WO2004032963A3 - Photokinetic delivery of biologically active substances using pulsed incoherent light - Google Patents

Photokinetic delivery of biologically active substances using pulsed incoherent light Download PDF

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Publication number
WO2004032963A3
WO2004032963A3 PCT/US2003/031532 US0331532W WO2004032963A3 WO 2004032963 A3 WO2004032963 A3 WO 2004032963A3 US 0331532 W US0331532 W US 0331532W WO 2004032963 A3 WO2004032963 A3 WO 2004032963A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically active
active substances
incoherent light
pulsed incoherent
cellular
Prior art date
Application number
PCT/US2003/031532
Other languages
French (fr)
Other versions
WO2004032963A2 (en
WO2004032963A9 (en
Inventor
Edward R Kraft
Gabriela Kulp
Original Assignee
Photokinetix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photokinetix Inc filed Critical Photokinetix Inc
Priority to EP03774568A priority Critical patent/EP1556061B1/en
Priority to DE60313353T priority patent/DE60313353T2/en
Priority to AU2003282683A priority patent/AU2003282683A1/en
Priority to CA2500713A priority patent/CA2500713C/en
Publication of WO2004032963A2 publication Critical patent/WO2004032963A2/en
Publication of WO2004032963A3 publication Critical patent/WO2004032963A3/en
Publication of WO2004032963A9 publication Critical patent/WO2004032963A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates generally to transdermal and transmembrane delivery of biologically active substances through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular membrane surface, tissue or membrane. The invention provides compositions and methods for enhanced transdermal and transmembrane delivery of biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods.
PCT/US2003/031532 2002-10-04 2003-10-03 Photokinetic delivery of biologically active substances using pulsed incoherent light WO2004032963A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03774568A EP1556061B1 (en) 2002-10-04 2003-10-03 Photokinetic delivery of biologically active substances using pulsed incoherent light
DE60313353T DE60313353T2 (en) 2002-10-04 2003-10-03 PHOTOKINETIC DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES USING PULSATIVE INKOHAERENTEM LIGHT.
AU2003282683A AU2003282683A1 (en) 2002-10-04 2003-10-03 Photokinetic delivery of biologically active substances using pulsed incoherent light
CA2500713A CA2500713C (en) 2002-10-04 2003-10-03 Photokinetic delivery of biologically active substances using pulsed incoherent light

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41636102P 2002-10-04 2002-10-04
US60/416,361 2002-10-04
US47950103P 2003-06-17 2003-06-17
US60/479,501 2003-06-17

Publications (3)

Publication Number Publication Date
WO2004032963A2 WO2004032963A2 (en) 2004-04-22
WO2004032963A3 true WO2004032963A3 (en) 2004-12-16
WO2004032963A9 WO2004032963A9 (en) 2005-04-28

Family

ID=32096146

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031532 WO2004032963A2 (en) 2002-10-04 2003-10-03 Photokinetic delivery of biologically active substances using pulsed incoherent light

Country Status (7)

Country Link
US (2) US7458982B2 (en)
EP (1) EP1556061B1 (en)
AT (1) ATE359802T1 (en)
AU (1) AU2003282683A1 (en)
CA (1) CA2500713C (en)
DE (1) DE60313353T2 (en)
WO (1) WO2004032963A2 (en)

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US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
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US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
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US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
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US7854753B2 (en) 2010-12-21
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