WO2004081524A3 - Measurement site dependent data preprocessing method for robust calibration and prediction - Google Patents

Measurement site dependent data preprocessing method for robust calibration and prediction Download PDF

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Publication number
WO2004081524A3
WO2004081524A3 PCT/US2004/007002 US2004007002W WO2004081524A3 WO 2004081524 A3 WO2004081524 A3 WO 2004081524A3 US 2004007002 W US2004007002 W US 2004007002W WO 2004081524 A3 WO2004081524 A3 WO 2004081524A3
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WO
WIPO (PCT)
Prior art keywords
measurement
tissue
variation
sample
applying
Prior art date
Application number
PCT/US2004/007002
Other languages
French (fr)
Other versions
WO2004081524B1 (en
WO2004081524A2 (en
Inventor
Alexander D Lorenz
Timothy L Ruchti
Thomas B Blank
Kevin H Hazen
Original Assignee
Sensys Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sensys Medical Inc filed Critical Sensys Medical Inc
Publication of WO2004081524A2 publication Critical patent/WO2004081524A2/en
Publication of WO2004081524A3 publication Critical patent/WO2004081524A3/en
Publication of WO2004081524B1 publication Critical patent/WO2004081524B1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495—Calibrating or testing of in-vivo probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Abstract

A solution for reducing interference in noninvasive spectroscopic measurements of tissue and blood analytes is provided. The noninvasive measurement of blood chemistry involves collecting a tissue measurement (301), preprocessing the measurement for enhancing the analytical signal and attenuating noises (302) applying a basis set to the preprocessed tissue measurement (304) to transform the preprocessed tissue measurement (303), performing an outlier detection (305), making a bias correction term (306), applying a multivariate calibration model to the transformed tissue measurement (307), and determining the measurement of the analyte digitally or/and graphically (308). By applying a basis set representing various tissue components to a collected sample measurement, measurement interferences resulting from the heterogeneity of tissue, sampling site differences, patient-to-patient variation, physiological variation, and instrumental differences are reduced. Consequently, the transformed sample measurements are more suitable for developing calibrations that are robust with respect to sample-to-sample variation, variation through time, and instrument related differences.
PCT/US2004/007002 2003-03-07 2004-03-05 Measurement site dependent data preprocessing method for robust calibration and prediction WO2004081524A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/384,023 US7010336B2 (en) 1997-08-14 2003-03-07 Measurement site dependent data preprocessing method for robust calibration and prediction
US10/384,023 2003-03-07

Publications (3)

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WO2004081524A2 WO2004081524A2 (en) 2004-09-23
WO2004081524A3 true WO2004081524A3 (en) 2005-05-06
WO2004081524B1 WO2004081524B1 (en) 2005-07-07

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Family Applications (1)

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PCT/US2004/007002 WO2004081524A2 (en) 2003-03-07 2004-03-05 Measurement site dependent data preprocessing method for robust calibration and prediction

Country Status (2)

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US (1) US7010336B2 (en)
WO (1) WO2004081524A2 (en)

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Also Published As

Publication number Publication date
US20030216627A1 (en) 2003-11-20
US7010336B2 (en) 2006-03-07
WO2004081524B1 (en) 2005-07-07
WO2004081524A2 (en) 2004-09-23

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