WO2004073794A3 - Device, methods and sponges for iontophoretic drug delivery - Google Patents

Device, methods and sponges for iontophoretic drug delivery Download PDF

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Publication number
WO2004073794A3
WO2004073794A3 PCT/IL2004/000167 IL2004000167W WO2004073794A3 WO 2004073794 A3 WO2004073794 A3 WO 2004073794A3 IL 2004000167 W IL2004000167 W IL 2004000167W WO 2004073794 A3 WO2004073794 A3 WO 2004073794A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
tissue
methods
disclosed
administration
Prior art date
Application number
PCT/IL2004/000167
Other languages
French (fr)
Other versions
WO2004073794A2 (en
Inventor
Abraham J Domb
Original Assignee
Yissum Res Dev Co
Abraham J Domb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Abraham J Domb filed Critical Yissum Res Dev Co
Priority to US10/546,204 priority Critical patent/US8290579B2/en
Publication of WO2004073794A2 publication Critical patent/WO2004073794A2/en
Publication of WO2004073794A3 publication Critical patent/WO2004073794A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

Disclosed are devices and methods for administration of charged drugs to tissues of the oral cavity and for intra-tissue administration. The disclosed drug applicator for intra-tissue use includes an introducer such as a needle or catheter that is adapted to penetrate into a living tissue. The introducer has a drug-providing portion, and the applicator has current-generating element to pass through it an electrical current. Passing an electrical current through the drug-providing portion causes the drug to eject into treated tissue. Also disclosed are charged drugs suitable for iontophoretic administration, which include a bioactive agent encapsulated in charged nano-particles.
PCT/IL2004/000167 2003-02-19 2004-02-19 Device, methods and sponges for iontophoretic drug delivery WO2004073794A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/546,204 US8290579B2 (en) 2003-02-19 2004-02-19 Device, methods and sponges for iontophoretic drug delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44771303P 2003-02-19 2003-02-19
US60/447,713 2003-02-19

Publications (2)

Publication Number Publication Date
WO2004073794A2 WO2004073794A2 (en) 2004-09-02
WO2004073794A3 true WO2004073794A3 (en) 2004-11-25

Family

ID=32908486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2004/000167 WO2004073794A2 (en) 2003-02-19 2004-02-19 Device, methods and sponges for iontophoretic drug delivery

Country Status (2)

Country Link
US (1) US8290579B2 (en)
WO (1) WO2004073794A2 (en)

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US20060004431A1 (en) * 2004-07-01 2006-01-05 Fuller Thomas A Prophylactic bactericidal implant
JP2009502261A (en) * 2005-07-25 2009-01-29 ナノテクノロジー ビクトリア ピーティーワイ リミテッド Microarray device
JP2007037868A (en) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc Transdermal administration device and its controlling method
US20070078375A1 (en) * 2005-09-30 2007-04-05 Transcutaneous Technologies Inc. Iontophoretic delivery of active agents conjugated to nanoparticles
CA2623660A1 (en) * 2005-09-30 2007-04-05 Tti Ellebeau, Inc. Electrode structure for iontophoresis used to administer drug enclosed in nanoparticle and iontophoresis device making use of the same
WO2007079193A2 (en) 2005-12-30 2007-07-12 Tti Ellebeau, Inc. Iontophoretic systems, devices, and methods of delivery of active agents to biological interface
RU2009103771A (en) * 2006-07-05 2010-08-10 ТиТиАй ЭЛЛЕБО, ИНК. (JP) DELIVERY DEVICE, INCLUDING SELF-ASSEMBLY BRANCHED POLYMERS, AND METHOD OF APPLICATION
CA2674038C (en) 2006-12-28 2015-12-01 Argentumcidalelectrics, Inc. Ex vivo antimicrobial devices and methods
EP2123259A1 (en) * 2007-01-16 2009-11-25 Hokkaido University Liposome preparation for iontophoresis having antioxidant component encapsulated therein
JP2010187707A (en) * 2007-06-12 2010-09-02 Hokkaido Univ Liposome preparation for iontophoresis comprising insulin encapsulated therein
US8280481B2 (en) * 2007-11-02 2012-10-02 Tyco Healthcare Group Lp Electrodes possessing pH indicator
WO2010025430A2 (en) * 2008-08-29 2010-03-04 Nancy Josephine Polich Homeopathic therapeutic method
WO2010108541A1 (en) * 2009-03-25 2010-09-30 Gt Elektrotechnische Produkte Gmbh Polyurethane gels and method for the production thereof
US10022335B2 (en) 2011-03-03 2018-07-17 Nancy Josephine Polich Homeopathic therapeutic method and compositions
US8956157B2 (en) * 2012-01-31 2015-02-17 Alexander Philippovich Rutberg Apparatus and method for treatment of periodontal disease
RU2637634C1 (en) * 2016-10-21 2017-12-05 Владимир Иосифович Лозинский Antibacterial protein sponge for chemotherapy of infected wounds and method of its production

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WO1999040967A1 (en) * 1998-02-13 1999-08-19 Hadasit Medical Research Services & Development Company Ltd. A device for iontophoretic administration of drugs
US6048545A (en) * 1994-06-24 2000-04-11 Biozone Laboratories, Inc. Liposomal delivery by iontophoresis
WO2001012260A1 (en) * 1999-08-18 2001-02-22 Young Wook Choi Iontophoretic device to enhance skin penetration of bioactive material(s) and/or drug carrier(s)
US20020183685A1 (en) * 1999-02-10 2002-12-05 Gmp Drug Delivery, Inc. Iontophoresis, electroporation and combination patches for local drug delivery to body tissues

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US5298017A (en) * 1992-12-29 1994-03-29 Alza Corporation Layered electrotransport drug delivery system
US5401239A (en) * 1993-03-11 1995-03-28 Physion S.R.L. Electromotive treatment of catheter-rerelated infections
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CN1095681C (en) * 1996-06-20 2002-12-11 久光制药株式会社 Device structure for iontophoresis
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Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005361A1 (en) * 1992-08-28 1994-03-17 Cortrak Medical, Inc. Polymer matrix drug delivery apparatus and method
EP0774272A1 (en) * 1994-06-17 1997-05-21 Hisamitsu Pharmaceutical Co. Inc. Electrode for iontophoresis and device using the same
US6048545A (en) * 1994-06-24 2000-04-11 Biozone Laboratories, Inc. Liposomal delivery by iontophoresis
WO1997004832A1 (en) * 1995-07-25 1997-02-13 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound
US5833647A (en) * 1995-10-10 1998-11-10 The Penn State Research Foundation Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery
WO1999040967A1 (en) * 1998-02-13 1999-08-19 Hadasit Medical Research Services & Development Company Ltd. A device for iontophoretic administration of drugs
US20020183685A1 (en) * 1999-02-10 2002-12-05 Gmp Drug Delivery, Inc. Iontophoresis, electroporation and combination patches for local drug delivery to body tissues
WO2001012260A1 (en) * 1999-08-18 2001-02-22 Young Wook Choi Iontophoretic device to enhance skin penetration of bioactive material(s) and/or drug carrier(s)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICOLI S. ET AL.: "Design of triptorelin loaded nanospheres for transdermal iontophoretic administration", INT. J. OF PHARMACEUTICS, vol. 214, 2001, pages 31 - 35, XP002285730 *

Also Published As

Publication number Publication date
US20060161097A1 (en) 2006-07-20
US8290579B2 (en) 2012-10-16
WO2004073794A2 (en) 2004-09-02

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