WO2004076426A1 - 3-methyl-2- (3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexancarbonyl-amino)-buttersäurederivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose - Google Patents
3-methyl-2- (3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexancarbonyl-amino)-buttersäurederivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose Download PDFInfo
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- WO2004076426A1 WO2004076426A1 PCT/EP2004/001578 EP2004001578W WO2004076426A1 WO 2004076426 A1 WO2004076426 A1 WO 2004076426A1 EP 2004001578 W EP2004001578 W EP 2004001578W WO 2004076426 A1 WO2004076426 A1 WO 2004076426A1
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- Prior art keywords
- methyl
- alkyl
- phenyl
- amino
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Classifications
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
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JP2006501885A JP2006519193A (ja) | 2003-02-27 | 2004-02-19 | 2型糖尿病およびアテローム性動脈硬化症の治療のためのpparモジュレーターとしての3−メチル−2−(3−(2−フェニル−オキサゾール−4−イルメトキシ)−シクロヘキサンカルボニル−アミノ酪酸誘導体および関連化合物 |
AT04712494T ATE430738T1 (de) | 2003-02-27 | 2004-02-19 | 3-methyl-2- (3- (2-phenyl-oxazol-4-ylmethoxy)- cyclohexancarbonyl-amino)-buttersäurederivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose |
DK04712494T DK1599453T3 (da) | 2003-02-27 | 2004-02-19 | 3-Methyl-2-(3-(2-phenyloxazol-4-ylmethyoxy)cyclohexancarbonylamino)smörsyrederivater og beslægtede forbindelser som PPAR modulatorer til behandling af type 2 diabetes og atherosklerose |
EP04712494A EP1599453B1 (de) | 2003-02-27 | 2004-02-19 | 3-methyl-2- (3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexancarbonyl-amino)-buttersäurederivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose |
YUP-2005/0594A RS20050594A (en) | 2003-02-27 | 2004-02-19 | 3-methyl-2-(3-(2-phenyl-oxazol-4- ylmethoxy)- cyclohexanecarbonyl- amino butyric acid derivatives and related compounds as ppar modulators for the treatment of type 2 diabetes and atherosclerosis |
DE502004009453T DE502004009453D1 (de) | 2003-02-27 | 2004-02-19 | 3-methyl-2- (3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexancarbonyl-amino)-buttersäurederivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose |
AU2004215672A AU2004215672B2 (en) | 2003-02-27 | 2004-02-19 | 3-methyl-2- (3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexanecarbonyl-amino butyric acid derivatives and related compounds as PPAR modulators for the treatment of type 2 diabetes and atherosclerosis |
CA002516620A CA2516620A1 (en) | 2003-02-27 | 2004-02-19 | 3-methyl-2- (3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexanecarbonyl-amino butyric acid derivatives and related compounds as ppar modulators for the treatment of type 2 diabetes and atherosclerosis |
BRPI0407814-4A BRPI0407814A (pt) | 2003-02-27 | 2004-02-19 | derivados de ácido 3-metil-2-(3-(2-fenil-oxazol-4-ilmetoxi)-ciclohexonaca rbonil-amino)-butìrico e compostos afins como moduladores ppar para o tratamento do diabetes tipo 2 e aterosclerose |
MXPA05008951A MXPA05008951A (es) | 2003-02-27 | 2004-02-19 | Derivados de acido 3-metil -2-(3- (2-fenil -oxazol-4 -ilmetoxi) -ciclohexanocarbonil -aminobutirico y compuestos relacionados como moduladores de ppar para el tratamiento de diabetes de tipo 2 y aterosclerosis. |
TNP2005000206A TNSN05206A1 (en) | 2003-02-27 | 2005-08-26 | 3-methyl-2-(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexanecarbonyl-amino butyric acid derivatives and related compounds as ppar modulators for the treatment of type 2 diabetes and atherosclerosis |
HR20050742A HRP20050742A2 (en) | 2003-02-27 | 2005-08-26 | 3-methyl-2-(3-(2-phenyl-oxazol-4-ylmethoxy)-cyclohexanecarbonyl-amino butyric acid derivatives and related compounds as ppar modulators for the treatment of type 2 diabetes and atherosclerosis |
NO20054396A NO20054396L (no) | 2003-02-27 | 2005-09-22 | 3-metyl-2-(3-(2-fenyl-oksazol-4-ylmetoksy)-cykloheksankarbonyl-amino)-smorsyrederivater og lignende forbindelser som PPAR-modulatorer til behandling av type 2 diabetes og aterosklerose |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE10308355A DE10308355A1 (de) | 2003-02-27 | 2003-02-27 | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
DE10308355.3 | 2003-02-27 |
Publications (1)
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WO2004076426A1 true WO2004076426A1 (de) | 2004-09-10 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/EP2004/001579 WO2004076427A1 (de) | 2003-02-27 | 2004-02-19 | 3-(2-phenyl-oxazol-4- ylmethoxy)-cyclohexylmethoxy -essigsäure derivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose |
PCT/EP2004/001586 WO2004076428A1 (de) | 2003-02-27 | 2004-02-19 | 4-(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butansäure derivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose |
PCT/EP2004/001578 WO2004076426A1 (de) | 2003-02-27 | 2004-02-19 | 3-methyl-2- (3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexancarbonyl-amino)-buttersäurederivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose |
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Application Number | Title | Priority Date | Filing Date |
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PCT/EP2004/001579 WO2004076427A1 (de) | 2003-02-27 | 2004-02-19 | 3-(2-phenyl-oxazol-4- ylmethoxy)-cyclohexylmethoxy -essigsäure derivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose |
PCT/EP2004/001586 WO2004076428A1 (de) | 2003-02-27 | 2004-02-19 | 4-(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butansäure derivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose |
Country Status (34)
Country | Link |
---|---|
US (5) | US7259177B2 (de) |
EP (3) | EP1599452B1 (de) |
JP (3) | JP2006519194A (de) |
KR (3) | KR20050105492A (de) |
CN (3) | CN100439347C (de) |
AR (3) | AR043432A1 (de) |
AT (3) | ATE430738T1 (de) |
AU (3) | AU2004215672B2 (de) |
BR (3) | BRPI0407907A (de) |
CA (3) | CA2517386A1 (de) |
CL (2) | CL2004000391A1 (de) |
CO (2) | CO5690578A2 (de) |
DE (4) | DE10308355A1 (de) |
DK (3) | DK1599455T3 (de) |
EC (2) | ECSP055986A (de) |
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MA (3) | MA27736A1 (de) |
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PE (3) | PE20040959A1 (de) |
PL (3) | PL378437A1 (de) |
PT (3) | PT1599453E (de) |
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RU (3) | RU2005130002A (de) |
SA (1) | SA04250153A (de) |
TN (2) | TNSN05204A1 (de) |
TW (3) | TW200510352A (de) |
UY (2) | UY28209A1 (de) |
WO (3) | WO2004076427A1 (de) |
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WO2002100403A1 (en) * | 2001-06-07 | 2002-12-19 | Eli Lilly And Company | Modulators of peroxisome proliferator activated receptors (ppar) |
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WO2006015716A2 (de) * | 2004-08-07 | 2006-02-16 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur herstellung der enantiomeren formen von cis-konfigurierten 3-hydroxycyclohexancarbonsäure-derivaten unter verwendung von hydrolasen |
WO2006015716A3 (de) * | 2004-08-07 | 2006-06-22 | Sanofi Aventis Deutschland | Verfahren zur herstellung der enantiomeren formen von cis-konfigurierten 3-hydroxycyclohexancarbonsäure-derivaten unter verwendung von hydrolasen |
WO2006066694A1 (de) * | 2004-12-15 | 2006-06-29 | Sanofi-Aventis Deutschland Gmbh | VERFAHREN ZUR HERSTELLUNG VON OXAZOLEN DURCH KONDENSATION VON AROMATISCHEN ALDEHYDEN MIT α-KETOXIMEN ZU N-OXIDEN UND NACHFOLGENDE REAKTION MIT AKTIVIERTEN SÄUREDERIVATEN |
US7544809B2 (en) | 2004-12-15 | 2009-06-09 | Sanofi-Aventis Deutschland Gmbh | Method for the preparation of oxazoles by condensing aromatic aldehydes with α-ketoximes to form n-oxides and reacting same with activated acid derivatives |
US7825144B2 (en) | 2004-12-15 | 2010-11-02 | Sanofi-Aventis Deutschland Gmbh | Method for the production of oxazoles by condensing aromatic aldehydes with α-ketoximes to N-oxides and then reacting the same with activated acid derivatives |
WO2007039177A2 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
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