WO2004024155A1 - 貼付剤 - Google Patents
貼付剤 Download PDFInfo
- Publication number
- WO2004024155A1 WO2004024155A1 PCT/JP2003/011689 JP0311689W WO2004024155A1 WO 2004024155 A1 WO2004024155 A1 WO 2004024155A1 JP 0311689 W JP0311689 W JP 0311689W WO 2004024155 A1 WO2004024155 A1 WO 2004024155A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- patch
- polyisobutylene
- molecular weight
- mass
- patch according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Definitions
- the present invention relates to a patch which enables long-term administration of phenol for 2 days or more.
- a transdermal system is characterized in that an adhesive base containing a certain concentration of styrene-isoprene-styrene block copolymer (SIS) and polyisobutylene (PIB) is further incorporated with phenynil. It relates to an absorption patch. Height
- fenninyl patch As conventional fenninyl patches, there is a fenninyl patch of Lisa Barbe Eve (see, for example, Patent Document 1), and fenninyl using an ion beam containing a drug salt and an organic acid salt.
- a mixed adhesive base containing SIS and PIB is disclosed (for example, see Patent Documents 2 and 3).
- reservoir-type patches have the following problems: (1) Since the drug is encapsulated as a solution or semi-solid in the drug storage layer, a highly precise manufacturing process is required to prevent volatilization and leakage of the contents. It has the drawback that the manufacturing method must be complicated due to the requirement and the fact that a drug release rate controlling membrane is required in terms of structure, and the number of components constituting the formulation increases. ing.
- ion-pair type patches have the following disadvantages: 1 Since a large amount of organic acid must be added for stable ion-pair formation, there are many restrictions on the manufacturing process (crushing, mixing, film formation, and drying). Due to the complexity of the manufacturing method and the high drug release or absorbability, there is a drawback that the drug withdraws rapidly during drug application and is not suitable for long-term drug efficacy exceeding one day. ing.
- Patent Document 1
- Patent Document 2
- the present invention provides a simple production method, has a long-lasting property, and further has an adhesive property to the skin.
- the purpose of the present invention is to provide a transdermal patch for fenninyl which has excellent followability. Disclosure of the invention
- the present invention relates to a patch having a support and an adhesive layer on one surface of the support, wherein the adhesive layer comprises fensyl, an adhesive base, and a tackifying resin, which are active ingredients.
- the adhesive base comprises polyisobutylene and a styrene-isoprene-styrene block copolymer, and the blending amount of the polyisobutylene is 8 to 15% by mass, and the polyisobutylene and styrene-isoprene-styrene are included.
- the present invention also relates to the above patch, wherein the concentration of the phenyl group is 1 to 6% by mass.
- the present invention relates to the above-mentioned patch, wherein the polyisobutylene comprises a high molecular weight polyisobutylene and a low molecular weight polyisobutylene.
- the present invention also relates to the above patch, wherein the high molecular weight polyisobutylene has an average molecular weight of 900,000 to 2,500,000.
- the present invention relates to the above patch, wherein the average molecular weight of the low molecular weight polyisobutylene is from 30,000 to 65,000.
- the present invention also relates to the patch, wherein the tackifying resin is an aliphatic saturated hydrocarbon resin.
- the present invention relates to the above-mentioned patch, wherein the amount of the tackifying resin is from 40 to 50% by mass. Furthermore, the present invention relates to the above patch, further comprising a transdermal absorption enhancer in the adhesive layer.
- the present invention relates to the above patch, wherein the transdermal absorption enhancer is one or more selected from the group consisting of isopropyl myristate, isopropyl noremitate, sorbitan monooleate, and oleyl alcohol. .
- the present invention relates to the above patch, which has an area of 10 to 75 cm 2 when applied.
- the fenninyl transdermal patch of the present invention has an adhesive base on a support, and the adhesive base contains SIS and PIB at a specific concentration of approximately 1: 1. And a tackifying resin is further contained.
- This configuration allows for long-term administration of fenuxinil. That is, according to the patch of the present invention, the blood concentration of fensil can be maintained at 1 ng / ml or more even 48 to 72 hours after application (see the results of the blood kinetic test). ). In the patch of the present invention, since there is no cohesion of the adhesive and no plaster residue, the burden on the patient due to long-term administration can be reduced.
- the patch of the present invention does not require a drug-release-rate-controlling adhesive layer unlike a reservoir-type patch, and is less susceptible to ion-pair-type patches than the production process (mixing, film formation, drying). Since it can be easily set, it can be manufactured by a simpler manufacturing method than the conventional fenbuyl transdermal patch.
- FIG. 1 is a graph showing changes in the plasma concentration of phenylphenyl in female egrets when the patch of the present invention (Example 2) was applied.
- the pharmacologically active substance in the fenuxil transdermal patch of the present invention is fenquinol itself and does not include a salt thereof.
- the phenyl is contained in the adhesive layer.
- the amount of phenynil was 1 based on the weight of the entire adhesive layer of the patch of the present invention. It is preferred to blend in an amount of up to 5% by mass. By adjusting the blending amount to 1% by mass or more, it becomes easy to obtain a sufficient permeation amount as a transdermal patch, and by decreasing the amount to 6% by mass or less, the physical properties of the preparation itself due to crystallization are adversely affected. The effects can be reliably eliminated.
- the content of phenynil is 1 to 6% because a high blood concentration can be achieved. Further, when the amount of the phenyl compound is 1 to 4% by mass, it is preferable in terms of the physical properties of the preparation and adhesion, and particularly preferably 2 to 4% by mass.
- the pressure-sensitive adhesive layer of the patch of the present invention contains a pressure-sensitive adhesive base and a tackifying resin.
- the adhesive base is composed of PIB and SIS.
- the blending amount of PIB is 8 to 15% by mass, preferably 8 to 13% by mass, and more preferably 8 to 10% by mass.
- PIB When PIB contains high molecular weight PIB and low molecular weight PIB, it has a function as an adhesive and is suitable in terms of adhesive physical properties.
- the average molecular weight of the high molecular weight PIB is preferably from 900,000 to 2,500,000, more preferably from 900,000 to L, 250,000.
- the average molecular weight of the low molecular weight PIB is preferably 30,000 to 65,000, and more preferably 30,000 to 53,000.
- the adhesive base is mixed with SIB in addition to PIB, and their concentration ratio is 2: 3 to 3: 2, preferably 1: 1.
- concentration ratio is 2: 3 to 3: 2, preferably 1: 1.
- a resin system can be mentioned as a preferable example.
- Aliphatic saturated hydrocarbon resins are particularly preferred, and hydrogenated petroleum resins are even more preferred.
- An example of hydrogenated petroleum resin is Alcon P-100 (trade name: Arakawa Chemical).
- the concentration of the tackifier resin is preferably from 40 to 50% by mass, more preferably from 42 to 50% by mass, and even more preferably from 44.5 to 50% by mass of the whole adhesive layer.
- the concentration of the tackifier resin By setting the concentration of the tackifier resin to 50% by mass or less, it becomes easy to prevent the plaster from becoming too hard and reducing the adhesion to the skin. Further, when the content is 40% by mass or more, it becomes easy to obtain a sufficient adhesive force, which makes it suitable for long-term administration.
- the adhesive base of the patch of the present invention may contain a percutaneous absorption enhancer of fenninyl.
- the percutaneous absorption enhancer may be any compound as long as it is one or two or more compounds that have been confirmed to have a percutaneous absorption promoting effect of the drug. Examples thereof include fatty acids having 6 to 20 carbon atoms, and fatty acids. Aliphatic alcohols, fatty acid esters or ethers, aromatic organic acids, aromatic alcohols, aromatic organic acid esters or ethers.
- lactate esters acetate esters, monoterbene compounds, sesquiterpene compounds, azone (A zone) or derivatives thereof, glycerin fatty acid esters, sorbin fatty acid esters, polysorbate, polyethylene Glycol fatty acid esters, polyoxyethylene hardened castor oil type, sucrose fatty acid esters and the like can be mentioned.
- Preferred examples are caprylic acid, capric acid, caproic acid, lauric acid, myristic acid, normitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, lauryl alcohol, myristyl alcohol, oleyl alcohol, cetyl alcohol , Methyl laurate, isopropyl myristate, myristyl myristate, octyl dodecyl myristate, cetyl palmitate, salicylic acid, methyl salicylate, ethylene glycol salicylate, cinnamate, methyl cinnamate, cresol, cetyl lactate, acetic acid Ethyl, propyl acetate, isopropyl myristate, isopropylate palmitate, sorbitan monooleate, geraniol, thymol, eugenol, terbineol, 1-menthol, borneoyl
- the absorption enhancer is incorporated in an amount of 0.01 to 20% by mass, more preferably 0.1 to 10% by mass, especially 0.5 to 3% by mass, based on the weight of the whole adhesive layer of the preparation of the present invention. Preferably. By reducing the content of the absorption enhancer to 20% by mass or less, it is possible to prevent irritation to the skin such as redness and edema. Is obtained. '.
- a hydrophilic polymer can be blended as necessary to absorb aqueous components such as sweat generated from the skin.
- the hydrophilic polymer include light caustic anhydride, cellulose derivatives (carboxymethylcellulose (CMC), sodium carboxymethylcellulose (CMCNa), methylcellulose (MC;), hydroxypropylmethylcellulol (HPMC;), and hydroxypropylcellulose.
- HPC hydroxyethyl cellulose
- HEC hydroxyethyl cellulose
- starch derivatives pullulane
- polyvinyl alcohol PV A
- polyvinyl pyrrolidone PVP
- vinyl acetate VA
- carboxyvinyl polymer CVP
- Ethyl vinyl acetate EVA
- Eudragit Gelatin, Polyacrylic acid, Polyacrylic acid soda, Polyisobutylene maleic anhydride copolymer, Alginic acid, Sodium alginate, Carrageenan, Arabic gum, Tragant, Karaja gum, Polyvinyl meta Preference is given to acrylates, and particularly preferred are light anhydrous silicic acid and cellulose derivatives (CMCNa, HPMC, HPC, MC).
- CMCNa light anhydrous silicic acid and cellulose derivatives
- CMCNa light anhydrous silicic acid and cellulose derivatives
- the adhesive layer of the patch of the present invention may optionally contain other components such as a crosslinking agent, a preservative, and an antioxidant.
- Crosslinking agents include thermosetting of amino resin, phenol resin, epoxy resin, alkyd resin, unsaturated polyester, etc.
- Preferred are an inorganic resin, an isocyanate compound, a block isocyanate compound, an organic crosslinking agent, and an inorganic crosslinking agent such as a metal or a metal compound.
- the pressure-sensitive adhesive layer of the patch of the present invention is preferably composed of a non-aqueous base. By using a non-aqueous base, the effects of the present invention can be more effectively obtained.
- a fat or oil may be added to the adhesive layer as a softener.
- the fats and oils for example, liquid paraffin, squalane, olive oil, tobacco oil, basic oil, laccase oil and the like are preferable, and liquid paraffin is particularly preferable.
- the fats and oils may be blended in an amount of 1 to 70% by mass, more preferably 10 to 60% by mass, especially 20 to 50% by mass, based on the weight of the whole adhesive layer of the preparation of the present invention. preferable.
- the adhesive layer of the patch of the present invention can be produced by any conventional method.
- the present formulation can be obtained by adding other components to an organic solvent solution of the polymer to be blended, stirring, spreading on a support, and drying. If the polymer to be compounded can be applied by the hot melt method, dissolve the polymer component at a high temperature, then add other components, stir, and spread on the support. This formulation can be obtained.
- the other layers and components constituting them are not particularly limited as long as the pressure-sensitive adhesive layer is composed of the above composition and has a support for supporting the adhesive layer. It may be composed of any layer.
- the patch of the present invention can include, in addition to the support and the adhesive layer, a release liner provided on the adhesive layer.
- the support may be, for example, cloth, nonwoven fabric, polyurethane, polyester, polyvinyl acetate, polyvinylidene chloride, polyethylene, polyethylene terephthalate, polybutylene terephthalate, paper, aluminum sheet, or a composite thereof. Can be made of materials.
- fenninyl is absorbed through the skin for a longer period of time than conventional transdermal preparations, so that it is difficult for patients who have difficulty in oral administration of narcotic analgesics. It will be a more effective means of pain relief.
- the continuous subcutaneous administration method which is an invasive administration method, it is of course possible to administer non-invasively and to reduce the burden on the patient.
- the dosage can also be easily adjusted according to the patient's condition, age, weight, sex, etc., by cutting the preparation.
- the area of the patch of the present invention at the time of application is not particularly limited, but is preferably 10 to 60 cm 2 , more preferably 15 to 55 cm 2 , and still more preferably 20 to 5 ° cm ” 2 . By setting the content to 2 or less, the handling at the time of application becomes preferable, and by setting the content to 10 cm 2 or more, it becomes easy to maintain a sufficient blood concentration of the active ingredient. )
- liquid paraffin and fenninyl were stirred at room temperature, a toluene solution of the base was added and stirred, spread on a PET film, dried at 110 ° C for 15 minutes, and a 50-zm adhesive layer was formed.
- the patch of the present invention was obtained by a conventional method.
- Examples 2 to 4 and Comparative Examples 1 to 4 PIB, SIS and A patch was prepared in the same manner as in Example 1, except that the content of benzoyl was as shown below and in Table 1, and the contents of the other components were adjusted accordingly.
- the flux, adhesive strength, holding power (cohesion), adhesiveness (softness of the preparation, using placebo), and plaster residue (using placebo) of each of the above preparations were evaluated by the following methods.
- changes in the blood concentration of fenbutyryl at the time of application of the patch obtained in Example 2 were evaluated using a heron.
- the skin on the back of the hairless mouse was peeled off, and the dermis side was used as the receptor side layer, and attached to a flow-through cell in which warm water at 37 ° C was circulated around the outer periphery.
- a patch (preparation area of 5 cm 2 ) was applied to the stratum corneum side of the skin, and saline was used as the receiving layer at 5 m 1 / hr every 2 hours for 24 hours.
- One solution was sampled, its flow rate was measured, and the drug concentration was measured using high performance liquid chromatography.
- the drug permeation rate per hour was calculated from the obtained measured values, and the drug permeation rate per unit area of the skin in a steady state was obtained.
- Table 1 shows the maximum value of the drug permeation rate (maximum skin permeation rate) obtained during the 24 hours from the start of the test.
- the tape preparation obtained in Example 2 was cut so as to have a size of 14 cm 2, and a blood kinetics test was performed on a heron as follows. That is, one of the above-mentioned preparations was applied to five Japanese white ⁇ herons (18 weeks old, female, about 3 kg in weight) with their backs shaved, and peeled off after 72 hours. Blood is collected from the auricular vein 1, 2, 4, 8, 12, 24, 48, 72, 74, 76, and 80 hours after application of the drug product, and the plasma concentration of phenynil in the obtained plasma is determined by LC / MS / MS. Quantified by the method. Fig. 1 shows the measured time course of the plasma phenyl concentration as a mean value SD.
- the patch of the present invention was good in all of adhesive strength, holding power, adhesiveness, and plaster residue.
- Comparative Examples 1 and 3 were poor in adhesive strength and adhesion.
- Comparative Example 4 had drawbacks in holding power and plaster residue, and Comparative Example 2 also had poor adhesion.
- PIB 8 10 13 10 0 20 7 13 Alcon (P-100) 44.5 46.5 50.0 46.0 46.5 46.5 46.5 46.5 Liquid paraffin 36.7 30.7 21.2 29.2 30.7 30.7 30.7 30.7 Fentanyl
- the holding power and the plaster residue are comparisons between placebos that do not contain phenynil.
- the effect of phenynil on these physical properties is small, it is considered that the patch of the present invention containing fenynil has good adhesiveness and plaster residue.
- the patch of the present invention is an index of skin permeability: elux also showed a sufficient value (Table 1).
- the patch of the present invention not only imparts sufficient skin permeability of fenuxinil, but also excels in adhesive strength, holding power, adhesiveness, and plaster residue. .
- the plasma concentration of fenninyl in the egret plasma reached a steady state approximately 8 hours after application, and was maintained at 1 ngZml or more until 72 hours after application (FIG. 1). .
- the manufacturing method is simple, it has a long-lasting property, and furthermore, it is excellent in the adhesiveness to skin and the follow-up property, and it provides the transdermal patch for fenfurnyl.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003272878A AU2003272878A1 (en) | 2002-09-13 | 2003-09-12 | Adhesive patch |
JP2004535959A JP4758101B2 (ja) | 2002-09-13 | 2003-09-12 | 貼付剤 |
US10/527,710 US7785622B2 (en) | 2002-09-13 | 2003-09-12 | Adhesive patch for fentanyl administration |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002268392 | 2002-09-13 | ||
JP2002-268392 | 2002-09-13 |
Publications (1)
Publication Number | Publication Date |
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WO2004024155A1 true WO2004024155A1 (ja) | 2004-03-25 |
Family
ID=31986760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/011689 WO2004024155A1 (ja) | 2002-09-13 | 2003-09-12 | 貼付剤 |
Country Status (4)
Country | Link |
---|---|
US (1) | US7785622B2 (ja) |
JP (1) | JP4758101B2 (ja) |
AU (1) | AU2003272878A1 (ja) |
WO (1) | WO2004024155A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007008927A (ja) * | 2005-06-01 | 2007-01-18 | Saitama Daiichi Seiyaku Kk | 貼付剤 |
JP2008061862A (ja) * | 2006-09-08 | 2008-03-21 | Hisamitsu Pharmaceut Co Inc | 貼付剤製品 |
JP2008273865A (ja) * | 2007-04-27 | 2008-11-13 | Yuutoku Yakuhin Kogyo Kk | 外用貼付剤 |
WO2009096354A1 (ja) | 2008-01-28 | 2009-08-06 | Teikoku Seiyaku Co., Ltd. | フェンタニル含有外用貼付剤 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4758101B2 (ja) * | 2002-09-13 | 2011-08-24 | 久光製薬株式会社 | 貼付剤 |
EP2111857A1 (de) | 2008-04-25 | 2009-10-28 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff hiervon |
EP2295046B1 (de) | 2009-09-14 | 2012-12-19 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon |
EP2462927A1 (en) * | 2010-12-03 | 2012-06-13 | Hexal AG | Transdermal therapeutic system comprising fentanyl |
WO2012142452A2 (en) | 2011-04-13 | 2012-10-18 | Biosafe Technologies, Inc. | Cleaning, insecticide, insect repellant, glue solvent and anti-irritation composition |
EP2599478A1 (de) | 2011-11-30 | 2013-06-05 | Acino AG | Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon |
ES2738303T5 (es) * | 2012-06-20 | 2022-09-12 | Medrx Co Ltd | Composición de preparación adhesiva obtenida mezclando un fármaco, un disolvente orgánico, una base de pomada lipófila y un polvo |
WO2019079291A1 (en) | 2017-10-17 | 2019-04-25 | Lubrizol Advanced Materials, Inc. | COMPOSITION AND DEVICE FOR ADMINISTERING ACTIVE AGENTS ON SKIN SURFACES |
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WO1997042952A1 (fr) * | 1996-05-13 | 1997-11-20 | Hisamitsu Pharmaceutical Co., Inc. | Preparation en ruban percutanee contenant du fentanyl |
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2003
- 2003-09-12 JP JP2004535959A patent/JP4758101B2/ja not_active Expired - Lifetime
- 2003-09-12 AU AU2003272878A patent/AU2003272878A1/en not_active Abandoned
- 2003-09-12 US US10/527,710 patent/US7785622B2/en active Active
- 2003-09-12 WO PCT/JP2003/011689 patent/WO2004024155A1/ja active Application Filing
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JPS53117034A (en) * | 1977-03-22 | 1978-10-13 | Kuraray Co Ltd | Adhesive mass composition |
WO1997042952A1 (fr) * | 1996-05-13 | 1997-11-20 | Hisamitsu Pharmaceutical Co., Inc. | Preparation en ruban percutanee contenant du fentanyl |
JPH09315957A (ja) * | 1996-05-28 | 1997-12-09 | Hisamitsu Pharmaceut Co Inc | 経皮治療用装置 |
JPH11152222A (ja) * | 1997-11-19 | 1999-06-08 | Nichiban Co Ltd | 皮膚貼付用粘着剤組成物 |
WO2000025792A1 (fr) * | 1998-10-29 | 2000-05-11 | Hisamitsu Pharmaceutical Co., Inc. | Preparation adhesive contenant de l'oestradiol |
WO2001043729A1 (fr) * | 1999-12-15 | 2001-06-21 | Hisamitsu Pharmaceutical Co., Inc. | Preparations d'adhesifs |
WO2001078690A1 (fr) * | 2000-04-18 | 2001-10-25 | Hisamitsu Pharmaceutical Co., Inc. | Piece contenant un agent anti-inflammatoire |
WO2002069942A1 (fr) * | 2001-03-07 | 2002-09-12 | Hisamitsu Pharmaceutical Co., Inc. | Timbre adhesif |
JP2003137773A (ja) * | 2001-10-31 | 2003-05-14 | Hisamitsu Pharmaceut Co Inc | 積層支持体を有する貼付剤 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2007008927A (ja) * | 2005-06-01 | 2007-01-18 | Saitama Daiichi Seiyaku Kk | 貼付剤 |
JP2008061862A (ja) * | 2006-09-08 | 2008-03-21 | Hisamitsu Pharmaceut Co Inc | 貼付剤製品 |
JP2008273865A (ja) * | 2007-04-27 | 2008-11-13 | Yuutoku Yakuhin Kogyo Kk | 外用貼付剤 |
WO2009096354A1 (ja) | 2008-01-28 | 2009-08-06 | Teikoku Seiyaku Co., Ltd. | フェンタニル含有外用貼付剤 |
JPWO2009096354A1 (ja) * | 2008-01-28 | 2011-05-26 | 帝國製薬株式会社 | フェンタニル含有外用貼付剤 |
JP5431969B2 (ja) * | 2008-01-28 | 2014-03-05 | 帝國製薬株式会社 | フェンタニル含有外用貼付剤 |
US9517211B2 (en) | 2008-01-28 | 2016-12-13 | Teikoku Seiyaku Co., Ltd. | Fentanyl-containing patch for external use |
US10376474B2 (en) | 2008-01-28 | 2019-08-13 | Teikoku Seiyaku Co., Ltd. | Fentanyl-containing patch for external use |
Also Published As
Publication number | Publication date |
---|---|
US20070009588A1 (en) | 2007-01-11 |
JPWO2004024155A1 (ja) | 2006-01-05 |
JP4758101B2 (ja) | 2011-08-24 |
AU2003272878A1 (en) | 2004-04-30 |
US7785622B2 (en) | 2010-08-31 |
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