WO2004033651A3 - Erythropoietin: remodeling and glycoconjugation of erythropoietin - Google Patents
Erythropoietin: remodeling and glycoconjugation of erythropoietin Download PDFInfo
- Publication number
- WO2004033651A3 WO2004033651A3 PCT/US2003/031974 US0331974W WO2004033651A3 WO 2004033651 A3 WO2004033651 A3 WO 2004033651A3 US 0331974 W US0331974 W US 0331974W WO 2004033651 A3 WO2004033651 A3 WO 2004033651A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- erythropoietin
- remodeling
- glycoconjugation
- peptide
- addition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0315178-6A BR0315178A (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
MXPA05003730A MXPA05003730A (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin. |
US10/530,972 US7696163B2 (en) | 2001-10-10 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
CA002501832A CA2501832A1 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
NZ539415A NZ539415A (en) | 2002-10-09 | 2003-10-08 | Remodelling and glycoconjugation of erythropoietin |
EP03777555A EP1581622A4 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
AU2003287035A AU2003287035B2 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
JP2005501139A JP5413548B2 (en) | 2002-10-09 | 2003-10-08 | Erythropoietin: Remodeling and glycoconjugation of erythropoietin |
IL167920A IL167920A (en) | 2002-10-09 | 2005-04-07 | Cell-free in vitro method of forming a covalent conjugate between an erythropoietin peptide and poly(ethylene glycol), pharmaceutical compositions comprising said covalent conjugate and use thereof in the preparation of medicaments for stimulating proliferation, differentiation and activation of myeloid progenitor cells |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2002/032263 WO2003031464A2 (en) | 2001-10-10 | 2002-10-09 | Remodeling and glycoconjugation of peptides |
USPCT/US02/32263 | 2002-10-09 | ||
US10/287,994 US7138371B2 (en) | 2001-10-10 | 2002-11-05 | Remodeling and glycoconjugation of peptides |
US10/287,994 | 2002-11-05 | ||
US36077003A | 2003-01-06 | 2003-01-06 | |
US10/360,770 | 2003-01-06 | ||
US36077903A | 2003-02-19 | 2003-02-19 | |
US10/360,779 | 2003-02-19 | ||
US10/410,945 US7214660B2 (en) | 2001-10-10 | 2003-04-09 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US10/410,945 | 2003-04-09 |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US36077003A Continuation-In-Part | 2001-10-10 | 2003-01-06 | |
US36077903A Continuation-In-Part | 2001-10-10 | 2003-02-19 | |
US10/410,945 Continuation-In-Part US7214660B2 (en) | 2001-10-10 | 2003-04-09 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004033651A2 WO2004033651A2 (en) | 2004-04-22 |
WO2004033651A3 true WO2004033651A3 (en) | 2006-03-30 |
Family
ID=37767763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/031974 WO2004033651A2 (en) | 2001-10-10 | 2003-10-08 | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
Country Status (7)
Country | Link |
---|---|
US (3) | US7214660B2 (en) |
EP (1) | EP1581622A4 (en) |
JP (1) | JP5413548B2 (en) |
AU (1) | AU2003287035B2 (en) |
CA (1) | CA2501832A1 (en) |
MX (1) | MXPA05003730A (en) |
WO (1) | WO2004033651A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8716033B2 (en) | 2006-02-10 | 2014-05-06 | Life Technologies Corporation | Oligosaccharide modification and labeling of proteins |
US8840879B2 (en) | 2004-03-11 | 2014-09-23 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US8916518B2 (en) | 2002-03-06 | 2014-12-23 | Fresenius Kabi Deutschland Gmbh | Coupling proteins to a modified polysaccharide |
Families Citing this family (171)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
US7179617B2 (en) * | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7795210B2 (en) * | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7696163B2 (en) * | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7399613B2 (en) * | 2001-10-10 | 2008-07-15 | Neose Technologies, Inc. | Sialic acid nucleotide sugars |
MXPA04012496A (en) * | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Pegylated factor vii glycoforms. |
US7803777B2 (en) * | 2003-03-14 | 2010-09-28 | Biogenerix Ag | Branched water-soluble polymers and their conjugates |
SG155777A1 (en) * | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
US20080146782A1 (en) * | 2006-10-04 | 2008-06-19 | Neose Technologies, Inc. | Glycerol linked pegylated sugars and glycopeptides |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
AU2004240553A1 (en) | 2003-05-09 | 2004-12-02 | Neose Technologies, Inc. | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
US9005625B2 (en) * | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
US8633157B2 (en) * | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20080305992A1 (en) * | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
KR20060120141A (en) * | 2003-11-24 | 2006-11-24 | 네오스 테크놀로지스, 인크. | Glycopegylated erythropoietin |
US7956032B2 (en) * | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
US20080318850A1 (en) * | 2003-12-03 | 2008-12-25 | Neose Technologies, Inc. | Glycopegylated Factor Ix |
US20080015142A1 (en) * | 2003-12-03 | 2008-01-17 | Defrees Shawn | Glycopegylated Follicle Stimulating Hormone |
NZ547554A (en) * | 2003-12-03 | 2009-09-25 | Biogenerix Ag | Glycopegylated granulocyte colony stimulating factor |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
WO2005070138A2 (en) * | 2004-01-08 | 2005-08-04 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
KR101100059B1 (en) * | 2004-06-30 | 2011-12-29 | 넥타르 테라퓨틱스 | Polymer-factor ix moiety conjugates |
EP1771066A2 (en) * | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1 |
EP1799249A2 (en) | 2004-09-10 | 2007-06-27 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
CA2585758C (en) | 2004-10-29 | 2017-08-01 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
FR2879204B1 (en) * | 2004-12-15 | 2007-02-16 | Lab Francais Du Fractionnement | CYTOTOXIC ANTIBODY AGAINST HEMATOPOIETIC B-TYPE HEMATOPOIETIC PROLIFERATIONS |
US20100009902A1 (en) * | 2005-01-06 | 2010-01-14 | Neose Technologies, Inc. | Glycoconjugation Using Saccharyl Fragments |
ES2449195T3 (en) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Glycopegylated granulocyte colony stimulating factor |
KR20070110902A (en) * | 2005-03-11 | 2007-11-20 | 프레제니우스 카비 도이치란트 게엠베하 | Production of bioactive glycoproteins from inactive starting material |
EP1866427A4 (en) * | 2005-03-30 | 2010-09-01 | Novo Nordisk As | Manufacturing process for the production of peptides grown in insect cell lines |
US20070154992A1 (en) * | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
WO2006127910A2 (en) * | 2005-05-25 | 2006-11-30 | Neose Technologies, Inc. | Glycopegylated erythropoietin formulations |
US20080255026A1 (en) * | 2005-05-25 | 2008-10-16 | Glycopegylated Factor 1X | Glycopegylated Factor Ix |
EP1937719A4 (en) * | 2005-08-19 | 2010-11-24 | Novo Nordisk As | Glycopegylated factor vii and factor viia |
US20070105755A1 (en) * | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
KR20080043301A (en) * | 2005-09-14 | 2008-05-16 | 아레스 트레이딩 에스.에이. | Method for the quantitative determination of poloxamers |
AU2006304856A1 (en) * | 2005-10-21 | 2007-04-26 | Synageva Biopharma Corp. | Glycolated and glycosylated poultry derived therapeutic proteins |
US20090048440A1 (en) * | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
JP2009531289A (en) * | 2006-02-10 | 2009-09-03 | ライフ テクノロジーズ コーポレーション | Method for modifying and labeling proteins with oligosaccharides |
MX2008014744A (en) | 2006-05-19 | 2009-02-10 | Glycofi Inc | Erythropoietin compositions. |
WO2008011633A2 (en) * | 2006-07-21 | 2008-01-24 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
WO2008057683A2 (en) * | 2006-10-03 | 2008-05-15 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
US20080207487A1 (en) * | 2006-11-02 | 2008-08-28 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
WO2008065372A2 (en) | 2006-11-28 | 2008-06-05 | Nautilus Biotech, S.A. | Modified erythropoietin polypeptides and uses thereof for treatment |
DK2101821T3 (en) * | 2006-12-15 | 2014-10-06 | Baxter Healthcare Sa | Factor VIIA (poly) sialic acid conjugate with extended half-life in vivo |
AR065083A1 (en) * | 2007-02-02 | 2009-05-13 | Amgen Inc | HEPCIDINE, HEPCIDINE ANTAGONISTS AND METHODS OF USE |
PL2144923T3 (en) * | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Methods of treatment using glycopegylated g-csf |
US20090053167A1 (en) * | 2007-05-14 | 2009-02-26 | Neose Technologies, Inc. | C-, S- and N-glycosylation of peptides |
WO2008151258A2 (en) * | 2007-06-04 | 2008-12-11 | Neose Technologies, Inc. | O-linked glycosylation using n-acetylglucosaminyl transferases |
ES2551123T3 (en) * | 2007-06-12 | 2015-11-16 | Ratiopharm Gmbh | Improved process for the production of nucleotide sugars |
US7968811B2 (en) * | 2007-06-29 | 2011-06-28 | Harley-Davidson Motor Company Group, Inc. | Integrated ignition and key switch |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
AU2008304111B2 (en) | 2007-09-27 | 2014-04-24 | Amgen Inc. | Pharmaceutical formulations |
EP3381445B1 (en) | 2007-11-15 | 2023-10-25 | Amgen Inc. | Aqueous formulation of antibody stablised by antioxidants for parenteral administration |
JP5647899B2 (en) * | 2008-01-08 | 2015-01-07 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | Glycoconjugation of polypeptides using oligosaccharyltransferase |
EP2574628B1 (en) | 2008-01-25 | 2015-05-20 | Amgen Inc. | Ferroportin antibodies and methods of use |
AU2009219232B2 (en) | 2008-02-27 | 2014-02-27 | Novo Nordisk A/S | Conjugated Factor VIII molecules |
EP2294087B1 (en) | 2008-05-01 | 2014-05-14 | Amgen, Inc. | Anti-hepcidin antibodies and methods of use |
JP5624535B2 (en) | 2008-05-02 | 2014-11-12 | シアトル ジェネティクス,インコーポレーテッド | Methods and compositions for preparing antibodies and antibody derivatives having low core fucosylation |
US9035027B2 (en) | 2008-06-03 | 2015-05-19 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
AU2009313902B9 (en) | 2008-11-13 | 2014-03-27 | The General Hospital Corporation | Methods and compositions for regulating iron homeostasis by modulation of BMP-6 |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
PT2459224T (en) | 2009-07-27 | 2016-09-05 | Baxalta Inc | Blood coagulation protein conjugates |
TWI537006B (en) * | 2009-07-27 | 2016-06-11 | 巴克斯歐塔公司 | Blood coagulation protein conjugates |
RU2533619C2 (en) | 2009-07-27 | 2014-11-20 | Лайпоксен Текнолоджиз Лимитед | Glycopolysialylation of proteins, which are not blood clotting proteins |
CA2778105C (en) | 2009-10-23 | 2019-04-02 | Amgen Inc. | Vial adapter and system |
KR102513760B1 (en) | 2010-06-07 | 2023-03-27 | 암젠 인크 | Drug delivery device |
AU2011285852B2 (en) | 2010-08-03 | 2014-12-11 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
US9504702B2 (en) | 2010-08-05 | 2016-11-29 | Seattle Genetics, Inc. | Methods of inhibition of protein fucosylation in vivo using fucose analogs |
KR20130139884A (en) | 2010-08-26 | 2013-12-23 | 애브비 인코포레이티드 | Dual variable domain immunoglobulins and uses thereof |
TWI557135B (en) | 2010-11-03 | 2016-11-11 | 介控生化科技公司 | Modified factor ix polypeptides and uses thereof |
CA2822591C (en) | 2010-12-22 | 2020-12-29 | Baxter International Inc. | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
AU2012236573B2 (en) | 2011-03-31 | 2016-06-02 | Amgen Inc. | Vial adapter and system |
CA3021845C (en) | 2011-04-20 | 2022-03-29 | Amgen Inc. | Autoinjector apparatus |
US9650433B2 (en) * | 2011-05-20 | 2017-05-16 | Momenta Pharmaceuticals, Inc. | Modified glycoproteins |
ES2675035T3 (en) | 2011-10-14 | 2018-07-05 | Amgen, Inc | Injector and assembly method |
TW201333035A (en) | 2011-12-30 | 2013-08-16 | Abbvie Inc | Dual specific binding proteins directed against IL-13 and/or IL-17 |
US9255210B2 (en) | 2012-03-02 | 2016-02-09 | Nippon Soda Co., Ltd. | Olefin based polymer-combined organic-inorganic composite and composition for forming same |
WO2013163297A1 (en) * | 2012-04-25 | 2013-10-31 | Momenta Pharmaceuticals, Inc. | Modified glycoproteins |
NZ630849A (en) | 2012-06-08 | 2016-04-29 | Alkermes Inc | Ligands modified by circular permutation as agonists and antagonists |
MX363385B (en) | 2012-08-23 | 2019-03-20 | Seattle Genetics Inc | Treatment of sickle cell disease and inflammatory conditions. |
US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
KR20180008921A (en) | 2012-11-01 | 2018-01-24 | 애브비 인코포레이티드 | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
JP2015535464A (en) | 2012-11-21 | 2015-12-14 | アムジエン・インコーポレーテツド | Drug delivery device |
CN105189555B (en) * | 2013-03-11 | 2020-07-24 | 建新公司 | Highly glycosylated binding polypeptides |
CA2904661C (en) | 2013-03-15 | 2022-03-15 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US10092703B2 (en) | 2013-03-15 | 2018-10-09 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
CA2904448A1 (en) | 2013-03-15 | 2014-09-18 | Tariq Ghayur | Dual specific binding proteins directed against il-1.beta. and/or il-17 |
RU2668391C2 (en) | 2013-03-15 | 2018-09-28 | ИНТРИНСИК ЛАЙФСАЙЕНСИС ЭлЭлСи | Anti-hepcidin antibodies and uses thereof |
JP6670740B2 (en) | 2013-03-22 | 2020-03-25 | アムジエン・インコーポレーテツド | Injector and assembly method |
KR102458637B1 (en) | 2013-10-24 | 2022-10-24 | 암겐 인코포레이티드 | Injector and method of assembly |
AU2014340174B2 (en) | 2013-10-24 | 2019-09-12 | Amgen Inc. | Drug delivery system with temperature-sensitive control |
WO2015119906A1 (en) | 2014-02-05 | 2015-08-13 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
JP6640113B2 (en) | 2014-05-07 | 2020-02-05 | アムジエン・インコーポレーテツド | Auto-injector with impact reducing element |
JP6822843B2 (en) | 2014-06-03 | 2021-01-27 | アムジエン・インコーポレーテツド | Systems and methods for remotely processing data collected by drug delivery devices |
EP3197915A4 (en) | 2014-09-22 | 2018-12-19 | Intrinsic Lifesciences LLC | Humanized anti-hepcidin antibodies and uses thereof |
CA2957960C (en) | 2014-10-14 | 2023-08-22 | Amgen, Inc. | Drug injection device with visual and audible indicators |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
WO2016100055A1 (en) | 2014-12-19 | 2016-06-23 | Amgen Inc. | Drug delivery device with live button or user interface field |
JP6716566B2 (en) | 2014-12-19 | 2020-07-01 | アムジエン・インコーポレーテツド | Drug delivery device with proximity sensor |
EP3258988B1 (en) | 2015-02-17 | 2019-08-28 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
ES2905870T3 (en) | 2015-02-27 | 2022-04-12 | Amgen Inc | Drug delivery device having a needle guard mechanism with an adjustable threshold resistance to movement of the needle guard |
TW201710286A (en) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | Binding proteins against VEGF, PDGF, and/or their receptors |
WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
WO2017100501A1 (en) | 2015-12-09 | 2017-06-15 | Amgen Inc. | Auto-injector with signaling cap |
US11154661B2 (en) | 2016-01-06 | 2021-10-26 | Amgen Inc. | Auto-injector with signaling electronics |
MY189113A (en) | 2016-03-02 | 2022-01-26 | Eisai R&D Man Co Ltd | Eribulin-based antibody-drug conjugates and methods of use |
WO2017160799A1 (en) | 2016-03-15 | 2017-09-21 | Amgen Inc. | Reducing probability of glass breakage in drug delivery devices |
US11541168B2 (en) | 2016-04-29 | 2023-01-03 | Amgen Inc. | Drug delivery device with messaging label |
WO2017192287A1 (en) | 2016-05-02 | 2017-11-09 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
AU2017263558B2 (en) | 2016-05-13 | 2022-12-22 | Amgen Inc. | Vial sleeve assembly |
WO2017200989A1 (en) | 2016-05-16 | 2017-11-23 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
US11541176B2 (en) | 2016-06-03 | 2023-01-03 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
EP3478342A1 (en) | 2016-07-01 | 2019-05-08 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
WO2018034784A1 (en) | 2016-08-17 | 2018-02-22 | Amgen Inc. | Drug delivery device with placement detection |
RU2762607C2 (en) | 2016-09-13 | 2021-12-21 | Аллерган, Инк. | Stabilized non-protein compositions of clostridial toxin |
EP3532127A1 (en) | 2016-10-25 | 2019-09-04 | Amgen Inc. | On-body injector |
MX2019008432A (en) | 2017-01-17 | 2019-11-18 | Amgen Inc | Injection devices and related methods of use and assembly. |
AU2018221351B2 (en) | 2017-02-17 | 2023-02-23 | Amgen Inc. | Insertion mechanism for drug delivery device |
CA3048520A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Drug delivery device with sterile fluid flowpath and related method of assembly |
EP3592403A1 (en) | 2017-03-06 | 2020-01-15 | Amgen Inc. | Drug delivery device with activation prevention feature |
JP2020509839A (en) | 2017-03-07 | 2020-04-02 | アムジエン・インコーポレーテツド | Needle insertion due to overpressure |
KR20240005194A (en) | 2017-03-09 | 2024-01-11 | 암겐 인코포레이티드 | Insertion mechanism for drug delivery device |
CN110446499A (en) * | 2017-03-20 | 2019-11-12 | 豪夫迈·罗氏有限公司 | A kind of method of external glycosyl engineering erythropoiesis stimulating protein |
KR102517342B1 (en) | 2017-03-28 | 2023-03-31 | 암겐 인코포레이티드 | Plunger rod and syringe assembly systems and methods |
AU2018282077B2 (en) | 2017-06-08 | 2023-11-23 | Amgen Inc. | Torque driven drug delivery device |
EP3634539A1 (en) | 2017-06-08 | 2020-04-15 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
MX2019015472A (en) | 2017-06-22 | 2020-02-19 | Amgen Inc | Device activation impact/shock reduction. |
MA49461A (en) | 2017-06-23 | 2020-04-29 | Amgen Inc | ELECTRONIC DRUG DELIVERY DEVICE INCLUDING A CAP ACTIVATED BY A SWITCH ASSEMBLY |
IL270784B2 (en) | 2017-07-14 | 2023-11-01 | Amgen Inc | Needle insertion-retraction system having dual torsion spring system |
IL271173B1 (en) | 2017-07-21 | 2023-12-01 | Amgen Inc | Gas permeable sealing member for drug container and methods of assembly |
WO2019022950A1 (en) | 2017-07-25 | 2019-01-31 | Amgen Inc. | Drug delivery device with container access system and related method of assembly |
EP3658203B1 (en) | 2017-07-25 | 2022-08-31 | Amgen Inc. | Drug delivery device with gear module and related method of assembly |
EP3664863A2 (en) | 2017-08-09 | 2020-06-17 | Amgen Inc. | Hydraulic-pneumatic pressurized chamber drug delivery system |
US11077246B2 (en) | 2017-08-18 | 2021-08-03 | Amgen Inc. | Wearable injector with sterile adhesive patch |
US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
US11491212B1 (en) | 2017-09-27 | 2022-11-08 | Catalyst Biosciences, Inc. | Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B |
EP3691717B1 (en) | 2017-10-04 | 2023-02-08 | Amgen Inc. | Flow adapter for drug delivery device |
WO2019070552A1 (en) | 2017-10-06 | 2019-04-11 | Amgen Inc. | Drug delivery device with interlock assembly and related method of assembly |
EP3694578A1 (en) | 2017-10-09 | 2020-08-19 | Amgen Inc. | Drug delivery device with drive assembly and related method of assembly |
MA50528A (en) | 2017-11-03 | 2020-09-09 | Amgen Inc | SYSTEMS AND APPROACHES TO STERILIZE A DRUG DELIVERY DEVICE |
EP3707075A1 (en) | 2017-11-06 | 2020-09-16 | Amgen Inc. | Fill-finish assemblies and related methods |
JP2021501616A (en) | 2017-11-06 | 2021-01-21 | アムジエン・インコーポレーテツド | Drug delivery device with placement and flow detection |
EP3706826A1 (en) | 2017-11-10 | 2020-09-16 | Amgen Inc. | Plungers for drug delivery devices |
MX2020004996A (en) | 2017-11-16 | 2020-08-27 | Amgen Inc | Door latch mechanism for drug delivery device. |
WO2019099322A1 (en) | 2017-11-16 | 2019-05-23 | Amgen Inc. | Autoinjector with stall and end point detection |
US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
WO2020023336A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
US20210260279A1 (en) | 2018-07-24 | 2021-08-26 | Amgen Inc. | Hybrid drug delivery devices with optional grip portion and related method of preparation |
WO2020023444A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Delivery devices for administering drugs |
CA3103682A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Delivery devices for administering drugs |
MA53320A (en) | 2018-07-31 | 2021-11-03 | Amgen Inc | FLUID PATH ASSEMBLY FOR DRUG DELIVERY DEVICE |
JP2022500095A (en) | 2018-09-24 | 2022-01-04 | アムジエン・インコーポレーテツド | Intervention dosing system and method |
AU2019350660A1 (en) | 2018-09-28 | 2021-03-18 | Amgen Inc. | Muscle wire escapement activation assembly for a drug delivery device |
JP2022503983A (en) | 2018-10-02 | 2022-01-12 | アムジエン・インコーポレーテツド | Injection system for drug delivery with internal force transmission |
CA3112214A1 (en) | 2018-10-05 | 2020-04-09 | Amgen Inc. | Drug delivery device having dose indicator |
WO2020081479A1 (en) | 2018-10-15 | 2020-04-23 | Amgen Inc. | Drug delivery device having damping mechanism |
EA202191038A1 (en) | 2018-10-15 | 2021-07-06 | Эмджен Инк. | METHOD OF PLATFORM ASSEMBLY FOR MEDICINE DELIVERY DEVICE |
US11213620B2 (en) | 2018-11-01 | 2022-01-04 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
US20220031953A1 (en) | 2018-11-01 | 2022-02-03 | Amgen Inc. | Drug delivery devices with partial needle retraction |
EP3873563A1 (en) | 2018-11-01 | 2021-09-08 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
MX2021012557A (en) | 2019-04-24 | 2021-11-12 | Amgen Inc | Syringe sterilization verification assemblies and methods. |
US20220273887A1 (en) | 2019-08-23 | 2022-09-01 | Amgen Inc. | Drug delivery device with configurable needle shield engagement components and related methods |
WO2021154414A2 (en) | 2020-01-29 | 2021-08-05 | Catalyst Biosciences, Inc. | Gene therapy for hemophilia b with a chimeric aav capsid vector encoding modified factor ix polypeptides |
CA3217207A1 (en) | 2021-05-21 | 2022-11-24 | Amgen Inc. | Method of optimizing a filling recipe for a drug container |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4414147A (en) * | 1981-04-17 | 1983-11-08 | Massachusetts Institute Of Technology | Methods of decreasing the hydrophobicity of fibroblast and other interferons |
US6183738B1 (en) * | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
Family Cites Families (382)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1479268A (en) * | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
GB1451798A (en) | 1973-08-02 | 1976-10-06 | Ici Ltd | Prostanoic acid derivatives |
CH596313A5 (en) * | 1975-05-30 | 1978-03-15 | Battelle Memorial Institute | |
US4385260A (en) * | 1975-09-09 | 1983-05-24 | Beckman Instruments, Inc. | Bargraph display |
JPS57206622A (en) * | 1981-06-10 | 1982-12-18 | Ajinomoto Co Inc | Blood substitute |
US4451566A (en) | 1981-12-04 | 1984-05-29 | Spencer Donald B | Methods and apparatus for enzymatically producing ethanol |
US4438253A (en) | 1982-11-12 | 1984-03-20 | American Cyanamid Company | Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same |
DE3308806A1 (en) | 1983-03-12 | 1984-09-13 | Basf Ag, 6700 Ludwigshafen | FUNGICIDAL AGENTS, SUBSTITUTED GLUCOPYRANOSYLAMINE AND METHOD FOR CONTROLLING FUNGI |
JPS59172425A (en) | 1983-03-18 | 1984-09-29 | Nippon Chemiphar Co Ltd | Novel blood coagulation factor derivative, its preparation and blood coagulation promoting agent containing the same |
US4496689A (en) * | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US4565653A (en) * | 1984-03-30 | 1986-01-21 | Pfizer Inc. | Acyltripeptide immunostimulants |
US4879236A (en) | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
US4675414A (en) | 1985-03-08 | 1987-06-23 | The United States Of America As Represented By The Secretary Of The Navy | Maleimidomethyl-carbonate polyethers |
GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
WO1987000056A1 (en) | 1985-06-26 | 1987-01-15 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
JPS6238172A (en) * | 1985-08-12 | 1987-02-19 | 株式会社 高研 | Production of anti-thrombotic medical material |
SE451849B (en) | 1985-12-11 | 1987-11-02 | Svenska Sockerfabriks Ab | VIEW TO SYNTHETIZE GYCLOSIDIC BINDINGS AND USE OF THIS RECEIVED PRODUCTS |
IT1213029B (en) | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | PARAMAGNETIC METAL ION CHELATES. |
US4767702A (en) | 1986-02-06 | 1988-08-30 | Cohenford Menashi A | Paper strip assay for neisseria species |
EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | Method for enhancing glycoprotein stability. |
US4925796A (en) * | 1986-03-07 | 1990-05-15 | Massachusetts Institute Of Technology | Method for enhancing glycoprotein stability |
US5272066A (en) | 1986-03-07 | 1993-12-21 | Massachusetts Institute Of Technology | Synthetic method for enhancing glycoprotein stability |
US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
IL82834A (en) | 1987-06-09 | 1990-11-05 | Yissum Res Dev Co | Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom |
US4847325A (en) | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
US5153265A (en) * | 1988-01-20 | 1992-10-06 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
GB8810808D0 (en) | 1988-05-06 | 1988-06-08 | Wellcome Found | Vectors |
US5169933A (en) * | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
US5874261A (en) | 1988-09-02 | 1999-02-23 | The Trustees Of The University Of Pennsylvania | Method for the purification of glycosyltransferases |
US5218092A (en) | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
US5104651A (en) | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
US5047335A (en) | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
JP2989002B2 (en) | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | Chemically modified granulocyte colony stimulating factor |
EP0449968B1 (en) | 1988-12-23 | 1999-02-24 | Genentech, Inc. | Process for the preparation of human dnase |
WO1990008164A1 (en) | 1989-01-19 | 1990-07-26 | The Upjohn Company | Somatotropin analogs |
WO1990008823A1 (en) | 1989-01-31 | 1990-08-09 | The Upjohn Company | Somatotropin analogs |
US5194376A (en) | 1989-02-28 | 1993-03-16 | University Of Ottawa | Baculovirus expression system capable of producing foreign gene proteins at high levels |
US5059535A (en) | 1989-04-12 | 1991-10-22 | Chembiomed, Ltd. | Process for the separation and purification of sialyl transferases |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
ES2247656T3 (en) | 1989-04-19 | 2006-03-01 | Enzon, Inc. | A PROCESS TO FORM A MODIFIED POLYPEPTIDE THAT INCLUDES A POLYPEPTIDE AND A POLYCHYLENE OXIDE. |
US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5342940A (en) | 1989-05-27 | 1994-08-30 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, process for preparing the same |
US5977307A (en) * | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
US5527527A (en) * | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
US5182107A (en) * | 1989-09-07 | 1993-01-26 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
US5154924A (en) * | 1989-09-07 | 1992-10-13 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
US5672683A (en) | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
US5032519A (en) | 1989-10-24 | 1991-07-16 | The Regents Of The Univ. Of California | Method for producing secretable glycosyltransferases and other Golgi processing enzymes |
US5312808A (en) | 1989-11-22 | 1994-05-17 | Enzon, Inc. | Fractionation of polyalkylene oxide-conjugated hemoglobin solutions |
IL96477A0 (en) | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
US5324663A (en) | 1990-02-14 | 1994-06-28 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
US5595900A (en) | 1990-02-14 | 1997-01-21 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
DE4009630C2 (en) | 1990-03-26 | 1995-09-28 | Reinhard Prof Dr Dr Brossmer | CMP-activated fluorescent sialic acids and processes for their preparation |
EP0481038B1 (en) | 1990-04-16 | 2002-10-02 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
US5583042A (en) | 1990-04-16 | 1996-12-10 | Neose Pharmaceuticals, Inc. | Apparatus for the synthesis of saccharide compositions |
GB9107846D0 (en) | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
US5951972A (en) | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
US5399345A (en) | 1990-05-08 | 1995-03-21 | Boehringer Mannheim, Gmbh | Muteins of the granulocyte colony stimulating factor |
US5219564A (en) | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
CU22302A1 (en) | 1990-09-07 | 1995-01-31 | Cigb | Codifying nucleotidic sequence for a protein of the external membrane of neisseria meningitidis and the use of that protein in preparing vaccines. |
AU650893B2 (en) | 1990-07-10 | 1994-07-07 | Boehringer Ingelheim International Gmbh | O-glycosylated alpha-2 interferon |
DE4028800A1 (en) | 1990-09-11 | 1992-03-12 | Behringwerke Ag | GENETIC SIALYLATION OF GLYCOPROTEINS |
US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
US5164374A (en) | 1990-12-17 | 1992-11-17 | Monsanto Company | Use of oligosaccharides for treatment of arthritis |
US5833982A (en) | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
US5861374A (en) | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
AU672357B2 (en) | 1991-02-28 | 1996-10-03 | Novo Nordisk A/S | Modified factor VII |
US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
JPH06506217A (en) | 1991-03-18 | 1994-07-14 | エンゾン,インコーポレーテッド | Hydrazine-containing conjugates of polypeptides or glycopolypeptides and polymers |
AU668505B2 (en) | 1991-03-18 | 1996-05-09 | Scripps Research Institute, The | Oligosaccharide enzyme substrates and inhibitors: methods and compositions |
US5278299A (en) | 1991-03-18 | 1994-01-11 | Scripps Clinic And Research Foundation | Method and composition for synthesizing sialylated glycosyl compounds |
US5212075A (en) | 1991-04-15 | 1993-05-18 | The Regents Of The University Of California | Compositions and methods for introducing effectors to pathogens and cells |
ATE196548T1 (en) | 1991-05-10 | 2000-10-15 | Genentech Inc | SELECTING AGONISTS AND ANTAGONISTS OF LIGANDS |
SE9201544L (en) | 1991-05-31 | 1992-12-01 | Ciba Geigy Ag | MAKE SUBSTANTIAL GYCOSYL TRANSFER PHASES |
GB2256197B (en) | 1991-05-31 | 1995-11-22 | Ciba Geigy Ag | Yeast as host for expression of heterologous glycosyl transferase enzymes |
US5374655A (en) | 1991-06-10 | 1994-12-20 | Alberta Research Council | Methods for the synthesis of monofucosylated oligosaccharides terminating in di-N-acetyllactosaminyl structures |
US5352670A (en) * | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
KR950014915B1 (en) | 1991-06-19 | 1995-12-18 | 주식회사녹십자 | Asialoglycoprotein-conjugated compounds |
US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
EP0863154A1 (en) | 1991-10-12 | 1998-09-09 | The Regents Of The University Of California | Use of thiol redox proteins for reducing protein intramolecular disulfide bonds, for improving the quality of cereal products, dough and baked goods |
US6319695B1 (en) | 1991-10-15 | 2001-11-20 | The Scripps Research Insitute | Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose |
AU665599B2 (en) | 1991-11-08 | 1996-01-11 | Hemosol Inc. | Hemoglobins as drug delivery agents |
US5384249A (en) | 1991-12-17 | 1995-01-24 | Kyowa Hakko Kogyo Co., Ltd. | α2→3 sialyltransferase |
IT1260468B (en) | 1992-01-29 | 1996-04-09 | METHOD FOR MAINTAINING THE ACTIVITY OF PROTEOLYTIC ENZYMES MODIFIED WITH POLYETHYLENGLYCOL | |
US5858751A (en) | 1992-03-09 | 1999-01-12 | The Regents Of The University Of California | Compositions and methods for producing sialyltransferases |
CZ220494A3 (en) | 1992-03-09 | 1995-03-15 | Univ California | Composition and methods of identification and synthesis of siallyltransferases |
US5962294A (en) | 1992-03-09 | 1999-10-05 | The Regents Of The University Of California | Compositions and methods for the identification and synthesis of sialyltransferases |
AU3937593A (en) | 1992-03-25 | 1993-10-21 | New York University | Trans-sialidase and methods of use and making thereof |
US6037452A (en) * | 1992-04-10 | 2000-03-14 | Alpha Therapeutic Corporation | Poly(alkylene oxide)-Factor VIII or Factor IX conjugate |
JPH0686684A (en) | 1992-05-26 | 1994-03-29 | Monsanto Co | Synthesis of sialo conjugation |
US5614184A (en) * | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
EP0664710A4 (en) | 1992-08-07 | 1998-09-30 | Progenics Pharm Inc | NON-PEPTIDYL MOIETY-CONJUGATED CD4-GAMMA2 AND CD4-IgG2 IMMUNOCONJUGATES, AND USES THEREOF. |
AU5006993A (en) | 1992-08-21 | 1994-03-15 | Enzon, Inc. | Novel attachment of polyalkylene oxides to bio-effecting substances |
JP3979678B2 (en) | 1992-08-24 | 2007-09-19 | サントリー株式会社 | Novel glycosyltransferase, gene encoding the same, and method for producing the enzyme |
WO1994005332A2 (en) | 1992-09-01 | 1994-03-17 | Berlex Laboratories, Inc. | Glycolation of glycosylated macromolecules |
US5308460A (en) | 1992-10-30 | 1994-05-03 | Glyko, Incorporated | Rapid synthesis and analysis of carbohydrates |
US6361977B1 (en) | 1992-11-24 | 2002-03-26 | S. Christopher Bauer | Methods of using multivariant IL-3 hematopoiesis fusion protein |
NZ250375A (en) | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
CA2110543A1 (en) | 1992-12-09 | 1994-06-10 | David E. Wright | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives thereof |
NO934477L (en) * | 1992-12-09 | 1994-06-10 | Ortho Pharma Corp | PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereof |
WO1994015625A1 (en) | 1993-01-15 | 1994-07-21 | Enzon, Inc. | Factor viii - polymeric conjugates |
US5349001A (en) | 1993-01-19 | 1994-09-20 | Enzon, Inc. | Cyclic imide thione activated polyalkylene oxides |
US5321095A (en) | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
US5202413A (en) | 1993-02-16 | 1993-04-13 | E. I. Du Pont De Nemours And Company | Alternating (ABA)N polylactide block copolymers |
US6180134B1 (en) | 1993-03-23 | 2001-01-30 | Sequus Pharmaceuticals, Inc. | Enhanced ciruclation effector composition and method |
SG49117A1 (en) | 1993-03-29 | 1998-05-18 | Kyowa Hakko Kogyo Kk | Alfa -1, 3-fucosyltransferase |
US5374541A (en) * | 1993-05-04 | 1994-12-20 | The Scripps Research Institute | Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides |
US5409817A (en) | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
AU6663294A (en) | 1993-05-14 | 1994-12-12 | Upjohn Company, The | Cloned dna encoding a udp-galnac:polypeptide,n-acetylgalactos aminyltransferase |
JPH08510729A (en) | 1993-05-14 | 1996-11-12 | サイテル コーポレイション | Sialyl Le <ab> x analogues as inhibitors of cell adhesion |
PT699075E (en) | 1993-05-21 | 2002-05-31 | Novo Nordisk As | MODIFIED FACTOR VII FOR INHIBITION OF VASCULAR RESTENOSE AND PLATELET DEPOSITION |
AU7097094A (en) | 1993-06-01 | 1994-12-20 | Enzon, Inc. | Carbohydrate-modified polymer conjugates with erythropoietic activity |
US5621039A (en) * | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
JPH09503905A (en) | 1993-07-15 | 1997-04-22 | ネオゼ ファーマシューティカルス | Method for synthesizing sugar composition |
DE4325317C2 (en) | 1993-07-29 | 1998-05-20 | Univ Dresden Tech | Process for the radioactive labeling of immunoglobulins |
IL192290A0 (en) | 1993-08-17 | 2008-12-29 | Kirin Amgen Inc | Erythropoietin analogs |
JPH0770195A (en) | 1993-08-23 | 1995-03-14 | Yutaka Mizushima | Sugar-modified interferon |
US6485930B1 (en) | 1993-09-15 | 2002-11-26 | The Scripps Research Institute | Mannosyl transfer with regeneration of GDP-mannose |
CN1057775C (en) | 1993-09-22 | 2000-10-25 | 味之素株式会社 | Anti-thrombus active piptide and preparation method thereof |
US5874075A (en) | 1993-10-06 | 1999-02-23 | Amgen Inc. | Stable protein: phospholipid compositions and methods |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
US5443953A (en) | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
US5369017A (en) * | 1994-02-04 | 1994-11-29 | The Scripps Research Institute | Process for solid phase glycopeptide synthesis |
JP3516272B2 (en) | 1994-02-10 | 2004-04-05 | 株式会社成和化成 | Cosmetic base material |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5492841A (en) * | 1994-02-18 | 1996-02-20 | E. I. Du Pont De Nemours And Company | Quaternary ammonium immunogenic conjugates and immunoassay reagents |
PL181064B1 (en) | 1994-03-07 | 2001-05-31 | Dendritech Inc | Biologically active and/or oriented conjugates of dendrimers |
US5432059A (en) * | 1994-04-01 | 1995-07-11 | Specialty Laboratories, Inc. | Assay for glycosylation deficiency disorders |
US5646113A (en) | 1994-04-07 | 1997-07-08 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
US5545553A (en) | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
EP0785276A4 (en) | 1994-09-29 | 2002-01-09 | Ajinomoto Kk | Modification of peptide and protein |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US5834251A (en) * | 1994-12-30 | 1998-11-10 | Alko Group Ltd. | Methods of modifying carbohydrate moieties |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
SE9501285L (en) | 1995-04-06 | 1996-10-07 | Johanna Ljung | Process for producing biologically active proteins |
US5876980A (en) * | 1995-04-11 | 1999-03-02 | Cytel Corporation | Enzymatic synthesis of oligosaccharides |
US5922577A (en) * | 1995-04-11 | 1999-07-13 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
US5728554A (en) * | 1995-04-11 | 1998-03-17 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
ES2180757T3 (en) | 1995-04-11 | 2003-02-16 | Neose Technologies Inc | ENZYMATIC SYNTHESIS IMPROVED OF OLIGOSACARIDS. |
US6030815A (en) * | 1995-04-11 | 2000-02-29 | Neose Technologies, Inc. | Enzymatic synthesis of oligosaccharides |
US5695760A (en) | 1995-04-24 | 1997-12-09 | Boehringer Inglehiem Pharmaceuticals, Inc. | Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation |
AU5920096A (en) | 1995-05-15 | 1996-11-29 | Constantin A. Bona | Carbohydrate-mediated coupling of peptides to immunoglobulins |
US6015555A (en) * | 1995-05-19 | 2000-01-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
US5824864A (en) | 1995-05-25 | 1998-10-20 | Pioneer Hi-Bred International, Inc. | Maize gene and protein for insect control |
US5858752A (en) | 1995-06-07 | 1999-01-12 | The General Hospital Corporation | Fucosyltransferase genes and uses thereof |
AU6255096A (en) | 1995-06-07 | 1996-12-30 | Mount Sinai School Of Medicine Of The City University Of New York, The | Pegylated modified proteins |
US6127153A (en) | 1995-06-07 | 2000-10-03 | Neose Technologies, Inc. | Method of transferring at least two saccharide units with a polyglycosyltransferase, a polyglycosyltransferase and gene encoding a polyglycosyltransferase |
US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
CN1192256A (en) | 1995-07-27 | 1998-09-02 | Cytec技术有限公司 | Synthetic cationic polymers as promoters for ASA sizing |
US5770420A (en) | 1995-09-08 | 1998-06-23 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
EP1568771A3 (en) | 1995-09-21 | 2006-05-17 | Genentech, Inc. | Human growth hormone variants |
SE9503380D0 (en) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
US5716812A (en) * | 1995-12-12 | 1998-02-10 | The University Of British Columbia | Methods and compositions for synthesis of oligosaccharides, and the products formed thereby |
WO1997021822A2 (en) | 1995-12-12 | 1997-06-19 | The University Of British Columbia | Methods and compositions for synthesis of oligosaccharides using mutant glycosidase enzymes |
CA2165041C (en) | 1995-12-12 | 2005-07-05 | The University Of British Columbia | Methods and compositions for synthesis of oligosaccharides, and the products formed thereby |
JP3065925B2 (en) | 1996-01-30 | 2000-07-17 | 日清製油株式会社 | Active oxygen species scavenger and anti-fading agent |
AU731261B2 (en) | 1996-03-08 | 2001-03-29 | Regents Of The University Of Michigan, The | Murine alpha(1,3)fucosyltransferase Fuc-TVII, DNA encoding the same, method for preparing the same, antibodies recognizing the same, immunoassays for detecting the same, plasmids containing such DNA, and cells containing such plasmid |
ATE341344T1 (en) | 1996-08-02 | 2006-10-15 | Ortho Mcneil Pharm Inc | POLYPEPTIDES WITH SINGLE COVALENTLY BONDED N-TERMINAL WATER SOLUBLE POLYMER |
WO1998006422A1 (en) | 1996-08-13 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Hematopoietic stem cell proliferating agents |
US20020064546A1 (en) | 1996-09-13 | 2002-05-30 | J. Milton Harris | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor |
ATE304546T1 (en) | 1996-10-10 | 2005-09-15 | Neose Technologies Inc | PURIFICATION OF CARBOHYDRATES USING REVERSE OSMOSIS AND NANOFILTRATION |
NZ336539A (en) * | 1996-10-15 | 2000-09-29 | Liposome Co Inc | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
CN1244214A (en) | 1996-11-08 | 2000-02-09 | 尼澳斯技术股份有限公司 | Improved expression vectors |
WO1998031826A1 (en) | 1997-01-16 | 1998-07-23 | Cytel Corporation | Practical in vitro sialylation of recombinant glycoproteins |
EP0921817B1 (en) | 1997-01-29 | 2001-03-28 | PolyMASC Pharmaceuticals plc | Pegylation process |
DE19709787A1 (en) | 1997-03-11 | 1998-09-17 | Bayer Ag | Oligosaccaride and their derivatives as well as a chemo-enzymatic process for their production |
US5945314A (en) * | 1997-03-31 | 1999-08-31 | Abbott Laboratories | Process for synthesizing oligosaccharides |
US6323322B1 (en) | 1997-04-30 | 2001-11-27 | Enzon, Inc. | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof |
JPH10307356A (en) | 1997-05-08 | 1998-11-17 | Konica Corp | Silver halide emulsion and silver halide photographic sensitive material using the same |
US6075134A (en) * | 1997-05-15 | 2000-06-13 | The Regents Of The University Of California | Glycoconjugates and methods |
WO1998055630A2 (en) | 1997-06-06 | 1998-12-10 | The Governors Of The University Of Alberta | Alpha-1,3-fucosyltransferase of helicobacter pylori |
ES2244066T3 (en) | 1997-06-24 | 2005-12-01 | Genentech, Inc. | PROCEDURE AND COMPOSITIONS OF GALACTOSILATED GLICOPROTEINS. |
AU8269898A (en) | 1997-06-27 | 1999-01-19 | Regents Of The University Of California, The | Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor |
US20030027257A1 (en) * | 1997-08-21 | 2003-02-06 | University Technologies International, Inc. | Sequences for improving the efficiency of secretion of non-secreted protein from mammalian and insect cells |
WO1999013063A1 (en) | 1997-09-09 | 1999-03-18 | Nycomed Imaging As | Factor vii fragments and analogs thereof and their use in the treatment of blood clottng disorders |
EP1028751B1 (en) | 1997-10-31 | 2008-12-31 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
CA2312843A1 (en) | 1997-12-01 | 1999-06-10 | Neose Technologies Inc. | Enzymatic synthesis of gangliosides |
EP0924298A1 (en) * | 1997-12-18 | 1999-06-23 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Protein expression in baculovirus vector expression systems |
ES2211033T3 (en) | 1998-01-07 | 2004-07-01 | Debio Recherche Pharmaceutique S.A. | DEGRADABLE HETEROBIFUNCTIONAL POLYETHYLENGLYCOL ACRYLATES AND GELS AND CONJUGATES DERIVED FROM SUCH ACRYLATES |
EP1061954B1 (en) | 1998-03-12 | 2004-06-09 | Nektar Therapeutics Al, Corporation | Poly(ethylene glycol) derivatives with proximal reactive groups |
EP1091751A4 (en) | 1998-03-25 | 2005-01-19 | Sloan Kettering Institutefor C | Trimeric antigenic o-linked glycopeptide conjugates, methods of preparation and uses thereof |
DK1071700T3 (en) | 1998-04-20 | 2010-06-07 | Glycart Biotechnology Ag | Glycosylation modification of antibodies to enhance antibody-dependent cellular cytotoxicity |
ES2242396T3 (en) | 1998-04-28 | 2005-11-01 | Applied Research Systems Ars Holding N.V. | CONJUGATES OF PEG-LHRH ANALOGS. |
US20030166525A1 (en) | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
PT1121156E (en) | 1998-10-16 | 2006-05-31 | Biogen Idec Inc | CONJUGATES OF INTERFERRO-BETA-1A POLYMERS AND THEIR USES |
US7304150B1 (en) | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
CA2348822A1 (en) | 1998-10-30 | 2000-05-11 | Novozymes A/S | Glycosylated proteins having reduced allergenicity |
ATE408006T1 (en) | 1998-11-13 | 2008-09-15 | Henrick Clausen | UDP-GALACTOSE: BETA-I(N)-ACETYL-GLUCOSAMINE BETA1, 3 GALACTOSYL TRANSFERASES, BETA3GAL-T5 |
DE19852729A1 (en) * | 1998-11-16 | 2000-05-18 | Werner Reutter | Recombinant glycoproteins, processes for their preparation, medicaments containing them and their use |
JP2002530087A (en) | 1998-11-18 | 2002-09-17 | ネオーズ テクノロジーズ, インコーポレイテッド | Inexpensive production of oligosaccharides |
US6465220B1 (en) | 1998-12-21 | 2002-10-15 | Glycozym Aps | Glycosylation using GalNac-T4 transferase |
ATE246202T1 (en) | 1999-01-29 | 2003-08-15 | Hoffmann La Roche | GCSF CONJUGATES |
US6503744B1 (en) | 1999-02-01 | 2003-01-07 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
US6949372B2 (en) | 1999-03-02 | 2005-09-27 | The Johns Hopkins University | Engineering intracellular sialylation pathways |
AU769842B2 (en) | 1999-04-22 | 2004-02-05 | Astrazeneca Ab | Assay for detecting phospho-N-acetylmuramyl-pentapeptide translocase activity |
PE20010288A1 (en) * | 1999-07-02 | 2001-03-07 | Hoffmann La Roche | ERYTHROPOYETIN DERIVATIVES |
US6261805B1 (en) * | 1999-07-15 | 2001-07-17 | Boyce Thompson Institute For Plant Research, Inc. | Sialyiation of N-linked glycoproteins in the baculovirus expression vector system |
WO2001005434A2 (en) | 1999-07-20 | 2001-01-25 | Amgen Inc. | Hyaluronic acid-protein conjugates |
US6534300B1 (en) | 1999-09-14 | 2003-03-18 | Genzyme Glycobiology Research Institute, Inc. | Methods for producing highly phosphorylated lysosomal hydrolases |
US6716626B1 (en) | 1999-11-18 | 2004-04-06 | Chiron Corporation | Human FGF-21 nucleic acids |
CA2393200C (en) | 1999-12-02 | 2011-07-12 | Zymogenetics, Inc. | Methods for targeting cells that express fibroblast growth receptor-3 or-2 |
US6348558B1 (en) | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
US6376604B2 (en) | 1999-12-22 | 2002-04-23 | Shearwater Corporation | Method for the preparation of 1-benzotriazolylcarbonate esters of poly(ethylene glycol) |
EP1270642B1 (en) | 1999-12-24 | 2011-08-31 | Kyowa Hakko Kirin Co., Ltd. | Branched polyalkylene glycols |
WO2001049830A2 (en) | 1999-12-30 | 2001-07-12 | Maxygen Aps | Improved lysosomal enzymes and lysosomal enzyme activators |
WO2001051510A2 (en) | 2000-01-10 | 2001-07-19 | Maxygen Holdings Ltd | G-csf conjugates |
US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
RU2278123C2 (en) | 2000-02-11 | 2006-06-20 | Максиджен Холдингз Лтд. | Molecules similar to factor vii or viia |
WO2001058493A1 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
AU2001232337A1 (en) | 2000-02-18 | 2001-08-27 | Kanagawa Academy Of Science And Technology | Pharmaceutical composition, reagent and method for intracerebral delivery of pharmaceutically active ingredient or labeling substance |
US20010041683A1 (en) | 2000-03-09 | 2001-11-15 | Schmitz Harold H. | Cocoa sphingolipids, cocoa extracts containing sphingolipids and methods of making and using same |
WO2001068565A2 (en) | 2000-03-16 | 2001-09-20 | The Regents Of The University Of California | Chemoselective ligation by use of a phosphine |
US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
AU2001254624A1 (en) | 2000-05-03 | 2001-11-12 | Novo-Nordisk A/S | Human coagulation factor vii variants |
US6905683B2 (en) | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
US7338932B2 (en) | 2000-05-11 | 2008-03-04 | Glycozym Aps | Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments |
WO2001088117A2 (en) | 2000-05-12 | 2001-11-22 | Neose Technologies, Inc. | In vitro fucosylation recombinant glycopeptides |
CA2408685C (en) | 2000-05-15 | 2011-02-01 | F. Hoffmann-La Roche Ag | Liquid pharmaceutical composition containing an erythropoietin derivate |
ES2290142T3 (en) | 2000-05-16 | 2008-02-16 | Bolder Biotechnology, Inc. | METHODS FOR REPLEGATION OF PROTEINS CONTAINING FREE CISTEINE RESIDUES. |
EP1522590B1 (en) | 2000-06-28 | 2009-08-26 | Glycofi, Inc. | Methods for producing modified glycoproteins |
EP1299535A2 (en) | 2000-06-30 | 2003-04-09 | Maxygen Aps | Peptide extended glycosylated polypeptides |
US6423826B1 (en) | 2000-06-30 | 2002-07-23 | Regents Of The University Of Minnesota | High molecular weight derivatives of vitamin K-dependent polypeptides |
KR100396983B1 (en) | 2000-07-29 | 2003-09-02 | 이강춘 | Highly reactive branched polymer and proteins or peptides conjugated with the polymer |
AU2001283740A1 (en) | 2000-08-17 | 2002-02-25 | University Of British Columbia | Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours |
WO2002013873A2 (en) | 2000-08-17 | 2002-02-21 | Synapse Technologies, Inc. | P97-active agent conjugates and their methods of use |
CA2422216C (en) | 2000-10-02 | 2010-03-16 | Novo Nordisk A/S | Method for the production of vitamin k-dependent proteins |
US20020142964A1 (en) | 2000-11-02 | 2002-10-03 | Nissen Torben Lauesgaard | Single-chain polypeptides |
US20020082384A1 (en) | 2000-11-27 | 2002-06-27 | Antonio Verdini | Process for folding chemically synthesized polypeptides |
WO2002044196A1 (en) | 2000-11-28 | 2002-06-06 | University Of Massachusetts | Methods and reagents for introducing a sulfhydryl group into the 5'-terminus of rna |
DE60144439D1 (en) * | 2000-12-20 | 2011-05-26 | Hoffmann La Roche | CONJUGATES OF ERYTHROPOIETIN (EPO) WITH POLYETHYLENE GLYCOL (PEG) |
JP4656814B2 (en) | 2000-12-20 | 2011-03-23 | エフ.ホフマン−ラ ロシュ アーゲー | Erythropoietin conjugate |
US7892730B2 (en) | 2000-12-22 | 2011-02-22 | Sagres Discovery, Inc. | Compositions and methods for cancer |
PA8536201A1 (en) | 2000-12-29 | 2002-08-29 | Kenneth S Warren Inst Inc | PROTECTION AND IMPROVEMENT OF CELLS, FABRICS AND ORGANS RESPONDING TO Erythropoietin |
US6531121B2 (en) | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
SE0004932D0 (en) | 2000-12-31 | 2000-12-31 | Apbiotech Ab | A method for mixed mode adsorption and mixed mode adsorbents |
EP2080771A3 (en) | 2001-02-27 | 2010-01-06 | Maxygen Aps | New interferon beta-like molecules |
US7235638B2 (en) | 2001-03-22 | 2007-06-26 | Novo Nordisk Healthcare A/G | Coagulation factor VII derivatives |
RU2338752C2 (en) | 2001-03-22 | 2008-11-20 | Ново Нордиск Хелт Кэр Аг | Derivatives of factor of vii blood coagulation |
US20020168323A1 (en) * | 2001-05-11 | 2002-11-14 | Igor Gonda | Optimization of the molecular properties and formulation of proteins delivered by inhalation |
US7271150B2 (en) | 2001-05-14 | 2007-09-18 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Modified growth hormone |
DE60236522D1 (en) | 2001-07-11 | 2010-07-08 | Maxygen Inc | G-CSF CONJUGATES |
KR100453877B1 (en) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | METHOD OF MANUFACTURING Ig-FUSION PROTEINS BY CONCATAMERIZATION, TNFR/Fc FUSION PROTEINS MANUFACTURED BY THE METHOD, DNA CODING THE PROTEINS, VECTORS INCLUDING THE DNA, AND CELLS TRANSFORMED BY THE VECTOR |
WO2003011879A1 (en) | 2001-08-01 | 2003-02-13 | Neose Technologies, Inc. | Neutral glycosphingolipids and glycosyl-sphingosines and methods for isolating the same |
WO2003017949A2 (en) | 2001-08-29 | 2003-03-06 | Neose Technologies, Inc. | Novel synthetic ganglioside derivatives and compositions thereof |
US6930086B2 (en) * | 2001-09-25 | 2005-08-16 | Hoffmann-La Roche Inc. | Diglycosylated erythropoietin |
US7052868B2 (en) | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7439043B2 (en) | 2001-10-10 | 2008-10-21 | Neose Technologies, Inc. | Galactosyl nucleotide sugars |
US7399613B2 (en) | 2001-10-10 | 2008-07-15 | Neose Technologies, Inc. | Sialic acid nucleotide sugars |
US7696163B2 (en) | 2001-10-10 | 2010-04-13 | Novo Nordisk A/S | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
US7179617B2 (en) | 2001-10-10 | 2007-02-20 | Neose Technologies, Inc. | Factor IX: remolding and glycoconjugation of Factor IX |
US7226903B2 (en) | 2001-10-10 | 2007-06-05 | Neose Technologies, Inc. | Interferon beta: remodeling and glycoconjugation of interferon beta |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
EP2042196B1 (en) | 2001-10-10 | 2016-07-13 | ratiopharm GmbH | Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF) |
US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US8008252B2 (en) | 2001-10-10 | 2011-08-30 | Novo Nordisk A/S | Factor VII: remodeling and glycoconjugation of Factor VII |
US7297511B2 (en) | 2001-10-10 | 2007-11-20 | Neose Technologies, Inc. | Interferon alpha: remodeling and glycoconjugation of interferon alpha |
US7265085B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycoconjugation methods and proteins/peptides produced by the methods |
US7795210B2 (en) | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US6784154B2 (en) | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
EP1461445B1 (en) | 2001-11-28 | 2008-08-20 | Neose Technologies, Inc. | Glycoprotein remodeling using endoglycanases |
US7473680B2 (en) | 2001-11-28 | 2009-01-06 | Neose Technologies, Inc. | Remodeling and glycoconjugation of peptides |
US7368108B2 (en) | 2001-11-28 | 2008-05-06 | Neose Technologies, Inc. | Glycopeptide remodeling using amidases |
US20060035224A1 (en) | 2002-03-21 | 2006-02-16 | Johansen Jack T | Purification methods for oligonucleotides and their analogs |
EP1504023A4 (en) | 2002-05-03 | 2006-03-22 | Neose Technologies Inc | Recombinant glycosyltransferase fusion proteins |
MXPA04012496A (en) | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Pegylated factor vii glycoforms. |
DK1517710T3 (en) | 2002-06-21 | 2011-07-18 | Novo Nordisk Healthcare Ag | Pegylated factor VII glycoforms |
DE10232916B4 (en) | 2002-07-19 | 2008-08-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Apparatus and method for characterizing an information signal |
ATE506450T1 (en) | 2002-07-23 | 2011-05-15 | Biogenerix Ag | SYNTHESIS OF OLIGOSACCHARIDES, GLYCOLIPIDS AND GLYCOPROTEINS USING BACTERIAL GLYCOSYL TRANSFERASES |
AU2003254665C1 (en) | 2002-08-01 | 2010-08-19 | National Research Council Of Canada | Campylobacter glycans and glycopeptides |
ES2575014T3 (en) | 2002-08-02 | 2016-06-23 | Glaxosmithkline Biologicals S.A. | Neisseria vaccine compositions comprising a combination of antigens |
WO2004021993A2 (en) * | 2002-09-05 | 2004-03-18 | The General Hospital Corporation | Modified asialo-interferons and uses thereof |
EP1539210A4 (en) | 2002-09-06 | 2006-06-07 | Bayer Pharmaceuticals Corp | Modified glp-1 receptor agonists and their pharmacological methods of use |
ZA200502320B (en) | 2002-09-20 | 2006-10-25 | Pharmacia Corp | Process for decreasing aggregate levels of pegylated protein |
ES2293088T3 (en) | 2002-09-25 | 2008-03-16 | Novo Nordisk Health Care Ag | POLIPEPTIDES OF FACTOR VII OF HUMAN COAGULATION. |
AU2003266931B2 (en) | 2002-09-30 | 2010-01-21 | Bayer Healthcare Llc | FVII or FVIIa variants having increased clotting activity |
US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
NZ539415A (en) | 2002-10-09 | 2008-12-24 | Neose Technologies Inc | Remodelling and glycoconjugation of erythropoietin |
AU2003275952A1 (en) | 2002-11-08 | 2004-06-07 | Glycozym Aps | Inactivated ga1 - nac - transferases, methods for inhibitors of such transferases and their use |
JP4412461B2 (en) | 2002-11-20 | 2010-02-10 | 日油株式会社 | Modified bio-related substance, production method thereof and intermediate |
US7459436B2 (en) * | 2002-11-22 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
US20050064540A1 (en) | 2002-11-27 | 2005-03-24 | Defrees Shawn Ph.D | Glycoprotein remodeling using endoglycanases |
EP1424344A1 (en) | 2002-11-29 | 2004-06-02 | Aventis Behring Gesellschaft mit beschränkter Haftung | Modified cDNA factor VIII and its derivates |
DK1428878T3 (en) | 2002-12-13 | 2008-12-08 | Bioceuticals Arzneimittel Ag | Process for the production and purification of erythropoietin |
PT1667708E (en) | 2002-12-26 | 2012-09-14 | Mountain View Pharmaceuticals | Polyethylene glycol conjugates of interferon-beta-1b with enhanced in vitro biological potency |
US7041635B2 (en) | 2003-01-28 | 2006-05-09 | In2Gen Co., Ltd. | Factor VIII polypeptide |
DK1596887T3 (en) | 2003-02-26 | 2022-06-20 | Nektar Therapeutics | Polymer-Factor VIII conjugate |
US7803777B2 (en) | 2003-03-14 | 2010-09-28 | Biogenerix Ag | Branched water-soluble polymers and their conjugates |
WO2004083259A2 (en) | 2003-03-18 | 2004-09-30 | Neose Technologies Inc. | Activated forms of water-soluble polymers |
CN1832959A (en) | 2003-03-19 | 2006-09-13 | 伊莱利利公司 | Polyethelene glycol link glp-1 compounds |
SG155777A1 (en) | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
US20080146782A1 (en) | 2006-10-04 | 2008-06-19 | Neose Technologies, Inc. | Glycerol linked pegylated sugars and glycopeptides |
US7691603B2 (en) | 2003-04-09 | 2010-04-06 | Novo Nordisk A/S | Intracellular formation of peptide conjugates |
US7718363B2 (en) | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
PT2298347E (en) | 2003-05-06 | 2016-01-29 | Biogen Hemophilia Inc | Clotting factor chimeric proteins for treatment of a hemostatic disorder |
AU2004240553A1 (en) | 2003-05-09 | 2004-12-02 | Neose Technologies, Inc. | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
WO2004101597A2 (en) | 2003-05-13 | 2004-11-25 | Frutarom Ltd. | Methods for the reduction of disulfide bonds |
US7074755B2 (en) * | 2003-05-17 | 2006-07-11 | Centocor, Inc. | Erythropoietin conjugate compounds with extended half-lives |
EP1481985A1 (en) | 2003-05-28 | 2004-12-01 | Innogenetics N.V. | Modified hepatitis C virus (HCV) NS3 for medical treatment |
GB0315457D0 (en) | 2003-07-01 | 2003-08-06 | Celltech R&D Ltd | Biological products |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
BRPI0412671A (en) | 2003-08-08 | 2006-10-03 | Fresenius Kabi De Gmbh | conjugates of a polymer and a protein linked by an oxime linking group |
US20060198819A1 (en) | 2003-08-08 | 2006-09-07 | Novo Nordisk Healthcare A/G | Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest |
BRPI0409650A (en) | 2003-09-09 | 2006-04-25 | Warren Pharmaceuticals Inc | methods for regulating hematocrit and human levels, artificial erythropoietin products, methods for preparing an erythropoietin product and for treating anemia in patients at risk of tissue damage, and, pharmaceutical composition |
US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
KR20060120141A (en) | 2003-11-24 | 2006-11-24 | 네오스 테크놀로지스, 인크. | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
NZ547554A (en) | 2003-12-03 | 2009-09-25 | Biogenerix Ag | Glycopegylated granulocyte colony stimulating factor |
US20080318850A1 (en) | 2003-12-03 | 2008-12-25 | Neose Technologies, Inc. | Glycopegylated Factor Ix |
EP1694315A4 (en) | 2003-12-03 | 2009-10-28 | Novo Nordisk As | Glycopegylated factor ix |
US20080015142A1 (en) | 2003-12-03 | 2008-01-17 | Defrees Shawn | Glycopegylated Follicle Stimulating Hormone |
US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
WO2005070138A2 (en) | 2004-01-08 | 2005-08-04 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
US20080058245A1 (en) | 2004-01-09 | 2008-03-06 | Johnson Karl F | Vectors for Recombinant Protein Expression in E. Coli |
US20070105770A1 (en) | 2004-01-21 | 2007-05-10 | Novo Nordisk A/S | Transglutaminase mediated conjugation of peptides |
AU2005208897B2 (en) | 2004-01-26 | 2011-05-19 | Ratiopharm Gmbh | Branched polymeric sugars and nucleotides thereof |
EP1735340A2 (en) | 2004-03-17 | 2006-12-27 | Eli Lilly And Company | Glycol linked fgf-21 compounds |
JP5826446B2 (en) | 2004-05-04 | 2015-12-02 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | O-linked sugar chain-forming polypeptide and method for producing the peptide |
US20070037966A1 (en) | 2004-05-04 | 2007-02-15 | Novo Nordisk A/S | Hydrophobic interaction chromatography purification of factor VII polypeptides |
WO2005121331A2 (en) | 2004-06-03 | 2005-12-22 | Neose Technologies, Inc. | Truncated galnact2 polypeptides and nucleic acids |
WO2005121332A2 (en) | 2004-06-03 | 2005-12-22 | Neose Technologies, Inc. | Truncated st6galnaci polypeptides and nucleic acids |
KR101100059B1 (en) | 2004-06-30 | 2011-12-29 | 넥타르 테라퓨틱스 | Polymer-factor ix moiety conjugates |
US20060029573A1 (en) | 2004-06-30 | 2006-02-09 | Chun Shen | Pegylated interferon alpha-1b |
WO2006014466A2 (en) | 2004-07-02 | 2006-02-09 | The Kenneth S. Warren Institute, Inc. | Novel carbamylated epo and method for its production |
WO2006014349A2 (en) | 2004-07-02 | 2006-02-09 | The Kenneth S. Warren Institute, Inc. | Method of producing fully carbamylated erythropoietin |
EP1771066A2 (en) | 2004-07-13 | 2007-04-11 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1 |
WO2006020372A2 (en) | 2004-07-23 | 2006-02-23 | Neose Technologies, Inc. | Enzymatic modification of glycopeptides |
SE0401951D0 (en) | 2004-07-29 | 2004-07-29 | Amersham Biosciences Ab | Chromatography method |
JP2008507990A (en) | 2004-08-02 | 2008-03-21 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Conjugate of FVII |
US20060024286A1 (en) | 2004-08-02 | 2006-02-02 | Paul Glidden | Variants of tRNA synthetase fragments and uses thereof |
KR20070043051A (en) | 2004-08-17 | 2007-04-24 | 쳇엘베 베링 게엠베하 | Modified vitamin k dependent polypeptides |
EP1799249A2 (en) | 2004-09-10 | 2007-06-27 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
JP2008514215A (en) | 2004-09-29 | 2008-05-08 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Modified protein |
CA2585758C (en) | 2004-10-29 | 2017-08-01 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
US20090054623A1 (en) | 2004-12-17 | 2009-02-26 | Neose Technologies, Inc. | Lipo-Conjugation of Peptides |
US8080391B2 (en) | 2004-12-22 | 2011-12-20 | Ambrx, Inc. | Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer |
US20100009902A1 (en) | 2005-01-06 | 2010-01-14 | Neose Technologies, Inc. | Glycoconjugation Using Saccharyl Fragments |
ES2449195T3 (en) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Glycopegylated granulocyte colony stimulating factor |
WO2006078645A2 (en) | 2005-01-19 | 2006-07-27 | Neose Technologies, Inc. | Heterologous polypeptide expression using low multiplicity of infection of viruses |
PA8660701A1 (en) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | SMALL AGONISTS AND THEIR USES |
ATE527371T1 (en) | 2005-03-24 | 2011-10-15 | Biogenerix Ag | EXPRESSION OF SOLUBLE, ACTIVE, EUKARYOTIC GLUCOSYL TRANSFERASES IN PROKARYOTIC ORGANISMS |
EP1866427A4 (en) | 2005-03-30 | 2010-09-01 | Novo Nordisk As | Manufacturing process for the production of peptides grown in insect cell lines |
EP1871801A2 (en) | 2005-04-01 | 2008-01-02 | Novo Nordisk Health Care AG | Blood coagulation fviii analogues |
US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
DK2311972T3 (en) | 2005-05-11 | 2015-04-27 | Eth Zuerich | Recombinant N-glycosylated proteins from prokaryotic cells |
US20080255026A1 (en) | 2005-05-25 | 2008-10-16 | Glycopegylated Factor 1X | Glycopegylated Factor Ix |
WO2006127910A2 (en) | 2005-05-25 | 2006-11-30 | Neose Technologies, Inc. | Glycopegylated erythropoietin formulations |
US20110003744A1 (en) | 2005-05-25 | 2011-01-06 | Novo Nordisk A/S | Glycopegylated Erythropoietin Formulations |
WO2006134173A2 (en) | 2005-06-17 | 2006-12-21 | Novo Nordisk Health Care Ag | Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine |
EP1937719A4 (en) | 2005-08-19 | 2010-11-24 | Novo Nordisk As | Glycopegylated factor vii and factor viia |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090055942A1 (en) | 2005-09-14 | 2009-02-26 | Novo Nordisk Healthcare A/G | Human Coagulation Factor VII Polypeptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
DE202006020194U1 (en) | 2006-03-01 | 2007-12-06 | Bioceuticals Arzneimittel Ag | G-CSF liquid formulation |
KR20090013816A (en) | 2006-05-24 | 2009-02-05 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Factor ix analogues having prolonged in vivo half life |
WO2008011633A2 (en) | 2006-07-21 | 2008-01-24 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
ITMI20061624A1 (en) | 2006-08-11 | 2008-02-12 | Bioker Srl | SINGLE-CONJUGATE SITE-SPECIFIC OF G-CSF |
WO2008025856A2 (en) | 2006-09-01 | 2008-03-06 | Novo Nordisk Health Care Ag | Modified glycoproteins |
WO2008057683A2 (en) | 2006-10-03 | 2008-05-15 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
US20080207487A1 (en) | 2006-11-02 | 2008-08-28 | Neose Technologies, Inc. | Manufacturing process for the production of polypeptides expressed in insect cell-lines |
PL2144923T3 (en) | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Methods of treatment using glycopegylated g-csf |
US20090053167A1 (en) | 2007-05-14 | 2009-02-26 | Neose Technologies, Inc. | C-, S- and N-glycosylation of peptides |
WO2008151258A2 (en) | 2007-06-04 | 2008-12-11 | Neose Technologies, Inc. | O-linked glycosylation using n-acetylglucosaminyl transferases |
ES2551123T3 (en) | 2007-06-12 | 2015-11-16 | Ratiopharm Gmbh | Improved process for the production of nucleotide sugars |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
JP5647899B2 (en) | 2008-01-08 | 2015-01-07 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | Glycoconjugation of polypeptides using oligosaccharyltransferase |
-
2003
- 2003-04-09 US US10/410,945 patent/US7214660B2/en not_active Expired - Fee Related
- 2003-10-08 WO PCT/US2003/031974 patent/WO2004033651A2/en active Search and Examination
- 2003-10-08 MX MXPA05003730A patent/MXPA05003730A/en active IP Right Grant
- 2003-10-08 CA CA002501832A patent/CA2501832A1/en not_active Abandoned
- 2003-10-08 AU AU2003287035A patent/AU2003287035B2/en not_active Ceased
- 2003-10-08 EP EP03777555A patent/EP1581622A4/en not_active Withdrawn
- 2003-10-08 JP JP2005501139A patent/JP5413548B2/en not_active Expired - Fee Related
-
2005
- 2005-07-15 US US11/183,218 patent/US20060088906A1/en not_active Abandoned
-
2007
- 2007-02-02 US US11/701,949 patent/US8716240B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4414147A (en) * | 1981-04-17 | 1983-11-08 | Massachusetts Institute Of Technology | Methods of decreasing the hydrophobicity of fibroblast and other interferons |
US6183738B1 (en) * | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
Non-Patent Citations (2)
Title |
---|
See also references of EP1581622A4 * |
TAKEUCHI M. ET AL: "Role of Sugar Chains in the in vitro Biological Activity of Human Erythropoietin Produced in Recombinant Chinese Hamster Ovary Cells", J. BIOL. CHEM., vol. 265, no. 21, 25 July 1990 (1990-07-25), pages 12127 - 12130, XP002031640 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8916518B2 (en) | 2002-03-06 | 2014-12-23 | Fresenius Kabi Deutschland Gmbh | Coupling proteins to a modified polysaccharide |
US8840879B2 (en) | 2004-03-11 | 2014-09-23 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US8716033B2 (en) | 2006-02-10 | 2014-05-06 | Life Technologies Corporation | Oligosaccharide modification and labeling of proteins |
US8785212B2 (en) | 2006-02-10 | 2014-07-22 | Life Technologies Corporation | Oligosaccharide modification and labeling of proteins |
Also Published As
Publication number | Publication date |
---|---|
US8716240B2 (en) | 2014-05-06 |
AU2003287035A1 (en) | 2004-05-04 |
MXPA05003730A (en) | 2005-12-14 |
WO2004033651A2 (en) | 2004-04-22 |
US20080187955A1 (en) | 2008-08-07 |
JP2006522738A (en) | 2006-10-05 |
EP1581622A2 (en) | 2005-10-05 |
US20070042458A1 (en) | 2007-02-22 |
US7214660B2 (en) | 2007-05-08 |
EP1581622A4 (en) | 2007-08-01 |
AU2003287035B2 (en) | 2009-07-30 |
CA2501832A1 (en) | 2004-04-22 |
JP5413548B2 (en) | 2014-02-12 |
US20060088906A1 (en) | 2006-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004033651A3 (en) | Erythropoietin: remodeling and glycoconjugation of erythropoietin | |
WO2003031464A3 (en) | Remodeling and glycoconjugation of peptides | |
WO2004099231A3 (en) | Glycopegylation methods and proteins/peptides produced by the methods | |
WO2001064920A3 (en) | Hybrid expression of neisserial proteins | |
BR0209242A (en) | Starch functional aminopolidiorganosiloxanes | |
DE29806504U1 (en) | Azide-free, gas generating composition | |
WO2003029264A3 (en) | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof | |
IL161229A0 (en) | Methods and compositions relating to restricted expression lentiviral vectors and their applications. | |
WO2003011115A3 (en) | Peptide-based multimeric targeted contrast agents | |
WO2006029094A3 (en) | Erythropoietin derivatives with altered immunogenicity | |
RS50660B (en) | Dihydrotetrabenazines and pharmaceutical compositions containing them | |
WO2002072865A3 (en) | Methods, kits and compositions of combination oligomers | |
WO2005087793A3 (en) | Immunostimulatory compositions and uses thereof | |
WO2003087313A3 (en) | Enhanced silk exsertion under stress | |
WO2004087874A3 (en) | Novel nucleic acids and polypeptides | |
ZA200604874B (en) | Pharmaceutical compositions | |
BR0315178A (en) | Erythropoietin: remodeling and glycoconjugation of erythropoietin | |
DE59902827D1 (en) | Azide-free, gas generating composition | |
EP2305311A3 (en) | Glycoconjugation of peptides | |
AU2002252310A1 (en) | Transgenic proteins from multi-gene systems, methods, compositions, uses and the like relating thereto | |
MXPA05009428A (en) | Compositions and methods for preventing and treating endotoxin-related diseases and conditions. | |
AU2003220557A1 (en) | Multiple sclerosis-related immunoglobulin derived proteins, compositions, methods and uses | |
WO2004075028A3 (en) | Systems and methods for variable rebate and incentive programs | |
WO2003097593A3 (en) | Protease inhibitors | |
WO2004092736A3 (en) | Derivatives of azithromycin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 167920 Country of ref document: IL Ref document number: PA/a/2005/003730 Country of ref document: MX Ref document number: 2005501139 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2501832 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003287035 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 539415 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003777555 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 200503558 Country of ref document: ZA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 836/KOLNP/2005 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20038A54668 Country of ref document: CN |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWP | Wipo information: published in national office |
Ref document number: 2003777555 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007027068 Country of ref document: US Ref document number: 10530972 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 10530972 Country of ref document: US |
|
DPE2 | Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101) |