WO2004031749A3 - Spectroscopic analysis system and method - Google Patents

Spectroscopic analysis system and method Download PDF

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Publication number
WO2004031749A3
WO2004031749A3 PCT/US2003/030997 US0330997W WO2004031749A3 WO 2004031749 A3 WO2004031749 A3 WO 2004031749A3 US 0330997 W US0330997 W US 0330997W WO 2004031749 A3 WO2004031749 A3 WO 2004031749A3
Authority
WO
WIPO (PCT)
Prior art keywords
radiation
cavity
spectroscopic analysis
nucleic acid
analysis system
Prior art date
Application number
PCT/US2003/030997
Other languages
French (fr)
Other versions
WO2004031749A2 (en
Inventor
Andrew Berlin
Christopher Gerth
Tae-Woong Koo
Original Assignee
Intel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/262,349 external-priority patent/US8088628B2/en
Application filed by Intel Corp filed Critical Intel Corp
Priority to EP03774515A priority Critical patent/EP1546688A2/en
Priority to CN038233711A priority patent/CN1685217B/en
Priority to AU2003282896A priority patent/AU2003282896A1/en
Priority to JP2004541968A priority patent/JP4947900B2/en
Publication of WO2004031749A2 publication Critical patent/WO2004031749A2/en
Publication of WO2004031749A3 publication Critical patent/WO2004031749A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G01N2021/052—Tubular type; cavity type; multireflective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/655—Stimulated Raman
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Spectroscopic analysis systems and methods for analyzing samples are disclosed. An analysis system may contain an electromagnetic radiation source to provide radiation, a spectroscopic analysis chamber to perform a coherent Raman spectroscopy (e.g., stimulated Raman or coherent anti-Stokes Raman spectroscopy), and a radiation detector to detect radiation based on the spectroscopy. The chamber may have a resonant cavity to contain a sample for analysis, at least one window to the cavity to transmit the first radiation into the cavity and to transmit a second radiation out, a plurality of reflectors affixed to a housing of the cavity to reflect radiation of a predetermined frequency, the plurality of reflectors separated by a distance that is sufficient to resonate the radiation. The spectroscopic analysis system may be coupled with a nucleic acid sequencing system to receive a single nucleic acid derivative in solution and identify the derivative to sequence the nucleic acid.
PCT/US2003/030997 2002-09-30 2003-09-30 Spectroscopic analysis system and method WO2004031749A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03774515A EP1546688A2 (en) 2002-09-30 2003-09-30 Spectroscopic analysis system and method
CN038233711A CN1685217B (en) 2002-09-30 2003-09-30 Spectroscopic analysis system and method
AU2003282896A AU2003282896A1 (en) 2002-09-30 2003-09-30 Spectroscopic analysis system and method
JP2004541968A JP4947900B2 (en) 2002-09-30 2003-09-30 Spectroscopic analysis system and method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/262,349 2002-09-30
US10/262,349 US8088628B2 (en) 2002-09-30 2002-09-30 Stimulated and coherent anti-stokes raman spectroscopic methods for the detection of molecules
US10/675,884 2003-09-29
US10/675,884 US20040142484A1 (en) 2002-09-30 2003-09-29 Spectroscopic analysis system and method

Publications (2)

Publication Number Publication Date
WO2004031749A2 WO2004031749A2 (en) 2004-04-15
WO2004031749A3 true WO2004031749A3 (en) 2004-06-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030997 WO2004031749A2 (en) 2002-09-30 2003-09-30 Spectroscopic analysis system and method

Country Status (6)

Country Link
US (4) US20040142484A1 (en)
EP (1) EP1546688A2 (en)
JP (1) JP4947900B2 (en)
CN (1) CN1685217B (en)
AU (1) AU2003282896A1 (en)
WO (1) WO2004031749A2 (en)

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WO2004031749A2 (en) 2004-04-15
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US8513002B2 (en) 2013-08-20
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US8009288B2 (en) 2011-08-30
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