLOGICAL METHODS, vol. 88, no. 2, August 2000 (2000-08-01), pages 125 - 134, XP002316716, ISSN: 0166-0934 *
JERONIMO CARMEN ET AL: "Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma", JOURNAL OF THE NATIONAL CANCER INSTITUTE (BETHESDA), vol. 93, no. 22, 21 November 2001 (2001-11-21), pages 1747 - 1752, XP002316654, ISSN: 0027-8874 *
LAU WEN MIN ET AL: "Identification of cervical cancer-specific molecular markers by cDNA library cloning and microarray analysis", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 43, March 2002 (2002-03-01), & 93RD ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; SAN FRANCISCO, CALIFORNIA, USA; APRIL 06-10, 2002, pages 452, XP008045588, ISSN: 0197-016X *
LIN ZHAOSHENG ET AL: "Comparative microarray analysis of gene expression during activation of human peripheral blood T-cells and leukemic Jurkat T-cells", BLOOD, vol. 98, no. 11 Part 1, 16 November 2001 (2001-11-16), & 43RD ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY, PART 1; ORLANDO, FLORIDA, USA; DECEMBER 07-11, 2001, pages 238a, XP008045622, ISSN: 0006-4971 *
NARAYAN G ET AL: "Promoters of DAPK, CDH1 and RARB genes are frequently methylated in cervical carcinoma and show no association with clinical outcome or microsatellite instability", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 71, no. 4 Supplement, October 2002 (2002-10-01), & 52ND ANNUAL MEETING OF THE AMERICAN SOCIETY OF HUMAN GENETICS; BALTIMORE, MD, USA; OCTOBER 15-19, 2002, pages 247, XP008042136, ISSN: 0002-9297 *
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TONG JOANNA H M ET AL: "Hypermethylation of RASSF1A gene in cervical cancer and high grade cervical intraepithelial neoplasia", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 43, March 2002 (2002-03-01), & 93RD ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; SAN FRANCISCO, CALIFORNIA, USA; APRIL 06-10, 2002, pages 1116, XP001182980, ISSN: 0197-016X *
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