WO2004047622A3 - Substantially non-immunogenic injectable collagen - Google Patents

Substantially non-immunogenic injectable collagen Download PDF

Info

Publication number
WO2004047622A3
WO2004047622A3 PCT/US2003/037769 US0337769W WO2004047622A3 WO 2004047622 A3 WO2004047622 A3 WO 2004047622A3 US 0337769 W US0337769 W US 0337769W WO 2004047622 A3 WO2004047622 A3 WO 2004047622A3
Authority
WO
WIPO (PCT)
Prior art keywords
substantially non
injectable collagen
immunogenic
collagen
article
Prior art date
Application number
PCT/US2003/037769
Other languages
French (fr)
Other versions
WO2004047622A2 (en
Inventor
Kevin R Stone
Original Assignee
Crosscart Inc
Kevin R Stone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crosscart Inc, Kevin R Stone filed Critical Crosscart Inc
Priority to AU2003302387A priority Critical patent/AU2003302387A1/en
Publication of WO2004047622A2 publication Critical patent/WO2004047622A2/en
Publication of WO2004047622A3 publication Critical patent/WO2004047622A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Abstract

The invention provides an article of manufacture comprising a substantially non-immunogenic injectable collagen for implantation into humans. The invention further provides methods for preparing injectable collagen material by removing collagen -containing material from a non-human animal; washing in saline and alcohol; subjecting material to cellular disruption treatment; and digesting the material with a proteoglycan- depleting factor and/or glycosidase and optionally following with a capping treatment. The invention also provides an article of manufacture produced by the method. The injectable collagen material of the invention are substantially non-immunogenic and have substantially the same mechanical properties as a corresponding native soft tissue.
PCT/US2003/037769 2002-11-26 2003-11-26 Substantially non-immunogenic injectable collagen WO2004047622A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003302387A AU2003302387A1 (en) 2002-11-26 2003-11-26 Substantially non-immunogenic injectable collagen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42907802P 2002-11-26 2002-11-26
US60/429,078 2002-11-26

Publications (2)

Publication Number Publication Date
WO2004047622A2 WO2004047622A2 (en) 2004-06-10
WO2004047622A3 true WO2004047622A3 (en) 2004-12-29

Family

ID=32393502

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/037769 WO2004047622A2 (en) 2002-11-26 2003-11-26 Substantially non-immunogenic injectable collagen

Country Status (3)

Country Link
US (2) US7064187B2 (en)
AU (1) AU2003302387A1 (en)
WO (1) WO2004047622A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1649582A (en) * 2002-03-08 2005-08-03 帕拉特克药品公司 Amino-methyl substituted tetracycline compounds
WO2004032980A1 (en) * 2002-10-04 2004-04-22 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
JP2007501683A (en) * 2003-05-22 2007-02-01 エラン ファーマ インターナショナル リミテッド Sterilization of nanoparticle active substance dispersions by gamma irradiation
US7157428B2 (en) * 2003-11-26 2007-01-02 Histogenics, Corp. Method for treatment and repair of meniscal injuries
CA2608993A1 (en) * 2005-05-19 2006-11-23 Albiorex, Llc Terminal sterilization of injectable collagen products
EP2502492A3 (en) 2005-10-31 2012-12-19 Velico Medical, Inc. Novel alpha-galactosidases
ES2637314T3 (en) * 2005-10-31 2017-10-11 Velico Medical, Inc. New alpha-galactosidases
US20070117176A1 (en) * 2005-11-18 2007-05-24 Srinivasan Aishwarya Process for the extraction of atelopeptide collagen from a collagenous source by microbial treatment
DE202008008627U1 (en) * 2008-03-07 2009-07-23 Aap Biomaterials Gmbh & Co. Kg Implant for wound cover
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
CN105561391A (en) 2012-05-11 2016-05-11 Rti外科手术有限公司 Xenograft soft tissue implants and methods of making and using
EA201591621A1 (en) 2013-03-04 2015-12-30 ДЕРМЕЛЛ, ЭлЭлСи ди/би/эй ИТЕРНОДЖЕН, ЭлЭлСи SUITABLE FOR INJECTION ABLE FOR POLYMERIZATION IN SITU COLLAGENIC COMPOSITION
KR102312720B1 (en) 2013-03-15 2021-10-13 알로소스 Cell repopulated collagen matrix for soft tissue repair and regeneration
WO2015066668A1 (en) 2013-11-04 2015-05-07 Lifecell Corporation Methods of removing alpha-galactose
WO2015173812A1 (en) * 2014-05-12 2015-11-19 Rappaport Family Institute For Research In The Medical Sciences Compositions comprising il-31 and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523291A (en) * 1993-09-07 1996-06-04 Datascope Investment Corp. Injectable compositions for soft tissue augmentation
US5989498A (en) * 1994-03-04 1999-11-23 St. Jude Medical, Inc. Electron-beam sterilization of biological materials
US6231608B1 (en) * 1995-06-07 2001-05-15 Crosscart, Inc. Aldehyde and glycosidase-treated soft and bone tissue xenografts

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5071741A (en) 1988-04-18 1991-12-10 Cryolife, Inc. Cryoprotective agent and its use in cryopreservation of cellular matter
US5171660A (en) 1989-04-26 1992-12-15 Cryolife, Inc. Process of revitalizing cells and tissue prior to cryopreservation
US5131850A (en) 1989-11-03 1992-07-21 Cryolife, Inc. Method for cryopreserving musculoskeletal tissues
US5160313A (en) 1991-05-14 1992-11-03 Cryolife, Inc. Process for preparing tissue for transplantation
US6284284B1 (en) 1995-06-06 2001-09-04 Advanced Tissue Sciences, Inc. Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US6231613B1 (en) 1998-12-15 2001-05-15 Enteric Medical Technologies, Inc. Methods for soft tissue augmentation in mammals
EP1154734B1 (en) 1999-02-12 2014-10-01 ProChon Biotech Ltd. Injectable collagen-based system for delivery of cells
US20020082594A1 (en) 1999-10-02 2002-06-27 Cary Hata Injectable biomaterial and methods for use thereof
US7184827B1 (en) 2000-01-24 2007-02-27 Stuart D. Edwards Shrinkage of dilatations in the body
US6444222B1 (en) 2001-05-08 2002-09-03 Verigen Transplantation Services International Ag Reinforced matrices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523291A (en) * 1993-09-07 1996-06-04 Datascope Investment Corp. Injectable compositions for soft tissue augmentation
US5989498A (en) * 1994-03-04 1999-11-23 St. Jude Medical, Inc. Electron-beam sterilization of biological materials
US6231608B1 (en) * 1995-06-07 2001-05-15 Crosscart, Inc. Aldehyde and glycosidase-treated soft and bone tissue xenografts

Also Published As

Publication number Publication date
AU2003302387A8 (en) 2004-06-18
US20040192603A1 (en) 2004-09-30
US7064187B2 (en) 2006-06-20
US20060194733A1 (en) 2006-08-31
WO2004047622A2 (en) 2004-06-10
AU2003302387A1 (en) 2004-06-18
US7595377B2 (en) 2009-09-29

Similar Documents

Publication Publication Date Title
WO2000047132A8 (en) Aldehyde and glycosidase-treated soft and bone tissue xenografts
WO2004047622A3 (en) Substantially non-immunogenic injectable collagen
EP1511445A4 (en) Sterilized xenograft tissue
US9957477B2 (en) Method for enzymatic treatment of tissue products
AU2018200162B2 (en) Method for enzymatic treatment of tissue products
CN105169483B (en) A kind of preparation method and its acellular matrix gel of acellular matrix gel
KR102126140B1 (en) Preparation of high purity collagen particles and uses thereof
Xu et al. A porcine-derived acellular dermal scaffold that supports soft tissue regeneration: removal of terminal galactose-α-(1, 3)-galactose and retention of matrix structure
WO2006101885A3 (en) Soft tissue processing
US20190151507A1 (en) Method for enzymatic treatment of tissue products
DE60238416D1 (en) PLASMA PROTEIN MATRITZES AND METHOD FOR THEIR PRODUCTION
WO2003037161A3 (en) Ion treated hydrogel
JP6816202B2 (en) Enzyme treatment method for tissue products
SG137858A1 (en) Implantable biomaterial and method for the preparation thereof
US20120022233A1 (en) Collagen implant
DE69937892D1 (en) IMPLANT MATERIAL
CN102727934B (en) Manufacturing method and application of inductive artificial periosteum
CA3007417A1 (en) Methods and systems for stiffening of tissue for improved processing
da Silveira Gerzson et al. Barrier membranes for GBR: characteristics and indication

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP