WO2004023104A3 - Coated capillary electrophoresis tubes and system - Google Patents

Coated capillary electrophoresis tubes and system Download PDF

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Publication number
WO2004023104A3
WO2004023104A3 PCT/US2003/028761 US0328761W WO2004023104A3 WO 2004023104 A3 WO2004023104 A3 WO 2004023104A3 US 0328761 W US0328761 W US 0328761W WO 2004023104 A3 WO2004023104 A3 WO 2004023104A3
Authority
WO
WIPO (PCT)
Prior art keywords
capillary
coated
tubes
polymer layer
coated capillary
Prior art date
Application number
PCT/US2003/028761
Other languages
French (fr)
Other versions
WO2004023104A2 (en
Inventor
Chitra K Ratnayake
Isabel C Flores
Original Assignee
Beckman Coulter Inc
Chitra K Ratnayake
Isabel C Flores
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc, Chitra K Ratnayake, Isabel C Flores filed Critical Beckman Coulter Inc
Priority to DE60331556T priority Critical patent/DE60331556D1/en
Priority to EP03794672A priority patent/EP1540325B1/en
Priority to JP2004534830A priority patent/JP4550575B2/en
Priority to AU2003298957A priority patent/AU2003298957A1/en
Priority to CA002498001A priority patent/CA2498001C/en
Publication of WO2004023104A2 publication Critical patent/WO2004023104A2/en
Publication of WO2004023104A3 publication Critical patent/WO2004023104A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44752—Controlling the zeta potential, e.g. by wall coatings

Abstract

The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to the inner capillary surface. The capillary tube has an inner surface that is coated with a first polymer layer having a plurality of polymer groups comprising polyethylene imine, designated herein as (CH2CH2NH)x . The inner surface of the capillary typically has a second polymer layer covalently bonded to the first polymer layer. The invention includes a capillary tube where two or more than two polymer groups are covalently bonded to each other by a cross-linker. Also provided are an electrophoresis system the uses the coated capillary tubes, a method of performing electrophoresis that utilizes the coated capillary tubes, and a process for preparing the coated capillary tubes.
PCT/US2003/028761 2002-09-09 2003-09-09 Coated capillary electrophoresis tubes and system WO2004023104A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60331556T DE60331556D1 (en) 2002-09-09 2003-09-09 COATED CAPILLAR ELECTROPHORESEE AND SYSTEM
EP03794672A EP1540325B1 (en) 2002-09-09 2003-09-09 Coated capillary electrophoresis tubes and system
JP2004534830A JP4550575B2 (en) 2002-09-09 2003-09-09 Coated capillary electrophoresis tubes and systems
AU2003298957A AU2003298957A1 (en) 2002-09-09 2003-09-09 Coated capillary electrophoresis tubes and system
CA002498001A CA2498001C (en) 2002-09-09 2003-09-09 Coated capillary electrophoresis tubes and system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/238,703 2002-09-09
US10/238,703 US6923895B2 (en) 2002-09-09 2002-09-09 Coated capillary electrophoresis tubes and system

Publications (2)

Publication Number Publication Date
WO2004023104A2 WO2004023104A2 (en) 2004-03-18
WO2004023104A3 true WO2004023104A3 (en) 2004-06-10

Family

ID=31977747

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/028761 WO2004023104A2 (en) 2002-09-09 2003-09-09 Coated capillary electrophoresis tubes and system

Country Status (7)

Country Link
US (3) US6923895B2 (en)
EP (2) EP1540325B1 (en)
JP (1) JP4550575B2 (en)
AU (1) AU2003298957A1 (en)
CA (1) CA2498001C (en)
DE (1) DE60331556D1 (en)
WO (1) WO2004023104A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8663973B2 (en) * 2004-07-26 2014-03-04 Tufts University Controlled alteration of pores using fluid flow and fabrication of articles thereby
US8425861B2 (en) 2007-04-04 2013-04-23 Netbio, Inc. Methods for rapid multiplexed amplification of target nucleic acids
CA2874870C (en) 2012-07-16 2020-07-07 Sharath Chandra MAHAVADI Capillary electrophoresis for reservoir fluid analysis at wellsite and laboratory
US10018590B2 (en) 2013-08-15 2018-07-10 Schlumberger Technology Corporation Capillary electrophoresis for subterranean applications
JP2018500153A (en) * 2014-10-30 2018-01-11 ベックマン コールター， インコーポレイテッド Compositions and methods for coating surfaces
CN108604526B (en) 2015-12-31 2021-07-20 圣母大学 ESI-MS via electrokinetic pump drive interface
JP7209693B2 (en) * 2017-04-24 2023-01-20 ユニバーシティ・オブ・ノートル・ダム・デュ・ラック Tunable electroosmotic polymer-coated capillaries

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US20020034580A1 (en) * 1999-03-08 2002-03-21 Caliper Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety

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Publication number Priority date Publication date Assignee Title
US4551245A (en) * 1985-04-22 1985-11-05 J. T. Baker Chemical Co. Acylated polyethylenimine bound chromatographic packing
US20020034580A1 (en) * 1999-03-08 2002-03-21 Caliper Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FIGEYS D. ET AL.: "Capillary electrophoresis of peptides and proteins at neutral pH in capillaries covalently coated with polyethyleneimine", JOURNAL OF CHROMATOGRAPHY, vol. 695, 1997, pages 163 - 168, XP004125693 *
See also references of EP1540325A4 *
TOWNS J.K. ET AL.: "Polyethyleneimine-bonded phases in the separation of proteins by capillary electrophoresis", JOURNAL OF CHROMATOGRAPHY, vol. 516, 1990, pages 69 - 78, XP000938667 *

Also Published As

Publication number Publication date
AU2003298957A1 (en) 2004-03-29
EP1540325A2 (en) 2005-06-15
US6923895B2 (en) 2005-08-02
EP2161570A1 (en) 2010-03-10
DE60331556D1 (en) 2010-04-15
US20050224356A1 (en) 2005-10-13
CA2498001A1 (en) 2004-03-18
US20110064869A1 (en) 2011-03-17
JP2005538363A (en) 2005-12-15
CA2498001C (en) 2009-11-24
US7857955B2 (en) 2010-12-28
JP4550575B2 (en) 2010-09-22
WO2004023104A2 (en) 2004-03-18
AU2003298957A8 (en) 2004-03-29
EP1540325B1 (en) 2010-03-03
EP1540325A4 (en) 2007-09-26
US20040045828A1 (en) 2004-03-11

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