WO2004059290A8 - Methods and apparatus for electrosmear analysis - Google Patents
Methods and apparatus for electrosmear analysisInfo
- Publication number
- WO2004059290A8 WO2004059290A8 PCT/US2003/041174 US0341174W WO2004059290A8 WO 2004059290 A8 WO2004059290 A8 WO 2004059290A8 US 0341174 W US0341174 W US 0341174W WO 2004059290 A8 WO2004059290 A8 WO 2004059290A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- analysis
- methods
- electrosmear
- smear
- cells
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/0005—Field flow fractionation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/02—Separators
- B03C5/022—Non-uniform field separators
- B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/24—Details of magnetic or electrostatic separation for measuring or calculating parameters, efficiency, etc.
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/0005—Field flow fractionation
- G01N2030/004—Field flow fractionation characterised by opposing force
- G01N2030/0065—Dielectric FFF, i.e. opposing forces dominate hydrodynamic lift forces and steric effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/0005—Field flow fractionation
- G01N2030/007—Field flow fractionation programming of driving force
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003302333A AU2003302333A1 (en) | 2002-12-20 | 2003-12-22 | Methods and apparatus for electrosmear analysis |
CA002511331A CA2511331A1 (en) | 2002-12-20 | 2003-12-22 | Methods and apparatus for electrosmear analysis |
EP03810889A EP1583956A4 (en) | 2002-12-20 | 2003-12-22 | Methods and apparatus for electrosmear analysis |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43593802P | 2002-12-20 | 2002-12-20 | |
US60/435,938 | 2002-12-20 | ||
US47571703P | 2003-06-04 | 2003-06-04 | |
US60/475,717 | 2003-06-04 |
Publications (4)
Publication Number | Publication Date |
---|---|
WO2004059290A2 WO2004059290A2 (en) | 2004-07-15 |
WO2004059290A9 WO2004059290A9 (en) | 2004-10-07 |
WO2004059290A8 true WO2004059290A8 (en) | 2004-12-16 |
WO2004059290A3 WO2004059290A3 (en) | 2005-01-13 |
Family
ID=32685419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/041174 WO2004059290A2 (en) | 2002-12-20 | 2003-12-22 | Methods and apparatus for electrosmear analysis |
Country Status (5)
Country | Link |
---|---|
US (2) | US7105081B2 (en) |
EP (1) | EP1583956A4 (en) |
AU (1) | AU2003302333A1 (en) |
CA (1) | CA2511331A1 (en) |
WO (1) | WO2004059290A2 (en) |
Families Citing this family (29)
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US9283597B2 (en) * | 2002-12-02 | 2016-03-15 | Cfd Research Corporation | Miniaturized electrothermal flow induced infusion pump |
US8974652B2 (en) * | 2004-05-28 | 2015-03-10 | Board Of Regents, The University Of Texas System | Programmable fluidic processors |
US7267752B2 (en) * | 2004-07-28 | 2007-09-11 | University Of Rochester | Rapid flow fractionation of particles combining liquid and particulate dielectrophoresis |
CN101500694B (en) | 2006-05-09 | 2012-07-18 | 先进液体逻辑公司 | Droplet manipulation systems |
US20090205962A1 (en) * | 2007-07-11 | 2009-08-20 | West Virginia University | Electrophoresis device and method |
EP2042239A1 (en) * | 2007-09-10 | 2009-04-01 | Koninklijke Philips Electronics N.V. | Dielectrophoretic device and method for cell membrane studies |
US8740600B1 (en) * | 2007-10-09 | 2014-06-03 | Isopur Technologies, Inc. | Apparatus for agglomerating particles in a non-conductive liquid |
CN102037351A (en) | 2008-04-03 | 2011-04-27 | 加利福尼亚大学董事会 | Ex-vivo multi-dimensional system for the separation and isolation of cells, vesicles, nanoparticles and biomarkers |
US9602777B2 (en) | 2008-04-25 | 2017-03-21 | Roche Diagnostics Hematology, Inc. | Systems and methods for analyzing body fluids |
US9017610B2 (en) * | 2008-04-25 | 2015-04-28 | Roche Diagnostics Hematology, Inc. | Method of determining a complete blood count and a white blood cell differential count |
AU2009274015B2 (en) * | 2008-07-22 | 2013-04-11 | Massachusetts Institute Of Technology | Amplified electrokinetic fluid pumping switching and desalting |
US20120031759A1 (en) * | 2009-01-30 | 2012-02-09 | Natural And Medical Sciences Institute At The University Of Tubingen | Dielectrophoretic device with actuator |
JP5241044B2 (en) * | 2009-02-10 | 2013-07-17 | パナソニック株式会社 | Fine particle measuring apparatus and fine particle measuring method |
GB2476235B (en) | 2009-12-15 | 2013-07-10 | Meng-Han Kuok | Microfluidics apparatus and methods |
US8702939B2 (en) * | 2010-09-15 | 2014-04-22 | Mcmaster University | Electrotaxis methods and devices |
JP2012095550A (en) * | 2010-10-29 | 2012-05-24 | Sony Corp | Cell sorting apparatus, cell sorting chip, and cell sorting method |
KR101359708B1 (en) * | 2012-04-04 | 2014-02-10 | 글로벌광통신 (주) | microorganism measurement apparatus |
WO2013158686A1 (en) | 2012-04-16 | 2013-10-24 | Biological Dynamics, Inc. | Nucleic acid sample preparation |
US8932815B2 (en) | 2012-04-16 | 2015-01-13 | Biological Dynamics, Inc. | Nucleic acid sample preparation |
EP3039416B1 (en) * | 2013-08-29 | 2022-05-04 | Precision for Medicine (TX), Inc. | Method and apparatus for isolation, capture and molecular analysis of target particles |
WO2015051372A1 (en) * | 2013-10-04 | 2015-04-09 | Michigan Technological University | Methods and systems for identifying a particle using dielectrophoresis |
US20150273231A1 (en) * | 2014-03-31 | 2015-10-01 | Electronics And Telecommunications Research Institute | Plasma system |
JP2017512483A (en) | 2014-04-08 | 2017-05-25 | バイオロジカル ダイナミクス,インク. | Improved apparatus for isolation of biological material |
AU2017237187B2 (en) | 2016-03-24 | 2022-12-08 | Biological Dynamics, Inc. | Disposable fluidic cartridge and components |
US10818379B2 (en) | 2017-05-08 | 2020-10-27 | Biological Dynamics, Inc. | Methods and systems for analyte information processing |
EP3727693A4 (en) | 2017-12-19 | 2021-08-25 | Biological Dynamics, Inc. | Methods and devices for detection of multiple analytes from a biological sample |
WO2019195196A1 (en) | 2018-04-02 | 2019-10-10 | Biological Dynamics, Inc. | Dielectric materials |
EP3674003A1 (en) * | 2018-12-28 | 2020-07-01 | IHP GmbH - Innovations for High Performance Microelectronics / Leibniz-Institut für innovative Mikroelektronik | Identifying and counting particles using dielectrophoresis |
US20200408726A1 (en) * | 2019-06-25 | 2020-12-31 | Wyatt Technology Corporation | Sealing a field flow fractionator |
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US4250026A (en) * | 1979-05-14 | 1981-02-10 | University Of Utah | Continuous steric FFF device for the size separation of particles |
US4782015A (en) * | 1984-03-30 | 1988-11-01 | Syntex (U.S.A.) Inc. | Method for determining the presence of malignant cells |
GB2237645B (en) | 1989-08-17 | 1994-05-04 | Orbit Radical Instr And Equipm | Electron spin resonance spectrometers |
US5795457A (en) * | 1990-01-30 | 1998-08-18 | British Technology Group Ltd. | Manipulation of solid, semi-solid or liquid materials |
JP3104995B2 (en) * | 1991-01-31 | 2000-10-30 | ワーナー−ランバート・コンパニー | Substituted heteroaryl analogs of 4,6-di-tert-butyl-5-hydroxy-1,3-pyrimidine useful as anti-inflammatory agents |
DE4127405C2 (en) * | 1991-08-19 | 1996-02-29 | Fraunhofer Ges Forschung | Process for the separation of mixtures of microscopic dielectric particles suspended in a liquid or a gel and device for carrying out the process |
US5191899A (en) | 1991-12-12 | 1993-03-09 | Baal Associates, Inc. | Pap smear collection device with bristles oriented in a plane |
US5357977A (en) * | 1993-04-23 | 1994-10-25 | St. Mary's Hospital And Medical Center, Inc. | Cytological sampling method and device |
US6403367B1 (en) * | 1994-07-07 | 2002-06-11 | Nanogen, Inc. | Integrated portable biological detection system |
US5626734A (en) * | 1995-08-18 | 1997-05-06 | University Technologies International, Inc. | Filter for perfusion cultures of animal cells and the like |
US5888370A (en) | 1996-02-23 | 1999-03-30 | Board Of Regents, The University Of Texas System | Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation |
US6641708B1 (en) * | 1996-01-31 | 2003-11-04 | Board Of Regents, The University Of Texas System | Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation |
US5993630A (en) | 1996-01-31 | 1999-11-30 | Board Of Regents The University Of Texas System | Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation |
US6387707B1 (en) * | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
GB9615775D0 (en) | 1996-07-26 | 1996-09-04 | British Tech Group | Apparatus and method for characterising particles using dielectrophoresis |
US5858192A (en) * | 1996-10-18 | 1999-01-12 | Board Of Regents, The University Of Texas System | Method and apparatus for manipulation using spiral electrodes |
JP2002516742A (en) * | 1998-05-29 | 2002-06-11 | インダストリアル リサーチ リミテッド | Method and apparatus for concentration and / or movement of particles or cells into position |
US6294063B1 (en) | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
US6352838B1 (en) | 1999-04-07 | 2002-03-05 | The Regents Of The Universtiy Of California | Microfluidic DNA sample preparation method and device |
US6437551B1 (en) | 1999-11-02 | 2002-08-20 | The Regents Of The University Of California | Microfabricated AC impedance sensor |
US6436662B1 (en) | 2000-04-04 | 2002-08-20 | Digene Corporation | Device and method for cytology slide preparation |
ATE304174T1 (en) * | 2000-06-14 | 2005-09-15 | Univ Texas | SYSTEMS AND METHODS FOR CELL PART POPULATION ANALYSIS |
CA2421939A1 (en) * | 2000-09-27 | 2002-04-04 | Aviva Biosciences Corporation | Apparatus for switchng and manipulating particles and method of use thereof |
CA2424941A1 (en) * | 2000-10-10 | 2002-04-18 | Aviva Biosciences Corporation | An integrated biochip system for sample preparation and analysis |
-
2003
- 2003-12-22 EP EP03810889A patent/EP1583956A4/en not_active Withdrawn
- 2003-12-22 WO PCT/US2003/041174 patent/WO2004059290A2/en not_active Application Discontinuation
- 2003-12-22 US US10/743,698 patent/US7105081B2/en not_active Expired - Fee Related
- 2003-12-22 AU AU2003302333A patent/AU2003302333A1/en not_active Abandoned
- 2003-12-22 CA CA002511331A patent/CA2511331A1/en not_active Abandoned
-
2006
- 2006-07-24 US US11/492,327 patent/US7862702B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20040178068A1 (en) | 2004-09-16 |
WO2004059290A3 (en) | 2005-01-13 |
EP1583956A2 (en) | 2005-10-12 |
CA2511331A1 (en) | 2004-07-15 |
EP1583956A4 (en) | 2009-07-15 |
US7862702B2 (en) | 2011-01-04 |
WO2004059290A2 (en) | 2004-07-15 |
US20060254920A1 (en) | 2006-11-16 |
AU2003302333A1 (en) | 2004-07-22 |
WO2004059290A9 (en) | 2004-10-07 |
US7105081B2 (en) | 2006-09-12 |
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