WO2004050040A3 - Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof - Google Patents
Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof Download PDFInfo
- Publication number
- WO2004050040A3 WO2004050040A3 PCT/US2003/038642 US0338642W WO2004050040A3 WO 2004050040 A3 WO2004050040 A3 WO 2004050040A3 US 0338642 W US0338642 W US 0338642W WO 2004050040 A3 WO2004050040 A3 WO 2004050040A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- benzodiazepine
- dimethoxyphenyl
- methoxy
- hydroxy
- ethyl
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003293405A AU2003293405A1 (en) | 2002-12-03 | 2003-12-03 | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
CA002508542A CA2508542A1 (en) | 2002-12-03 | 2003-12-03 | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
MXPA05005895A MXPA05005895A (en) | 2002-12-03 | 2003-12-03 | Pharmaceutical composition of 1-(3, 4-dimethoxyphenyl) -4-methyl-5 -ethyl-7- methoxy-8 -hydroxy -5h-2, 3-benzodiazepine and uses thereof. |
JP2004557606A JP2006510634A (en) | 2002-12-03 | 2003-12-03 | Pharmaceutical composition of 1- (3,4-dimethoxyphenyl) -4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and use thereof |
EP03790352A EP1567161A4 (en) | 2002-12-03 | 2003-12-03 | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43077102P | 2002-12-03 | 2002-12-03 | |
US60/430,771 | 2002-12-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004050040A2 WO2004050040A2 (en) | 2004-06-17 |
WO2004050040A3 true WO2004050040A3 (en) | 2005-03-31 |
Family
ID=32469527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/038642 WO2004050040A2 (en) | 2002-12-03 | 2003-12-03 | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
Country Status (7)
Country | Link |
---|---|
US (1) | US7745431B2 (en) |
EP (1) | EP1567161A4 (en) |
JP (1) | JP2006510634A (en) |
AU (1) | AU2003293405A1 (en) |
CA (1) | CA2508542A1 (en) |
MX (1) | MXPA05005895A (en) |
WO (1) | WO2004050040A2 (en) |
Families Citing this family (30)
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EP2062583B1 (en) | 1999-04-30 | 2012-12-26 | The Regents of the University of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
US20050113460A1 (en) * | 1999-04-30 | 2005-05-26 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
US20060025388A1 (en) * | 1999-04-30 | 2006-02-02 | Glick Gary D | Compositions and methods relating to novel compounds and targets thereof |
US7144880B2 (en) * | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
EP1567161A4 (en) | 2002-12-03 | 2008-09-03 | Vela Acquisition Corp | Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof |
US6638928B1 (en) * | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
US7022700B2 (en) * | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
US7265106B2 (en) * | 2003-05-09 | 2007-09-04 | Vela Aquisition Corporation | Method for isolating (R)-tofisopam |
US20060128955A1 (en) * | 2003-05-09 | 2006-06-15 | Vela Pharmaceuticals, Inc. | Method of isolating (R)-tofisopam |
US20070021412A1 (en) * | 2003-05-16 | 2007-01-25 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine |
EP1624875A4 (en) * | 2003-05-16 | 2010-01-20 | Vela Acquisition Corp | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine |
US20050272723A1 (en) * | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
AR049384A1 (en) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | PURINA DERIVATIVES |
US20060052369A1 (en) * | 2004-09-07 | 2006-03-09 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
EP1845996A4 (en) | 2005-01-03 | 2009-04-29 | Univ Michigan | Compositions and methods relating to novel compounds and targets thereof |
US7541355B2 (en) * | 2005-05-23 | 2009-06-02 | Vela Acquisition Corporation | Conversion process for 2,3-benzodiazepine enantiomers |
WO2007053193A2 (en) * | 2005-06-01 | 2007-05-10 | The Regents Of The University Of Michigan | Unsolvated benzodiazepine compositions and methods |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
CA2628193C (en) | 2005-11-01 | 2012-08-14 | The Regents Of The University Of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
US7759338B2 (en) * | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
MX2008015488A (en) * | 2006-06-09 | 2009-02-12 | Univ Michigan | Compositions and methods relating to novel compounds and targets thereof. |
MX2009009645A (en) | 2007-03-09 | 2009-11-19 | Univ Michigan | Compositions and methods relating to novel compounds and targets thereof. |
CA2698248C (en) | 2007-09-14 | 2017-08-29 | The Regents Of The University Of Michigan | Phenyl acyl guanidine derivatives as f1f0-atpase inhibitors and the use thereof |
AU2008323945B2 (en) | 2007-11-06 | 2013-11-28 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
AU2009291632B2 (en) | 2008-09-11 | 2013-04-04 | The Regents Of The University Of Michigan | Aryl guanidine F1F0-ATPase inhibitors and related methods |
US8604023B2 (en) | 2009-04-17 | 2013-12-10 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
WO2011035124A1 (en) | 2009-09-18 | 2011-03-24 | The Regents Of The University Of Michigan | Benzodiazepinone compounds and methods of treatment using same |
CU20090172A7 (en) | 2009-10-09 | 2011-10-05 | Ct De Investigación Y Desarrollo De Medicamentos | TRICYCLIC AND TETRACYCLIC SYSTEMS WITH ACTIVITY ON THE CENTRAL AND VASCULAR NERVOUS SYSTEM |
CA2780333C (en) | 2009-11-17 | 2016-05-24 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
WO2011062766A2 (en) | 2009-11-17 | 2011-05-26 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
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US20040254173A1 (en) | 2003-06-13 | 2004-12-16 | Leventer Steven M. | Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines |
US20070032479A1 (en) | 2003-12-03 | 2007-02-08 | Leventer Steven M | Treatment of inflammatory disorders of the epithelium with low dose 2,3-benzodiazepines |
-
2003
- 2003-12-03 EP EP03790352A patent/EP1567161A4/en not_active Withdrawn
- 2003-12-03 US US10/728,261 patent/US7745431B2/en not_active Expired - Fee Related
- 2003-12-03 JP JP2004557606A patent/JP2006510634A/en active Pending
- 2003-12-03 CA CA002508542A patent/CA2508542A1/en not_active Abandoned
- 2003-12-03 WO PCT/US2003/038642 patent/WO2004050040A2/en active Application Filing
- 2003-12-03 AU AU2003293405A patent/AU2003293405A1/en not_active Abandoned
- 2003-12-03 MX MXPA05005895A patent/MXPA05005895A/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3736315A (en) * | 1966-12-09 | 1973-05-29 | Egyt Gyogyszervegyeszeti Gyar | 1-(3,4-dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodi-azepine |
US6080736A (en) * | 1999-10-27 | 2000-06-27 | Janus Pharmaceuticals, Inc. | Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam |
Non-Patent Citations (1)
Title |
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See also references of EP1567161A4 * |
Also Published As
Publication number | Publication date |
---|---|
US7745431B2 (en) | 2010-06-29 |
EP1567161A2 (en) | 2005-08-31 |
AU2003293405A8 (en) | 2004-06-23 |
US20040157833A1 (en) | 2004-08-12 |
CA2508542A1 (en) | 2004-06-17 |
MXPA05005895A (en) | 2006-02-08 |
EP1567161A4 (en) | 2008-09-03 |
AU2003293405A1 (en) | 2004-06-23 |
WO2004050040A2 (en) | 2004-06-17 |
JP2006510634A (en) | 2006-03-30 |
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