WO2004037120A3 - Implantable medical devices using zinc - Google Patents

Implantable medical devices using zinc Download PDF

Info

Publication number
WO2004037120A3
WO2004037120A3 PCT/US2003/033752 US0333752W WO2004037120A3 WO 2004037120 A3 WO2004037120 A3 WO 2004037120A3 US 0333752 W US0333752 W US 0333752W WO 2004037120 A3 WO2004037120 A3 WO 2004037120A3
Authority
WO
WIPO (PCT)
Prior art keywords
zinc
enhanced
coupled
stent
implantable devices
Prior art date
Application number
PCT/US2003/033752
Other languages
French (fr)
Other versions
WO2004037120A2 (en
Inventor
Pamela Cifra
Michael D Dake
Christopher Elkins
Jacob M Waugh
Original Assignee
Essentia Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Essentia Biosystems Inc filed Critical Essentia Biosystems Inc
Priority to CA002503492A priority Critical patent/CA2503492A1/en
Priority to EP03777868A priority patent/EP1560543A2/en
Priority to PCT/US2003/033752 priority patent/WO2004037120A2/en
Priority to AU2003286660A priority patent/AU2003286660A1/en
Priority to JP2004547124A priority patent/JP2006503657A/en
Publication of WO2004037120A2 publication Critical patent/WO2004037120A2/en
Publication of WO2004037120A3 publication Critical patent/WO2004037120A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth

Abstract

Implantable devices (10) using zinc, and methods therefore, provide one or more advantageous effects to a tissue. In one embodiment, at least one zinc-containing component is coupled with a stent via one or more zinc chelators to enhance resistance of the stent to plaque formation and in-stent restenosis. Elastin production may also be enhanced by devices coupled with zinc. Enhanced elastin production may be used, for example, to treat a blood vessel in a location at or near an aneurysm. In some embodiments, both elastin production and plaque resistance are enhanced. For example, zinc may be applied via a gel or other carrier substance to a venous graft for enhancing elastin and resisting plaque formation. Implantable devices (10) coupled with zinc may provide improved results of medical and surgical procedures involving implantable devices, thus reducing the need for repeat procedures.
PCT/US2003/033752 2002-10-25 2003-10-22 Implantable medical devices using zinc WO2004037120A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002503492A CA2503492A1 (en) 2002-10-25 2003-10-22 Implantable medical devices using zinc
EP03777868A EP1560543A2 (en) 2002-10-25 2003-10-22 Implantable medical devices using zinc
PCT/US2003/033752 WO2004037120A2 (en) 2002-10-25 2003-10-22 Implantable medical devices using zinc
AU2003286660A AU2003286660A1 (en) 2002-10-25 2003-10-22 Implantable medical devices using zinc
JP2004547124A JP2006503657A (en) 2002-10-25 2003-10-22 Implantable medical device using zinc

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42127802P 2002-10-25 2002-10-25
US42133602P 2002-10-25 2002-10-25
US60/421,278 2002-10-25
US60/421,336 2002-10-25
PCT/US2003/033752 WO2004037120A2 (en) 2002-10-25 2003-10-22 Implantable medical devices using zinc

Publications (2)

Publication Number Publication Date
WO2004037120A2 WO2004037120A2 (en) 2004-05-06
WO2004037120A3 true WO2004037120A3 (en) 2005-04-07

Family

ID=39273388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033752 WO2004037120A2 (en) 2002-10-25 2003-10-22 Implantable medical devices using zinc

Country Status (5)

Country Link
EP (1) EP1560543A2 (en)
JP (1) JP2006503657A (en)
AU (1) AU2003286660A1 (en)
CA (1) CA2503492A1 (en)
WO (1) WO2004037120A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109589456B (en) * 2017-09-30 2024-03-19 元心科技(深圳)有限公司 Implantable device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620194B2 (en) * 1995-04-19 2003-09-16 Boston Scientific Scimed, Inc. Drug coating with topcoat
US6716444B1 (en) * 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2777193B1 (en) * 1998-04-14 2001-06-08 Coletica PARTICLE WITH A CHELATING HYDROXAMIC GROUP OF METAL IONS AND THEIR USE IN COSMETICS OR PHARMACY
IT1303735B1 (en) * 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S CROSS-LINKED HYALURONIC ACIDS AND THEIR MEDICAL USES.
US7182953B2 (en) * 1999-12-15 2007-02-27 Celgene Corporation Methods and compositions for the prevention and treatment of atherosclerosis restenosis and related disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620194B2 (en) * 1995-04-19 2003-09-16 Boston Scientific Scimed, Inc. Drug coating with topcoat
US6776792B1 (en) * 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US6716444B1 (en) * 2000-09-28 2004-04-06 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same

Also Published As

Publication number Publication date
AU2003286660A1 (en) 2004-05-13
EP1560543A2 (en) 2005-08-10
JP2006503657A (en) 2006-02-02
WO2004037120A2 (en) 2004-05-06
CA2503492A1 (en) 2004-05-06

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