WO2004033651A3 - Erythropoietin: remodeling and glycoconjugation of erythropoietin - Google Patents

Erythropoietin: remodeling and glycoconjugation of erythropoietin Download PDF

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Publication number
WO2004033651A3
WO2004033651A3 PCT/US2003/031974 US0331974W WO2004033651A3 WO 2004033651 A3 WO2004033651 A3 WO 2004033651A3 US 0331974 W US0331974 W US 0331974W WO 2004033651 A3 WO2004033651 A3 WO 2004033651A3
Authority
WO
WIPO (PCT)
Prior art keywords
erythropoietin
remodeling
glycoconjugation
peptide
addition
Prior art date
Application number
PCT/US2003/031974
Other languages
French (fr)
Other versions
WO2004033651A2 (en
Inventor
Frees Shawn De
David Zopf
Robert Bayer
Caryn Bowe
David Hakes
Xi Chen
Original Assignee
Neose Technologies Inc
Frees Shawn De
David Zopf
Robert Bayer
Caryn Bowe
David Hakes
Xi Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/032263 external-priority patent/WO2003031464A2/en
Priority to US10/530,972 priority Critical patent/US7696163B2/en
Priority to AU2003287035A priority patent/AU2003287035B2/en
Priority to EP03777555A priority patent/EP1581622A4/en
Priority to NZ539415A priority patent/NZ539415A/en
Priority to MXPA05003730A priority patent/MXPA05003730A/en
Application filed by Neose Technologies Inc, Frees Shawn De, David Zopf, Robert Bayer, Caryn Bowe, David Hakes, Xi Chen filed Critical Neose Technologies Inc
Priority to BR0315178-6A priority patent/BR0315178A/en
Priority to CA002501832A priority patent/CA2501832A1/en
Priority to JP2005501139A priority patent/JP5413548B2/en
Publication of WO2004033651A2 publication Critical patent/WO2004033651A2/en
Priority to IL167920A priority patent/IL167920A/en
Publication of WO2004033651A3 publication Critical patent/WO2004033651A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
PCT/US2003/031974 2001-10-10 2003-10-08 Erythropoietin: remodeling and glycoconjugation of erythropoietin WO2004033651A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2005501139A JP5413548B2 (en) 2002-10-09 2003-10-08 Erythropoietin: Remodeling and glycoconjugation of erythropoietin
AU2003287035A AU2003287035B2 (en) 2002-10-09 2003-10-08 Erythropoietin: remodeling and glycoconjugation of erythropoietin
EP03777555A EP1581622A4 (en) 2002-10-09 2003-10-08 Erythropoietin: remodeling and glycoconjugation of erythropoietin
NZ539415A NZ539415A (en) 2002-10-09 2003-10-08 Remodelling and glycoconjugation of erythropoietin
MXPA05003730A MXPA05003730A (en) 2002-10-09 2003-10-08 Erythropoietin: remodeling and glycoconjugation of erythropoietin.
US10/530,972 US7696163B2 (en) 2001-10-10 2003-10-08 Erythropoietin: remodeling and glycoconjugation of erythropoietin
BR0315178-6A BR0315178A (en) 2002-10-09 2003-10-08 Erythropoietin: remodeling and glycoconjugation of erythropoietin
CA002501832A CA2501832A1 (en) 2002-10-09 2003-10-08 Erythropoietin: remodeling and glycoconjugation of erythropoietin
IL167920A IL167920A (en) 2002-10-09 2005-04-07 Cell-free in vitro method of forming a covalent conjugate between an erythropoietin peptide and poly(ethylene glycol), pharmaceutical compositions comprising said covalent conjugate and use thereof in the preparation of medicaments for stimulating proliferation, differentiation and activation of myeloid progenitor cells

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
PCT/US2002/032263 WO2003031464A2 (en) 2001-10-10 2002-10-09 Remodeling and glycoconjugation of peptides
USPCT/US02/32263 2002-10-09
US10/287,994 2002-11-05
US10/287,994 US7138371B2 (en) 2001-10-10 2002-11-05 Remodeling and glycoconjugation of peptides
US36077003A 2003-01-06 2003-01-06
US10/360,770 2003-01-06
US36077903A 2003-02-19 2003-02-19
US10/360,779 2003-02-19
US10/410,945 2003-04-09
US10/410,945 US7214660B2 (en) 2001-10-10 2003-04-09 Erythropoietin: remodeling and glycoconjugation of erythropoietin

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US36077003A Continuation-In-Part 2001-10-10 2003-01-06
US36077903A Continuation-In-Part 2001-10-10 2003-02-19
US10/410,945 Continuation-In-Part US7214660B2 (en) 2001-10-10 2003-04-09 Erythropoietin: remodeling and glycoconjugation of erythropoietin

Publications (2)

Publication Number Publication Date
WO2004033651A2 WO2004033651A2 (en) 2004-04-22
WO2004033651A3 true WO2004033651A3 (en) 2006-03-30

Family

ID=37767763

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031974 WO2004033651A2 (en) 2001-10-10 2003-10-08 Erythropoietin: remodeling and glycoconjugation of erythropoietin

Country Status (7)

Country Link
US (3) US7214660B2 (en)
EP (1) EP1581622A4 (en)
JP (1) JP5413548B2 (en)
AU (1) AU2003287035B2 (en)
CA (1) CA2501832A1 (en)
MX (1) MXPA05003730A (en)
WO (1) WO2004033651A2 (en)

Cited By (3)

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US8716033B2 (en) 2006-02-10 2014-05-06 Life Technologies Corporation Oligosaccharide modification and labeling of proteins
US8840879B2 (en) 2004-03-11 2014-09-23 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
US8916518B2 (en) 2002-03-06 2014-12-23 Fresenius Kabi Deutschland Gmbh Coupling proteins to a modified polysaccharide

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US20060088906A1 (en) 2006-04-27
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CA2501832A1 (en) 2004-04-22
US8716240B2 (en) 2014-05-06
US20070042458A1 (en) 2007-02-22
AU2003287035A1 (en) 2004-05-04
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