WO2004043347A3 - Calcitonin drug-oligomer conjugates, and uses thereof - Google Patents

Calcitonin drug-oligomer conjugates, and uses thereof Download PDF

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Publication number
WO2004043347A3
WO2004043347A3 PCT/US2003/033618 US0333618W WO2004043347A3 WO 2004043347 A3 WO2004043347 A3 WO 2004043347A3 US 0333618 W US0333618 W US 0333618W WO 2004043347 A3 WO2004043347 A3 WO 2004043347A3
Authority
WO
WIPO (PCT)
Prior art keywords
calcitonin drug
conjugates
oligomer conjugates
oligomer
disclosed
Prior art date
Application number
PCT/US2003/033618
Other languages
French (fr)
Other versions
WO2004043347A2 (en
Inventor
Nnochiri N Ekwuribe
Balasingam Radhakrishnan
Original Assignee
Nobex Corp
Nnochiri N Ekwuribe
Balasingam Radhakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp, Nnochiri N Ekwuribe, Balasingam Radhakrishnan filed Critical Nobex Corp
Priority to AU2003286617A priority Critical patent/AU2003286617A1/en
Priority to AT03777823T priority patent/ATE551064T1/en
Priority to EP03777823A priority patent/EP1569676B1/en
Publication of WO2004043347A2 publication Critical patent/WO2004043347A2/en
Publication of WO2004043347A3 publication Critical patent/WO2004043347A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Abstract

Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.
PCT/US2003/033618 2002-11-08 2003-10-24 Calcitonin drug-oligomer conjugates, and uses thereof WO2004043347A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003286617A AU2003286617A1 (en) 2002-11-08 2003-10-24 Calcitonin drug-oligomer conjugates, and uses thereof
AT03777823T ATE551064T1 (en) 2002-11-08 2003-10-24 CALCITONIN DRUG OLIGOMER CONJUGATES AND USES THEREOF
EP03777823A EP1569676B1 (en) 2002-11-08 2003-10-24 Calcitonin drug-oligomer conjugates, and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/166,355 US7713932B2 (en) 2001-06-04 2002-11-08 Calcitonin drug-oligomer conjugates, and uses thereof
US10/166,355 2002-11-08

Publications (2)

Publication Number Publication Date
WO2004043347A2 WO2004043347A2 (en) 2004-05-27
WO2004043347A3 true WO2004043347A3 (en) 2004-12-02

Family

ID=32228439

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033618 WO2004043347A2 (en) 2002-11-08 2003-10-24 Calcitonin drug-oligomer conjugates, and uses thereof

Country Status (6)

Country Link
US (2) US7713932B2 (en)
EP (1) EP1569676B1 (en)
AT (1) ATE551064T1 (en)
AU (1) AU2003286617A1 (en)
TW (1) TWI322158B (en)
WO (1) WO2004043347A2 (en)

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US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US7713932B2 (en) * 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
CA2504287A1 (en) * 2002-11-26 2004-06-10 Nobex Corporation Natriuretic compounds, conjugates, and uses thereof
WO2006076471A2 (en) * 2005-01-12 2006-07-20 Nobex Corporation Bnp conjugates and methods of use
US8835379B2 (en) 2009-10-30 2014-09-16 Novo Nordisk A/S Derivatives of CGRP
IN2014CN03214A (en) 2011-10-21 2015-07-03 Seachaid Pharmaceuticals Inc

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US20040091452A1 (en) 2004-05-13
AU2003286617A8 (en) 2004-06-03
US8030269B2 (en) 2011-10-04
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WO2004043347A2 (en) 2004-05-27
ATE551064T1 (en) 2012-04-15

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