WO2004075032A3 - In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes - Google Patents

In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes Download PDF

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Publication number
WO2004075032A3
WO2004075032A3 PCT/US2004/005785 US2004005785W WO2004075032A3 WO 2004075032 A3 WO2004075032 A3 WO 2004075032A3 US 2004005785 W US2004005785 W US 2004005785W WO 2004075032 A3 WO2004075032 A3 WO 2004075032A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
monitor
confirm
excitation light
systems
Prior art date
Application number
PCT/US2004/005785
Other languages
French (fr)
Other versions
WO2004075032A2 (en
Inventor
Robert D Black
Natasha Bolick
Original Assignee
Sicel Technologies Inc
Robert D Black
Natasha Bolick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicel Technologies Inc, Robert D Black, Natasha Bolick filed Critical Sicel Technologies Inc
Priority to EP04711947A priority Critical patent/EP1594551A2/en
Priority to AU2004214420A priority patent/AU2004214420A1/en
Priority to CA002516497A priority patent/CA2516497A1/en
Priority to JP2006503890A priority patent/JP4607859B2/en
Publication of WO2004075032A2 publication Critical patent/WO2004075032A2/en
Publication of WO2004075032A3 publication Critical patent/WO2004075032A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network

Abstract

Methods, systems, devices and computer program product include: (i) administering a fluorescent analyte to a subject; (ii) repetitively emitting excitation light from an implanted sensor over a desired monitoring period; (iii) detecting fluorescence intensity in response to the excitation light using the implanted sensor that outputs the excitation light; and (iv) using data associated with the detected fluorescence intensity to perform at least one of: (a) calculate the concentration or dose of the analyte received proximate to the implanted sensor site; (b) evaluate the pharmacodynamic or pharmacokinetic activity of the fluorescent analyte; (c) confirm Ab attachment to a tumor site; (d) monitor a non-target site to confirm it is not unduly affected by a therapy; (e) monitor for changes in cellular properties; (f) use the calculated dose or concentration data to adjust or customize a therapeutic amount of the analyte administered to the subject; (g) confirm micelle concentration at a target site and then stimulate toxin release based on the confirmation; and (h) monitor for the expression of a protein produced from a gene therapy modification. In particular embodiments, the intensity of the excitation signals emitted to the localized tissue can be varied in a predetermined manner to generate optical profiling data of the response of the tissue proximate the sensor.
PCT/US2004/005785 2003-02-19 2004-02-17 In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes WO2004075032A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP04711947A EP1594551A2 (en) 2003-02-19 2004-02-17 In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
AU2004214420A AU2004214420A1 (en) 2003-02-19 2004-02-17 In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
CA002516497A CA2516497A1 (en) 2003-02-19 2004-02-17 In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes
JP2006503890A JP4607859B2 (en) 2003-02-19 2004-02-17 In vivo fluorescent sensor, system and related methods operating in conjunction with a fluorescent analyte

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44834903P 2003-02-19 2003-02-19
US60/448,349 2003-02-19
US47170603P 2003-05-19 2003-05-19
US60/471,706 2003-05-19

Publications (2)

Publication Number Publication Date
WO2004075032A2 WO2004075032A2 (en) 2004-09-02
WO2004075032A3 true WO2004075032A3 (en) 2005-04-14

Family

ID=32912293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/005785 WO2004075032A2 (en) 2003-02-19 2004-02-17 In vivo fluorescence sensors, systems, and related methods operating in conjunction with fluorescent analytes

Country Status (6)

Country Link
US (3) US7510699B2 (en)
EP (1) EP1594551A2 (en)
JP (1) JP4607859B2 (en)
AU (1) AU2004214420A1 (en)
CA (1) CA2516497A1 (en)
WO (1) WO2004075032A2 (en)

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