WO2004082625A3 - Self-emulsifying compositions, methods of use and preparation - Google Patents

Self-emulsifying compositions, methods of use and preparation Download PDF

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Publication number
WO2004082625A3
WO2004082625A3 PCT/US2004/008076 US2004008076W WO2004082625A3 WO 2004082625 A3 WO2004082625 A3 WO 2004082625A3 US 2004008076 W US2004008076 W US 2004008076W WO 2004082625 A3 WO2004082625 A3 WO 2004082625A3
Authority
WO
WIPO (PCT)
Prior art keywords
self
emulsifying
compositions
prepared
preparation
Prior art date
Application number
PCT/US2004/008076
Other languages
French (fr)
Other versions
WO2004082625A2 (en
Inventor
Zhi-Jian Yu
Stanley W Huth
Lauren L Crawford
James N Cook
Original Assignee
Advanced Medical Optics Inc
Zhi-Jian Yu
Stanley W Huth
Lauren L Crawford
James N Cook
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medical Optics Inc, Zhi-Jian Yu, Stanley W Huth, Lauren L Crawford, James N Cook filed Critical Advanced Medical Optics Inc
Priority to AU2004222295A priority Critical patent/AU2004222295B2/en
Priority to JP2006507252A priority patent/JP2006526579A/en
Priority to BRPI0408516-7A priority patent/BRPI0408516A/en
Priority to EP04757532A priority patent/EP1603607A2/en
Priority to CA002519300A priority patent/CA2519300A1/en
Publication of WO2004082625A2 publication Critical patent/WO2004082625A2/en
Publication of WO2004082625A3 publication Critical patent/WO2004082625A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Abstract

Preparation of self-emulsifying compositions which are prepared without mechanical homogenization is described. These self-emulsifying compositions are prepared using one or two surfactants. This provides the advantage of a low weight ratio of emulsifying component to oil component and fewer chemical toxicity concerns, resulting in comfort and safety advantages over emulsions employing more than two emulsifiers. Consequently, the self-mulsifying compositions described are ideally suited for ophthalmic applications including administration of therapeutics to the eye. Self-emulsifying compositions prepared by the disclosed method are described.
PCT/US2004/008076 2003-03-18 2004-03-17 Self-emulsifying compositions, methods of use and preparation WO2004082625A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2004222295A AU2004222295B2 (en) 2003-03-18 2004-03-17 Self-emulsifying compositions, methods of use and preparation
JP2006507252A JP2006526579A (en) 2003-03-18 2004-03-17 Self-emulsifying composition, its use and production method
BRPI0408516-7A BRPI0408516A (en) 2003-03-18 2004-03-17 self-emulsifying compositions, methods of use and preparation
EP04757532A EP1603607A2 (en) 2003-03-18 2004-03-17 Self-emulsifying compositions, methods of use and preparation
CA002519300A CA2519300A1 (en) 2003-03-18 2004-03-17 Self-emulsifying compositions, methods of use and preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/392,375 US20040185068A1 (en) 2003-03-18 2003-03-18 Self-emulsifying compositions, methods of use and preparation
US10/392,375 2003-03-18

Publications (2)

Publication Number Publication Date
WO2004082625A2 WO2004082625A2 (en) 2004-09-30
WO2004082625A3 true WO2004082625A3 (en) 2004-11-18

Family

ID=32987875

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/008076 WO2004082625A2 (en) 2003-03-18 2004-03-17 Self-emulsifying compositions, methods of use and preparation

Country Status (8)

Country Link
US (2) US20040185068A1 (en)
EP (1) EP1603607A2 (en)
JP (1) JP2006526579A (en)
CN (1) CN1791383A (en)
AU (1) AU2004222295B2 (en)
BR (1) BRPI0408516A (en)
CA (1) CA2519300A1 (en)
WO (1) WO2004082625A2 (en)

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Also Published As

Publication number Publication date
CN1791383A (en) 2006-06-21
JP2006526579A (en) 2006-11-24
EP1603607A2 (en) 2005-12-14
BRPI0408516A (en) 2006-03-07
AU2004222295B2 (en) 2008-07-17
US20040191284A1 (en) 2004-09-30
WO2004082625A2 (en) 2004-09-30
US20040185068A1 (en) 2004-09-23
CA2519300A1 (en) 2004-09-30
AU2004222295A1 (en) 2004-09-30

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