WO2004043336A3 - Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases - Google Patents
Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases Download PDFInfo
- Publication number
- WO2004043336A3 WO2004043336A3 PCT/US2003/011325 US0311325W WO2004043336A3 WO 2004043336 A3 WO2004043336 A3 WO 2004043336A3 US 0311325 W US0311325 W US 0311325W WO 2004043336 A3 WO2004043336 A3 WO 2004043336A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- cytokine inhibitory
- selective cytokine
- compositions
- management
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000004127 Cytokines Human genes 0.000 title abstract 2
- 108090000695 Cytokines Proteins 0.000 title abstract 2
- 208000014767 Myeloproliferative disease Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 abstract 1
- 238000012261 overproduction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/21—Interferons [IFN]
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- A—HUMAN NECESSITIES
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- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0316002-5A BR0316002A (en) | 2002-11-06 | 2003-04-13 | Methods of treating or preventing and controlling a myeloproliferative disease, reducing or preventing an adverse effect associated with the administration of a second active agent in a patient suffering from a myeloproliferative disease, and enhancing the therapeutic efficacy of a myeloproliferative disease treatment, composition. pharmaceutical and kit |
US10/534,324 US20060165649A1 (en) | 2002-11-06 | 2003-04-13 | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
JP2004551394A JP2006507324A (en) | 2002-11-06 | 2003-04-13 | Compositions comprising selective cytokine inhibitors for the treatment and management of myeloproliferative diseases and methods of use thereof |
CA002505003A CA2505003A1 (en) | 2002-11-06 | 2003-04-13 | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
MXPA05004777A MXPA05004777A (en) | 2002-11-06 | 2003-04-13 | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases. |
EP03811178A EP1569903A4 (en) | 2002-11-06 | 2003-04-13 | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
AU2003226361A AU2003226361B2 (en) | 2002-11-06 | 2003-04-13 | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
NZ540384A NZ540384A (en) | 2002-11-06 | 2003-04-13 | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
IL168444A IL168444A (en) | 2002-11-06 | 2005-05-05 | Selective cytokine inhibitory drugs for use in treating, preventing or managing a myeloproliferative diseases, a pharmaceutical composition and a kit comprising same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42473102P | 2002-11-06 | 2002-11-06 | |
US60/424,731 | 2002-11-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004043336A2 WO2004043336A2 (en) | 2004-05-27 |
WO2004043336A3 true WO2004043336A3 (en) | 2004-07-29 |
Family
ID=32312867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/011325 WO2004043336A2 (en) | 2002-11-06 | 2003-04-13 | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
Country Status (13)
Country | Link |
---|---|
US (1) | US20060165649A1 (en) |
EP (1) | EP1569903A4 (en) |
JP (1) | JP2006507324A (en) |
KR (1) | KR20050072790A (en) |
CN (1) | CN1720226A (en) |
AU (1) | AU2003226361B2 (en) |
BR (1) | BR0316002A (en) |
CA (1) | CA2505003A1 (en) |
IL (1) | IL168444A (en) |
MX (1) | MXPA05004777A (en) |
NZ (1) | NZ540384A (en) |
WO (1) | WO2004043336A2 (en) |
ZA (1) | ZA200503653B (en) |
Families Citing this family (7)
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US20050100529A1 (en) * | 2003-11-06 | 2005-05-12 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for the treatment and management of asbestos-related diseases and disorders |
WO2005112917A1 (en) * | 2004-05-05 | 2005-12-01 | Celgene Corporation | Methods of using and compositions comprising selective cytokine inhibitory drugs for the treatment and management of myeloproliferative diseases |
US7700608B2 (en) | 2004-08-04 | 2010-04-20 | Shire Holdings Ag | Quinazoline derivatives and their use in the treatment of thrombocythemia |
PT3300601T (en) * | 2007-02-16 | 2022-04-21 | Celator Pharmaceuticals Inc | Fixed drug ratios for treatment of hematopoietic cancers and proliferative disorders |
EP2114415A4 (en) | 2007-02-23 | 2012-10-17 | Univ Louisville Res Found | Methods and compounds for the targeted delivery of agents to bone for interaction therewith |
WO2017030892A1 (en) | 2015-08-14 | 2017-02-23 | Reaction Biology Corp. | Histone deacetylase inhibitors and methods for use thereof |
CN112402613A (en) * | 2019-08-23 | 2021-02-26 | 中国科学院上海药物研究所 | Use of PDE3 inhibitors in combination with cytokines for the treatment of tumors |
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2003
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- 2003-04-13 CN CNA038257637A patent/CN1720226A/en active Pending
- 2003-04-13 ZA ZA200503653A patent/ZA200503653B/en unknown
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- 2003-04-13 MX MXPA05004777A patent/MXPA05004777A/en active IP Right Grant
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US5698579A (en) * | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
Non-Patent Citations (7)
Title |
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CANEPA L. ET AL: "Antitumor activity of thalidomide in idopathic myelofibrosis", HAEMATOLOGICA, vol. 86, no. 11, November 2001 (2001-11-01), pages 12 - 14, XP008103511 * |
HAO ET AL: "Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative Disorder", MOLEC. CELL. BIOL., vol. 20, no. 4, February 2000 (2000-02-01), pages 1149 - 1161, XP002978089 * |
LUNDBERG ET AL: "Bone Marrow in Polycythemia Vera, Chronic Myelocytic Leukemia, and MyelofibrosisHas an Increased Vascularity", AM. J. PATHOL., vol. 157, no. 1, July 2000 (2000-07-01), pages 15 - 19, XP002978092 * |
PRUNERI ET AL: "Angiogenesis in myelodysplastic syndromes", BR. J. CANCER, vol. 81, no. 8, 1999, pages 1398 - 1401, XP002978091 * |
SCHANDENE ET AL: "Interferon alpha prevents spontaneous apoptosis of clonal Th2 cells associated with chronic hypereosinophilia", BLOOD, vol. 96, no. 13, 15 December 2000 (2000-12-15), pages 4285 - 4292, XP002978088 * |
SILVER R.T.: "Interferon-Alpha 2b: A New Treatment for Polycythemia Vera", ANNALS OF INTERNAL MEDICINE, vol. 119, no. 11, 1 December 1993 (1993-12-01), pages 1091 - 1092, XP002978090 * |
VACCA A. ET AL: "Angiogenesis in hematologic malignancies", HAEMATOLOGICA, vol. 86, no. 11, November 2001 (2001-11-01), pages 1 - 5, XP008103510 * |
Also Published As
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AU2003226361B2 (en) | 2009-01-22 |
BR0316002A (en) | 2005-09-13 |
CA2505003A1 (en) | 2004-05-27 |
NZ540384A (en) | 2008-06-30 |
AU2003226361A1 (en) | 2004-06-03 |
EP1569903A4 (en) | 2009-07-29 |
WO2004043336A2 (en) | 2004-05-27 |
IL168444A (en) | 2010-12-30 |
CN1720226A (en) | 2006-01-11 |
MXPA05004777A (en) | 2005-07-22 |
US20060165649A1 (en) | 2006-07-27 |
KR20050072790A (en) | 2005-07-12 |
JP2006507324A (en) | 2006-03-02 |
ZA200503653B (en) | 2006-08-30 |
EP1569903A2 (en) | 2005-09-07 |
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