WO2004021983A3 - In situ polymerizing medical compositions - Google Patents

In situ polymerizing medical compositions Download PDF

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Publication number
WO2004021983A3
WO2004021983A3 PCT/US2003/027255 US0327255W WO2004021983A3 WO 2004021983 A3 WO2004021983 A3 WO 2004021983A3 US 0327255 W US0327255 W US 0327255W WO 2004021983 A3 WO2004021983 A3 WO 2004021983A3
Authority
WO
WIPO (PCT)
Prior art keywords
formation
tissue
crosslinking
medical compositions
situ polymerizing
Prior art date
Application number
PCT/US2003/027255
Other languages
French (fr)
Other versions
WO2004021983A2 (en
Inventor
Michael T Milbocker
Original Assignee
Promethean Surgical Devices Ll
Michael T Milbocker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promethean Surgical Devices Ll, Michael T Milbocker filed Critical Promethean Surgical Devices Ll
Priority to AU2003268318A priority Critical patent/AU2003268318A1/en
Publication of WO2004021983A2 publication Critical patent/WO2004021983A2/en
Publication of WO2004021983A3 publication Critical patent/WO2004021983A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/428—Lactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C08G18/12—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/4009—Two or more macromolecular compounds not provided for in one single group of groups C08G18/42 - C08G18/64
    • C08G18/4018—Mixtures of compounds of group C08G18/42 with compounds of group C08G18/48
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4887—Polyethers containing carboxylic ester groups derived from carboxylic acids other than acids of higher fatty oils or other than resin acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666—Compounds of group C08G18/48 or C08G18/52
    • C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6674—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
    • C08G18/6677—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203 having at least three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00—Compositions for preparing biodegradable polymers

Abstract

Isocyanate-capped biocompatible and optionally biodegradable polymers provide a liquid polymer composition, which can be implanted into a living mammal and which forms an adhesive, a coating, or a solid implant by in situ polymerization and crosslinking upon contact with body fluid or tissue. Formation of the polymerized material typically also involves crosslinking with surrounding tissue and formation of a tissue bond. Methods of using the novel liquid polymers of the invention in mammals are disclosed for providing wound sealing and bonding, formation of a protective barrier to prevent post-surgical adhesions, formation of tissue implants, and release of biologically active agents.
PCT/US2003/027255 2002-09-03 2003-09-03 In situ polymerizing medical compositions WO2004021983A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003268318A AU2003268318A1 (en) 2002-09-03 2003-09-03 In situ polymerizing medical compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40761302P 2002-09-03 2002-09-03
US60/407,613 2002-09-03

Publications (2)

Publication Number Publication Date
WO2004021983A2 WO2004021983A2 (en) 2004-03-18
WO2004021983A3 true WO2004021983A3 (en) 2004-07-08

Family

ID=31978504

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/027255 WO2004021983A2 (en) 2002-09-03 2003-09-03 In situ polymerizing medical compositions

Country Status (2)

Country Link
AU (1) AU2003268318A1 (en)
WO (1) WO2004021983A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006004854A1 (en) * 2004-06-30 2006-01-12 Tyco Healthcare Group Lp Isocyanate-based compositions and their use
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
WO2009036083A2 (en) * 2007-09-12 2009-03-19 Curexo Usa, Inc. Polymer compositions for controllable drug delivery
EP2095832A1 (en) 2008-02-28 2009-09-02 Bayer MaterialScience AG Post-operative adhesion barriers
WO2011140517A2 (en) 2010-05-07 2011-11-10 Medicus Biosciences, Llc Methods for treating diseases of the lung
US11083821B2 (en) 2011-08-10 2021-08-10 C.P. Medical Corporation Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules
US10111985B2 (en) 2011-08-10 2018-10-30 Medicus Biosciences, Llc Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules
EP2612846A1 (en) 2012-01-09 2013-07-10 Bayer MaterialScience AG Beta amino acid esters and use of same
EP2846847B1 (en) 2012-05-11 2020-03-25 C.P. Medical Corporation Biocompatible hydrogel treatments for retinal detachment
CA2903829C (en) 2013-03-14 2021-09-07 Medicus Biosciences Llc Biocompatible hydrogel polymer matrix for delivery of cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3898197A (en) * 1972-02-18 1975-08-05 Commw Scient Ind Res Org Blocked polyisocyanate composition for the treatment of keratinous materials
US4132839A (en) * 1976-10-12 1979-01-02 W. R. Grace & Co. Biodegradable hydrophilic foams and method
US4829099A (en) * 1987-07-17 1989-05-09 Bioresearch, Inc. Metabolically acceptable polyisocyanate adhesives
US5430072A (en) * 1990-02-01 1995-07-04 Imperial Chemical Industries Plc Manufacture of polymeric foams

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3898197A (en) * 1972-02-18 1975-08-05 Commw Scient Ind Res Org Blocked polyisocyanate composition for the treatment of keratinous materials
US4132839A (en) * 1976-10-12 1979-01-02 W. R. Grace & Co. Biodegradable hydrophilic foams and method
US4829099A (en) * 1987-07-17 1989-05-09 Bioresearch, Inc. Metabolically acceptable polyisocyanate adhesives
US5430072A (en) * 1990-02-01 1995-07-04 Imperial Chemical Industries Plc Manufacture of polymeric foams

Also Published As

Publication number Publication date
WO2004021983A2 (en) 2004-03-18
AU2003268318A1 (en) 2004-03-29
AU2003268318A8 (en) 2004-03-29

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