WO2004024328B1 - Method and apparatus for aligning elongated microbeads in order to interrogate the same - Google Patents
Method and apparatus for aligning elongated microbeads in order to interrogate the sameInfo
- Publication number
- WO2004024328B1 WO2004024328B1 PCT/US2003/028862 US0328862W WO2004024328B1 WO 2004024328 B1 WO2004024328 B1 WO 2004024328B1 US 0328862 W US0328862 W US 0328862W WO 2004024328 B1 WO2004024328 B1 WO 2004024328B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microbeads
- plate
- grooves
- code
- grating
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 63
- 239000011325 microbead Substances 0.000 title claims abstract 44
- 239000011324 bead Substances 0.000 claims abstract 13
- 230000003287 optical effect Effects 0.000 claims abstract 12
- 239000011521 glass Substances 0.000 claims abstract 8
- 239000000126 substance Substances 0.000 claims abstract 5
- 239000011295 pitch Substances 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005388 borosilicate glass Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 238000000708 deep reactive-ion etching Methods 0.000 claims 1
- 238000005530 etching Methods 0.000 claims 1
- 239000005350 fused silica glass Substances 0.000 claims 1
- 230000005484 gravity Effects 0.000 claims 1
- 238000001746 injection moulding Methods 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 abstract 2
Classifications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
- G03H1/02—Details of features involved during the holographic process; Replication of holograms without interference recording
- G03H1/0272—Substrate bearing the hologram
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00461—Beads and reaction vessel together
- B01J2219/00463—Directed sorting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/0047—Pins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00547—Bar codes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
- B01J2219/00572—Chemical means
- B01J2219/00576—Chemical means fluorophore
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0668—Trapping microscopic beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H2210/00—Object characteristics
- G03H2210/50—Nature of the object
- G03H2210/53—Coded object not directly interpretable, e.g. encrypted object, barcode
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H2230/00—Form or shape of the hologram when not registered to the substrate
- G03H2230/10—Microhologram not registered to the substrate
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H2270/00—Substrate bearing the hologram
- G03H2270/20—Shape
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
- G03H2270/00—Substrate bearing the hologram
- G03H2270/20—Shape
- G03H2270/24—Having particular size, e.g. microscopic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Abstract
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2003/028862 WO2004024328A1 (en) | 2002-09-12 | 2003-09-12 | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
EP03749663A EP1575707A1 (en) | 2002-09-12 | 2003-09-12 | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
CA2498933A CA2498933C (en) | 2002-09-12 | 2003-09-12 | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
US10/661,836 US7399643B2 (en) | 2002-09-12 | 2003-09-12 | Method and apparatus for aligning microbeads in order to interrogate the same |
AU2003267192A AU2003267192A1 (en) | 2002-09-12 | 2003-09-12 | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41054102P | 2002-09-12 | 2002-09-12 | |
US60/410,541 | 2002-09-12 | ||
US64568903A | 2003-08-20 | 2003-08-20 | |
US10/645,686 US20040075907A1 (en) | 2002-08-20 | 2003-08-20 | Diffraction grating-based encoded micro-particles for multiplexed experiments |
US10/645,686 | 2003-08-20 | ||
US10/645,689 | 2003-08-20 | ||
PCT/US2003/028862 WO2004024328A1 (en) | 2002-09-12 | 2003-09-12 | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004024328A1 WO2004024328A1 (en) | 2004-03-25 |
WO2004024328B1 true WO2004024328B1 (en) | 2004-06-03 |
Family
ID=39959537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/028862 WO2004024328A1 (en) | 2002-09-12 | 2003-09-12 | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
Country Status (5)
Country | Link |
---|---|
US (1) | US7399643B2 (en) |
EP (1) | EP1575707A1 (en) |
AU (1) | AU2003267192A1 (en) |
CA (1) | CA2498933C (en) |
WO (1) | WO2004024328A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7830575B2 (en) | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
US8049893B2 (en) | 2003-01-22 | 2011-11-01 | Illumina, Inc. | Methods of identifying analytes and using encoded particles |
US8333325B2 (en) | 2002-08-20 | 2012-12-18 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
US8565475B2 (en) | 2003-08-20 | 2013-10-22 | Illumina, Inc. | Optical system and method for reading encoded microbeads |
US8614852B2 (en) | 2002-08-20 | 2013-12-24 | Illumina, Inc. | Elongated microparticles having an optically detectable code configured to at least one of reflect or filter light |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7901630B2 (en) * | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
US7923260B2 (en) * | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
US20100255603A9 (en) * | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
JP4180964B2 (en) * | 2003-04-18 | 2008-11-12 | 日立ソフトウエアエンジニアリング株式会社 | Bead array structure, manufacturing method thereof, and bead array method of capillary bead array |
EP1673614A1 (en) * | 2003-10-01 | 2006-06-28 | CiDra Corporation | Optical reader for diffraction grating-based encoded optical identification elements |
US7433123B2 (en) * | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
US20050266432A1 (en) * | 2004-02-26 | 2005-12-01 | Illumina, Inc. | Haplotype markers for diagnosing susceptibility to immunological conditions |
US7951580B2 (en) | 2004-04-21 | 2011-05-31 | The Regents Of The University Of California | Automated, programmable, high throughput, multiplexed assay system for cellular and biological assays |
WO2006020363A2 (en) * | 2004-07-21 | 2006-02-23 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
JP4427411B2 (en) | 2004-07-28 | 2010-03-10 | 日立ソフトウエアエンジニアリング株式会社 | Bead array device and bead array method |
US20080144036A1 (en) | 2006-12-19 | 2008-06-19 | Asml Netherlands B.V. | Method of measurement, an inspection apparatus and a lithographic apparatus |
US7791727B2 (en) | 2004-08-16 | 2010-09-07 | Asml Netherlands B.V. | Method and apparatus for angular-resolved spectroscopic lithography characterization |
US7695954B2 (en) | 2004-10-04 | 2010-04-13 | The Regents Of The University Of California | Micropatterned plate with micro-pallets for addressable biochemical analysis |
RU2007116801A (en) * | 2004-10-04 | 2008-11-10 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния (Us) | STRUCTURED MICROTABLET WITH MICROPLATES FOR ADDRESSABLE BIOCHEMICAL ANALYSIS |
US20060134324A1 (en) * | 2004-11-17 | 2006-06-22 | Illumina, Inc. | Filament with easily removed protective coating and methods for stripping the same |
US20060172339A1 (en) * | 2004-11-29 | 2006-08-03 | Perkinelmer Las, Inc. | Particle-based multiplex assay for identifying glycosylation |
US8232092B2 (en) | 2005-08-09 | 2012-07-31 | Maxwell Sensors, Inc. | Apparatus and method for digital magnetic beads analysis |
US20090201504A1 (en) * | 2005-08-09 | 2009-08-13 | Maxwell Sensors, Inc. | Hydrodynamic focusing for analyzing rectangular microbeads |
US7329860B2 (en) | 2005-11-23 | 2008-02-12 | Illumina, Inc. | Confocal imaging methods and apparatus |
US7803751B2 (en) * | 2005-12-09 | 2010-09-28 | Illumina, Inc. | Compositions and methods for detecting phosphomonoester |
KR100709762B1 (en) * | 2005-12-22 | 2007-04-23 | 주식회사 대우일렉트로닉스 | Optical multiplexer and method for manufacturing thereof, method and apparatus for recording multiplexed optical information, method and apparatus for reproducing multiplexed optical information |
US20090104613A1 (en) * | 2005-12-23 | 2009-04-23 | Perkinelmer Las, Inc. | Methods and compositions relating to multiplexed genomic gain and loss assays |
WO2007075910A2 (en) * | 2005-12-23 | 2007-07-05 | Perkinelmer Las, Inc. | Methods and compositions for detecting enzymatic activity |
BRPI0620420B1 (en) | 2005-12-23 | 2016-08-09 | Perkinelmer Las Inc | method to evaluate genomic DNA |
EP1969337A4 (en) * | 2005-12-23 | 2010-01-27 | Perkinelmer Las Inc | Multiplex assays using magnetic and non-magnetic particles |
US7932037B2 (en) * | 2007-12-05 | 2011-04-26 | Perkinelmer Health Sciences, Inc. | DNA assays using amplicon probes on encoded particles |
US20100009373A1 (en) * | 2005-12-23 | 2010-01-14 | Perkinelmer Health Sciences, Inc. | Methods and compositions relating to multiplex genomic gain and loss assays |
US7914988B1 (en) | 2006-03-31 | 2011-03-29 | Illumina, Inc. | Gene expression profiles to predict relapse of prostate cancer |
KR101087809B1 (en) | 2006-04-10 | 2011-11-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Systems for collection of single cells and colonies |
US7550271B2 (en) * | 2006-04-28 | 2009-06-23 | Perkinelmer Las, Inc. | Detecting phospho-transfer activity |
AU2007323920B2 (en) * | 2006-11-13 | 2013-09-19 | Perkinelmer Health Sciences, Inc. | Detecting molecular interactions |
US20080242560A1 (en) * | 2006-11-21 | 2008-10-02 | Gunderson Kevin L | Methods for generating amplified nucleic acid arrays |
US8288110B2 (en) * | 2006-12-04 | 2012-10-16 | Perkinelmer Health Sciences, Inc. | Biomarkers for detecting cancer |
US20080241831A1 (en) * | 2007-03-28 | 2008-10-02 | Jian-Bing Fan | Methods for detecting small RNA species |
US20080279874A1 (en) * | 2007-05-07 | 2008-11-13 | Wyeth | Compositions and methods for modulation of plk1 kinase activity |
JP5719591B2 (en) | 2007-06-08 | 2015-05-20 | バイオジェン アイデック エムエー インコーポレイティドBiogen Idec Inc. | Biomarker for predicting anti-TNF responsiveness or non-responsiveness |
US8748085B2 (en) | 2007-07-25 | 2014-06-10 | The Regents Of The University Of California | Use of photosensitized Epon epoxy resin 1002F for MEMS and bioMEMS applications |
US9487745B2 (en) | 2007-07-27 | 2016-11-08 | The Regents Of The University Of California | Micro-patterned plate composed of an array of releasable elements surrounded with solid or gel walls |
CN102341693B (en) | 2009-03-07 | 2013-11-20 | 惠普开发有限公司 | Analyzer and method for sensing using the same |
US20110046009A1 (en) * | 2009-08-24 | 2011-02-24 | Perkinelmer Health Sciences, Inc. | Methods for detecting dna methylation using encoded particles |
US8717172B2 (en) * | 2009-09-09 | 2014-05-06 | Absolute Software Corporation | Alert for real-time risk of theft or loss |
CN102630250A (en) | 2009-09-25 | 2012-08-08 | 基因诊断测试公司 | Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases |
US8524450B2 (en) * | 2009-10-30 | 2013-09-03 | Illumina, Inc. | Microvessels, microparticles, and methods of manufacturing and using the same |
US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
US9216412B2 (en) | 2009-11-23 | 2015-12-22 | Cyvek, Inc. | Microfluidic devices and methods of manufacture and use |
JP5701894B2 (en) | 2009-11-23 | 2015-04-15 | サイヴェク・インコーポレイテッド | Method and apparatus for performing an assay |
US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
ES2596655T3 (en) | 2010-02-01 | 2017-01-11 | Illumina Inc. | Focusing procedures and optical systems and assemblies that use them |
US10273544B2 (en) | 2010-02-11 | 2019-04-30 | Dana-Farber Cancer Institute, Inc. | Methods for predicting likelihood of responding to treatment |
US8481903B2 (en) * | 2010-03-06 | 2013-07-09 | Alexander Triener | Systems, methods, and apparatuses including a moveable optical component for detecting optical signals from a sample |
US8951781B2 (en) | 2011-01-10 | 2015-02-10 | Illumina, Inc. | Systems, methods, and apparatuses to image a sample for biological or chemical analysis |
WO2012170936A2 (en) | 2011-06-09 | 2012-12-13 | Illumina, Inc. | Patterned flow-cells useful for nucleic acid analysis |
US9566560B2 (en) | 2011-10-06 | 2017-02-14 | Illumina, Inc. | Array domains having rotated patterns |
WO2013063382A2 (en) | 2011-10-28 | 2013-05-02 | Illumina, Inc. | Microarray fabrication system and method |
EP2822688B1 (en) | 2012-03-08 | 2019-09-25 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
EP2978860B8 (en) | 2013-03-27 | 2019-12-11 | BlueGnome Ltd | Assessment of risk of aneuploidy |
KR102122932B1 (en) * | 2013-08-08 | 2020-06-15 | 삼성전기주식회사 | Multi-layered ceramic capacitor and board for mounting the same |
WO2015109234A1 (en) | 2014-01-16 | 2015-07-23 | Illumina, Inc. | Gene expression panel for prognosis of prostate cancer recurrence |
CN104035152B (en) * | 2014-06-06 | 2016-05-25 | 上海大学 | A kind of method of utilizing droplet ejection technology to make micro-nano grating |
EP4089398A1 (en) | 2015-03-24 | 2022-11-16 | Illumina, Inc. | Carrier assemblies and systems for imaging samples for biological or chemical analysis |
WO2016156576A1 (en) | 2015-04-02 | 2016-10-06 | Hmnc Value Gmbh | Method of treatment using genetic predictors of a response to treatment with crhr1 antagonists |
ES2724100T3 (en) | 2015-04-02 | 2019-09-06 | HMNC Diagnostics GmbH | Genetic prediction factors of a response to treatment with CRHR1 antagonists |
WO2016196210A2 (en) | 2015-05-29 | 2016-12-08 | Illumina, Inc. | Sample carrier and assay system for conducting designated reactions |
WO2017034868A1 (en) | 2015-08-24 | 2017-03-02 | Illumina, Inc. | In-line pressure accumulator and flow-control system for biological or chemical assays |
CN105326572B (en) * | 2015-11-04 | 2017-08-29 | 庄源东 | A kind of surgical laser alignment system guide device |
US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
WO2018064116A1 (en) | 2016-09-28 | 2018-04-05 | Illumina, Inc. | Methods and systems for data compression |
USD832457S1 (en) * | 2017-01-10 | 2018-10-30 | Musculoskeletal Transplant Foundation | Tissue graft retainer |
US11375710B2 (en) | 2017-01-10 | 2022-07-05 | Musculoskeletal Transplant Foundation | Packaging system for tissue grafts |
US10695157B2 (en) | 2017-01-10 | 2020-06-30 | Musculoskeletal Transplant Foundation | Packaging system for tissue grafts |
WO2018136117A1 (en) | 2017-01-20 | 2018-07-26 | Omniome, Inc. | Allele-specific capture of nucleic acids |
EP3565900B1 (en) | 2017-01-20 | 2021-04-07 | Omniome, Inc. | Genotyping by polymerase binding |
US11492666B2 (en) | 2017-02-15 | 2022-11-08 | Pacific Biosciences Of California, Inc. | Distinguishing sequences by detecting polymerase dissociation |
US10161003B2 (en) | 2017-04-25 | 2018-12-25 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
US11408885B2 (en) | 2017-08-31 | 2022-08-09 | Massachusetts Institute Of Technology | Compositions and multiplex assays for characterizing active proteases and their inhibitors |
USD864414S1 (en) | 2017-10-03 | 2019-10-22 | Musculoskeletal Transplant Foundation | Tissue graft retainer |
US10582994B2 (en) | 2018-03-06 | 2020-03-10 | Musculoskeletal Transplant Foundation | Implant packaging assembly |
US10400272B1 (en) | 2018-04-26 | 2019-09-03 | Omniome, Inc. | Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes |
CA3101337A1 (en) | 2018-05-31 | 2019-12-05 | Omniome, Inc. | Increased signal to noise in nucleic acid sequencing |
AU2019312152A1 (en) | 2018-07-24 | 2021-02-18 | Pacific Biosciences Of California, Inc. | Serial formation of ternary complex species |
GB2574746B (en) | 2018-09-17 | 2020-06-03 | Omniome Inc | Engineered polymerases for improved sequencing |
GB2578528B (en) | 2018-12-04 | 2021-02-24 | Omniome Inc | Mixed-phase fluids for nucleic acid sequencing and other analytical assays |
US11499189B2 (en) | 2019-02-14 | 2022-11-15 | Pacific Biosciences Of California, Inc. | Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes |
US11377655B2 (en) | 2019-07-16 | 2022-07-05 | Pacific Biosciences Of California, Inc. | Synthetic nucleic acids having non-natural structures |
EP4028407B1 (en) | 2019-09-10 | 2023-08-16 | Pacific Biosciences of California, Inc. | Reversible modification of nucleotides |
CN114599795A (en) | 2019-10-18 | 2022-06-07 | 加利福尼亚太平洋生物科学股份有限公司 | Methods and compositions for capping nucleic acids |
WO2021092431A1 (en) | 2019-11-08 | 2021-05-14 | Omniome, Inc. | Engineered polymerases for improved sequencing by binding |
CN115243792A (en) | 2020-02-04 | 2022-10-25 | 加利福尼亚太平洋生物科学股份有限公司 | Flow cell and methods of making and using the same |
CA3173798A1 (en) | 2020-03-03 | 2021-09-10 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing double stranded nucleic acids |
WO2021209463A1 (en) | 2020-04-14 | 2021-10-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for detecting the presence of coronavirus-specific antibodies in a subject |
EP4146822A1 (en) | 2020-05-05 | 2023-03-15 | Pacific Biosciences of California, Inc. | Compositions and methods for modifying polymerase-nucleic acid complexes |
USD954993S1 (en) | 2020-06-17 | 2022-06-14 | Musculoskeletal Transplant Foundation | Tissue graft retainer |
WO2022043415A1 (en) | 2020-08-27 | 2022-03-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for detecting the presence of pemphigus-specific autoantibodies in a sample |
US20230215515A1 (en) | 2021-12-23 | 2023-07-06 | Illumina Software, Inc. | Facilitating secure execution of external workflows for genomic sequencing diagnostics |
WO2023122363A1 (en) | 2021-12-23 | 2023-06-29 | Illumina Software, Inc. | Dynamic graphical status summaries for nucelotide sequencing |
WO2023129764A1 (en) | 2021-12-29 | 2023-07-06 | Illumina Software, Inc. | Automatically switching variant analysis model versions for genomic analysis applications |
Family Cites Families (173)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3916182A (en) | 1972-08-21 | 1975-10-28 | Western Electric Co | Periodic dielectric waveguide filter |
FR2197495A5 (en) | 1972-08-25 | 1974-03-22 | Thomson Csf | |
US3891302A (en) | 1973-09-28 | 1975-06-24 | Western Electric Co | Method of filtering modes in optical waveguides |
US4011435A (en) | 1974-02-01 | 1977-03-08 | Ncr Corporation | Optical indicia marking and detection system |
US3968476A (en) | 1974-07-17 | 1976-07-06 | Sperry Rand Corporation | Spurious signal removal in optical processor fingerprint identification apparatus |
SE388694B (en) | 1975-01-27 | 1976-10-11 | Kabi Ab | WAY TO PROVIDE AN ANTIGEN EXV IN SAMPLES OF BODY WHEATS, USING POROST BERAR MATERIAL BONDED OR ADSORBING ANTIBODIES |
US4053433A (en) * | 1975-02-19 | 1977-10-11 | Minnesota Mining And Manufacturing Company | Method of tagging with color-coded microparticles |
US4023010A (en) | 1975-09-08 | 1977-05-10 | Ncr Corporation | Optical identification system and reader for reading optical gratings on a record medium |
US4053228A (en) | 1975-12-12 | 1977-10-11 | Michael Schiller | Finger identification |
DE2648180C2 (en) | 1976-02-18 | 1978-09-07 | Hoechst Ag, 6000 Frankfurt | Device for checking the authenticity of an identity carrier |
US4301139A (en) | 1979-06-21 | 1981-11-17 | Ames-Yissum Ltd. | Multilayer column chromatography specific binding assay method, test device and test kit |
DE3009404A1 (en) | 1980-03-12 | 1981-09-17 | Philips Patentverwaltung Gmbh, 2000 Hamburg | DEVICE FOR ADJUSTING A MOVABLE ELECTROACUTIC SOUND TRANSDUCER |
EP0047326B1 (en) | 1980-08-21 | 1984-10-31 | International Business Machines Corporation | Identification card comprising information in holographic form |
US4386274A (en) | 1980-11-10 | 1983-05-31 | Saul Altshuler | Isotope separation by standing waves |
DE3166630D1 (en) | 1981-02-03 | 1984-11-15 | Landis & Gyr Ag | Method for preventing the sucessful forgery of documents and device therefor |
US4447546A (en) | 1982-08-23 | 1984-05-08 | Myron J. Block | Fluorescent immunoassay employing optical fiber in capillary tube |
CA1237645A (en) | 1982-12-21 | 1988-06-07 | John H. Fisher | Assay technique |
US4937048A (en) | 1983-01-31 | 1990-06-26 | Olympus Optical Company Limited | Carrier transporting apparatus and carrier container for use in an immunological analysis |
GB8314523D0 (en) | 1983-05-25 | 1983-06-29 | Lowe C R | Diagnostic device |
DE3484505D1 (en) | 1983-12-19 | 1991-05-29 | Daiichi Pure Chemicals Co Ltd | IMMUNTEST. |
US4560881A (en) | 1984-03-13 | 1985-12-24 | Syntex (U.S.A.) Inc. | Method and apparatus for enhanced detection of electromagnetic signals |
IL75020A (en) * | 1984-05-10 | 1988-10-31 | Abbott Lab | Biotin-antibiotin immunoassay for the detection of ligands |
USRE33581E (en) | 1984-06-25 | 1991-04-30 | Immunoassay using optical interference detection | |
US4647544A (en) | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
EP0191063B1 (en) | 1984-08-13 | 1992-05-13 | United Technologies Corporation | Method for impressing grating within fiber optics |
GB8423204D0 (en) | 1984-09-14 | 1984-10-17 | Comtech Res Unit | Assay technique and equipment |
US4740468A (en) | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
GB8509492D0 (en) | 1985-04-12 | 1985-05-15 | Plessey Co Plc | Optical assay |
US4701754A (en) * | 1985-04-18 | 1987-10-20 | Fmc Corporation | Indicator device for substance receiving wells in a microtiter plate |
US4685480A (en) | 1985-08-30 | 1987-08-11 | Abbott Laboratories | Combined washer and aspirator |
US4716121A (en) | 1985-09-09 | 1987-12-29 | Ord, Inc. | Fluorescent assays, including immunoassays, with feature of flowing sample |
US4748110A (en) | 1985-09-25 | 1988-05-31 | Abbott Laboratories | Immunoassay for HTLV-III antigens |
US4678752A (en) | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
US4958376A (en) | 1985-12-27 | 1990-09-18 | Grumman Aerospace Corporation | Robotic vision, optical correlation system |
US5160701A (en) | 1986-02-18 | 1992-11-03 | Abbott Laboratories | Solid-phase analytical device and method for using same |
US4740688A (en) | 1986-03-20 | 1988-04-26 | Smiths Industries Public Limited Company | Optical transducers with wavelength coding |
GB8607975D0 (en) * | 1986-04-01 | 1986-05-08 | Fisons Plc | Devices |
GB8612221D0 (en) | 1986-05-20 | 1986-06-25 | Amersham Int Plc | Assaying species in sample |
US5143853A (en) | 1986-06-25 | 1992-09-01 | Trustees Of Tufts College | Absorbance modulated fluorescence detection methods and sensors |
US5114864A (en) | 1986-06-25 | 1992-05-19 | Trustees Of Tufts College | Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations |
US4822746A (en) | 1986-06-25 | 1989-04-18 | Trustees Of Tufts College | Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors |
GB8618133D0 (en) | 1986-07-24 | 1986-09-03 | Pa Consulting Services | Biosensors |
US5030558A (en) | 1986-11-07 | 1991-07-09 | Syntex (U.S.A.) Inc. | Qualitative immunochromatographic method and device |
US5141848A (en) | 1987-01-21 | 1992-08-25 | Abbott Laboratories | Confirmatory immunoassay using microparticle separation |
GB8705649D0 (en) | 1987-03-10 | 1987-04-15 | Pa Consulting Services | Assay sensor |
GB8713649D0 (en) | 1987-06-11 | 1987-07-15 | Pa Consulting Services | Biological assay |
SE458968B (en) | 1987-06-16 | 1989-05-22 | Wallac Oy | BIOSPECIFIC ANALYTICAL PROCEDURE FOR MULTIPLE ANALYTICS WHICH DO NOT INCLUDE PARTICULAR COATING AND LABELING WITH FLUORESCING LABEL SUBSTANCES |
US4921805A (en) | 1987-07-29 | 1990-05-01 | Life Technologies, Inc. | Nucleic acid capture method |
AU604364B2 (en) | 1987-08-13 | 1990-12-13 | Dow Chemical Company, The | Sulfur dioxide removal from gas streams using hydroxyalkyl substituted piperazinones |
US4816659A (en) | 1987-10-13 | 1989-03-28 | Control Module Inc. | Bar code reader head |
US4841140A (en) | 1987-11-09 | 1989-06-20 | Honeywell Inc. | Real-time color comparator |
DE3905481C2 (en) | 1988-02-23 | 2003-01-09 | Sony Corp | Method and device for optical data traffic |
GB8807486D0 (en) | 1988-03-29 | 1988-05-05 | Ares Serono Res & Dev Ltd | Waveguide sensor |
US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
US5166813A (en) | 1988-05-31 | 1992-11-24 | Nygene Corporation | Optical evaluation using a hologram barrier filter |
US5089387A (en) | 1988-07-07 | 1992-02-18 | Adeza Biomedical Corporation | Dna probe diffraction assay and reagents |
US5033826A (en) | 1989-03-27 | 1991-07-23 | Hewlett-Packard Company | High temporal resolution optical instrument |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5003600A (en) | 1989-08-03 | 1991-03-26 | The United States Of America As Represented By The Department Of Energy | Diffraction gratings used as identifying markers |
US5291006A (en) | 1989-08-11 | 1994-03-01 | Nhk Spring Co., Ltd. | Authenticity identifying system for information storage cards |
US5200794A (en) | 1989-08-11 | 1993-04-06 | Nhk Spring Co., Ltd. | Optical head for an optical authenticity identifing system |
US5442433A (en) | 1989-08-11 | 1995-08-15 | Nhk Spring Co., Ltd. | Identification system for an article having individually attached patches |
US5095194A (en) | 1989-10-12 | 1992-03-10 | Joseph Barbanell | Holographic credit card with automatical authentication and verification |
US5065008A (en) | 1989-10-18 | 1991-11-12 | Fuji Photo Film Co., Ltd. | Scanning microscope and scanning mechanism for the same |
US5115121A (en) | 1990-01-05 | 1992-05-19 | Control Module Inc. | Variable-sweep bar code reader |
US5090807A (en) | 1990-01-10 | 1992-02-25 | Environmental Research Institute Of Michigan | Real time optical pre-detection processing of multispectral image data |
US5138468A (en) | 1990-02-02 | 1992-08-11 | Dz Company | Keyless holographic lock |
JPH0834003B2 (en) | 1990-03-08 | 1996-03-29 | 直弘 丹野 | Optical waveguide storage medium and optical reproducing device |
EP0455067B1 (en) | 1990-05-03 | 2003-02-26 | F. Hoffmann-La Roche Ag | Micro-optical sensor |
US5067155A (en) | 1990-05-09 | 1991-11-19 | Control Module Inc. | Method and means to limit access to computer systems |
EP0745689A3 (en) | 1990-05-11 | 1996-12-11 | Microprobe Corporation | A dipstick for a nucleic acid hybridization assay |
GB9014263D0 (en) | 1990-06-27 | 1990-08-15 | Dixon Arthur E | Apparatus and method for spatially- and spectrally- resolvedmeasurements |
US5129974A (en) | 1990-08-23 | 1992-07-14 | Colorcode Unlimited Corporation | Microlabelling system and method of making thin labels |
US5239178A (en) | 1990-11-10 | 1993-08-24 | Carl Zeiss | Optical device with an illuminating grid and detector grid arranged confocally to an object |
US5105305A (en) | 1991-01-10 | 1992-04-14 | At&T Bell Laboratories | Near-field scanning optical microscope using a fluorescent probe |
US5244636A (en) | 1991-01-25 | 1993-09-14 | Trustees Of Tufts College | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
US5104209A (en) | 1991-02-19 | 1992-04-14 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Communications | Method of creating an index grating in an optical fiber and a mode converter using the index grating |
US5367588A (en) | 1992-10-29 | 1994-11-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Communications | Method of fabricating Bragg gratings using a silica glass phase grating mask and mask used by same |
DE4111903A1 (en) | 1991-04-12 | 1992-10-15 | Bayer Ag | SPECTROSCOPY-CORRECTED LIGHT-SCREEN MICROSCOPY |
JP2769393B2 (en) | 1991-04-26 | 1998-06-25 | 直弘 丹野 | 3D optical recording device |
US5196350A (en) | 1991-05-29 | 1993-03-23 | Omnigene, Inc. | Ligand assay using interference modulation |
US5144461A (en) | 1991-06-20 | 1992-09-01 | Horan Philip R | Portable holographic recording apparatus |
US5627040A (en) * | 1991-08-28 | 1997-05-06 | Becton Dickinson And Company | Flow cytometric method for autoclustering cells |
JP2561186B2 (en) | 1991-09-11 | 1996-12-04 | 日本発条株式会社 | Object identification structure |
US5349442A (en) | 1991-09-20 | 1994-09-20 | Eg&G Idaho, Inc. | Hand held phase-shifting diffraction moire interferometer |
US5465176A (en) | 1991-12-19 | 1995-11-07 | Control Module Inc. | Method of embossing repeating patterns on a substrate, the patterns having different rates of repetition |
US5742432A (en) * | 1991-12-19 | 1998-04-21 | Bianco; James S. | Apparatus for manufacture of diffraction gratings for identification means |
WO1993012506A1 (en) | 1991-12-19 | 1993-06-24 | Control Module Inc. | Secure optomagnetic identification |
US5432329A (en) | 1992-02-07 | 1995-07-11 | American Bank Note Holographics | Automated holographic optical recognition and decoding system for verification |
US5374818A (en) | 1992-03-09 | 1994-12-20 | Control Module Inc. | Identification means with integral memory device |
US5376313A (en) | 1992-03-27 | 1994-12-27 | Abbott Laboratories | Injection molding a plastic assay cuvette having low birefringence |
WO2004099881A1 (en) * | 1992-04-24 | 2004-11-18 | Keishi Saitoh | Photoreceptor member |
DE69321548T2 (en) * | 1992-05-01 | 1999-04-15 | Sumitomo Electric Industries | METHOD FOR IDENTIFYING AN OPTICAL LINE |
US5291027A (en) | 1992-07-08 | 1994-03-01 | Toppan Printing Co., Ltd. | Optical identification multiple diffraction grating mark member and card using the same |
US5372783A (en) | 1992-08-03 | 1994-12-13 | Sapidyne, Inc. | Assay system |
US5342790A (en) | 1992-10-30 | 1994-08-30 | Becton Dickinson And Company | Apparatus for indirect fluorescent assay of blood samples |
DE69407628T2 (en) | 1993-02-01 | 1998-08-27 | Matsushita Electric Ind Co Ltd | Waveguide image transmission device and fingerprint identification device |
US5364797A (en) | 1993-05-20 | 1994-11-15 | Mobil Oil Corp. | Sensor device containing mesoporous crystalline material |
US20020197456A1 (en) * | 1993-06-30 | 2002-12-26 | Pope Edward J. A. | Integrated electro-luminescent biochip |
EP0644508B1 (en) * | 1993-08-31 | 1999-12-22 | Control Module, Inc. | Secure optical identification method and means |
US5426297A (en) | 1993-09-27 | 1995-06-20 | United Technologies Corporation | Multiplexed Bragg grating sensors |
US5352582A (en) | 1993-10-28 | 1994-10-04 | Hewlett-Packard Company | Holographic based bio-assay |
US5610287A (en) * | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
US5388173A (en) | 1993-12-20 | 1995-02-07 | United Technologies Corporation | Method and apparatus for forming aperiodic gratings in optical fibers |
JPH07210071A (en) * | 1994-01-25 | 1995-08-11 | Nhk Spring Co Ltd | Discrimination system for object |
US5461475A (en) | 1994-02-02 | 1995-10-24 | Physical Optics Corporation | Binary optical spectrum analyzer |
US5468649A (en) | 1994-02-15 | 1995-11-21 | Abbott Laboratories | Process for labeling acridinium to microparticles and application in an instrument |
US5682244A (en) * | 1994-03-25 | 1997-10-28 | Barlow; Clyde H. | Automated optical detection of tissue perfusion by microspheres |
US5607188A (en) * | 1994-06-24 | 1997-03-04 | Imation Corp. | Marking of optical disc for customized identification |
US5712912A (en) * | 1995-07-28 | 1998-01-27 | Mytec Technologies Inc. | Method and apparatus for securely handling a personal identification number or cryptographic key using biometric techniques |
US5528045A (en) | 1995-04-06 | 1996-06-18 | Becton Dickinson And Company | Particle analyzer with spatially split wavelength filter |
US6025129A (en) * | 1995-04-25 | 2000-02-15 | Irori | Remotely programmable matrices with memories and uses thereof |
US6340588B1 (en) * | 1995-04-25 | 2002-01-22 | Discovery Partners International, Inc. | Matrices with memories |
US5874214A (en) * | 1995-04-25 | 1999-02-23 | Irori | Remotely programmable matrices with memories |
US6352854B1 (en) * | 1995-04-25 | 2002-03-05 | Discovery Partners International, Inc. | Remotely programmable matrices with memories |
US6017754A (en) * | 1995-08-24 | 2000-01-25 | Invitrogen Corporation | System for isolating and identifying eukaryotic cells transfected with genes and vectors, host cells and methods thereof |
US5633724A (en) * | 1995-08-29 | 1997-05-27 | Hewlett-Packard Company | Evanescent scanning of biochemical array |
DE69638321D1 (en) * | 1995-10-11 | 2011-03-03 | Luminex Corp | SIMULTANEOUS MULTI-ANALYSIS OF CLINICAL SAMPLES |
US5736330A (en) * | 1995-10-11 | 1998-04-07 | Luminex Corporation | Method and compositions for flow cytometric determination of DNA sequences |
WO1997014983A1 (en) * | 1995-10-16 | 1997-04-24 | Sumitomo Electric Industries, Ltd. | Optical fiber diffraction grating, production method thereof and laser light source |
US5633975A (en) * | 1995-11-14 | 1997-05-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Security system responsive to optical fiber having Bragg grating |
EP0876251B1 (en) * | 1995-12-05 | 2000-08-02 | Sherbrooke Securities Limited | Charge card |
NL1001876C2 (en) * | 1995-12-12 | 1997-06-17 | Ing Groep Nv | Method for affixing a security badge to an object, such as a bank card, credit card, ID or part of an engine or machine. |
US5729365A (en) * | 1996-01-11 | 1998-03-17 | Sandia Corporation | Computer generated holographic microtags |
GB9602542D0 (en) * | 1996-02-08 | 1996-04-10 | Fisons Plc | Analytical device |
US6355198B1 (en) * | 1996-03-15 | 2002-03-12 | President And Fellows Of Harvard College | Method of forming articles including waveguides via capillary micromolding and microtransfer molding |
US5721435A (en) * | 1996-04-09 | 1998-02-24 | Hewlett Packard Company | Methods and apparatus for measuring optical properties of biological and chemical substances |
BR9710836A (en) * | 1996-04-25 | 2000-10-24 | Spectrametrix Inc | Analyte assay using particle marks |
CA2259254C (en) * | 1996-07-08 | 2008-02-19 | Animas Corporation | Implantable sensor and system for in vivo measurement and control of fluid constituent levels |
US5874187A (en) * | 1996-08-15 | 1999-02-23 | Lucent Technologies Incorporated | Photo recording medium |
US6027694A (en) * | 1996-10-17 | 2000-02-22 | Texperts, Inc. | Spillproof microplate assembly |
GB9703078D0 (en) * | 1997-02-14 | 1997-04-02 | Univ Southampton | Optical fibre and optical fibre device |
DE19707227A1 (en) * | 1997-02-24 | 1998-08-27 | Bodenseewerk Perkin Elmer Co | Light scanner |
HUP0003152A3 (en) * | 1997-02-28 | 2002-09-30 | Burstein Lab Inc Irvine | Laboratory in a disk |
US6692912B1 (en) * | 1997-03-05 | 2004-02-17 | Matrix Technologies Corporation | Nucleic acid-containing polymerizable complex |
US6542673B1 (en) * | 1997-03-13 | 2003-04-01 | Cirrex Corp. | Identifier system and components for optical assemblies |
US6046925A (en) * | 1997-04-14 | 2000-04-04 | The Regents Of The University Of California | Photochromic fluorescent proteins and optical memory storage devices based on fluorescent proteins |
CH693517A5 (en) * | 1997-06-06 | 2003-09-15 | Ovd Kinegram Ag | Surface pattern. |
US6096496A (en) * | 1997-06-19 | 2000-08-01 | Frankel; Robert D. | Supports incorporating vertical cavity emitting lasers and tracking apparatus for use in combinatorial synthesis |
US6174648B1 (en) * | 1997-07-08 | 2001-01-16 | Oki Electric Industry Co., Ltd. | Optical filter fabrication method using fiber holder with spiral groove and phase mask with spiral diffraction grating |
US6043880A (en) * | 1997-09-15 | 2000-03-28 | Becton Dickinson And Company | Automated optical reader for nucleic acid assays |
ATE220465T1 (en) * | 1997-10-29 | 2002-07-15 | Calum E Macaulay | APPARATUS AND METHOD FOR MICROSCOPY USING SPACIALLY MODULATED LIGHT |
US6060256A (en) * | 1997-12-16 | 2000-05-09 | Kimberly-Clark Worldwide, Inc. | Optical diffraction biosensor |
JPH11235536A (en) * | 1998-02-23 | 1999-08-31 | Takeda Chem Ind Ltd | Bead separator |
US6560017B1 (en) * | 1998-03-02 | 2003-05-06 | James S. Bianco | Compound secure optical identification method and means |
US6035082A (en) * | 1998-03-16 | 2000-03-07 | Luna Innovations, Inc. | Process for preparing an optical fiber sensor with enhanced sensitivity |
US6242056B1 (en) * | 1998-05-08 | 2001-06-05 | Innovative Concepts Unlimited, Llc | Process for applying light-emission-enhancement microbead paint compositions |
GB9811655D0 (en) * | 1998-05-29 | 1998-07-29 | Univ Cambridge Tech | Methods and materials for producing holographic sensors |
US5907407A (en) * | 1998-08-10 | 1999-05-25 | Innovative Lasers Corporation | ILS sensors for alcohol detection within vehicles |
GB9820163D0 (en) * | 1998-09-17 | 1998-11-11 | Sentec Ltd | Micro-fabricated coded labels, reading systems and their applications |
US6221579B1 (en) * | 1998-12-11 | 2001-04-24 | Kimberly-Clark Worldwide, Inc. | Patterned binding of functionalized microspheres for optical diffraction-based biosensors |
US6194563B1 (en) * | 1999-03-26 | 2001-02-27 | Vysis, Inc. | Solid phase nucleic acid labeling by transamination |
WO2000061198A1 (en) * | 1999-04-12 | 2000-10-19 | Hitachi Chemical Co., Ltd. | Method of producing probe arrays for biological materials using fine particles |
US6908737B2 (en) * | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
US6371370B2 (en) * | 1999-05-24 | 2002-04-16 | Agilent Technologies, Inc. | Apparatus and method for scanning a surface |
US6356681B1 (en) * | 1999-07-09 | 2002-03-12 | Corning Incorporated | Method and apparatus for trimming the optical path length of optical fiber components |
US6660147B1 (en) * | 1999-07-16 | 2003-12-09 | Applera Corporation | High density electrophoresis device and method |
EP1206577B1 (en) * | 1999-08-13 | 2006-03-01 | Yale University | Binary encoded sequence tags |
US6874639B2 (en) * | 1999-08-23 | 2005-04-05 | Spectra Systems Corporation | Methods and apparatus employing multi-spectral imaging for the remote identification and sorting of objects |
US20020006664A1 (en) * | 1999-09-17 | 2002-01-17 | Sabatini David M. | Arrayed transfection method and uses related thereto |
EP2365096A1 (en) * | 2000-03-22 | 2011-09-14 | Life Technologies Corporation | Methods of using semiconductor nanocrystals in bead-based nucleic acid assays |
US6759235B2 (en) * | 2000-04-06 | 2004-07-06 | Quantum Dot Corporation | Two-dimensional spectral imaging system |
US6533183B2 (en) * | 2000-05-03 | 2003-03-18 | Novo Nordisk A/S | Coding of cartridges for an injection device |
DE60134849D1 (en) * | 2000-05-19 | 2008-08-28 | Aclara Biosciences Inc | ORIENTATION OF AN OPTICAL DETECTION SYSTEM WITH A CAPILLARY CHANNEL IN A MICROFLUID LABORATORY CHIP |
WO2001090225A1 (en) * | 2000-05-22 | 2001-11-29 | Kabushiki Kaisya Advance | Novel method for forming polymer pattern |
WO2001091814A2 (en) * | 2000-05-30 | 2001-12-06 | Viridis Biotech Inc. | Polyubiquitin based hydrogel and uses thereof |
US6481364B2 (en) * | 2000-07-21 | 2002-11-19 | James Woyjeck | Anchoring device and methods of use |
US6545758B1 (en) * | 2000-08-17 | 2003-04-08 | Perry Sandstrom | Microarray detector and synthesizer |
US20030082568A1 (en) * | 2000-11-27 | 2003-05-01 | Phan Brigitte Chau | Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets |
US6522406B1 (en) * | 2001-04-20 | 2003-02-18 | Nanometrics Incorporated | Correcting the system polarization sensitivity of a metrology tool having a rotatable polarizer |
EP1430335B1 (en) * | 2001-08-27 | 2017-01-11 | Steyphi Services DE LLC | Amplitude and phase control in distributed optical structures |
US7335153B2 (en) * | 2001-12-28 | 2008-02-26 | Bio Array Solutions Ltd. | Arrays of microparticles and methods of preparation thereof |
US8765484B2 (en) * | 2002-02-07 | 2014-07-01 | The Regents Of The University Of California | Optically encoded particles |
-
2003
- 2003-09-12 WO PCT/US2003/028862 patent/WO2004024328A1/en not_active Application Discontinuation
- 2003-09-12 US US10/661,836 patent/US7399643B2/en active Active
- 2003-09-12 CA CA2498933A patent/CA2498933C/en not_active Expired - Lifetime
- 2003-09-12 EP EP03749663A patent/EP1575707A1/en not_active Withdrawn
- 2003-09-12 AU AU2003267192A patent/AU2003267192A1/en not_active Abandoned
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8333325B2 (en) | 2002-08-20 | 2012-12-18 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
US8614852B2 (en) | 2002-08-20 | 2013-12-24 | Illumina, Inc. | Elongated microparticles having an optically detectable code configured to at least one of reflect or filter light |
US8049893B2 (en) | 2003-01-22 | 2011-11-01 | Illumina, Inc. | Methods of identifying analytes and using encoded particles |
US9268983B2 (en) | 2003-01-22 | 2016-02-23 | Illumina, Inc. | Optical system and method for reading encoded microbeads |
US8565475B2 (en) | 2003-08-20 | 2013-10-22 | Illumina, Inc. | Optical system and method for reading encoded microbeads |
US7830575B2 (en) | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
Also Published As
Publication number | Publication date |
---|---|
EP1575707A1 (en) | 2005-09-21 |
US20040132205A1 (en) | 2004-07-08 |
US7399643B2 (en) | 2008-07-15 |
AU2003267192A1 (en) | 2004-04-30 |
WO2004024328A1 (en) | 2004-03-25 |
CA2498933C (en) | 2012-08-28 |
CA2498933A1 (en) | 2004-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004024328B1 (en) | Method and apparatus for aligning elongated microbeads in order to interrogate the same | |
US9268983B2 (en) | Optical system and method for reading encoded microbeads | |
US7901630B2 (en) | Diffraction grating-based encoded microparticle assay stick | |
US7611836B2 (en) | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities | |
US20060160208A1 (en) | Multi-well plate with alignment grooves for encoded microparticles | |
CA2538801A1 (en) | Improved method and apparatus for aligning microbeads in order to interrogate the same | |
US7092160B2 (en) | Method of manufacturing of diffraction grating-based optical identification element | |
US7306827B2 (en) | Method and machine for replicating holographic gratings on a substrate | |
US7799558B1 (en) | Ligand binding assays on microarrays in closed multiwell plates | |
US20040126875A1 (en) | Assay stick | |
US7791802B2 (en) | Optical identification element having a non-waveguide substrate | |
US20040130761A1 (en) | Chemical synthesis using diffraction grating-based encoded optical elements | |
WO2005079544A3 (en) | Multi-well plate with alignment grooves for encoded microparticles | |
US20060286663A1 (en) | Method for producing a colorimetric resonant reflection biosensor on rigid surfaces | |
JP2005505441A (en) | Microfabricated lens, its manufacturing method and application | |
EP0660924A1 (en) | Optical biosensor matrix | |
WO2002046721A2 (en) | Optical discs for measuring analytes | |
US20050219539A1 (en) | Microchemical system | |
US7863037B1 (en) | Ligand binding assays on microarrays in closed multiwell plates | |
GB2427022A (en) | An encoded carrier for analysing a chemical species using surface plasmon resonance | |
CN113993455A (en) | Improvements in or relating to optical elements | |
EP1190235B1 (en) | Imaging assay analysis for microsamples | |
WO2023100203A1 (en) | Optical sensor, support for said optical sensor and detection system to detect the presence and/or concentration of an analyte in a solution | |
EP1540394B1 (en) | Method of manufacturing of a diffraction grating-based optical identification element |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
B | Later publication of amended claims |
Effective date: 20040329 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2498933 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003749663 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2003749663 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |