WO2004082796A3 - Systems and methods of blood-based therapies having a microfluidic membraneless exchange device - Google Patents

Systems and methods of blood-based therapies having a microfluidic membraneless exchange device Download PDF

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Publication number
WO2004082796A3
WO2004082796A3 PCT/US2004/007966 US2004007966W WO2004082796A3 WO 2004082796 A3 WO2004082796 A3 WO 2004082796A3 US 2004007966 W US2004007966 W US 2004007966W WO 2004082796 A3 WO2004082796 A3 WO 2004082796A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
blood
removal
sample fluid
systems
Prior art date
Application number
PCT/US2004/007966
Other languages
French (fr)
Other versions
WO2004082796A2 (en
Inventor
Edward F Leonard
Alan C West
Nina C Shapley
Zhongliang Tang
Original Assignee
Univ Columbia
Edward F Leonard
Alan C West
Nina C Shapley
Zhongliang Tang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Edward F Leonard, Alan C West, Nina C Shapley, Zhongliang Tang filed Critical Univ Columbia
Priority to AT04757489T priority Critical patent/ATE510605T1/en
Priority to JP2006507233A priority patent/JP4489761B2/en
Priority to EP04757489A priority patent/EP1622691B1/en
Priority to CA2518667A priority patent/CA2518667C/en
Publication of WO2004082796A2 publication Critical patent/WO2004082796A2/en
Priority to US11/127,905 priority patent/US20060076295A1/en
Publication of WO2004082796A3 publication Critical patent/WO2004082796A3/en
Priority to US12/509,395 priority patent/US7850633B2/en
Priority to US12/942,519 priority patent/US8021318B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/11—Laminar flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Abstract

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of 'small' molecules, 'middle' molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
PCT/US2004/007966 2003-03-14 2004-03-15 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device WO2004082796A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AT04757489T ATE510605T1 (en) 2003-03-14 2004-03-15 SYSTEMS AND METHODS FOR BLOOD BASED THERAPY USING A MEMBRANELESS MICROFLUID EXCHANGE DEVICE
JP2006507233A JP4489761B2 (en) 2003-03-14 2004-03-15 System and method for blood-based therapy with a microfluidic membraneless device
EP04757489A EP1622691B1 (en) 2003-03-14 2004-03-15 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
CA2518667A CA2518667C (en) 2003-03-14 2004-03-15 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US11/127,905 US20060076295A1 (en) 2004-03-15 2005-05-12 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US12/509,395 US7850633B2 (en) 2003-03-14 2009-07-24 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US12/942,519 US8021318B2 (en) 2003-03-14 2010-11-09 Methods of blood-based therapies having a microfluidic membraneless exchange device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45457903P 2003-03-14 2003-03-14
US60/454,579 2003-03-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/801,366 Continuation-In-Part US20040225249A1 (en) 2003-03-14 2004-03-15 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device

Publications (2)

Publication Number Publication Date
WO2004082796A2 WO2004082796A2 (en) 2004-09-30
WO2004082796A3 true WO2004082796A3 (en) 2006-02-16

Family

ID=33029896

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007966 WO2004082796A2 (en) 2003-03-14 2004-03-15 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device

Country Status (6)

Country Link
US (4) US20040225249A1 (en)
EP (1) EP1622691B1 (en)
JP (1) JP4489761B2 (en)
AT (1) ATE510605T1 (en)
CA (1) CA2518667C (en)
WO (1) WO2004082796A2 (en)

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