WO2004082822A3 - Methods for isolating crystalline form i of 5-azacytidine - Google Patents

Methods for isolating crystalline form i of 5-azacytidine Download PDF

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Publication number
WO2004082822A3
WO2004082822A3 PCT/US2004/007896 US2004007896W WO2004082822A3 WO 2004082822 A3 WO2004082822 A3 WO 2004082822A3 US 2004007896 W US2004007896 W US 2004007896W WO 2004082822 A3 WO2004082822 A3 WO 2004082822A3
Authority
WO
WIPO (PCT)
Prior art keywords
azacytidine
crystalline form
methods
isolating crystalline
isolating
Prior art date
Application number
PCT/US2004/007896
Other languages
French (fr)
Other versions
WO2004082822A2 (en
Inventor
Dumitru Ionescu
Peter Blumbergs
Gary L Silvey
Original Assignee
Pharmion Corp
Ash Stevens Inc
Dumitru Ionescu
Peter Blumbergs
Gary L Silvey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32987551&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2004082822(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to ES04721078T priority Critical patent/ES2425474T3/en
Priority to BRPI0408506-0A priority patent/BRPI0408506A/en
Priority to AU2004222274A priority patent/AU2004222274B2/en
Priority to PL04721078T priority patent/PL1608634T3/en
Priority to JP2006507211A priority patent/JP4792550B2/en
Application filed by Pharmion Corp, Ash Stevens Inc, Dumitru Ionescu, Peter Blumbergs, Gary L Silvey filed Critical Pharmion Corp
Priority to CA002518973A priority patent/CA2518973A1/en
Priority to SI200432065T priority patent/SI1608634T1/en
Priority to EP04721078.6A priority patent/EP1608634B1/en
Priority to DK04721078.6T priority patent/DK1608634T3/en
Priority to MXPA05009969A priority patent/MXPA05009969A/en
Publication of WO2004082822A2 publication Critical patent/WO2004082822A2/en
Publication of WO2004082822A3 publication Critical patent/WO2004082822A3/en
Priority to AU2010241198A priority patent/AU2010241198B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Abstract

The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
PCT/US2004/007896 2003-03-17 2004-03-16 Methods for isolating crystalline form i of 5-azacytidine WO2004082822A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
MXPA05009969A MXPA05009969A (en) 2003-03-17 2004-03-16 Methods for isolating crystalline form i of 5-azacytidine.
SI200432065T SI1608634T1 (en) 2003-03-17 2004-03-16 Methods for isolating crystalline form i of 5-azacytidine
AU2004222274A AU2004222274B2 (en) 2003-03-17 2004-03-16 Methods for isolating crystalline Form I of 5-azacytidine
PL04721078T PL1608634T3 (en) 2003-03-17 2004-03-16 Methods for isolating crystalline form i of 5-azacytidine
JP2006507211A JP4792550B2 (en) 2003-03-17 2004-03-16 Method for separating 5-azacytidine crystal form I
ES04721078T ES2425474T3 (en) 2003-03-17 2004-03-16 Methods for isolating the crystalline form I of 5-azacitidine
CA002518973A CA2518973A1 (en) 2003-03-17 2004-03-16 Methods for isolating crystalline form i of 5-azacytidine
BRPI0408506-0A BRPI0408506A (en) 2003-03-17 2004-03-16 processes for isolation of crystalline form i from 5-azacytidine
EP04721078.6A EP1608634B1 (en) 2003-03-17 2004-03-16 Methods for isolating crystalline form i of 5-azacytidine
DK04721078.6T DK1608634T3 (en) 2003-03-17 2004-03-16 PROCEDURES FOR INSULATING CRYSTALLINIC FORM OF 5-AZACYTIDINE
AU2010241198A AU2010241198B2 (en) 2003-03-17 2010-11-03 Methods for isolating crystalline Form I of 5-azacytidine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/390,530 US6943249B2 (en) 2003-03-17 2003-03-17 Methods for isolating crystalline Form I of 5-azacytidine
US10/390,530 2003-03-17

Publications (2)

Publication Number Publication Date
WO2004082822A2 WO2004082822A2 (en) 2004-09-30
WO2004082822A3 true WO2004082822A3 (en) 2005-07-07

Family

ID=32987551

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007896 WO2004082822A2 (en) 2003-03-17 2004-03-16 Methods for isolating crystalline form i of 5-azacytidine

Country Status (16)

Country Link
US (5) US6943249B2 (en)
EP (3) EP1608634B1 (en)
JP (1) JP4792550B2 (en)
AU (2) AU2004222274B2 (en)
BR (1) BRPI0408506A (en)
CA (1) CA2518973A1 (en)
CY (2) CY1114213T1 (en)
DK (2) DK2181988T3 (en)
EC (1) ECSP056023A (en)
ES (2) ES2425474T3 (en)
HU (1) HUE028268T2 (en)
MX (1) MXPA05009969A (en)
PL (2) PL1608634T3 (en)
PT (2) PT1608634E (en)
SI (2) SI1608634T1 (en)
WO (1) WO2004082822A2 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8902490A (en) * 1989-10-06 1991-05-01 Leonardus Mathijs Marie Nevels METHOD FOR CLEANING FLUE GASES
ATE314768T1 (en) * 2001-10-08 2006-01-15 Cit Alcatel METHOD FOR DISTRIBUTING LOAD BETWEEN SEVERAL COMMON EQUIPMENT IN A COMMUNICATIONS NETWORK AND NETWORK FOR APPLYING THE METHOD
US8404717B2 (en) * 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes using lenalidomide
US8404716B2 (en) 2002-10-15 2013-03-26 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US11116782B2 (en) 2002-10-15 2021-09-14 Celgene Corporation Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US7038038B2 (en) * 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US7192781B2 (en) * 2004-04-13 2007-03-20 Pharmion Corporation Methods for stabilizing 5-azacytidine in plasma
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US7759481B2 (en) * 2007-01-11 2010-07-20 Ivax Corporation Solid state forms of 5-azacytidine and processes for preparation thereof
US20110288042A1 (en) * 2007-08-02 2011-11-24 Chemagis Ltd. Stable highly pure azacitidine and preparation methods therefor
JP2010540556A (en) * 2007-09-26 2010-12-24 マウント サイナイ スクール オブ メディシン Azacitidine analogues and uses thereof
EP2211870A1 (en) * 2007-11-01 2010-08-04 Celgene Corporation Cytidine analogs for treatment of myelodysplastic syndromes
DK3782611T3 (en) * 2008-05-15 2022-09-05 Celgene Corp ORAL FORMULATIONS OF CYTIDINE ANALOGUES AND METHODS OF USING THEREOF
WO2010014883A2 (en) 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
KR101660549B1 (en) * 2008-08-08 2016-09-27 시노팜 타이완 리미티드 Process for making azacytosine nucleosides and their derivatives
EP2424845A4 (en) * 2009-04-27 2014-03-05 Reddys Lab Ltd Dr Preparation of decitabine
US20110042247A1 (en) * 2009-06-25 2011-02-24 Chandrasekhar Kocherlakota Formulations of azacitidine and its derivatives
CN103338753A (en) 2011-01-31 2013-10-02 细胞基因公司 Pharmaceutical compositions of cytidine analogs and methods of use thereof
AU2012236476A1 (en) * 2011-03-31 2013-05-02 Celgene International Sarl Systhesis of 5-azacytidine
WO2013022872A1 (en) 2011-08-10 2013-02-14 Celgene Corporation Gene methylation biomarkers and methods of use thereof
CA2849708A1 (en) 2011-09-23 2013-03-28 Celgene Corporation Romidepsin and 5 - azacitidine for use in treating lymphoma
WO2013049093A1 (en) 2011-09-26 2013-04-04 Celgene Corporation Combination therapy for chemoresistant cancers
MX357835B (en) 2011-11-03 2018-07-26 Millennium Pharm Inc Administration of nedd8-activating enzyme inhibitor and hypomethylating agent.
WO2013080221A2 (en) * 2011-12-01 2013-06-06 Hetero Research Foundation Process for alvimopan
CN104768532B (en) * 2012-10-25 2017-11-28 费森尤斯卡比肿瘤学有限公司 The pharmaceutical composition of the stabilization of the deoxycytidine of 5 azepine 2 '
WO2014076616A2 (en) * 2012-11-19 2014-05-22 Shilpa Medicare Limited Formulations of 5-azacytidine
US9765108B2 (en) 2012-11-19 2017-09-19 Shilpa Medicare Limited Formulation of 5-azacytidine
WO2014160698A1 (en) 2013-03-26 2014-10-02 Celgene Corporation SOLID FORMS COMPRISING 4-AMINO-I-β-D-RIBOFURANOSYL-1,3,5-TRIAZIN-2(1H)-ONE AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
CN103450303A (en) * 2013-09-04 2013-12-18 重庆泰濠制药有限公司 Azacitidine crystal form A and azacitidine crystal form B as well as preparation method thereof
LT3182996T (en) 2014-08-22 2023-03-10 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
US20160095925A1 (en) * 2014-10-01 2016-04-07 Cadila Healthcare Limited Stable formulation of azacitidine or salts thereof and their process for preparation
MD3362066T2 (en) 2015-10-15 2022-08-31 Les Laboratoires Servier Sas Combination therapy for treating malignancies
WO2017066611A1 (en) 2015-10-15 2017-04-20 Celgene Corporation Combination therapy for treating malignancies
WO2018074387A1 (en) * 2016-10-17 2018-04-26 第一三共株式会社 Combination therapy method using mdm2 inhibitor and dna methyltransferase inhibitor
CN109988207B (en) * 2017-12-29 2022-01-04 江苏豪森药业集团有限公司 Preparation method of azacitidine crystal form
CN110642901A (en) * 2019-11-11 2020-01-03 扬子江药业集团有限公司 Azacitidine methanolate, preparation method thereof, pharmaceutical composition and application
WO2022251663A2 (en) * 2021-05-27 2022-12-01 Emory University Novel universal anti-rna virus agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891623A (en) * 1971-05-04 1975-06-24 Schering Ag Process for preparing cytidines
US6723728B2 (en) * 2001-03-01 2004-04-20 Gilead Sciences, Inc. Polymorphic and other crystalline forms cis-FTC

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050899A (en) * 1963-12-22
CH527207A (en) 1968-05-08 1972-08-31 Ceskoslovenska Akademie Ved Process for the preparation of 1-glycosyl-5-azacytosines
CH507969A (en) * 1968-11-12 1971-05-31 Ceskoslovenska Akademie Ved Process for the preparation of 1-glycosyl-5-azacytosines
DE2012888C3 (en) 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Process for the preparation of 5-azapyrimidine nucleosides
FR2123632A6 (en) 1971-01-26 1972-09-15 Ceskoslovenska Akademie Ved Prepn of 5-azacytosines and 5-azacytidines - from bis trimethylsilyl-5-azacytosine
DE2508312A1 (en) * 1975-02-24 1976-09-02 Schering Ag NEW PROCESS FOR THE PRODUCTION OF NUCLEOSIDES
DE2757365A1 (en) * 1977-12-20 1979-06-21 Schering Ag NEW PROCESS FOR THE PRODUCTION OF NUCLEOSIDES
US5700640A (en) 1994-09-16 1997-12-23 Basf Aktiengesellschaft Inducers of gamma globin gene expression and screening assays therefor
US5539209A (en) 1994-10-17 1996-07-23 Trojan Technologies Inc. Method of cleaning fouling materials from a radiation module
JPH1053576A (en) * 1996-06-07 1998-02-24 Eisai Co Ltd Polymorphic crystal of donepezil hydrochloride and its production
TW513409B (en) 1996-06-07 2002-12-11 Eisai Co Ltd Polymorphs of donepezil hydrochloride
WO1998016186A2 (en) 1996-10-16 1998-04-23 Icn Pharmaceuticals, Inc. Monocyclic l-nucleosides, analogs and uses thereof
CA2375601C (en) * 1999-06-03 2008-07-29 Eisai Co., Ltd. Carbapenem compound crystals and injection preparations
WO2001004115A2 (en) * 1999-07-09 2001-01-18 Boehringer Ingelheim Pharmaceuticals, Inc. Novel process for synthesis of heteroaryl-substituted urea compounds
US20020048610A1 (en) 2000-01-07 2002-04-25 Cima Michael J. High-throughput formation, identification, and analysis of diverse solid-forms
IL154718A0 (en) 2000-09-07 2003-10-31 Kaneka Corp Methods for crystallization of hydroxycarboxylic acids
WO2004028454A2 (en) 2002-09-24 2004-04-08 Koronis Pharmaceuticals, Incorporated 1, 3, 5-triazines for treatment of viral diseases
US7189740B2 (en) 2002-10-15 2007-03-13 Celgene Corporation Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
AU2003286836A1 (en) 2002-10-31 2004-06-07 Supergen, Inc. Pharmaceutical formulations targeting specific regions of the gastrointestinal tract
EP1517893A2 (en) * 2003-02-03 2005-03-30 Teva Pharmaceutical Industries Limited Process for producing levetiracetam
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US7038038B2 (en) 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
US6877855B2 (en) 2003-07-08 2005-04-12 Dave Ng Spectacles with peripheral lens support
EP1667680A4 (en) 2003-08-29 2008-10-08 Aton Pharma Inc Combination methods of treating cancer
US7192781B2 (en) 2004-04-13 2007-03-20 Pharmion Corporation Methods for stabilizing 5-azacytidine in plasma
US20060063735A1 (en) 2004-09-17 2006-03-23 Supergen, Inc. Salts of 5-azacytidine
US20060069060A1 (en) 2004-09-27 2006-03-30 Sanjeev Redkar Salts of decitabine
US20060128654A1 (en) 2004-12-10 2006-06-15 Chunlin Tang Pharmaceutical formulation of cytidine analogs and derivatives
US20080057086A1 (en) 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
US7759481B2 (en) 2007-01-11 2010-07-20 Ivax Corporation Solid state forms of 5-azacytidine and processes for preparation thereof
EP2114152A1 (en) 2007-01-25 2009-11-11 Nevada Cancer Institute Use of acetylated or esterificated azacytidine, decitabine, or other nucleoside analogs as oral agents for the treatment of tumors or other dysplastic syndromes sensitive to hypomethylating agents
US20110288042A1 (en) 2007-08-02 2011-11-24 Chemagis Ltd. Stable highly pure azacitidine and preparation methods therefor
EP2048151A1 (en) 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
EP2211870A1 (en) 2007-11-01 2010-08-04 Celgene Corporation Cytidine analogs for treatment of myelodysplastic syndromes
DK3782611T3 (en) 2008-05-15 2022-09-05 Celgene Corp ORAL FORMULATIONS OF CYTIDINE ANALOGUES AND METHODS OF USING THEREOF
WO2010014883A2 (en) 2008-08-01 2010-02-04 Dr. Reddy's Laboratories Ltd. Azacitidine process and polymorphs
WO2010017374A1 (en) 2008-08-06 2010-02-11 Sicor Inc. Process for preparing azacytidine intermediate
KR101660549B1 (en) 2008-08-08 2016-09-27 시노팜 타이완 리미티드 Process for making azacytosine nucleosides and their derivatives
US20110042247A1 (en) 2009-06-25 2011-02-24 Chandrasekhar Kocherlakota Formulations of azacitidine and its derivatives
WO2011014541A1 (en) 2009-07-30 2011-02-03 Eagle Pharmaceuticals, Inc. Stable formulations of azacitidine
IT1399195B1 (en) 2010-03-30 2013-04-11 Chemi Spa PROCESS FOR THE SYNTHESIS OF AZACITIDINE AND DECITABINE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891623A (en) * 1971-05-04 1975-06-24 Schering Ag Process for preparing cytidines
US6723728B2 (en) * 2001-03-01 2004-04-20 Gilead Sciences, Inc. Polymorphic and other crystalline forms cis-FTC

Also Published As

Publication number Publication date
AU2010241198A1 (en) 2010-11-25
MXPA05009969A (en) 2006-02-17
EP1608634A4 (en) 2006-03-15
ES2425474T3 (en) 2013-10-15
US20100292180A1 (en) 2010-11-18
ES2575535T3 (en) 2016-06-29
HUE028268T2 (en) 2016-12-28
PT1608634E (en) 2013-08-27
AU2004222274B2 (en) 2010-11-04
EP2181988A1 (en) 2010-05-05
US20040186284A1 (en) 2004-09-23
BRPI0408506A (en) 2006-03-14
JP4792550B2 (en) 2011-10-12
US8481715B2 (en) 2013-07-09
AU2010241198B2 (en) 2012-05-10
US8975392B2 (en) 2015-03-10
PL1608634T3 (en) 2013-10-31
US20120245342A1 (en) 2012-09-27
DK2181988T3 (en) 2016-06-06
CY1117639T1 (en) 2017-04-26
SI2181988T1 (en) 2016-09-30
EP1608634A2 (en) 2005-12-28
DK1608634T3 (en) 2013-08-12
CY1114213T1 (en) 2016-08-31
US20050272675A1 (en) 2005-12-08
WO2004082822A2 (en) 2004-09-30
PL2181988T3 (en) 2016-11-30
US8211862B2 (en) 2012-07-03
SI1608634T1 (en) 2013-09-30
ECSP056023A (en) 2006-01-27
EP2181988B1 (en) 2016-05-11
PT2181988E (en) 2016-06-15
US7700770B2 (en) 2010-04-20
US20130274459A1 (en) 2013-10-17
EP2266965A1 (en) 2010-12-29
AU2004222274A1 (en) 2004-09-30
CA2518973A1 (en) 2004-09-30
US6943249B2 (en) 2005-09-13
JP2006523210A (en) 2006-10-12
EP1608634B1 (en) 2013-05-22

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