WO2004047619A3 - Tissue material and process for bioprosthesis - Google Patents

Tissue material and process for bioprosthesis Download PDF

Info

Publication number
WO2004047619A3
WO2004047619A3 PCT/US2003/037683 US0337683W WO2004047619A3 WO 2004047619 A3 WO2004047619 A3 WO 2004047619A3 US 0337683 W US0337683 W US 0337683W WO 2004047619 A3 WO2004047619 A3 WO 2004047619A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological material
bioprosthesis
tissue material
tissue
biomaterial
Prior art date
Application number
PCT/US2003/037683
Other languages
French (fr)
Other versions
WO2004047619A2 (en
Inventor
Narendra Vyavahare
Dan T Simionescu
Original Assignee
Univ Clemson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Clemson filed Critical Univ Clemson
Priority to AU2003298696A priority Critical patent/AU2003298696A1/en
Publication of WO2004047619A2 publication Critical patent/WO2004047619A2/en
Publication of WO2004047619A3 publication Critical patent/WO2004047619A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/909—Method or apparatus for assembling prosthetic

Abstract

A biomaterial useful for bioprostheses such as bioprosthetic heart valves is provided in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further characterized by having anisotropic properties wherein the biological material has a greater stiffness in one direction and a greater elasticity in a cross direction. For instance, the biological material has an elastin content of about 30% by weight. In one embodiment, the biological material is vena cava tissue.
PCT/US2003/037683 2002-11-26 2003-11-25 Tissue material and process for bioprosthesis WO2004047619A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003298696A AU2003298696A1 (en) 2002-11-26 2003-11-25 Tissue material and process for bioprosthesis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42919102P 2002-11-26 2002-11-26
US60/429,191 2002-11-26
US10/722,581 US7189259B2 (en) 2002-11-26 2003-11-24 Tissue material and process for bioprosthesis

Publications (2)

Publication Number Publication Date
WO2004047619A2 WO2004047619A2 (en) 2004-06-10
WO2004047619A3 true WO2004047619A3 (en) 2005-01-27

Family

ID=32829625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/037683 WO2004047619A2 (en) 2002-11-26 2003-11-25 Tissue material and process for bioprosthesis

Country Status (3)

Country Link
US (2) US7189259B2 (en)
AU (1) AU2003298696A1 (en)
WO (1) WO2004047619A2 (en)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6214054B1 (en) 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
DE10010074B4 (en) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for fastening and anchoring heart valve prostheses
DE10010073B4 (en) * 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anchoring for implantable heart valve prostheses
US7078163B2 (en) 2001-03-30 2006-07-18 Medtronic, Inc. Process for reducing mineralization of tissue used in transplantation
FR2828263B1 (en) * 2001-08-03 2007-05-11 Philipp Bonhoeffer DEVICE FOR IMPLANTATION OF AN IMPLANT AND METHOD FOR IMPLANTATION OF THE DEVICE
US6878168B2 (en) 2002-01-03 2005-04-12 Edwards Lifesciences Corporation Treatment of bioprosthetic tissues to mitigate post implantation calcification
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
ES2488766T3 (en) * 2002-01-25 2014-08-28 Biomedical Design, Inc. Calcification resistant fixation
US20040153145A1 (en) * 2002-11-26 2004-08-05 Clemson University Fixation method for bioprostheses
US7189259B2 (en) * 2002-11-26 2007-03-13 Clemson University Tissue material and process for bioprosthesis
US7955788B2 (en) * 2003-10-30 2011-06-07 Medtronic, Inc. Bioprosthetic tissue preparation with synthetic hydrogels
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
WO2006099016A2 (en) * 2005-03-09 2006-09-21 Providence Health System A composite multi-layered vascular graft prosthesis
US7252834B2 (en) * 2005-04-25 2007-08-07 Clemson University Research Foundation (Curf) Elastin stabilization of connective tissue
DE102005051849B4 (en) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Device for implantation and attachment of heart valve prostheses
DE102005052628B4 (en) * 2005-11-04 2014-06-05 Jenavalve Technology Inc. Self-expanding, flexible wire mesh with integrated valvular prosthesis for the transvascular heart valve replacement and a system with such a device and a delivery catheter
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
WO2008073582A2 (en) 2006-10-27 2008-06-19 Edwards Lifesciences Corporation Biological tissue for surgical implantation
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
AU2008250552B2 (en) 2007-05-15 2012-03-08 Jenavalve Technology Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
US20080294247A1 (en) * 2007-05-25 2008-11-27 Medical Entrepreneurs Ii, Inc. Prosthetic Heart Valve
US9101691B2 (en) 2007-06-11 2015-08-11 Edwards Lifesciences Corporation Methods for pre-stressing and capping bioprosthetic tissue
US20100249922A1 (en) * 2007-09-19 2010-09-30 St Jude Medical Inc. Fiber-reinforced synthetic sheets for prosthetic heart valve leaflets
US8784481B2 (en) 2007-09-28 2014-07-22 St. Jude Medical, Inc. Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features
US8679176B2 (en) 2007-12-18 2014-03-25 Cormatrix Cardiovascular, Inc Prosthetic tissue valve
US8257434B2 (en) 2007-12-18 2012-09-04 Cormatrix Cardiovascular, Inc. Prosthetic tissue valve
US8357387B2 (en) 2007-12-21 2013-01-22 Edwards Lifesciences Corporation Capping bioprosthetic tissue to reduce calcification
US8617899B2 (en) * 2008-02-14 2013-12-31 Palo Alto Research Center Incorporated Enhanced drop mixing using magnetic actuation
US20090214654A1 (en) * 2008-02-21 2009-08-27 Isenburg Jason C Treatment of aneurysm with application of connective tissue stabilization agent in combination with a delivery vehicle
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US9168130B2 (en) * 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8317858B2 (en) * 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US20100119605A1 (en) * 2008-11-12 2010-05-13 Isenburg Jason C Compositions for tissue stabilization
CN102438553A (en) * 2009-03-31 2012-05-02 天成医疗有限公司 Leaflet alignment fixture and methods therefor
US20100292779A1 (en) * 2009-05-15 2010-11-18 Helmut Straubinger Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system
CN102481390B (en) * 2009-09-02 2017-03-08 生命细胞公司 Blood vessel graft from acellular tissue matrix
WO2011044455A1 (en) * 2009-10-09 2011-04-14 Vatrix Medical, Inc. In vivo chemical stabilization of vulnerable plaque
FR2951549B1 (en) 2009-10-15 2013-08-23 Olivier Schussler PROCESS FOR OBTAINING IMPLANTABLE MEDICAL BIOPROTHESES
EP2542184B1 (en) 2010-03-01 2016-05-25 Colibri Heart Valve LLC Percutaneously deliverable heart valve and methods associated therewith
BR112012023769B1 (en) 2010-03-23 2020-11-10 Edwards Lifesciences Corporation method for preparing bioprosthetic tissue membrane material
US8858647B2 (en) 2010-05-05 2014-10-14 Barry Markman Method and apparatus for a process creating an internal tissue graft for animal and human reconstructive purposes
US11246697B2 (en) 2010-05-05 2022-02-15 Markman Biologics Corporation Method and apparatus for creating a reconstructive graft
US11701213B2 (en) 2010-05-05 2023-07-18 Markman Biologics Corporation Method and apparatus for creating a modified tissue graft
US9622845B2 (en) 2010-05-05 2017-04-18 Barry Markman Method and apparatus for creating a reconstructive graft
US11877921B2 (en) 2010-05-05 2024-01-23 Markman Biologics Corporation Method and apparatus for creating a modified tissue graft
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
CN103002833B (en) 2010-05-25 2016-05-11 耶拿阀门科技公司 Artificial heart valve and comprise artificial heart valve and support through conduit carry interior prosthese
US8906601B2 (en) 2010-06-17 2014-12-09 Edwardss Lifesciences Corporation Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
WO2012006124A2 (en) 2010-06-28 2012-01-12 Vela Biosystems Llc Method and apparatus for the endoluminal delivery of intravascular devices
US9579193B2 (en) 2010-09-23 2017-02-28 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
US10321998B2 (en) 2010-09-23 2019-06-18 Transmural Systems Llc Methods and systems for delivering prostheses using rail techniques
US9351829B2 (en) 2010-11-17 2016-05-31 Edwards Lifesciences Corporation Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability
AU2011343755A1 (en) 2010-12-14 2013-06-06 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
US8911468B2 (en) 2011-01-31 2014-12-16 Vatrix Medical, Inc. Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection
JP2014516695A (en) 2011-05-18 2014-07-17 バトリックス・メディカル・インコーポレイテッド Coated balloon for vascular stabilization
SG194880A1 (en) 2011-05-27 2013-12-30 Cormatrix Cardiovascular Inc Sterilized, acellular extracellular matrix compositions and methods ofmaking thereof
US9549817B2 (en) 2011-09-22 2017-01-24 Transmural Systems Llc Devices, systems and methods for repairing lumenal systems
US9510947B2 (en) 2011-10-21 2016-12-06 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient
DE202013011734U1 (en) 2012-05-16 2014-04-29 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. A catheter delivery system for inserting an expandable heart valve prosthesis and a medical device for treating a valvular defect
US20140005776A1 (en) 2012-06-29 2014-01-02 St. Jude Medical, Cardiology Division, Inc. Leaflet attachment for function in various shapes and sizes
US10238771B2 (en) 2012-11-08 2019-03-26 Edwards Lifesciences Corporation Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system
US9814573B2 (en) 2013-03-08 2017-11-14 St. Jude Medical, Cardiology Division, Inc. Method of preparing a tissue swatch for a bioprosthetic device
JP6563394B2 (en) 2013-08-30 2019-08-21 イェーナヴァルヴ テクノロジー インコーポレイテッド Radially foldable frame for an artificial valve and method for manufacturing the frame
US9615922B2 (en) 2013-09-30 2017-04-11 Edwards Lifesciences Corporation Method and apparatus for preparing a contoured biological tissue
US10959839B2 (en) 2013-10-08 2021-03-30 Edwards Lifesciences Corporation Method for directing cellular migration patterns on a biological tissue
US20170014115A1 (en) 2014-03-27 2017-01-19 Transmural Systems Llc Devices and methods for closure of transvascular or transcameral access ports
US11034928B2 (en) 2014-07-23 2021-06-15 Clemson University Research Foundation Modular bioreactor, compliance chamber for a bioreactor, and cell seeding apparatus
US10293082B2 (en) 2014-07-23 2019-05-21 Clemson University Research Foundation Decellularization method and system and decellularized tissue formed thereby
US10022225B2 (en) 2014-07-23 2018-07-17 Clemson University Research Foundation Self-adjusting tissue holder
CN107530168B (en) 2015-05-01 2020-06-09 耶拿阀门科技股份有限公司 Device and method with reduced pacemaker ratio in heart valve replacement
EP3349687B1 (en) 2015-09-15 2020-09-09 THE UNITED STATES OF AMERICA, represented by the S Devices for effectuating percutaneous glenn and fontan procedures
EP4183371A1 (en) 2016-05-13 2023-05-24 JenaValve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
JP7094965B2 (en) 2017-01-27 2022-07-04 イエナバルブ テクノロジー インク Heart valve imitation
US10350095B2 (en) 2017-08-17 2019-07-16 Incubar, LLC Prosthetic vascular valve and methods associated therewith
WO2019051476A1 (en) 2017-09-11 2019-03-14 Incubar, LLC Conduit vascular implant sealing device for reducing endoleak
CN109260517B (en) * 2018-09-19 2020-10-30 杭州启明医疗器械股份有限公司 Prefillable dry biological heart valve and preparation method thereof
EP3852683A1 (en) 2018-11-01 2021-07-28 Edwards Lifesciences Corporation Transcatheter pulmonic regenerative valve

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716370A (en) * 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
US5990379A (en) * 1994-11-15 1999-11-23 Kenton W. Gregory & Sisters Of Providence Prosthetic devices including elastin or elastin-based materials
US6342070B1 (en) * 1997-12-24 2002-01-29 Edwards Lifesciences Corp. Stentless bioprosthetic heart valve with patent coronary protuberances and method of surgical use thereof
US20030078659A1 (en) * 2001-10-23 2003-04-24 Jun Yang Graft element

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522579A (en) * 1980-01-10 1985-06-11 Rotondo Philip L Apparatus for making reinforced concrete products
US4378224A (en) * 1980-09-19 1983-03-29 Nimni Marcel E Coating for bioprosthetic device and method of making same
US4400833A (en) * 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
DE3238639A1 (en) * 1982-10-19 1984-04-19 Karlheinz 7900 Ulm Bachhuber METHOD FOR PRODUCING THIN SECTIONS OF BIOLOGICAL TISSUES AND CURABLE INFILTRATION AGENT FOR SUCH TISSUES
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
GB8413319D0 (en) * 1984-05-24 1984-06-27 Oliver Roy Frederick Biological material
IT1180531B (en) * 1984-09-21 1987-09-23 Ge Sv In Srl BICUSPID HEART VALVE PROSTHESIS
JP3133095B2 (en) * 1990-04-25 2001-02-05 兆岐 史 Gastrointestinal sclerosis agent
CA2441679A1 (en) * 1991-05-16 1992-11-26 3F Therapeutics, Inc. Cardiac valve
US5374539A (en) * 1991-06-17 1994-12-20 Nimni; Marcel E. Process for purifying collagen and generating bioprosthesis
US5376376A (en) * 1992-01-13 1994-12-27 Li; Shu-Tung Resorbable vascular wound dressings
US5480424A (en) * 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5931969A (en) 1994-07-29 1999-08-03 Baxter International Inc. Methods and apparatuses for treating biological tissue to mitigate calcification
EP0804255B1 (en) 1994-07-29 2001-10-04 Edwards Lifesciences Corporation Methods for treating implantable biological tissues to mitigate the calcification thereof
US5641373A (en) 1995-04-17 1997-06-24 Baxter International Inc. Method of manufacturing a radially-enlargeable PTFE tape-reinforced vascular graft
EP0821573A4 (en) * 1995-04-19 2000-08-09 St Jude Medical Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US6110206A (en) * 1995-09-15 2000-08-29 Crosscart, Inc. Anterior cruciate ligament xenografts
US6328763B1 (en) * 1995-10-06 2001-12-11 Cardiomend, Llc Optimized geometry of a tissue pattern for semilunar heart valve reconstruction
US6402780B2 (en) 1996-02-23 2002-06-11 Cardiovascular Technologies, L.L.C. Means and method of replacing a heart valve in a minimally invasive manner
US6532388B1 (en) 1996-04-30 2003-03-11 Medtronic, Inc. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
US5834449A (en) * 1996-06-13 1998-11-10 The Research Foundation Of State University Of New York Treatment of aortic and vascular aneurysms with tetracycline compounds
US5800531A (en) 1996-09-30 1998-09-01 Baxter International Inc. Bioprosthetic heart valve implantation device
US5899937A (en) 1997-03-05 1999-05-04 Cryolife, Inc. Pulsatile flow system for developing heart valves
US5928281A (en) 1997-03-27 1999-07-27 Baxter International Inc. Tissue heart valves
US5961549A (en) 1997-04-03 1999-10-05 Baxter International Inc. Multi-leaflet bioprosthetic heart valve
EP1018987B1 (en) 1997-04-04 2014-10-29 Barnes-Jewish Hospital Neocartilage and methods of use
EP1011699B1 (en) * 1997-09-11 2001-12-05 Purdue Research Foundation Galactosidase modified submucosal tissue
US6626939B1 (en) 1997-12-18 2003-09-30 Boston Scientific Scimed, Inc. Stent-graft with bioabsorbable structural support
US6071541A (en) * 1998-07-31 2000-06-06 Murad; Howard Pharmaceutical compositions and methods for managing skin conditions
US6214054B1 (en) 1998-09-21 2001-04-10 Edwards Lifesciences Corporation Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
DE19860712A1 (en) 1998-12-23 2000-07-13 Arnold & Richter Kg Film guide for a motion picture camera
AU757091B2 (en) 1999-01-26 2003-01-30 Edwards Lifesciences Corporation Flexible heart valve
US6558418B2 (en) 1999-01-26 2003-05-06 Edwards Lifesciences Corporation Flexible heart valve
US6278079B1 (en) 1999-02-09 2001-08-21 Edwards Lifesciences Corp. Laser cutting of fabric grafts
WO2000064371A1 (en) * 1999-04-27 2000-11-02 The Children's Hospital Of Philadelphia Stabilization of implantable bioprosthetic devices
JP2003509168A (en) 1999-09-22 2003-03-11 バクスター・インターナショナル・インコーポレイテッド Heart valve and biological tissue preparation method
US6416547B1 (en) 1999-10-06 2002-07-09 Edwards Lifesciences Corporation Heart valve carrier and rinse cage
US6479079B1 (en) * 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
US6228387B1 (en) * 2000-01-27 2001-05-08 Murray Borod Integrated comprehensive hemorrhoid treatment compositions and regimen
US6391538B1 (en) * 2000-02-09 2002-05-21 The Children's Hospital Of Philadelphia Stabilization of implantable bioprosthetic tissue
US6378221B1 (en) 2000-02-29 2002-04-30 Edwards Lifesciences Corporation Systems and methods for mapping and marking the thickness of bioprosthetic sheet
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US6539984B2 (en) 2000-07-12 2003-04-01 Edwards Lifesciences Corporation Method and apparatus for forming a heart valve wireform
US6409758B2 (en) 2000-07-27 2002-06-25 Edwards Lifesciences Corporation Heart valve holder for constricting the valve commissures and methods of use
US6458155B1 (en) 2000-09-01 2002-10-01 Edwards Lifesciences Corporation Fresh donor heart valve sizer and method of use
US20020073359A1 (en) 2000-09-08 2002-06-13 Wade Jennifer A. System and method for high priority machine check analysis
US6461382B1 (en) 2000-09-22 2002-10-08 Edwards Lifesciences Corporation Flexible heart valve having moveable commissures
US6506197B1 (en) 2000-11-15 2003-01-14 Ethicon, Inc. Surgical method for affixing a valve to a heart using a looped suture combination
US6444222B1 (en) * 2001-05-08 2002-09-03 Verigen Transplantation Services International Ag Reinforced matrices
GB0121985D0 (en) * 2001-09-11 2001-10-31 Isis Innovation Tissue engineering scaffolds
US7166464B2 (en) * 2001-12-11 2007-01-23 Cytograft Tissue Engineering, Inc. Method of culturing cells to produce a tissue sheet
US20030130729A1 (en) * 2002-01-04 2003-07-10 David Paniagua Percutaneously implantable replacement heart valve device and method of making same
DE10235237A1 (en) * 2002-08-01 2004-02-12 Symetis Ag In vitro preparation of homologous heart valves, useful for replacement of diseased valves, by inoculating biodegradable carrier with fibroblasts and attachment to a non-degradable stent
US20040153145A1 (en) * 2002-11-26 2004-08-05 Clemson University Fixation method for bioprostheses
US7189259B2 (en) * 2002-11-26 2007-03-13 Clemson University Tissue material and process for bioprosthesis
US7160299B2 (en) * 2003-05-01 2007-01-09 Sherwood Services Ag Method of fusing biomaterials with radiofrequency energy
AR047692A1 (en) * 2003-07-10 2006-02-08 Epix Medical Inc IMAGES OF STATIONARY WHITE
US7252834B2 (en) * 2005-04-25 2007-08-07 Clemson University Research Foundation (Curf) Elastin stabilization of connective tissue

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5990379A (en) * 1994-11-15 1999-11-23 Kenton W. Gregory & Sisters Of Providence Prosthetic devices including elastin or elastin-based materials
US5716370A (en) * 1996-02-23 1998-02-10 Williamson, Iv; Warren Means for replacing a heart valve in a minimally invasive manner
US6342070B1 (en) * 1997-12-24 2002-01-29 Edwards Lifesciences Corp. Stentless bioprosthetic heart valve with patent coronary protuberances and method of surgical use thereof
US20030078659A1 (en) * 2001-10-23 2003-04-24 Jun Yang Graft element

Also Published As

Publication number Publication date
WO2004047619A2 (en) 2004-06-10
US20070005132A1 (en) 2007-01-04
AU2003298696A1 (en) 2004-06-18
US20040158320A1 (en) 2004-08-12
US7189259B2 (en) 2007-03-13
US7753840B2 (en) 2010-07-13
AU2003298696A8 (en) 2004-06-18

Similar Documents

Publication Publication Date Title
WO2004047619A3 (en) Tissue material and process for bioprosthesis
WO2004047620A3 (en) Fixation method for bioprostheses
WO2005013863A3 (en) Prosthesis made of a fibre-reinforced hydrogel, method of manufacturing and use thereof
EP1203571A3 (en) Absorbent article
WO2005016175A3 (en) Meniscus preserving implant method and apparatus
WO2006115875A3 (en) Magnetic implants and methods for reshaping tissue
DK0774975T3 (en) Use of starch for kinetic transdermal applications
ATE555753T1 (en) DISC PROSTHESIS
ATE492243T1 (en) BIOPROSTHETIC HEART VALVE
WO2000047132A8 (en) Aldehyde and glycosidase-treated soft and bone tissue xenografts
WO2004019811A8 (en) Method and device for treating diseased valve
WO2006116245A3 (en) Selectively expandable composite structures for spinal arthroplasty
EP1649879A3 (en) Decellularized tissue
WO2007021659A3 (en) Devices and methods for disc nucleus replacement
WO1999047163A3 (en) Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
WO2007076261A3 (en) Intervertebral spacer and insertion tool
AU2002219008A1 (en) Method for decellularising foreign material for the production of bioprostheses
WO2002005750A3 (en) Osteoimplant and method of making same
EP1637105A4 (en) Absorbing material and absorptive article using the same
GB2331398A (en) Bearings and supports
WO2003032863A3 (en) Orthopedic stabilization device and method
WO2004090118A8 (en) Lactobacillus plantarum strain st-iii and its use in adjusting blood fat
WO2007007287A3 (en) Cosmetic makeup and/or care process
WO2004085098A3 (en) Metallic nanoparticles as orthopedic biomaterial
EP1477191A4 (en) Composite biomaterial containing phosphophoryn

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP