WO2004046315A3 - Compositions and methods utilizing human gamma-hydroxybutyrate receptor - Google Patents

Compositions and methods utilizing human gamma-hydroxybutyrate receptor Download PDF

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Publication number
WO2004046315A3
WO2004046315A3 PCT/US2003/036200 US0336200W WO2004046315A3 WO 2004046315 A3 WO2004046315 A3 WO 2004046315A3 US 0336200 W US0336200 W US 0336200W WO 2004046315 A3 WO2004046315 A3 WO 2004046315A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
hghb
compositions
chemical
methods utilizing
Prior art date
Application number
PCT/US2003/036200
Other languages
French (fr)
Other versions
WO2004046315A8 (en
WO2004046315A2 (en
Inventor
Michel Maitre
Cauter Eve Van
Christian Andriamampandry
Jean Paul Humbert
Omar Taleb
Original Assignee
Slowave Inc
Michel Maitre
Cauter Eve Van
Christian Andriamampandry
Jean Paul Humbert
Omar Taleb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slowave Inc, Michel Maitre, Cauter Eve Van, Christian Andriamampandry, Jean Paul Humbert, Omar Taleb filed Critical Slowave Inc
Priority to AU2003290797A priority Critical patent/AU2003290797A1/en
Publication of WO2004046315A2 publication Critical patent/WO2004046315A2/en
Publication of WO2004046315A8 publication Critical patent/WO2004046315A8/en
Publication of WO2004046315A3 publication Critical patent/WO2004046315A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Abstract

The present invention concerns compositions and methods related to isolating and using human GHB receptors (hGHB receptor), as well as agents that modify the physical, chemical, and biological properties or activities of hGHB receptors. Isolation of an hGHB receptor and the polynucleotide(s) encoding an hGHB receptor allow the use of biotechnological approaches to screen for and identify compounds that affect or modulate receptor activity. Compounds identified will typically have advantageous properties such as stimulation, enhancement, or induction of SWS; biologic, chemical, and/or storage stability; less toxicity; higher potency; higher selectivity; fewer side effects and/or other beneficial physical, biological and pharmacologic characteristics.
PCT/US2003/036200 2002-11-14 2003-11-14 Compositions and methods utilizing human gamma-hydroxybutyrate receptor WO2004046315A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003290797A AU2003290797A1 (en) 2002-11-14 2003-11-14 Compositions and methods utilizing human gamma-hydroxybutyrate receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42619002P 2002-11-14 2002-11-14
US60/426,190 2002-11-14

Publications (3)

Publication Number Publication Date
WO2004046315A2 WO2004046315A2 (en) 2004-06-03
WO2004046315A8 WO2004046315A8 (en) 2004-08-26
WO2004046315A3 true WO2004046315A3 (en) 2004-11-18

Family

ID=32326319

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/036200 WO2004046315A2 (en) 2002-11-14 2003-11-14 Compositions and methods utilizing human gamma-hydroxybutyrate receptor

Country Status (2)

Country Link
AU (1) AU2003290797A1 (en)
WO (1) WO2004046315A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080274A (en) * 1968-08-20 1978-03-21 American Can Company Photopolymerization of lactone-epoxide mixtures with aromatic diazonium salts as photocatalyst
WO2000020590A2 (en) * 1998-10-06 2000-04-13 Incyte Pharmaceuticals, Inc. G-protein coupled receptor proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080274A (en) * 1968-08-20 1978-03-21 American Can Company Photopolymerization of lactone-epoxide mixtures with aromatic diazonium salts as photocatalyst
WO2000020590A2 (en) * 1998-10-06 2000-04-13 Incyte Pharmaceuticals, Inc. G-protein coupled receptor proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CASTELLI ET AL: "Stereoselectivity of NCS-382 binding to gamma-hydroxybutyrate receptor in the rat brain", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 446, no. 1-3, 20 June 2002 (2002-06-20), pages 1 - 5, XP002982117 *

Also Published As

Publication number Publication date
AU2003290797A1 (en) 2004-06-15
AU2003290797A8 (en) 2004-06-15
WO2004046315A8 (en) 2004-08-26
WO2004046315A2 (en) 2004-06-03

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