WO2004045526A3 - Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms - Google Patents

Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms Download PDF

Info

Publication number
WO2004045526A3
WO2004045526A3 PCT/US2003/036557 US0336557W WO2004045526A3 WO 2004045526 A3 WO2004045526 A3 WO 2004045526A3 US 0336557 W US0336557 W US 0336557W WO 2004045526 A3 WO2004045526 A3 WO 2004045526A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemokine
growth
neoplasms
inhibition
associated receptors
Prior art date
Application number
PCT/US2003/036557
Other languages
French (fr)
Other versions
WO2004045526A2 (en
Inventor
Lillard W James
Nichole Hannah Pier
Singh Shailesh
Stiles K Johnathan
Original Assignee
Morehouse School Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morehouse School Of Medicine filed Critical Morehouse School Of Medicine
Priority to AU2003291549A priority Critical patent/AU2003291549A1/en
Publication of WO2004045526A2 publication Critical patent/WO2004045526A2/en
Publication of WO2004045526A3 publication Critical patent/WO2004045526A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Abstract

The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti­chemokine antibodies. It is possible to identify the particular chemokines, that are over-expressed in the tumor using methods of the invention, and administer antibodies against that over-expressed chemokine.
PCT/US2003/036557 2002-11-15 2003-11-14 Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms WO2004045526A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003291549A AU2003291549A1 (en) 2002-11-15 2003-11-14 Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42634702P 2002-11-15 2002-11-15
US60/426,347 2002-11-15

Publications (2)

Publication Number Publication Date
WO2004045526A2 WO2004045526A2 (en) 2004-06-03
WO2004045526A3 true WO2004045526A3 (en) 2005-03-31

Family

ID=32326333

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/036557 WO2004045526A2 (en) 2002-11-15 2003-11-14 Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms

Country Status (3)

Country Link
US (9) US7919083B2 (en)
AU (1) AU2003291549A1 (en)
WO (1) WO2004045526A2 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999027078A1 (en) * 1997-11-21 1999-06-03 Human Genome Sciences, Inc. Chemokine alpha-5
US20120135415A1 (en) * 2002-11-15 2012-05-31 Morehouse School Of Medicine Detecting cancer with anti-cxcl13 and anti-cxcr5 antibodies
US9233120B2 (en) 2002-11-15 2016-01-12 Jyant Technologies Anti-CCL25 and anti-CCR9 antibodies for the prevention and treatment of cancer and cancer cell migration
US20120064089A1 (en) * 2002-11-15 2012-03-15 Morehouse School Of Medicine Anti-cxcl16 and anti-cxcr6 antibodies for the prevention and treatment of cancer and cancer cell migration
US8512701B2 (en) * 2002-11-15 2013-08-20 Morehouse School Of Medicine Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration
US20050014165A1 (en) * 2003-07-18 2005-01-20 California Pacific Medical Center Biomarker panel for colorectal cancer
CA2501422C (en) * 2004-04-29 2014-08-12 University Of Rochester Lymphoid chemokines in the diagnosis, monitoring and treatment of autoimmune disease
US20100143899A1 (en) * 2005-05-17 2010-06-10 University Of Vermont And State Agricultural College Methods and products for diagnosing cancer
KR101484025B1 (en) * 2006-04-21 2015-01-19 얀센 바이오테크 인코포레이티드 Cxcl13 antagonists and their use for the treatment of inflammatory diseases
US8445442B2 (en) * 2007-04-26 2013-05-21 University Of Vermont And State Agricultural College CCL18 and CCL3 methods and compositions for detecting and treating cancer
US20090028866A1 (en) * 2007-07-27 2009-01-29 John Wayne Cancer Institute USE OF CCR9, CCL25/TECK, AND NITEGRIN alpha4 IN DIAGNOSIS AND TREATMENT OF MELANOMA METASTASIS IN THE SMALL INTESTINE
GB0718167D0 (en) 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
US20120082659A1 (en) * 2007-10-02 2012-04-05 Hartmut Land Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
KR101051435B1 (en) * 2008-10-22 2011-07-22 한국생명공학연구원 Colorectal cancer diagnostic kit using colorectal cancer-related markers and colorectal cancer diagnostic method using the same
KR101682257B1 (en) * 2008-10-31 2016-12-05 도레이 카부시키가이샤 Immunoassay method for human cxcl1 protein
PT2356462T (en) * 2008-11-11 2017-04-07 Univ Michigan Regents Anti-cxcr1 compositions and methods
WO2011040428A1 (en) * 2009-09-29 2011-04-07 学校法人慶應義塾 Anti-tumor agent and method for screening for same
WO2012031099A2 (en) 2010-09-02 2012-03-08 Vaccinex, Inc. Anti-cxcl13 antibodies and methods of using the same
US8435993B2 (en) 2010-12-07 2013-05-07 Philadelphia Health And Education Corporation Methods of inhibiting metastasis from cancer
CN106177930A (en) * 2010-12-14 2016-12-07 吉安特科技股份有限公司 Anti-cxcl 13 antibodies and anti-CXCR5 antibody purposes in the treatment or detection of malignant tumor
US20130338033A1 (en) * 2011-01-27 2013-12-19 Virginia Commonwealth University Diagnostic and Prognostic Markers for Metastasis
US9726666B2 (en) 2011-06-13 2017-08-08 Tla Targeted Immunotherapies Ab Diagnosing and treating inflammatory diseases
DK2717941T3 (en) * 2011-06-13 2020-07-13 Tla Targeted Immunotherapies Ab Treatment of cancer
WO2013131010A2 (en) * 2012-03-02 2013-09-06 Icahn School Of Medicine At Mount Sinai Function of chemokine receptor ccr8 in melanoma metastasis
JP6193275B2 (en) 2012-03-02 2017-09-06 ヴァクシネックス， インコーポレイテッド Methods for treating B cell mediated inflammatory diseases
TWI467172B (en) * 2012-10-24 2015-01-01 Po Lin Kuo Method for selecting candidate for treating breast cancer metastasis
US9790271B2 (en) 2013-01-31 2017-10-17 Vaccinex, Inc. Methods for increasing immunoglobulin A levels
WO2017140793A1 (en) 2016-02-16 2017-08-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Modulators of ccr9 for treating tumor resistance to immune responses
WO2017140803A1 (en) 2016-02-16 2017-08-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Modulators of tumor immune resistance for the treatment of cancer
BR112018076281A2 (en) 2016-06-20 2019-03-26 Kymab Limited immunocytocin, use of an immunocytocin, method, pharmaceutical composition, method for treating a proliferative disease in an animal, nucleic acid, vector, host and antibody or fragment thereof
EP3551047A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
US10980739B2 (en) 2016-12-14 2021-04-20 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
US11267817B2 (en) 2017-05-02 2022-03-08 Drexel University Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
CN107964045B (en) * 2017-12-18 2021-04-23 南京医科大学 Human-mouse chimeric anti-CXCR 2 full-molecular IgG and application thereof
US11028164B2 (en) * 2018-09-18 2021-06-08 I-Mab Biopharma Us Limited Anti-CXCL13 antibodies
WO2020106750A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
WO2021119482A1 (en) 2019-12-13 2021-06-17 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999050461A1 (en) * 1998-03-30 1999-10-07 Northwest Biotherapeutics, Inc. Therapeutic and diagnostic applications based on the role of the cxcr-4 gene in tumorigenesis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6723520B2 (en) * 1996-07-05 2004-04-20 Schering Corporation Antibodies that bind chemokine teck
US6110695A (en) * 1997-12-02 2000-08-29 The Regents Of The University Of California Modulating the interaction of the chemokine, B Lymphocyte Hemoattractant, and its Receptor, BLR1
US6863887B1 (en) * 1998-03-30 2005-03-08 Northwest Biotherapeutics, Inc. Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis
US6962980B2 (en) * 1999-09-24 2005-11-08 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US7361338B2 (en) * 1999-10-05 2008-04-22 Agensys, Inc. Methods to inhibit growth of prostate cancer cells
JP2004500412A (en) * 2000-03-31 2004-01-08 アイデック　ファーマスーティカルズ　コーポレイション Combination of anti-cytokine antibody or antagonist and anti-CD20 for treatment of B-cell lymphoma
EP1339872A2 (en) * 2000-09-19 2003-09-03 Whitehead Institute For Biomedical Research Genetic markers for tumors
US20040029114A1 (en) * 2001-01-24 2004-02-12 Eos Technology, Inc. Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
AU2002303194A1 (en) * 2001-03-30 2002-10-15 Origene Technologies, Inc Differentially-expressed and up-regulated polynucleotides and polypeptides in breast cancer
CA2445532A1 (en) * 2001-04-27 2002-11-07 Sunnybrook & Women's College Health Sciences Centre Breast cancer-associated genes and uses thereof
US7282338B2 (en) * 2001-06-07 2007-10-16 Chemocentryx, Inc. Cell migration assay
US7189507B2 (en) * 2001-06-18 2007-03-13 Pdl Biopharma, Inc. Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
US7538195B2 (en) * 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
US20110281814A1 (en) * 2009-01-30 2011-11-17 Genzyme Corporation Methods and compositions for treating breast cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999050461A1 (en) * 1998-03-30 1999-10-07 Northwest Biotherapeutics, Inc. Therapeutic and diagnostic applications based on the role of the cxcr-4 gene in tumorigenesis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZAMBELLO, R. ET AL.: "Upregulation of CXCR1 by proliferating cells in patients with lymphoproliferative disease of granular lymphocytes", BRITISH JOURNAL OF HAEMATOLOGY, vol. 120, March 2003 (2003-03-01), pages 765 - 773, XP002984890 *

Also Published As

Publication number Publication date
AU2003291549A8 (en) 2004-06-15
US20110150982A1 (en) 2011-06-23
US8097250B2 (en) 2012-01-17
US20110081408A1 (en) 2011-04-07
US20110091529A1 (en) 2011-04-21
US20110081406A1 (en) 2011-04-07
US7919083B2 (en) 2011-04-05
US20040170628A1 (en) 2004-09-02
US20110081407A1 (en) 2011-04-07
AU2003291549A1 (en) 2004-06-15
WO2004045526A2 (en) 2004-06-03
US20110091528A1 (en) 2011-04-21
US20130243761A1 (en) 2013-09-19
US20110123603A1 (en) 2011-05-26

Similar Documents

Publication Publication Date Title
WO2004045526A3 (en) Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms
IL245462A0 (en) Humanized anti-cmet antagonists
WO2005044307A3 (en) Methods of therapy for b cell-related cancers
WO2008070042A3 (en) High potency recombinant antibodies, methods for producing them and use in cancer therapy
MY145073A (en) Anti-glypican 3 antibody
MY151032A (en) Treatment of tnf? related disorders
WO2005081854A3 (en) Egf receptor epitope peptides and uses thereof
IL181473A0 (en) Humanized anti-beta 7 antagonists and uses therefor
AU2003294290A8 (en) Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation.
WO2004080418A3 (en) Nucleic acid compounds for inhibiting angiogenesis and tumor growth
WO2005070043A3 (en) Methods for treating non-melanoma cancers with paba
WO2006029219A3 (en) Human monoclonal anti-ctla4 antibodies in cancer treatment
TW200612988A (en) Adjuvant therapy with the use of anti-glypican 3 antibody
HK1160776A1 (en) Methods of treating cancer using il-21 and monoclonal antibody therapy
WO2004058191A3 (en) Multivalent lymphotoxin beta receptor agonists and therapeutic uses thereof
WO2006012616A3 (en) Therapeutic use of anti-tf-antigen antibody
WO2006009765A3 (en) Methods for the identification and use of compounds suitable for the treatment of drug resistant cancer cells
MXPA05008794A (en) Glycorpotein antigen sima135 expressed in metastatic human tumor cells.
EP1773883A4 (en) Antibodies against cancer produced using masked cancer cells as immunogen
WO2004074437A3 (en) Compositions and methods for cancer immunotherapy
AU2003215381A1 (en) EGFRvIII SPECIFIC MONOCLONAL ANTIBODY AND EGFRvIII RIBOZYMES AND USE TO DETECT, TREAT OR PREVENT EGFRvIII ASSOCIATED CANCER
SI1758610T1 (en) Methods of treating cancer using il-21 and monoclonal antibody therapy
MXPA05004126A (en) Use of antibodies to the gamma 2 chain of lallminin 5 to inhibit tumor growth and metastasis.
AU2002326318A1 (en) Targeting tumor cell antigens: antibodies useful for the diagnosis, prognosis, and treatment of cancer
WO2003051312A3 (en) E2f and cancer therapy

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA CN JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP