WO2004048928A3 - Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array - Google Patents

Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array Download PDF

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Publication number
WO2004048928A3
WO2004048928A3 PCT/US2003/037208 US0337208W WO2004048928A3 WO 2004048928 A3 WO2004048928 A3 WO 2004048928A3 US 0337208 W US0337208 W US 0337208W WO 2004048928 A3 WO2004048928 A3 WO 2004048928A3
Authority
WO
WIPO (PCT)
Prior art keywords
biomolecules
dimensional array
performing multiple
multiple simultaneous
manipulations
Prior art date
Application number
PCT/US2003/037208
Other languages
French (fr)
Other versions
WO2004048928A2 (en
Inventor
Michael R Emmert-Buck
Rodrigo F Chuaqui
Michael A Tangrea
Original Assignee
Us Health
Michael R Emmert-Buck
Rodrigo F Chuaqui
Michael A Tangrea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Michael R Emmert-Buck, Rodrigo F Chuaqui, Michael A Tangrea filed Critical Us Health
Priority to US10/535,521 priority Critical patent/US20060147926A1/en
Priority to AU2003297301A priority patent/AU2003297301A1/en
Publication of WO2004048928A2 publication Critical patent/WO2004048928A2/en
Publication of WO2004048928A3 publication Critical patent/WO2004048928A3/en
Priority to US12/587,976 priority patent/US8283158B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides

Abstract

This invention relates to methods and apparati for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array, such as a gel, membrane, tissue biopsy, etc. Such manipulations particularly include assays and nucleic acid amplification protocols.
PCT/US2003/037208 2002-11-25 2003-11-20 Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array WO2004048928A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/535,521 US20060147926A1 (en) 2002-11-25 2003-11-20 Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array
AU2003297301A AU2003297301A1 (en) 2002-11-25 2003-11-20 Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array
US12/587,976 US8283158B2 (en) 2002-11-25 2009-10-14 Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two dimensional array

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42875402P 2002-11-25 2002-11-25
US60/428,754 2002-11-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10535521 A-371-Of-International 2003-11-20
US12/587,976 Continuation US8283158B2 (en) 2002-11-25 2009-10-14 Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two dimensional array

Publications (2)

Publication Number Publication Date
WO2004048928A2 WO2004048928A2 (en) 2004-06-10
WO2004048928A3 true WO2004048928A3 (en) 2004-09-16

Family

ID=32393454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/037208 WO2004048928A2 (en) 2002-11-25 2003-11-20 Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array

Country Status (3)

Country Link
US (2) US20060147926A1 (en)
AU (1) AU2003297301A1 (en)
WO (1) WO2004048928A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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US20040053326A1 (en) * 2001-03-14 2004-03-18 Emmert-Buck Michael R. Transfer microdessection
JP5466237B2 (en) * 2008-10-13 2014-04-09 エフ．ホフマン−ラ ロシュ アーゲー Sub-pathotype and prognostic algorithms by gene expression profiling
WO2011068088A1 (en) * 2009-12-04 2011-06-09 株式会社日立製作所 GENE EXPRESSION ANALYSIS METHOD USING TWO DIMENSIONAL cDNA LIBRARY
EP2400304A1 (en) * 2010-06-22 2011-12-28 Centro de Investigación Cooperativa En Biomateriales ( CIC biomaGUNE) Method for the characterization of intermolecular interactions
CA3105949A1 (en) * 2018-07-18 2020-01-23 Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft Method for analyzing cell sample heterogeneity
CN114574582A (en) * 2022-03-21 2022-06-03 暨南大学 Transcriptomic standard and preparation method thereof

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US20040081979A1 (en) * 1999-07-26 2004-04-29 Vladimir Knezevic Methods, devices, arrays and kits for detecting and analyzing biomolecules
US20040081987A1 (en) * 1999-07-26 2004-04-29 20/20 Genesystems, Inc. Methods and arrays for detecting biomolecules

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Also Published As

Publication number Publication date
AU2003297301A1 (en) 2004-06-18
US8283158B2 (en) 2012-10-09
WO2004048928A2 (en) 2004-06-10
AU2003297301A8 (en) 2004-06-18
US20060147926A1 (en) 2006-07-06
US20100105056A1 (en) 2010-04-29

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