WO2004082525A3 - Sinus delivery of sustained release therapeutics - Google Patents

Sinus delivery of sustained release therapeutics Download PDF

Info

Publication number
WO2004082525A3
WO2004082525A3 PCT/US2004/007828 US2004007828W WO2004082525A3 WO 2004082525 A3 WO2004082525 A3 WO 2004082525A3 US 2004007828 W US2004007828 W US 2004007828W WO 2004082525 A3 WO2004082525 A3 WO 2004082525A3
Authority
WO
WIPO (PCT)
Prior art keywords
biodegradable implants
sustained release
sinus
release therapeutics
sinus delivery
Prior art date
Application number
PCT/US2004/007828
Other languages
French (fr)
Other versions
WO2004082525A2 (en
Inventor
Donald J Eaton
Mary L Moran
Rodney Brenneman
Original Assignee
Sinexus Inc
Donald J Eaton
Mary L Moran
Rodney Brenneman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinexus Inc, Donald J Eaton, Mary L Moran, Rodney Brenneman filed Critical Sinexus Inc
Priority to AU2004222340A priority Critical patent/AU2004222340B2/en
Priority to EP04720509.1A priority patent/EP1605863B1/en
Priority to JP2006507191A priority patent/JP2006520786A/en
Priority to EP16182023.8A priority patent/EP3103422A1/en
Priority to CA2518960A priority patent/CA2518960C/en
Publication of WO2004082525A2 publication Critical patent/WO2004082525A2/en
Publication of WO2004082525A3 publication Critical patent/WO2004082525A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/007—Injectors for solid bodies, e.g. suppositories
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants

Abstract

The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.
PCT/US2004/007828 2003-03-14 2004-03-12 Sinus delivery of sustained release therapeutics WO2004082525A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2004222340A AU2004222340B2 (en) 2003-03-14 2004-03-12 Sinus delivery of sustained release therapeutics
EP04720509.1A EP1605863B1 (en) 2003-03-14 2004-03-12 Sinus delivery of sustained release therapeutics
JP2006507191A JP2006520786A (en) 2003-03-14 2004-03-12 Sinus delivery of sustained-release therapeutic agents
EP16182023.8A EP3103422A1 (en) 2003-03-14 2004-03-12 Sinus delivery of sustained release therapeutics
CA2518960A CA2518960C (en) 2003-03-14 2004-03-12 Sinus delivery of sustained release therapeutics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45491803P 2003-03-14 2003-03-14
US60/454,918 2003-03-14

Publications (2)

Publication Number Publication Date
WO2004082525A2 WO2004082525A2 (en) 2004-09-30
WO2004082525A3 true WO2004082525A3 (en) 2006-04-13

Family

ID=33029929

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007828 WO2004082525A2 (en) 2003-03-14 2004-03-12 Sinus delivery of sustained release therapeutics

Country Status (6)

Country Link
US (16) US7544192B2 (en)
EP (2) EP1605863B1 (en)
JP (1) JP2006520786A (en)
AU (1) AU2004222340B2 (en)
CA (1) CA2518960C (en)
WO (1) WO2004082525A2 (en)

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US20090192489A1 (en) 2009-07-30
US7951132B2 (en) 2011-05-31
US7713255B2 (en) 2010-05-11
US20190143087A1 (en) 2019-05-16
US20160287854A1 (en) 2016-10-06
US7662141B2 (en) 2010-02-16
CA2518960A1 (en) 2004-09-30
US20120101429A1 (en) 2012-04-26
EP1605863B1 (en) 2016-09-07
US20090192490A1 (en) 2009-07-30
US20090238859A1 (en) 2009-09-24
US7951130B2 (en) 2011-05-31
US7691094B2 (en) 2010-04-06
AU2004222340A1 (en) 2004-09-30
EP1605863A4 (en) 2010-12-08
WO2004082525A2 (en) 2004-09-30
EP1605863A2 (en) 2005-12-21
US7544192B2 (en) 2009-06-09
US20110066135A1 (en) 2011-03-17
US7951135B2 (en) 2011-05-31
US7951133B2 (en) 2011-05-31
US20110004193A1 (en) 2011-01-06
US20090047327A1 (en) 2009-02-19
EP3103422A1 (en) 2016-12-14
JP2006520786A (en) 2006-09-14
CA2518960C (en) 2013-08-27
US20110004195A1 (en) 2011-01-06
US20090192491A1 (en) 2009-07-30
US7686798B2 (en) 2010-03-30
US20090192492A1 (en) 2009-07-30
US7951131B2 (en) 2011-05-31
US20110004196A1 (en) 2011-01-06
US20090047326A1 (en) 2009-02-19
US11291812B2 (en) 2022-04-05
US7662142B2 (en) 2010-02-16
AU2004222340B2 (en) 2009-11-12
US7951134B2 (en) 2011-05-31
US20050043706A1 (en) 2005-02-24
US8109918B2 (en) 2012-02-07
US20090192488A1 (en) 2009-07-30

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