WO2004041085A3 - Sample collector and analyser - Google Patents

Sample collector and analyser Download PDF

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Publication number
WO2004041085A3
WO2004041085A3 PCT/GB2003/004760 GB0304760W WO2004041085A3 WO 2004041085 A3 WO2004041085 A3 WO 2004041085A3 GB 0304760 W GB0304760 W GB 0304760W WO 2004041085 A3 WO2004041085 A3 WO 2004041085A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
collector
micro
analysis
analysis area
Prior art date
Application number
PCT/GB2003/004760
Other languages
French (fr)
Other versions
WO2004041085A2 (en
Inventor
Elaine Marie Mccash
Nicol John Murray
Dennis Camilleri
Original Assignee
Rapid Biosensor Systems Ltd
Elaine Marie Mccash
Nicol John Murray
Dennis Camilleri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0225760A external-priority patent/GB0225760D0/en
Priority claimed from GB0320712A external-priority patent/GB0320712D0/en
Application filed by Rapid Biosensor Systems Ltd, Elaine Marie Mccash, Nicol John Murray, Dennis Camilleri filed Critical Rapid Biosensor Systems Ltd
Priority to AU2003276454A priority Critical patent/AU2003276454A1/en
Publication of WO2004041085A2 publication Critical patent/WO2004041085A2/en
Publication of WO2004041085A3 publication Critical patent/WO2004041085A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/11—Filling or emptying of cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/0083—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements for taking gas samples
    • A61B2010/0087—Breath samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N2001/2244—Exhaled gas, e.g. alcohol detecting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0187—Mechanical sequence of operations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0193—Arrangements or apparatus for facilitating the optical investigation the sample being taken from a stream or flow to the measurement cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0325—Cells for testing reactions, e.g. containing reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0367—Supports of cells, e.g. pivotable
    • G01N2021/0371—Supports combined with sample intake
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0378—Shapes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N2021/8557—Special shaping of flow, e.g. using a by-pass line, jet flow, curtain flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N2021/8578—Gaseous flow
    • G01N2021/8585—Gaseous flow using porous sheets, e.g. for separating aerosols

Abstract

There is described a sample collector and analyser for collecting gaseously borne samples. A collector is described using a plunger system or a hemispherical arrangement, each with projections to concentrate the sample towards the sample analysis area. A sample collector with improved tube geometry is presented to collect and distribute the sample across a wide proportion of the sample analysis area and/or across a centrally positioned sample analysis area. A fluid delivery system for adding reagents or similar fluids to the samples collected by any of the collectors is also described. An optical system for the analysis of a sample, in particular but not exclusively to sample collection apparatus for collecting biological samples for analysis using evanescent waves is also described. Particularly, there are described a refractive micro-lens array and/or micro-diffraction grating and/or array of micro-optical components.
PCT/GB2003/004760 2002-11-05 2003-11-05 Sample collector and analyser WO2004041085A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003276454A AU2003276454A1 (en) 2002-11-05 2003-11-05 Sample collector and analyser

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0225760A GB0225760D0 (en) 2002-11-05 2002-11-05 Sample anaysis system
GB0225760.8 2002-11-05
GB0320712A GB0320712D0 (en) 2003-09-04 2003-09-04 Sample collection and concentration system
GB0320712.3 2003-09-04

Publications (2)

Publication Number Publication Date
WO2004041085A2 WO2004041085A2 (en) 2004-05-21
WO2004041085A3 true WO2004041085A3 (en) 2004-07-29

Family

ID=32313979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004760 WO2004041085A2 (en) 2002-11-05 2003-11-05 Sample collector and analyser

Country Status (2)

Country Link
AU (1) AU2003276454A1 (en)
WO (1) WO2004041085A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107884300A (en) * 2017-11-10 2018-04-06 农业部南京农业机械化研究所 A kind of cereal percentage of damage, percentage of impurity detection means and detection method

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788985A (en) * 1982-09-30 1988-12-06 Medtest Corporation Device for cell sampling in a body cavity
EP0520408A2 (en) * 1991-06-25 1992-12-30 Saliva Diagnostic Systems, Inc. Sampling device and sample adequacy system
US5450193A (en) * 1992-02-24 1995-09-12 Hewlett-Packard Company Raman spectroscopy of airway gases
US5494646A (en) * 1993-04-14 1996-02-27 Seymour; Eugene H. Sampling device and sample adequacy system
US5573009A (en) * 1989-09-21 1996-11-12 Epitope, Inc. Oral sample collection method
US5658531A (en) * 1991-11-01 1997-08-19 The University Of Birmingham Assay device
US6277646B1 (en) * 1997-05-05 2001-08-21 Dade Behring Inc. Fluid specimen collecting and testing apparatus
WO2002084266A2 (en) * 2001-04-11 2002-10-24 Rapid Biosensor Systems Limited Biological measurement system
WO2002082990A1 (en) * 2001-04-11 2002-10-24 Rio Grande Medical Technologies, Inc. System for non-invasive measurement of glucose in humans

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788985A (en) * 1982-09-30 1988-12-06 Medtest Corporation Device for cell sampling in a body cavity
US5573009A (en) * 1989-09-21 1996-11-12 Epitope, Inc. Oral sample collection method
EP0520408A2 (en) * 1991-06-25 1992-12-30 Saliva Diagnostic Systems, Inc. Sampling device and sample adequacy system
US5658531A (en) * 1991-11-01 1997-08-19 The University Of Birmingham Assay device
US5450193A (en) * 1992-02-24 1995-09-12 Hewlett-Packard Company Raman spectroscopy of airway gases
US5494646A (en) * 1993-04-14 1996-02-27 Seymour; Eugene H. Sampling device and sample adequacy system
US6277646B1 (en) * 1997-05-05 2001-08-21 Dade Behring Inc. Fluid specimen collecting and testing apparatus
WO2002084266A2 (en) * 2001-04-11 2002-10-24 Rapid Biosensor Systems Limited Biological measurement system
WO2002082990A1 (en) * 2001-04-11 2002-10-24 Rio Grande Medical Technologies, Inc. System for non-invasive measurement of glucose in humans

Also Published As

Publication number Publication date
AU2003276454A1 (en) 2004-06-07
WO2004041085A2 (en) 2004-05-21

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