WO2004046167A3 - Synthesis and self-assembly of abc triblock bola peptide - Google Patents

Synthesis and self-assembly of abc triblock bola peptide Download PDF

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Publication number
WO2004046167A3
WO2004046167A3 PCT/US2003/036397 US0336397W WO2004046167A3 WO 2004046167 A3 WO2004046167 A3 WO 2004046167A3 US 0336397 W US0336397 W US 0336397W WO 2004046167 A3 WO2004046167 A3 WO 2004046167A3
Authority
WO
WIPO (PCT)
Prior art keywords
bola
micelles
self
lyophilic
compositions
Prior art date
Application number
PCT/US2003/036397
Other languages
French (fr)
Other versions
WO2004046167A2 (en
Inventor
Samuel I Stupp
Bryan M Rabatic
Original Assignee
Univ Northwestern
Samuel I Stupp
Claussen Randal C
Bryan M Rabatic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northwestern, Samuel I Stupp, Claussen Randal C, Bryan M Rabatic filed Critical Univ Northwestern
Priority to AU2003298647A priority Critical patent/AU2003298647A1/en
Priority to US10/534,266 priority patent/US7683025B2/en
Publication of WO2004046167A2 publication Critical patent/WO2004046167A2/en
Publication of WO2004046167A3 publication Critical patent/WO2004046167A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Abstract

The present invention provides for bola amphiphiles compositions which have more than one lyophilic (hydrophilic) head group and a hydrophobic (hydrophobic) moiety capable of hydrogen bonding with other bola amphiphiles. These bola amphiphiles are capable of self assembling into micelles. The advantage of these bola amphiphiles is that they may self-assemble into micelles whose lyophilic head groups are located within the core and on the surface of the micelles. The lyophilic environment at the core and on the surface of the micelles may be different and may be controlled by the choice of head group moieties on the bola amphiphiles. The utility of these compositions is that they can be used to load or encapsulate polar drugs, DNA, mineralizable inorganic salts, or other molecules of interest within the polar interior of the micelle. Such compositions may also provide small water-filled ion-conducting channels within their structure suitable for use in micro electromechanical devices, as templates for nanowires or dielectrics, and as chemical sensors.
PCT/US2003/036397 2002-11-14 2003-11-14 Synthesis and self-assembly of abc triblock bola peptide WO2004046167A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003298647A AU2003298647A1 (en) 2002-11-14 2003-11-14 Synthesis and self-assembly of abc triblock bola peptide
US10/534,266 US7683025B2 (en) 2002-11-14 2003-11-14 Synthesis and self-assembly of ABC triblock bola peptide amphiphiles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42618902P 2002-11-14 2002-11-14
US60/426,189 2002-11-14

Publications (2)

Publication Number Publication Date
WO2004046167A2 WO2004046167A2 (en) 2004-06-03
WO2004046167A3 true WO2004046167A3 (en) 2005-07-07

Family

ID=32326318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/036397 WO2004046167A2 (en) 2002-11-14 2003-11-14 Synthesis and self-assembly of abc triblock bola peptide

Country Status (3)

Country Link
US (1) US7683025B2 (en)
AU (1) AU2003298647A1 (en)
WO (1) WO2004046167A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9147505B2 (en) 2011-11-02 2015-09-29 Ut-Battelle, Llc Large area controlled assembly of transparent conductive networks

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003054146A2 (en) 2001-11-14 2003-07-03 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003070749A2 (en) 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
WO2004072104A2 (en) 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
CN102225964A (en) 2003-12-05 2011-10-26 西北大学 Self-assembling peptide amphiphiles and related methods for growth factor delivery
WO2005056576A2 (en) 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
MX2007008826A (en) 2005-01-21 2007-11-15 Univ Northwestern Methods and compositions for encapsulation of cells.
KR20070108555A (en) 2005-03-04 2007-11-12 노오쓰웨스턴 유니버시티 Angiogenic heparin binding peptide amphiphiles
WO2007042833A2 (en) * 2005-10-14 2007-04-19 Dewan Fazlul Hoque Chowdhury Arnphiphilic nanotubes and micelles comprising same for use in the delivery of biologically active agents
GB0520902D0 (en) 2005-10-14 2005-11-23 Chowdhury Dewan F H Nanotubes
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US8366974B2 (en) * 2008-12-04 2013-02-05 Northwestern University Nanoscale lamellar photoconductor hybrids and methods of making same
KR20120012811A (en) * 2009-04-13 2012-02-10 노오쓰웨스턴 유니버시티 Novel peptide-based scaffolds for cartilage regeneration and methods for their use
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
WO2013033476A1 (en) * 2011-08-30 2013-03-07 Quanta Biodesign, Ltd. Branched discrette peg constructs
WO2014039503A1 (en) * 2012-09-04 2014-03-13 Lauren Sciences Llc Bolaamphiphilic compounds, compositions and uses thereof
WO2015048747A1 (en) 2013-09-30 2015-04-02 Northwestern University Targeted therapy for the prevention of restenosis in the cardiovascular system
US20160159869A1 (en) 2014-12-09 2016-06-09 Northwestern University Bmp-2-binding peptide amphiphile nanofibers
US20170051016A1 (en) 2015-08-17 2017-02-23 Northwestern University Anti-inflammatory nanofibers
EP3362079B1 (en) 2015-10-14 2022-04-06 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
WO2017108316A1 (en) 2015-12-24 2017-06-29 Unilever N.V. Tyrosinase inhibitors
US10738294B2 (en) 2016-09-26 2020-08-11 Northwestern University Tissue factor (TF)—targeted nanotherapy
WO2018075885A1 (en) 2016-10-21 2018-04-26 Northwestern University Anti-microbial supramolecular structures
US10818377B2 (en) 2016-11-16 2020-10-27 University Of Washington Computational design of self-assembling cyclic protein homo-oligomers
US20200339661A1 (en) * 2017-10-30 2020-10-29 Bret Ulery Triblock peptide amphiphiles, micelles and methods of use
US11517858B2 (en) * 2019-07-18 2022-12-06 National Technology & Engineering Solutions Of Sandia, Llc Polymer membrane with vertically aligned pore channels and controlled pore surface chemistry
US11964000B2 (en) 2020-04-10 2024-04-23 Northwestern University Cancer treatment methods using nanofiber stabilized growth factors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208111A (en) * 1990-08-25 1993-05-04 Bayer Aktiengesellschaft One- or multi-layered layer elements applied to supports and their production
WO1997020639A1 (en) * 1995-12-01 1997-06-12 Forskarpatent I Syd Ab Reversibly, non-covalent bound surface coating

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) * 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
EP0585368B1 (en) 1991-04-25 1997-08-06 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
ATE342295T1 (en) 1995-07-28 2006-11-15 Genzyme Corp BIODEGRADABLE MULTIBLOKHYDROGENS AND THEIR USE AS CARRIERS FOR CONTROLLED RELEASE PHARMACOLOGICALLY ACTIVE MATERIALS AND TISSUE CONTACT MATERIALS
FR2739860B1 (en) 1995-10-17 1998-01-02 Coletica AMPHIPHILIC COMPLEXES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THE SAME
US6051272A (en) 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
US6085206A (en) 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6458924B2 (en) * 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
CA2278106C (en) 1997-01-22 2005-04-12 Board Of Regents, The University Of Texas System Tissue factor methods and compositions for coagulation and tumor treatment
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6181909B1 (en) 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
AU1615599A (en) 1997-12-02 1999-06-16 Zen Bio, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
GB9801061D0 (en) 1998-01-20 1998-03-18 Univ Nottingham Patterning technique
SE519827C2 (en) 1998-03-30 2003-04-15 Viranative Ab Nutritional medium containing methionine and its use
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6548048B1 (en) 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
AU758178B2 (en) 1998-09-04 2003-03-20 Scios Inc. Hydrogel compositions for the controlled release administration of growth factors
CA2359318C (en) 1999-02-01 2009-06-30 Donald Elbert Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
WO2000045831A1 (en) 1999-02-02 2000-08-10 Thomas Jefferson University Peptides modulating activities of heparin, other glycosaminoglycans or proteoglycans
EP1159404A2 (en) 1999-03-02 2001-12-05 University of Massachusetts, a Public Institution of Higher Education of The Commonwealth of Massachusetts, Embryonic or stem-like cell lines produced by cross species nuclear transplantation
US6473730B1 (en) 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
ES2255257T3 (en) 1999-04-22 2006-06-16 Eidgenossische Technische Hochschule (Eth) CONTROLLED RELEASE OF GROWTH FACTORS FROM MATRICES CONTAINING HEPARINE.
JP2003503071A (en) 1999-06-30 2003-01-28 アドバンスド セル テクノロジー、インコーポレイテッド Cytoplasmic transfer to dedifferentiated recipient cells
US6444723B1 (en) 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
BR0110679A (en) * 2000-04-28 2004-04-20 Univ Dublin Amphophilic macrocyclic derivatives and their analogs
AU2001261505A1 (en) 2000-05-11 2001-11-20 University Of Southern California Machine translation techniques
JP4070605B2 (en) 2000-10-19 2008-04-02 アイトゲノッシスシェ・テヒニッシュ・ホーホシューレ・ツューリヒ Block copolymers for multifunctional self-assembled systems
MXPA03006566A (en) 2001-01-23 2004-10-15 Educational Testing Service Methods for automated essay analysis.
US7449180B2 (en) 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
ATE419333T1 (en) 2001-02-06 2009-01-15 Massachusetts Inst Technology PEPTIDE STRUCTURE ENCAPSULATION OF TISSUE CELLS AND USES THEREOF
WO2003006043A1 (en) 2001-07-10 2003-01-23 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
AU2002361601A1 (en) 2001-11-06 2003-05-19 Mark C. Fishman Stem and progenitor cell capture for tissue regeneration
WO2003054146A2 (en) 2001-11-14 2003-07-03 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003070749A2 (en) 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
WO2003084980A2 (en) 2002-04-02 2003-10-16 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
WO2003090255A2 (en) 2002-04-18 2003-10-30 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
WO2004003561A1 (en) 2002-06-27 2004-01-08 Northwestern University Peptide rod amphiphiles and self-assembly of same
WO2004024778A2 (en) 2002-07-23 2004-03-25 Northwestern University Self-assembled hybrid compositions and method of making, using and ordering same
US7534761B1 (en) 2002-08-21 2009-05-19 North Western University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
AU2003304152A1 (en) 2002-09-23 2005-01-21 Northwestern University Self-assembled peptide-amphiphiles and self-assembled peptide nanofiber networks presenting multiple signals
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
WO2005003292A2 (en) 2002-11-12 2005-01-13 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
WO2004072104A2 (en) 2003-02-11 2004-08-26 Northwestern University Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon
US7259140B2 (en) 2003-03-28 2007-08-21 Thomas Jefferson University Heparin-binding peptides and uses thereof
US20070141101A1 (en) 2003-04-10 2007-06-21 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
CN102225964A (en) 2003-12-05 2011-10-26 西北大学 Self-assembling peptide amphiphiles and related methods for growth factor delivery
WO2005056576A2 (en) 2003-12-05 2005-06-23 Northwestern University Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
US20050214257A1 (en) 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
MX2007008826A (en) 2005-01-21 2007-11-15 Univ Northwestern Methods and compositions for encapsulation of cells.
KR20070108555A (en) 2005-03-04 2007-11-12 노오쓰웨스턴 유니버시티 Angiogenic heparin binding peptide amphiphiles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208111A (en) * 1990-08-25 1993-05-04 Bayer Aktiengesellschaft One- or multi-layered layer elements applied to supports and their production
WO1997020639A1 (en) * 1995-12-01 1997-06-12 Forskarpatent I Syd Ab Reversibly, non-covalent bound surface coating

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9147505B2 (en) 2011-11-02 2015-09-29 Ut-Battelle, Llc Large area controlled assembly of transparent conductive networks

Also Published As

Publication number Publication date
AU2003298647A8 (en) 2004-06-15
WO2004046167A2 (en) 2004-06-03
US20060110437A1 (en) 2006-05-25
AU2003298647A1 (en) 2004-06-15
US7683025B2 (en) 2010-03-23

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