WO2004037326A3 - Mixing and delivery medical syringe system for therapeutic compositions - Google Patents

Mixing and delivery medical syringe system for therapeutic compositions Download PDF

Info

Publication number
WO2004037326A3
WO2004037326A3 PCT/US2003/033674 US0333674W WO2004037326A3 WO 2004037326 A3 WO2004037326 A3 WO 2004037326A3 US 0333674 W US0333674 W US 0333674W WO 2004037326 A3 WO2004037326 A3 WO 2004037326A3
Authority
WO
WIPO (PCT)
Prior art keywords
syringe system
mixing
barrel
medical syringe
delivery medical
Prior art date
Application number
PCT/US2003/033674
Other languages
French (fr)
Other versions
WO2004037326A2 (en
Inventor
Thomas V Ii Casey
Bud Damiano
Original Assignee
Boston Scient Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scient Ltd filed Critical Boston Scient Ltd
Priority to EP03777846A priority Critical patent/EP1553999A2/en
Priority to AU2003286639A priority patent/AU2003286639A1/en
Priority to CA002503052A priority patent/CA2503052A1/en
Publication of WO2004037326A2 publication Critical patent/WO2004037326A2/en
Publication of WO2004037326A3 publication Critical patent/WO2004037326A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/19Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst

Abstract

In one aspect the invention features a mixing and delivery medical syringe system including a barrel with first and second detachable sections, and first and second compartments communicable through a conduit. In another aspect the invention feature a mixing and delivery medical syringe system including a barrel having first and second compartments arranged in aprallel along the barrel, the compartments communicable through a pressure activated conduit. In still another aspect, the ivention features a kit for medicant mixing and delivery, including a syringe system, which includes a barrel assembled from multiple sections, including a first section having a first chamber, and a second section having a second chamber. The syringe system includes a conduit between the first and second chambers through which flow can be controlled. The kit further includes a first container containing a first composition, and a second container containing a second composition.
PCT/US2003/033674 2002-10-23 2003-10-22 Mixing and delivery medical syringe system for therapeutic compositions WO2004037326A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03777846A EP1553999A2 (en) 2002-10-23 2003-10-22 Mixing and delivery medical syringe system for therapeutic compositions
AU2003286639A AU2003286639A1 (en) 2002-10-23 2003-10-22 Mixing and delivery medical syringe system for therapeutic compositions
CA002503052A CA2503052A1 (en) 2002-10-23 2003-10-22 Mixing and delivery medical syringe system for therapeutic compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/278,248 2002-10-23
US10/278,248 US7883490B2 (en) 2002-10-23 2002-10-23 Mixing and delivery of therapeutic compositions

Publications (2)

Publication Number Publication Date
WO2004037326A2 WO2004037326A2 (en) 2004-05-06
WO2004037326A3 true WO2004037326A3 (en) 2004-12-23

Family

ID=32174560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033674 WO2004037326A2 (en) 2002-10-23 2003-10-22 Mixing and delivery medical syringe system for therapeutic compositions

Country Status (5)

Country Link
US (1) US7883490B2 (en)
EP (1) EP1553999A2 (en)
AU (1) AU2003286639A1 (en)
CA (1) CA2503052A1 (en)
WO (1) WO2004037326A2 (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
WO2001072281A2 (en) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7053134B2 (en) * 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) * 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7998106B2 (en) 2004-05-03 2011-08-16 Thorne Jr Gale H Safety dispensing system for hazardous substances
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
GB2409162B (en) * 2004-10-06 2005-12-14 Bhk Holding Ltd Materials,methods,and apparatus for treating a body cavity
US7581899B2 (en) * 2004-11-30 2009-09-01 James Alexander Corporation Dispenser and process
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
AU2006245950B2 (en) 2005-05-09 2012-01-12 Biosphere Medical S.A. Compositions and methods using microspheres and non-ionic contrast agents
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
EP2368581B1 (en) * 2006-01-30 2018-08-29 Biosphere Medical, Inc. Porous intravascular embolization particles and related methods
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
DE102006015238A1 (en) * 2006-03-30 2007-10-04 S&C Polymer Silicon- und Composite-Spezialitäten GmbH Disposable packaging for storage, mixing and extraction of multi-component materials for e.g. medicinal and dental applications, includes membrane ruptured by pointed object to permit mixing
US7976234B2 (en) 2006-04-28 2011-07-12 James Alexander Corporation Multi-chambered dispenser and process
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US8382704B2 (en) 2006-12-29 2013-02-26 Medrad, Inc. Systems and methods of delivering a dilated slurry to a patient
US8100294B2 (en) 2007-12-18 2012-01-24 James Alexander Corporation Container assembly
US8910830B2 (en) 2007-12-18 2014-12-16 James Alexander Corporation Container assembly
US8403178B2 (en) 2007-12-18 2013-03-26 James Alexander Corporation Container assembly
ATE548285T1 (en) 2008-01-29 2012-03-15 James Alexander Corp DONOR
US8834014B2 (en) * 2008-03-24 2014-09-16 Sashco, Inc. System for providing custom colored sealing compound
US8800816B2 (en) * 2009-03-24 2014-08-12 Sashco, Inc. System and method of providing individual quantities of custom colored sealing compound
US9107668B2 (en) * 2008-03-25 2015-08-18 Cook Medical Technologies Llc Embolic particle mixing syringe
JP2012507562A (en) * 2008-10-30 2012-03-29 ダビド リウ Microspherical porous biocompatible scaffold and manufacturing method and apparatus thereof
US20100256646A1 (en) * 2009-04-01 2010-10-07 Frank Pinal Orthobiologics delivery tool
US8657481B2 (en) 2010-01-15 2014-02-25 Spine Wave, Inc. Systems and methods for mixing fluids
EP2637716B1 (en) * 2010-11-08 2020-09-02 Aktivax, Inc. Beneficial agent dispenser
WO2012063825A1 (en) * 2010-11-10 2012-05-18 オリンパスメディカルシステムズ株式会社 Surgical device and ultrasonic treatment method
AU2010101255B4 (en) * 2010-11-15 2011-09-22 Lumsden, Andrew A prefilled syringe for administering buffered lignocaine
CA2773480C (en) * 2011-04-05 2014-12-30 Tyco Healthcare Group Lp Buffering agent delivery system for anesthetic syringe
US9751056B2 (en) 2012-01-23 2017-09-05 Merit Medical Systems, Inc. Mixing syringe
US8834449B2 (en) 2012-01-23 2014-09-16 Ikomed Technologies, Inc. Mixing syringe
WO2015006444A1 (en) * 2013-07-10 2015-01-15 Merit Medical Systems, Inc. Pre-loaded syringes and methods related thereto
US11260177B1 (en) * 2014-03-18 2022-03-01 Yasser Sadek Dental anesthetic buffer system
EP3380145B1 (en) * 2015-11-27 2019-11-13 Sanofi-Aventis Deutschland GmbH Injection apparatus
US20180085555A1 (en) * 2016-09-26 2018-03-29 Boston Scientific Scimed, Inc. Injection catheter
US11324673B2 (en) 2016-11-18 2022-05-10 Miraki Innovation Think Tank Llc Cosmetic appearance of skin
US11266761B2 (en) * 2016-12-05 2022-03-08 Cast21, Inc. System for forming a rigid support
MX2019011995A (en) 2017-04-05 2020-01-20 Miraki Innovation Think Tank Llc Point of delivery cold slurry generation.
JP7085762B2 (en) 2017-04-05 2022-06-17 ミラキ イノベーション シンク タンク エルエルシー Cold slurry confinement
US10500342B2 (en) 2017-08-21 2019-12-10 Miraki Innovation Think Tank Llc Cold slurry syringe
JP2022543820A (en) * 2019-08-06 2022-10-14 マイクロベンション インコーポレイテッド Syringe

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1099362A (en) * 1954-04-23 1955-09-05 D Antibiotiques Et De Biolog L Capsule syringe for drugs that only need to be mixed at the time of use
GB743789A (en) * 1953-02-22 1956-01-25 Hubert Percival Schofield Improvements in or relating to cartridges and the like tubular containers for use in dispensing liquids
FR1478062A (en) * 1965-04-30 1967-04-21 Ile D Etudes Et De Brevets Nov Injection syringe
US4254768A (en) * 1979-09-14 1981-03-10 Ty Perla J Hypodermic syringe
US4412836A (en) * 1979-04-27 1983-11-01 The West Company, Incorporated Syringe assembly
US4453934A (en) * 1981-11-11 1984-06-12 Contraves Ag Injection syringe for the successive injection of two liquids into the blood vessels of living bodies
EP0112574A1 (en) * 1982-12-27 1984-07-04 Meditec S.A. Two-compartment prefilled syringe
US5704918A (en) * 1992-12-01 1998-01-06 Higashikawa; Tetsuro Syringe

Family Cites Families (335)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2275154A (en) * 1940-07-10 1942-03-03 United Drug Company Method for making capsules
US2609347A (en) 1948-05-27 1952-09-02 Wilson Christopher Lumley Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom
JPS4820019B1 (en) 1969-06-05 1973-06-18
US3737398A (en) 1969-11-13 1973-06-05 D Yamaguchi Method of making a polyvinyl acetal sponge buff
CS179075B1 (en) 1974-11-26 1977-10-31 Stoy Vladimir Mode of manufacture of spherical particles from polymer
US4076640A (en) * 1975-02-24 1978-02-28 Xerox Corporation Preparation of spheroidized particles
US3957933A (en) 1975-03-05 1976-05-18 General Atomic Company Apparatus for producing microspherical particles and method for operating such apparatus
JPS51135958A (en) 1975-05-20 1976-11-25 Fuji Photo Film Co Ltd Method of making fine powder polymer having pores
US4025686A (en) 1975-06-26 1977-05-24 Owens-Corning Fiberglas Corporation Molded composite article and method for making the article
US4034759A (en) 1975-08-27 1977-07-12 Xomed, Inc. Moisture-expandable prosthesis
US4098728A (en) 1976-01-02 1978-07-04 Solomon Rosenblatt Medical surgical sponge and method of making same
US4055377A (en) 1976-08-03 1977-10-25 Minnesota Mining And Manufacturing Company Magnetically orientable retroreflectorization particles
GB1591924A (en) * 1976-10-25 1981-07-01 Berger Jenson & Nicholson Ltd Polymer aggregates
US4159719A (en) 1977-05-09 1979-07-03 Xomed, Inc. Moisture-expandable ear wick
US4437858A (en) * 1978-01-16 1984-03-20 Ty Perla J Separator disc and hypodermic syringe incorporating the same and method
ES478736A1 (en) 1978-03-23 1979-06-01 Hoechst Ag Polyvinyl alcohol pellets containing a plasticizer, and method for their preparation.
DE2834539A1 (en) 1978-08-07 1980-02-21 Basf Ag MACROPOROUS POLYMERS AS CARRIER MATERIAL FOR THE COVALENT BINDING OF PROTEINS
US4793980A (en) 1978-09-21 1988-12-27 Torobin Leonard B Hollow porous microspheres as substrates and containers for catalyst
US4243794A (en) 1978-10-10 1981-01-06 Minnesota Mining And Manufacturing Company Mixture of rough and spheroidized resin particles
US4198318A (en) * 1978-11-24 1980-04-15 Conoco, Inc. Production of high strength alumina spheres by hydrogelling corresponding slurries
US4268495A (en) 1979-01-08 1981-05-19 Ethicon, Inc. Injectable embolization and occlusion solution
US4246208A (en) * 1979-03-22 1981-01-20 Xerox Corporation Dust-free plasma spheroidization
US4346712A (en) 1979-04-06 1982-08-31 Kuraray Company, Ltd. Releasable balloon catheter
US4246794A (en) * 1979-07-23 1981-01-27 Huntington Alloys, Inc. Apparatus and method for ultrasonic inspection of round stock such as tubing, pipe and rod
HU184722B (en) 1980-02-18 1984-10-29 Laszlo Lazar Therapeutically suitable silicone rubber mixture and therapeuticaid
US4271281A (en) 1980-05-29 1981-06-02 American Hoechst Corporation Process for preparing styrenic polymer particles
DE3031737A1 (en) * 1980-08-22 1982-04-01 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING PEARL POLYMERISATS OF UNIFORM PARTICLE SIZE
CA1166413A (en) * 1980-10-30 1984-05-01 Edward E. Timm Process and apparatus for preparing uniform size polymer beads
US4681119A (en) 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
NZ199916A (en) 1981-03-11 1985-07-12 Unilever Plc Low density polymeric block material for use as carrier for included liquids
US4678814A (en) 1981-03-30 1987-07-07 California Institute Of Technology Polyacrolein microspheres
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US4622362A (en) 1981-03-30 1986-11-11 California Institute Of Technology Polyacrolein microspheres
CA1177811A (en) 1981-04-13 1984-11-13 Theo G. Spek Process for the preparation of silica particles; silica particles with a narrow pore diameter distribution, catalysts made therefrom and use of these catalysts
US4428869A (en) * 1981-08-20 1984-01-31 International Flavors & Fragrances Inc. Cologne consisting of microcapsule suspension
US4456693A (en) 1982-03-08 1984-06-26 W. R. Grace & Co. Hydrocracking catalyst
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4472552A (en) 1982-09-27 1984-09-18 W. R. Grace & Co. Continuous process for making solid, free-flowing water dispersible PVA-aldehyde reaction product
US4459145A (en) 1982-09-30 1984-07-10 The United States Of America As Represented By The United States Department Of Energy Fabrication of glass microspheres with conducting surfaces
JPS59131355A (en) 1983-01-17 1984-07-28 森下仁丹株式会社 Multiple soft capsule
DE3313947A1 (en) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
DE3834705A1 (en) 1988-10-07 1990-04-12 Schering Ag ULTRASONIC CONTRASTING AGENTS FROM GAS BUBBLES AND MICROPARTICLES CONTAINING FATTY ACID
DE3313946A1 (en) 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS
CA1225585A (en) * 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
US4492720A (en) * 1983-11-15 1985-01-08 Benjamin Mosier Method of preparing microspheres for intravascular delivery
US4573967A (en) * 1983-12-06 1986-03-04 Eli Lilly And Company Vacuum vial infusion system
US4671954A (en) 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
US4597505A (en) * 1984-04-09 1986-07-01 Continental Disc Corporation Rupture disc with selectively positioned initial buckling
US4551436A (en) 1984-04-11 1985-11-05 General Electric Company Fabrication of small dense silicon carbide spheres
DE3414924A1 (en) 1984-04-19 1985-10-31 Klaus Dr.med. Dr.med.habil. 8000 München Draenert COATED ANCHORAGE PART FOR IMPLANTS
US4674480A (en) 1984-05-25 1987-06-23 Lemelson Jerome H Drug compositions and methods of applying same
FR2566384B1 (en) * 1984-06-21 1986-09-05 Saint Gobain Vitrage IMPROVEMENTS IN TECHNIQUES FOR THE PRODUCTION OF GLASS MICROSPHERES
DE3527482A1 (en) 1984-07-31 1986-02-06 Fuji Spinning Co., Ltd., Tokio/Tokyo METHOD FOR PRODUCING GRAINY POROUS CHITOSAN
GB8419708D0 (en) * 1984-08-02 1984-09-05 Shell Int Research Preparation of silica spheres
US4623706A (en) 1984-08-23 1986-11-18 The Dow Chemical Company Process for preparing uniformly sized polymer particles by suspension polymerization of vibratorily excited monomers in a gaseous or liquid stream
JPS61101242A (en) 1984-10-22 1986-05-20 Showa Denko Kk Production of coated substance
US4789501A (en) * 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
US4675113A (en) 1984-11-28 1987-06-23 University Patents, Inc. Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
DE3568442D1 (en) 1984-12-06 1989-04-06 Kanegafuchi Chemical Ind A method of preparation of droplets
US5106903A (en) * 1984-12-17 1992-04-21 Lehigh University Preparation of large particle size monodisperse latexes
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
JPH0678460B2 (en) 1985-05-01 1994-10-05 株式会社バイオマテリアル・ユニバース Porous transparent polyvinyl alcohol gel
JPS61293911A (en) * 1985-06-24 1986-12-24 Teisan Seiyaku Kk Sustained release preparation
SE459005B (en) * 1985-07-12 1989-05-29 Aake Rikard Lindahl SET TO MANUFACTURE SPHERICAL POLYMER PARTICLES
USH915H (en) 1985-07-22 1991-05-07 Gibbs Marylu B Controlled macroporous copolymer properties by removal of impurities in the diluent
US4742086A (en) 1985-11-02 1988-05-03 Lion Corporation Process for manufacturing porous polymer
DE3543348A1 (en) 1985-12-07 1987-06-11 Bayer Ag PEARL-SHAPED CROSS-NETWORKED MIXED POLYMERS WITH EPOXY AND BASIC AMINO GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
JPS62169723A (en) * 1986-01-22 1987-07-25 Teisan Seiyaku Kk Sustained release preparation
GB8610024D0 (en) 1986-04-24 1986-05-29 Unilever Plc Porous structures
US4929400A (en) 1986-04-28 1990-05-29 California Institute Of Technology Production of monodisperse, polymeric microspheres
US5262176A (en) 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
JPS6317904A (en) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd Production of crosslinked porous polyvinyl alcohol particle
US4743507A (en) 1986-09-12 1988-05-10 Franses Elias I Nonspherical microparticles and method therefor
US5114421A (en) 1986-09-22 1992-05-19 Polak Robert B Medicament container/dispenser assembly
US4859711A (en) 1986-10-01 1989-08-22 Alcan International Limited Hollow microspheres
CA1287459C (en) 1986-10-01 1991-08-13 Mukesh Jain Process for the preparation of hollow microspheres
US5263992A (en) 1986-10-17 1993-11-23 Bio-Metric Systems, Inc. Biocompatible device with covalently bonded biocompatible agent
DE3787700T3 (en) 1986-10-29 1998-12-24 Kanegafuchi Chemical Ind Uniform polymer particles.
US5292814A (en) * 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
US4795741A (en) * 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
GB8713263D0 (en) 1987-06-05 1987-07-08 Unilever Plc Spheroidal silica
JPH0612993B2 (en) 1987-08-10 1994-02-23 株式会社クラレ Method for producing spherical microbe-immobilized moldings
US4819637A (en) * 1987-09-01 1989-04-11 Interventional Therapeutics Corporation System for artificial vessel embolization and devices for use therewith
JPH0762054B2 (en) 1987-10-13 1995-07-05 倉敷紡績株式会社 Crosslinked polymer particles
US4804366A (en) * 1987-10-29 1989-02-14 Baxter International Inc. Cartridge and adapter for introducing a beneficial agent into an intravenous delivery system
US4850978A (en) 1987-10-29 1989-07-25 Baxter International Inc. Drug delivery cartridge with protective cover
US4981625A (en) * 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
US4935009A (en) * 1988-06-10 1990-06-19 Caldwell James B Emergency drug injection system
FR2634376B1 (en) * 1988-07-21 1992-04-17 Farmalyoc NOVEL SOLID AND POROUS UNIT FORM COMPRISING MICROPARTICLES AND / OR NANOPARTICLES, AS WELL AS ITS PREPARATION
WO1990001969A1 (en) 1988-08-24 1990-03-08 Slepian Marvin J Biodegradable polymeric endoluminal sealing
DE3829938A1 (en) 1988-09-02 1990-03-29 Hermann Hofmann ORGANO-MINERAL DUENGER AND METHOD FOR THE PRODUCTION THEREOF
US4933372A (en) 1988-09-26 1990-06-12 Supelco, Inc. Porous rigid resins and process of preparation
US5047438A (en) 1988-09-26 1991-09-10 Supelco, Inc. Porous rigid resins and process of preparation
US5681576A (en) 1988-11-16 1997-10-28 Mdv Technologies, Inc. Method and composition for post surgical adhesion reduction
DE3841401A1 (en) 1988-12-08 1990-06-13 Martin Lemperle ALLOPLASTIC IMPLANT
US5258028A (en) 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US4946899A (en) 1988-12-16 1990-08-07 The University Of Akron Thermoplastic elastomers of isobutylene and process of preparation
GB8900376D0 (en) 1989-01-09 1989-03-08 Nycomed As Iodinated esters
FR2641692A1 (en) * 1989-01-17 1990-07-20 Nippon Zeon Co Plug for closing an opening for a medical application, and device for the closure plug making use thereof
US5091205A (en) * 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5032117A (en) 1989-01-30 1991-07-16 Motta Louis J Tandem syringe
GB8905934D0 (en) * 1989-03-15 1989-04-26 Dow Europ Sa A process for preparing adsorptive porous resin beads
US5888930A (en) * 1989-03-27 1999-03-30 Bend Research, Inc. Asymmetric microporous beads for controlled release
CA2017570C (en) * 1989-05-31 2000-12-19 James R. Gross Porous structure of an absorbent polymer
US5354290A (en) 1989-05-31 1994-10-11 Kimberly-Clark Corporation Porous structure of an absorbent polymer
US5116387A (en) 1989-06-09 1992-05-26 American Medical Systems, Inc. Preparation of injectable polymeric bodies
US5007940A (en) * 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5158573A (en) 1989-06-09 1992-10-27 American Medical Systems, Inc. Injectable polymeric bodies
US5190760A (en) * 1989-07-08 1993-03-02 Coopers Animal Health Limited Solid pharmaceutical composition
US5698271A (en) 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5253991A (en) 1989-11-20 1993-10-19 Sumitomo Cement Co., Ltd. Apparatus for producing spheroidal inorganic particulate material
US5409125A (en) * 1989-12-11 1995-04-25 Aktiebolaget Astra Unit dose container
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6306427B1 (en) 1989-12-28 2001-10-23 Rhone-Poulenc Nutrition Animale Pellets containing active ingredients protected against degradation in the rumen of ruminants
US5435645A (en) 1989-12-29 1995-07-25 Tecres Spa Process and apparatus for the mixing and direct emplacement of a two-component bone cement
US5147937A (en) 1990-03-22 1992-09-15 Rohm And Haas Company Process for making controlled, uniform-sized particles in the 1 to 50 micrometer range
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
JPH03297475A (en) 1990-04-16 1991-12-27 Ken Ishihara Controlling method for emission of medicine by means of resonance sound wave
US5514090A (en) 1990-04-24 1996-05-07 Science Incorporated Closed drug delivery system
US5137928A (en) 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
CA2016870C (en) 1990-05-15 1994-03-29 Arnie Drudik Dispenser for storing and mixing several components
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
JP2514087Y2 (en) * 1990-05-25 1996-10-16 幸三 牧田 Balloon with detachable double-sided check valve
US6291605B1 (en) 1990-06-06 2001-09-18 Clarence S. Freeman Polymerization process with spraying step
WO1991019483A1 (en) 1990-06-20 1991-12-26 Advanced Polymer Systems, Inc. Compositions and methods for the controlled release of soluble active substances
ATE130517T1 (en) 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd INTRAVASCULAR EMBOLIZING AGENT CONTAINING A SUBSTANCE INHIBITING ANGIOGENESIS.
US5484584A (en) * 1990-10-02 1996-01-16 Board Of Regents, The University Of Texas System Therapeutic and diagnostic use of modified polymeric microcapsules
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5120349A (en) 1990-12-07 1992-06-09 Landec Labs, Inc. Microcapsule having temperature-dependent permeability profile
US5171214A (en) 1990-12-26 1992-12-15 Abbott Laboratories Drug storage and delivery system
US5171217A (en) 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5147631A (en) 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
FR2676927B1 (en) 1991-05-29 1995-06-23 Ibf MICROSPHERES FOR USE IN THERAPEUTIC VASCULAR OCCLUSIONS AND INJECTABLE SOLUTIONS CONTAINING THEM.
DK0586524T3 (en) 1991-06-03 1997-05-20 Nycomed Imaging As
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US5216096A (en) 1991-09-24 1993-06-01 Japan Synthetic Rubber Co., Ltd. Process for the preparation of cross-linked polymer particles
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ATE154241T1 (en) * 1991-10-01 1997-06-15 Takeda Chemical Industries Ltd MICROPARTICLE SUMMARY FOR EXTENDED RELEASE AND PRODUCTION THE SAME
JP3356447B2 (en) * 1991-10-16 2002-12-16 テルモ株式会社 Vascular lesion embolic material composed of dried polymer gel
US5258042A (en) 1991-12-16 1993-11-02 Henry Ford Health System Intravascular hydrogel implant
DE69226203T2 (en) * 1991-12-20 1998-12-10 Allied Signal Inc MATERIALS WITH LOW DENSITY AND HIGH SPECIFIC SURFACE AND ARTICLES MOLDED THEREOF FOR USE IN METAL RECOVERY
US5260002A (en) 1991-12-23 1993-11-09 Vanderbilt University Method and apparatus for producing uniform polymeric spheres
CA2125647C (en) 1991-12-24 1997-12-30 Joseph A. Antonelli Dual stabilized microparticles
GB9200391D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200388D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
US5480644A (en) * 1992-02-28 1996-01-02 Jsf Consultants Ltd. Use of injectable biomaterials for the repair and augmentation of the anal sphincters
ES2135466T3 (en) 1992-03-06 1999-11-01 Nycomed Imaging As IMPROVEMENTS INTRODUCED IN CONTRAST AGENTS.
JP3004724B2 (en) 1992-04-06 2000-01-31 ユーロプラスティ インコーポレイテッド Treatment of reflux obstruction by microparticle injection
DE69306844T2 (en) 1992-04-10 1997-07-10 Mitsubishi Chem Corp Process for the preparation of spherical cross-linked acrylonitrile copolymers
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
AU4198793A (en) 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
US5807323A (en) 1992-08-13 1998-09-15 Science Incorporated Mixing and delivery syringe assembly
US6592859B1 (en) 1992-08-20 2003-07-15 Ethicon, Inc. Controlled expansion sphincter augmentation media
US5512604A (en) * 1992-08-28 1996-04-30 The Dow Chemical Company Porous copolymers having a cellular polymeric structure suitable for preparing ion-exchange resins and adsorbents
WO1994006477A1 (en) * 1992-09-16 1994-03-31 Holmes, Michael, John Improvements in or relating to contrast agents
WO1994006460A1 (en) 1992-09-21 1994-03-31 Vitaphore Corporation Embolization plugs for blood vessels
DE4232755A1 (en) 1992-09-26 1994-03-31 Schering Ag Microparticle preparations made from biodegradable copolymers
KR960001417B1 (en) 1992-09-26 1996-01-27 한국과학기술원 Method for preparing an improved porous polymer bead
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US5382260A (en) 1992-10-30 1995-01-17 Interventional Therapeutics Corp. Embolization device and apparatus including an introducer cartridge and method for delivering the same
US5369163A (en) 1992-11-13 1994-11-29 Rohm And Haas Company Process for preparing large dimension emulsion polymer particles, polymer product and uses thereof
US5690666A (en) 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
US5349957A (en) 1992-12-02 1994-09-27 Sterling Winthrop Inc. Preparation and magnetic properties of very small magnetite-dextran particles
JP3256583B2 (en) 1992-12-10 2002-02-12 株式会社リコー Electrophotographic toner and method for producing the same
US5288763A (en) * 1992-12-23 1994-02-22 The Johns Hopkins University School Of Medicine Porous, polymer beads and process of their preparation
US6482436B1 (en) 1993-01-29 2002-11-19 Ferx Incorporated Magnetically responsive composition
US5328936A (en) 1993-02-01 1994-07-12 Rohm And Haas Company Polymerization process for making porous polymeric particles
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5320639A (en) 1993-03-12 1994-06-14 Meadox Medicals, Inc. Vascular plug delivery system
US5567415A (en) 1993-05-12 1996-10-22 The Board Of Regents Of The University Of Nebraska Ultrasound contrast agents and methods for their manufacture and use
US5701899A (en) 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5695740A (en) 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5344867A (en) 1993-06-14 1994-09-06 The Bfgoodrich Company Vinylidene chloride emulsion interpolymer composition
US5716346A (en) * 1993-07-02 1998-02-10 Farris; Barry Method and apparatus for loading syringes without the need for hypodermic needles
ATE154757T1 (en) 1993-07-19 1997-07-15 Angiotech Pharm Inc ANTI-ANGIogenic AGENTS AND METHODS OF USE THEREOF
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5398851A (en) 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
US5397303A (en) * 1993-08-06 1995-03-14 River Medical, Inc. Liquid delivery device having a vial attachment or adapter incorporated therein
US5443495A (en) 1993-09-17 1995-08-22 Scimed Lifesystems Inc. Polymerization angioplasty balloon implant device
US5531716A (en) 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5556391A (en) 1993-10-01 1996-09-17 Merocel Corporation Surgical sponge device
US5445614A (en) * 1993-10-20 1995-08-29 Habley Medical Technology Corporation Pharmaceutical storage and mixing syringe
DE1258262T1 (en) * 1993-10-28 2003-04-10 Medrad Inc Contrast delivery system
PT682530E (en) 1993-12-15 2003-06-30 Bracco Research Sa UTEIS GAS MIXTURES AS CONTRAST MEANS FOR ULTRASSONS
WO1995019841A1 (en) 1994-01-21 1995-07-27 Bruce Nathaniel Gray Particulate material
WO1995022318A1 (en) 1994-02-17 1995-08-24 Pankaj Modi Drugs, vaccines and hormones in polylactide coated microspheres
US5569468A (en) 1994-02-17 1996-10-29 Modi; Pankaj Vaccine delivery system for immunization, using biodegradable polymer microspheres
US5417982A (en) 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres
WO1995025480A1 (en) 1994-03-18 1995-09-28 Cook Incorporated Helical embolization coil
US5431174A (en) 1994-04-04 1995-07-11 Via Medical Corporation Method of fluid delivery and collection
WO1995029661A1 (en) 1994-04-28 1995-11-09 Primed Halberstadt Medizintechnik Gmbh One-piece dispensing device for the contamination-free administration of medicaments (cytostatica)
US5534589A (en) * 1994-05-04 1996-07-09 Minnesota Mining And Manufacturing Company Repulpable plastic films
WO1995031485A1 (en) 1994-05-15 1995-11-23 Pharmacia Biotech Ab A method of manufacturing particles, and particles that can be produced in accordance with the method
JP2535785B2 (en) 1994-06-03 1996-09-18 工業技術院長 Vascular embolic agent
US5583162A (en) 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
US5639710A (en) 1994-07-06 1997-06-17 Zeneca Limited Solid microspheres for agriculturally active compounds and process for their production
ES2096521B1 (en) 1994-08-10 1997-11-16 Univ La Laguna BIODEGRADABLE SYNTHETIC POLYMER MICROSPHERES IN THE MANUFACTURE AND ELABORATION OF REACTIVE EQUIPMENT FOR THE PREPARATION OF RADIOPHARMACEUTICAL MEDICINES.
WO1996004954A1 (en) 1994-08-17 1996-02-22 Boston Scientific Corporation Implant, and method and device for inserting the implant
US6099864A (en) 1994-12-02 2000-08-08 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration In situ activation of microcapsules
US5827531A (en) 1994-12-02 1998-10-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microcapsules and methods for making
DK175166B1 (en) * 1995-01-03 2004-06-21 Cook William Europ Method of manufacturing an assembly for placing an embolization coil in the vascular system and such assembly as well as an apparatus for advancing the assembly
JP3625837B2 (en) 1995-01-27 2005-03-02 シメッド ライフ システムズ,インコーポレイテッド Embolic device
US6179817B1 (en) * 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
EP0730847B1 (en) 1995-03-07 2001-05-23 Menlo Care Inc. Controlled expansion sphincter augmentation media
US5569193A (en) 1995-03-22 1996-10-29 Abbott Laboratories Syringe system accommodating separately storable prefilled containers for two constituents
US5637087A (en) 1995-03-22 1997-06-10 Abbott Laboratories Prefilled, two-constituent syringe
US5876372A (en) * 1995-03-22 1999-03-02 Abbott Laboratories Syringe system accomodating seperate prefilled barrels for two constituents
US5785682A (en) 1995-03-22 1998-07-28 Abbott Laboratories Pre-filled syringe drug delivery system
ES2170853T3 (en) * 1995-03-28 2002-08-16 Fidia Advanced Biopolymers Srl NANOSPHERES THAT UNDERSTAND A BIOCOMPATIBLE POLISACARIDE.
US5779668A (en) 1995-03-29 1998-07-14 Abbott Laboratories Syringe barrel for lyophilization, reconstitution and administration
US5566729A (en) 1995-04-06 1996-10-22 Abbott Laboratories Drug reconstitution and administration system
US6428771B1 (en) 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
US6312407B1 (en) 1995-06-05 2001-11-06 Medtronic Percusurge, Inc. Occlusion of a vessel
US6214331B1 (en) * 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US5657756A (en) 1995-06-07 1997-08-19 Ctf Systems Inc. Method and systems for obtaining higher order gradiometer measurements with lower order gradiometers
US5766147A (en) 1995-06-07 1998-06-16 Winfield Medical Vial adaptor for a liquid delivery device
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
US5840387A (en) 1995-07-28 1998-11-24 Aegis Biosciences L.L.C. Sulfonated multiblock copolymer and uses therefor
US5558822A (en) 1995-08-16 1996-09-24 Gas Research Institute Method for production of spheroidized particles
US5888546A (en) * 1995-08-28 1999-03-30 The Regents Of The University Of California Embolic material for endovascular occlusion of abnormal vasculature and method for using the same
US5833361A (en) 1995-09-07 1998-11-10 Funk; James E. Apparatus for the production of small spherical granules
CA2161863A1 (en) 1995-10-31 1997-05-01 Michael Vivian Sefton Angiogenic material and uses thereof
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
EP0928182B1 (en) 1996-01-11 2002-05-08 Duoject Medical Systems Inc Delivery system for pharmaceuticals packed in pharmaceutical vials
US5702361A (en) * 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
US5895398A (en) 1996-02-02 1999-04-20 The Regents Of The University Of California Method of using a clot capture coil
US6051247A (en) * 1996-05-30 2000-04-18 University Of Florida Research Foundation, Inc. Moldable bioactive compositions
US5855615A (en) * 1996-06-07 1999-01-05 Menlo Care, Inc. Controller expansion sphincter augmentation media
US5792478A (en) 1996-07-08 1998-08-11 Advanced Uro Science Tissue injectable composition and method of use
US5695480A (en) 1996-07-29 1997-12-09 Micro Therapeutics, Inc. Embolizing compositions
US5741331A (en) * 1996-07-29 1998-04-21 Corvita Corporation Biostable elastomeric polymers having quaternary carbons
US5830178A (en) 1996-10-11 1998-11-03 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
TW421658B (en) 1996-07-31 2001-02-11 Kanebo Ltd Porious spherical particles and the preparation process for preparing thereof
US5813411A (en) 1996-08-20 1998-09-29 Menlo Care, Inc. Method of deforming tissue with a swollen hydrogel
US5902832A (en) 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US5785642A (en) 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
US5756127A (en) 1996-10-29 1998-05-26 Wright Medical Technology, Inc. Implantable bioresorbable string of calcium sulfate beads
US6139963A (en) 1996-11-28 2000-10-31 Kuraray Co., Ltd. Polyvinyl alcohol hydrogel and process for producing the same
DE29724255U1 (en) 1996-12-18 2000-10-05 Alpha Bioverfahrenstechnik Gmb Microcapsules
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
WO1998045191A1 (en) 1997-04-10 1998-10-15 Johns Hopkins University Gaz syringe and package therefor
JP4102459B2 (en) 1997-05-14 2008-06-18 森下仁丹株式会社 Seamless capsule for synthesizing biopolymer and method for producing the same
US6056844A (en) 1997-06-06 2000-05-02 Triton Systems, Inc. Temperature-controlled induction heating of polymeric materials
WO1998056435A1 (en) * 1997-06-13 1998-12-17 Micro Therapeutics, Inc. Contoured syringe and novel luer hub and methods for embolizing blood vessels
US6048908A (en) 1997-06-27 2000-04-11 Biopore Corporation Hydrophilic polymeric material
US5959073A (en) 1997-07-07 1999-09-28 Southwest Research Institute Method for preparing polymeric beads
US6056721A (en) 1997-08-08 2000-05-02 Sunscope International, Inc. Balloon catheter and method
AU8913998A (en) 1997-08-28 1999-03-22 Boston Scientific Corporation System for implanting a cross-linked polysaccharide fiber and methods of formingand inserting the fiber
US6538026B1 (en) 1997-09-11 2003-03-25 Provasis Therapeutics, Inc. Compositions useful for remodeling body spaces
US6476069B2 (en) 1997-09-11 2002-11-05 Provasis Therapeutics Inc. Compositions for creating embolic agents and uses thereof
WO1999023954A1 (en) 1997-11-07 1999-05-20 Salviac Limited Implantable occluder devices for medical use
US5951160A (en) 1997-11-20 1999-09-14 Biomet, Inc. Method and apparatus for packaging, mixing and delivering bone cement
DE19752585B4 (en) 1997-11-27 2007-06-28 Inotech Ag Device and method for encapsulating microbial, plant and animal cells or of biological and chemical substances
US5989237A (en) 1997-12-04 1999-11-23 Baxter International Inc. Sliding reconstitution device with seal
WO1999042147A1 (en) 1998-02-23 1999-08-26 Massachusetts Institute Of Technology Biodegradable shape memory polymers
ES2265186T3 (en) 1998-02-23 2007-02-01 Mnemoscience Gmbh POLYMERS WITH FORM MEMORY.
US6003566A (en) 1998-02-26 1999-12-21 Becton Dickinson And Company Vial transferset and method
US6059766A (en) 1998-02-27 2000-05-09 Micro Therapeutics, Inc. Gynecologic embolotherapy methods
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
AU2617099A (en) 1998-03-07 1999-09-20 Inotech Ag Method and device for capsulating microbial, plant and animal cells or biological and chemical substances
US6047861A (en) * 1998-04-15 2000-04-11 Vir Engineering, Inc. Two component fluid dispenser
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
US6224630B1 (en) 1998-05-29 2001-05-01 Advanced Bio Surfaces, Inc. Implantable tissue repair device
EP1082072B8 (en) 1998-06-04 2014-03-05 New York University Endovascular thin film devices for treating and preventing stroke
US6267154B1 (en) 1998-06-05 2001-07-31 Abbott Laboratories System for storing mixing and administering a drug
AU4726299A (en) * 1998-06-29 2000-01-17 Orbon Corporation Drug dispenser
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
US6099064A (en) 1998-07-10 2000-08-08 Lund Industries, Inc. Windshield visor for motor vehicles
US6264861B1 (en) 1998-08-05 2001-07-24 Xeikon Nv Method for producing rounded polymeric particles
US6315709B1 (en) 1998-08-07 2001-11-13 Stereotaxis, Inc. Magnetic vascular defect treatment system
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
CA2248592A1 (en) 1998-08-31 2000-02-29 Christopher D. Batich Microspheres for use in the treatment of cancer
FR2784580B1 (en) * 1998-10-16 2004-06-25 Biosepra Inc POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME
US6238335B1 (en) 1998-12-11 2001-05-29 Enteric Medical Technologies, Inc. Method for treating gastroesophageal reflux disease and apparatus for use therewith
JP2000189511A (en) 1998-12-25 2000-07-11 Kaneka Medeikkusu:Kk Embolization material
US6162377A (en) 1999-02-23 2000-12-19 Alberta Research Council Inc. Apparatus and method for the formation of uniform spherical particles
US6296604B1 (en) 1999-03-17 2001-10-02 Stereotaxis, Inc. Methods of and compositions for treating vascular defects
US6306425B1 (en) 1999-04-09 2001-10-23 Southern Research Institute Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol
US6368658B1 (en) * 1999-04-19 2002-04-09 Scimed Life Systems, Inc. Coating medical devices using air suspension
US6511472B1 (en) 1999-05-21 2003-01-28 Microtherapeutics, Inc. Interface needle and method for creating a blunt interface between delivered liquids
US6280457B1 (en) 1999-06-04 2001-08-28 Scimed Life Systems, Inc. Polymer covered vaso-occlusive devices and methods of producing such devices
CZ2002728A3 (en) 1999-08-27 2002-08-14 Southern Research Institute Injectable buprenorphine microparticle composition, medicinal form, and use thereof
FR2797769B1 (en) 1999-09-01 2003-07-25 Cis Bio Int RADIOPHARMACEUTICAL PRODUCTS AND THEIR PREPARATION PROCESS
JP2001079011A (en) 1999-09-14 2001-03-27 Akira Morimoto Embolization coil and its manufacture
US6277392B1 (en) 1999-09-16 2001-08-21 Carbon Medical Technologies, Inc. Tissue injectable composition
US6238403B1 (en) 1999-10-04 2001-05-29 Microvention, Inc. Filamentous embolic device with expansible elements
US6602261B2 (en) 1999-10-04 2003-08-05 Microvention, Inc. Filamentous embolic device with expansile elements
KR100335866B1 (en) * 2000-01-06 2002-05-10 박호군 Microspheric Embolic Materials Having Duel Structure of Poly(Vinyl Acetate) Core/Poly(Vinyl Alcohol) Shell, and Method for Preparing The Same
US6306419B1 (en) 2000-02-23 2001-10-23 Aegis Biosciences, Llc Medical uses of styrene sulfonate polymers
DE60139112D1 (en) 2000-03-06 2009-08-13 Boston Scient Ltd ULTRALSCHALL VISIBLE EMBOLIZING SUBSTANCES
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
ATE373682T1 (en) * 2000-03-13 2007-10-15 Biocure Inc EMBOLIC COMPOSITIONS
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
DE10026620A1 (en) 2000-05-29 2002-03-07 Gerhard Quelle Biocompatible material for cell and tissue implantation, useful e.g. for drug release or cosmetic tissue augmentation, consisting of spherical particles having (semi-)permeable or porous outer shell and internal cavity
US6355275B1 (en) * 2000-06-23 2002-03-12 Carbon Medical Technologies, Inc. Embolization using carbon coated microparticles
US6764463B1 (en) 2000-06-27 2004-07-20 Barry Farris Method and needleless apparatus for the storage of a first substance followed by subsequent mixing with a second substance and transfer without ambient air incursion
JP2002017848A (en) 2000-07-12 2002-01-22 Terumo Corp Intravitally injectable particulate and method for preparing the same
WO2002011696A2 (en) 2000-08-08 2002-02-14 Ev & M Active tissue augmentation materials and method
JP2004505761A (en) 2000-08-15 2004-02-26 ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ Small particles
US6394965B1 (en) 2000-08-15 2002-05-28 Carbon Medical Technologies, Inc. Tissue marking using biocompatible microparticles
US6703127B2 (en) 2000-09-27 2004-03-09 Microtek Laboratories, Inc. Macrocapsules containing microencapsulated phase change materials
AUPR098200A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Production of low density radionuclide containing microspheres
AUPR098300A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Polymer based radionuclide containing microspheres
AUPR098400A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Production of radionuclide coated microspheres and seeds
US6545097B2 (en) * 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
WO2003053325A2 (en) 2000-12-13 2003-07-03 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US6632531B2 (en) 2001-02-15 2003-10-14 Rohm And Haas Company Porous particles, their aqueous dispersions, and method of preparation
US6887857B2 (en) 2001-04-27 2005-05-03 Scimed Life Systems, Inc. Microparticle protection of therapeutic agents
US6723067B2 (en) * 2001-07-26 2004-04-20 David H. Nielson Apparatus for delivering aerosolized fibrin endoscopically to a wound
US20030032935A1 (en) * 2001-08-10 2003-02-13 Scimed Life Systems, Inc. Packages facilitating convenient mixing and delivery of liquids
US6692515B2 (en) * 2001-11-07 2004-02-17 Frank H. Boehm, Jr. Surgical kit for repairing leaks in fluid carrying vessels and organs and method thereof
EP1490119A1 (en) 2002-03-29 2004-12-29 Boston Scientific Limited Tissue treatment
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7218962B2 (en) 2002-03-29 2007-05-15 Boston Scientific Scimed, Inc. Magnetically enhanced injection catheter
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7838699B2 (en) 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US20040076582A1 (en) * 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7792568B2 (en) 2003-03-17 2010-09-07 Boston Scientific Scimed, Inc. MRI-visible medical devices
US7906148B2 (en) * 2003-07-31 2011-03-15 Boston Scientific Scimed, Inc. Latex medical articles for release of antimicrobial agents
US20050037047A1 (en) * 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB743789A (en) * 1953-02-22 1956-01-25 Hubert Percival Schofield Improvements in or relating to cartridges and the like tubular containers for use in dispensing liquids
FR1099362A (en) * 1954-04-23 1955-09-05 D Antibiotiques Et De Biolog L Capsule syringe for drugs that only need to be mixed at the time of use
FR1478062A (en) * 1965-04-30 1967-04-21 Ile D Etudes Et De Brevets Nov Injection syringe
US4412836A (en) * 1979-04-27 1983-11-01 The West Company, Incorporated Syringe assembly
US4254768A (en) * 1979-09-14 1981-03-10 Ty Perla J Hypodermic syringe
US4453934A (en) * 1981-11-11 1984-06-12 Contraves Ag Injection syringe for the successive injection of two liquids into the blood vessels of living bodies
EP0112574A1 (en) * 1982-12-27 1984-07-04 Meditec S.A. Two-compartment prefilled syringe
US5704918A (en) * 1992-12-01 1998-01-06 Higashikawa; Tetsuro Syringe

Also Published As

Publication number Publication date
AU2003286639A8 (en) 2004-05-13
AU2003286639A1 (en) 2004-05-13
EP1553999A2 (en) 2005-07-20
US7883490B2 (en) 2011-02-08
WO2004037326A2 (en) 2004-05-06
US20040092883A1 (en) 2004-05-13
CA2503052A1 (en) 2004-05-06

Similar Documents

Publication Publication Date Title
WO2004037326A3 (en) Mixing and delivery medical syringe system for therapeutic compositions
AU2003270833A1 (en) Fluid dispenser with shuttling mixing chamber
WO2006127841A3 (en) Multi-reservoir implantable pump with variable flow rate capabilities
WO2006031480A3 (en) Dual fluid cartridge for storing and dispensing fluids in unequal ratios
AU2003245757A1 (en) Vaporizer delivery ampoule
WO2006039512A8 (en) Fluid delivery system for use with an endoscope
WO2004078242A3 (en) Improvements in and relating to a pen-type injector
CA2440207A1 (en) Drug delivery system
PT2260892E (en) Multireservoir implantable drug delivery pumps
MXPA03007590A (en) Compositions and methods for enhancing drug delivery across and into ocular tissues.
IL175423A0 (en) Modular imbibition rate reducer for use with implantable osmotic pump
WO2006133103A3 (en) Reservoir for delivery of agents
HK1044723A1 (en) Mixing/charging port for medical treatment.
DE50209996D1 (en) MEDICAL PUMPING DEVICE
WO2002066100A8 (en) Syringes, connectors, and syringe and connector systems for use in fluid delivery systems
AU2003245414A1 (en) Dual fluid cartridge assembly
AU2003223680A1 (en) Transcutaneous fluid delivery system
WO2005028702A3 (en) Precursor delivery system
WO2007045791A3 (en) Fluid product dispensing pump
MX2009008364A (en) New salt.
ATE529154T1 (en) MICRO DEVICE FOR A MEDICINE DELIVERY SYSTEM HAVING A CARTRIDGE
HK1044725A1 (en) Mixing/charging port for medical treatment.
AU2002361445A1 (en) Medicament delivery device with replaceable cartridge
EP1647292A4 (en) Needleless syringe having medical agent accommodated therein
WO2005041936A3 (en) Methods of treatment of cancer using a composition comprising a cytotoxic drug and a porous carrier material

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2503052

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003777846

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003777846

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP